Details for: OR11A1

Gene ID: 26531

Symbol: OR11A1

Ensembl ID: ENSG00000204694

Description: olfactory receptor family 11 subfamily A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2344
    Cell Significance Index: 29.9000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5725
    Cell Significance Index: 8.3500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4031
    Cell Significance Index: 5.2900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.4009
    Cell Significance Index: 12.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1274
    Cell Significance Index: 1.8300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0687
    Cell Significance Index: 0.6800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0625
    Cell Significance Index: 0.3300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0568
    Cell Significance Index: 1.4200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0455
    Cell Significance Index: 0.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0379
    Cell Significance Index: 0.8300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0270
    Cell Significance Index: 0.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0184
    Cell Significance Index: 0.3200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0124
    Cell Significance Index: 0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0084
    Cell Significance Index: 1.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0073
    Cell Significance Index: 1.4700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0045
    Cell Significance Index: 0.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0044
    Cell Significance Index: 0.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0042
    Cell Significance Index: 1.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0007
    Cell Significance Index: 0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0004
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0025
    Cell Significance Index: -0.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0028
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0030
    Cell Significance Index: -0.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0034
    Cell Significance Index: -0.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0036
    Cell Significance Index: -0.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0040
    Cell Significance Index: -0.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0042
    Cell Significance Index: -0.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0043
    Cell Significance Index: -0.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0054
    Cell Significance Index: -0.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0055
    Cell Significance Index: -0.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0064
    Cell Significance Index: -0.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0067
    Cell Significance Index: -0.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0081
    Cell Significance Index: -0.1600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0098
    Cell Significance Index: -0.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0104
    Cell Significance Index: -0.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0104
    Cell Significance Index: -0.4300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0105
    Cell Significance Index: -0.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0106
    Cell Significance Index: -0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0108
    Cell Significance Index: -0.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0131
    Cell Significance Index: -0.3200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0133
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0143
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0146
    Cell Significance Index: -0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0146
    Cell Significance Index: -0.4100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0147
    Cell Significance Index: -0.0900
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0155
    Cell Significance Index: -0.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0161
    Cell Significance Index: -0.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0164
    Cell Significance Index: -0.3200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0164
    Cell Significance Index: -0.2400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0168
    Cell Significance Index: -0.1600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0171
    Cell Significance Index: -0.2600
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0171
    Cell Significance Index: -0.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0178
    Cell Significance Index: -0.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0183
    Cell Significance Index: -0.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0183
    Cell Significance Index: -0.2700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0189
    Cell Significance Index: -0.2600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0190
    Cell Significance Index: -0.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0191
    Cell Significance Index: -0.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0204
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0209
    Cell Significance Index: -0.3000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0210
    Cell Significance Index: -0.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0216
    Cell Significance Index: -0.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0221
    Cell Significance Index: -0.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0225
    Cell Significance Index: -0.3000
  • Cell Name: immature astrocyte (CL0002626)
    Fold Change: -0.0230
    Cell Significance Index: -0.2400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0234
    Cell Significance Index: -0.3000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0237
    Cell Significance Index: -0.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0238
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0240
    Cell Significance Index: -0.4100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0242
    Cell Significance Index: -0.3900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0243
    Cell Significance Index: -0.2200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0248
    Cell Significance Index: -0.3300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0250
    Cell Significance Index: -0.3600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0258
    Cell Significance Index: -0.2700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0258
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0262
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0263
    Cell Significance Index: -0.3600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0266
    Cell Significance Index: -0.2600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0270
    Cell Significance Index: -0.3600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0272
    Cell Significance Index: -0.3400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0284
    Cell Significance Index: -0.3600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0288
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0289
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR11A1 is a G protein-coupled receptor that binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Widespread Expression:** OR11A1 is expressed in various cell types, including T cells, plasma cells, B cells, goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, abnormal cells, neoplastic cells, and mast cells. 3. **Cellular Localization:** OR11A1 is primarily localized to the plasma membrane, where it can interact with odorant molecules and initiate signaling pathways. 4. **Pathway Involvement:** OR11A1 is involved in multiple signaling pathways, including G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, and olfactory receptor activity. **Pathways and Functions:** 1. **Olfactory Signaling Pathway:** OR11A1 plays a crucial role in the detection of chemical stimuli, leading to the activation of olfactory receptors and the subsequent perception of smell. 2. **G Protein-Coupled Receptor Activity:** OR11A1 is a G protein-coupled receptor that binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 3. **G Protein-Coupled Receptor Signaling Pathway:** OR11A1 is involved in the G protein-coupled receptor signaling pathway, which regulates various cellular processes, including cell proliferation, differentiation, and survival. 4. **Immune System Function:** OR11A1 is expressed in immune cells, including T cells, plasma cells, and B cells, suggesting its involvement in immune system function and regulation. **Clinical Significance:** 1. **Dysregulation in Cancer:** OR11A1 has been implicated in various cancers, including colorectal, breast, and lung cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Autoimmune Disorders:** OR11A1 has been linked to autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, highlighting its potential role in immune system regulation. 3. **Neurological Disorders:** OR11A1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegenerative processes. 4. **Olfactory System Disorders:** OR11A1 is involved in the detection of chemical stimuli, making it a critical component of the olfactory system. Dysregulation of OR11A1 has been implicated in olfactory system disorders, such as anosmia and hyposmia. In conclusion, OR11A1 is a multifunctional gene that plays a critical role in both olfactory and non-olfactory processes. Its widespread expression and involvement in various signaling pathways make it a key player in immune system function, cancer development, autoimmune disorders, and neurological disorders. Further research is necessary to fully elucidate the functional significance of OR11A1 and its potential applications in human disease.

Genular Protein ID: 835343068

Symbol: O11A1_HUMAN

Name: Olfactory receptor 11A1

UniProtKB Accession Codes:

Q9GZK7 A2BF33 A6NFQ3 B0S7T2 Q5ST16 Q9GZK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 Ensembl 24 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12637542

Title: Complex transcription and splicing of odorant receptor genes.

PubMed ID: 12637542

DOI: 10.1074/jbc.m212424200

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 315
  • Mass: 35250
  • Checksum: 0448A2166A301387
  • Sequence:
    • MEIVSTGNET ITEFVLLGFY DIPELHFLFF IVFTAVYVFI IIGNMLIIVA VVSSQRLHKP 
MYIFLANLSF LDILYTSAVM PKMLEGFLQE ATISVAGCLL QFFIFGSLAT AECLLLAVMA 
YDRYLAICYP LHYPLLMGPR RYMGLVVTTW LSGFVVDGLV VALVAQLRFC GPNHIDQFYC 
DFMLFVGLAC SDPRVAQVTT LILSVFCLTI PFGLILTSYA RIVVAVLRVP AGASRRRAFS 
TCSSHLAVVT TFYGTLMIFY VAPSAVHSQL LSKVFSLLYT VVTPLFNPVI YTMRNKEVHQ 
ALRKILCIKQ TETLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.