Details for: GFI1

Gene ID: 2672

Symbol: GFI1

Ensembl ID: ENSG00000162676

Description: growth factor independent 1 transcriptional repressor

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Transcriptional regulation of granulopoiesis
    (R-HSA-9616222)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of calcidiol 1-monooxygenase activity
    (GO:0010956)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of neuron projection development
    (GO:0010977)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of vitamin d biosynthetic process
    (GO:0010957)
  • Nuclear body
    (GO:0016604)
  • Nuclear matrix
    (GO:0016363)
  • Nucleus
    (GO:0005634)
  • Positive regulation of interleukin-6-mediated signaling pathway
    (GO:0070105)
  • Protein binding
    (GO:0005515)
  • Regulation of toll-like receptor signaling pathway
    (GO:0034121)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription repressor complex
    (GO:0017053)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 481
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7557
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 585
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1833
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.94
    Marker Score: 549
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5319
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.93
    Marker Score: 1888
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.74
    Marker Score: 1539
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 289
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2979
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9936
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.51
    Marker Score: 270
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.49
    Marker Score: 286
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.47
    Marker Score: 273
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.46
    Marker Score: 965.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.45
    Marker Score: 468
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.44
    Marker Score: 244
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.42
    Marker Score: 1187
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.41
    Marker Score: 128
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.4
    Marker Score: 445
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.36
    Marker Score: 156
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.36
    Marker Score: 3578
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 358
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.34
    Marker Score: 78
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.34
    Marker Score: 349
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.34
    Marker Score: 247
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.32
    Marker Score: 892
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.32
    Marker Score: 274
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.32
    Marker Score: 70
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.31
    Marker Score: 918
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.31
    Marker Score: 274
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 185
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 138
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.29
    Marker Score: 219
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.28
    Marker Score: 238
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.27
    Marker Score: 140
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.26
    Marker Score: 129
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.25
    Marker Score: 242
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.24
    Marker Score: 177
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.24
    Marker Score: 751
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.23
    Marker Score: 167
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.23
    Marker Score: 159
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.23
    Marker Score: 177
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.22
    Marker Score: 325
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.22
    Marker Score: 281
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.21
    Marker Score: 136
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.21
    Marker Score: 200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2
    Marker Score: 2063
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2
    Marker Score: 132
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.2
    Marker Score: 217
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.2
    Marker Score: 174
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.19
    Marker Score: 787
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.19
    Marker Score: 311
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.19
    Marker Score: 425
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.19
    Marker Score: 57
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.19
    Marker Score: 506
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.18
    Marker Score: 60
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.18
    Marker Score: 235
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.17
    Marker Score: 234
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.16
    Marker Score: 75
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.16
    Marker Score: 37
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.16
    Marker Score: 69
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.16
    Marker Score: 103
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.15
    Marker Score: 213
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.15
    Marker Score: 56
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.15
    Marker Score: 103
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 166
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.15
    Marker Score: 98
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.14
    Marker Score: 921

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Other Information

**Key characteristics:** - GFI1 is a protein that belongs to the GFI family of transcription factors. - It is a repressor, which means that it suppresses the expression of other genes. - GFI1 is expressed in a variety of cell types, including intestinal stem cells, transit amplifying cells, goblet cells, and cancer cells. - It is a key regulator of intestinal stem cell fate and development. **Pathways and functions:** - GFI1 negatively regulates the expression of genes involved in cell cycle regulation, proliferation, and differentiation. - It is also involved in the regulation of apoptosis. - In the context of cancer, GFI1 is often overexpressed and can promote tumor growth and metastasis. - It is a key regulator of intestinal stem cell fate and development. **Clinical significance:** - GFI1 is a potential target for cancer therapy. - Inhibition of GFI1 has been shown to inhibit tumor growth and metastasis in animal models of cancer. - GFI1 is a promising target for the treatment of cancer. **Additional information:** - GFI1 was discovered in 1990 in a screen for genes that are expressed in the developing intestine. - It is a highly conserved protein, with similar sequences found in organisms from worms to humans. - GFI1 is a member of the zinc finger family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression.

Genular Protein ID: 1957125953

Symbol: GFI1_HUMAN

Name: Zinc finger protein Gfi-1

UniProtKB Accession Codes:

Q99684 Q8N564

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 3 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9051000

Title: Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22.

PubMed ID: 9051000

DOI: 10.1038/sj.onc.1200910

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8754800

Title: Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor.

PubMed ID: 8754800

DOI: 10.1128/mcb.16.8.4024

PubMed ID: 11060035

Title: The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.

PubMed ID: 11060035

DOI: 10.1093/emboj/19.21.5845

PubMed ID: 12874834

Title: Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism.

PubMed ID: 12874834

DOI: 10.1002/jcb.10548

PubMed ID: 16287849

Title: Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.

PubMed ID: 16287849

DOI: 10.1128/mcb.25.23.10338-10351.2005

PubMed ID: 17646546

Title: Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1.

PubMed ID: 17646546

DOI: 10.1182/blood-2006-11-058602

PubMed ID: 17197705

Title: The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.

PubMed ID: 17197705

DOI: 10.1074/jbc.m607613200

PubMed ID: 18805794

Title: Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor.

PubMed ID: 18805794

DOI: 10.1074/jbc.m802320200

PubMed ID: 19026687

Title: Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth.

PubMed ID: 19026687

DOI: 10.1016/j.jneumeth.2008.10.031

PubMed ID: 19164764

Title: Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1.

PubMed ID: 19164764

DOI: 10.1073/pnas.0804863106

PubMed ID: 20547752

Title: Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65.

PubMed ID: 20547752

DOI: 10.1128/mcb.00087-10

PubMed ID: 20190815

Title: A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A.

PubMed ID: 20190815

DOI: 10.1038/onc.2010.48

PubMed ID: 12778173

Title: Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2.

PubMed ID: 12778173

DOI: 10.1038/ng1170

Sequence Information:

  • Length: 422
  • Mass: 45297
  • Checksum: 740A466F72C5FC72
  • Sequence:
    • MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE NVPAPSRADS TSNAGGAKAE PRDRLSPESQ 
LTEAPDRASA SPDSCEGSVC ERSSEFEDFW RPPSPSASPA SEKSMCPSLD EAQPFPLPFK 
PYSWSGLAGS DLRHLVQSYR PCGALERGAG LGLFCEPAPE PGHPAALYGP KRAAGGAGAG 
APGSCSAGAG ATAGPGLGLY GDFGSAAAGL YERPTAAAGL LYPERGHGLH ADKGAGVKVE 
SELLCTRLLL GGGSYKCIKC SKVFSTPHGL EVHVRRSHSG TRPFACEMCG KTFGHAVSLE 
QHKAVHSQER SFDCKICGKS FKRSSTLSTH LLIHSDTRPY PCQYCGKRFH QKSDMKKHTF 
IHTGEKPHKC QVCGKAFSQS SNLITHSRKH TGFKPFGCDL CGKGFQRKVD LRRHRETQHG 
LK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.