Details for: RBMXL2

Gene ID: 27288

Symbol: RBMXL2

Ensembl ID: ENSG00000170748

Description: RBMX like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8993
    Cell Significance Index: 6.7900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3042
    Cell Significance Index: 3.4000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2320
    Cell Significance Index: 2.5000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1510
    Cell Significance Index: 2.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1087
    Cell Significance Index: 1.4900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0563
    Cell Significance Index: 0.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0530
    Cell Significance Index: 1.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0525
    Cell Significance Index: 1.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0493
    Cell Significance Index: 3.1100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0174
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0151
    Cell Significance Index: 2.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0142
    Cell Significance Index: 1.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0105
    Cell Significance Index: 0.4900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0072
    Cell Significance Index: 0.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0006
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0006
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -1.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0009
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0015
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0018
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0023
    Cell Significance Index: -0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0029
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0035
    Cell Significance Index: -0.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0037
    Cell Significance Index: -0.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0045
    Cell Significance Index: -0.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0061
    Cell Significance Index: -0.8400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0073
    Cell Significance Index: -0.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0099
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0104
    Cell Significance Index: -0.8200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0122
    Cell Significance Index: -0.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0123
    Cell Significance Index: -0.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0133
    Cell Significance Index: -0.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0134
    Cell Significance Index: -0.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0141
    Cell Significance Index: -0.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0143
    Cell Significance Index: -0.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0146
    Cell Significance Index: -0.9000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0148
    Cell Significance Index: -0.1800
  • Cell Name: lung perichondrial fibroblast (CL4033026)
    Fold Change: -0.0157
    Cell Significance Index: -0.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0161
    Cell Significance Index: -0.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0188
    Cell Significance Index: -0.6000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0191
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0197
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0199
    Cell Significance Index: -0.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0202
    Cell Significance Index: -0.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0203
    Cell Significance Index: -0.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0206
    Cell Significance Index: -0.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0214
    Cell Significance Index: -0.8100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0221
    Cell Significance Index: -0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0231
    Cell Significance Index: -0.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0232
    Cell Significance Index: -0.6100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0246
    Cell Significance Index: -0.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0251
    Cell Significance Index: -0.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0260
    Cell Significance Index: -0.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0263
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0286
    Cell Significance Index: -0.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0289
    Cell Significance Index: -0.7200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0315
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0329
    Cell Significance Index: -0.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0339
    Cell Significance Index: -0.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0339
    Cell Significance Index: -0.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0343
    Cell Significance Index: -0.7400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0343
    Cell Significance Index: -0.2900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0344
    Cell Significance Index: -0.5200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0347
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0347
    Cell Significance Index: -0.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0353
    Cell Significance Index: -0.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0354
    Cell Significance Index: -1.0200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0360
    Cell Significance Index: -0.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0363
    Cell Significance Index: -0.7700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0365
    Cell Significance Index: -0.4600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0375
    Cell Significance Index: -0.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0376
    Cell Significance Index: -0.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0379
    Cell Significance Index: -0.7500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0381
    Cell Significance Index: -0.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0384
    Cell Significance Index: -0.9200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0384
    Cell Significance Index: -0.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0386
    Cell Significance Index: -0.5600
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0386
    Cell Significance Index: -0.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0388
    Cell Significance Index: -0.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0393
    Cell Significance Index: -0.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0401
    Cell Significance Index: -0.8000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0415
    Cell Significance Index: -0.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0417
    Cell Significance Index: -0.8200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0418
    Cell Significance Index: -0.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0419
    Cell Significance Index: -0.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0420
    Cell Significance Index: -1.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RBMXL2 is a member of the RNA-binding motif (RBM) protein family, characterized by its ability to bind to specific RNA sequences, thereby regulating RNA processing and stability. The protein's interaction with spliceosomal components, such as snRNAs and U12-type spliceosomal complexes, enables it to influence the splicing of mRNAs, leading to the production of diverse protein isoforms. RBMXL2's expression is widespread, with significant levels detected in endothelial cells, dendritic cells, and stem cells, underscoring its involvement in cell development and differentiation. **Pathways and Functions:** RBMXL2's involvement in RNA processing and cell development is mediated through its interactions with various RNA molecules. Specifically, its binding to snRNAs and U12-type spliceosomal complexes facilitates the regulation of alternative splicing, leading to the production of diverse protein isoforms. This process is crucial for maintaining cellular homeostasis and responding to environmental cues. Additionally, RBMXL2's expression in stem cells and progenitor cells suggests its role in regulating cell fate decisions and differentiation. **Clinical Significance:** Dysregulation of RBMXL2 has been implicated in various diseases, including cancer and immunological disorders. For instance, aberrant splicing of mRNAs regulated by RBMXL2 has been observed in certain types of cancer, such as leukemia and lymphoma. Furthermore, alterations in RBMXL2 expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, highlighting its importance in maintaining immune homeostasis. The identification of RBMXL2 as a key regulator of RNA processing and cell development has significant implications for the development of novel therapeutic strategies targeting this gene. In conclusion, RBMXL2 is a critical gene involved in regulating RNA processing and cell development. Its interactions with RNA molecules and its widespread expression in various cell types underscore its importance in maintaining cellular homeostasis and responding to environmental cues. Further research is necessary to fully elucidate the functions of RBMXL2 and its role in disease pathogenesis, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 665365350

Symbol: RMXL2_HUMAN

Name: RNA-binding motif protein, X-linked-like-2

UniProtKB Accession Codes:

O75526 Q6PEZ2 Q9NQU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10958650

Title: An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene.

PubMed ID: 10958650

DOI: 10.1093/hmg/9.14.2117

Sequence Information:

  • Length: 392
  • Mass: 42814
  • Checksum: CE7B79EF3C64197B
  • Sequence:
    • MVEADRPGKL FIGGLNLETD EKALEAEFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA 
DAKAAARDMN GKSLDGKAIK VAQATKPAFE SSRRGPPPPR SRGRPRFLRG TRGGGGGPRR 
SPSRGGPDDD GGYTADFDLR PSRAPMPMKR GPPPRRVGPP PKRAAPSGPA RSSGGGMRGR 
ALAVRGRDGY SGPPRREPLP PRRDPYLGPR DEGYSSRDGY SSRDYREPRG FAPSPGEYTH 
RDYGHSSVRD DCPLRGYSDR DGYGGRDRDY GDHLSRGSHR EPFESYGELR GAAPGRGTPP 
SYGGGGRYEE YRGYSPDAYS GGRDSYSSSY GRSDRYSRGR HRVGRPDRGL SLSMERGCPP 
QRDSYSRSGC RVPRGGGRLG GRLERGGGRS RY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.