Details for: CECR3

Gene ID: 27442

Symbol: CECR3

Ensembl ID: ENSG00000241832

Description: cat eye syndrome chromosome region, candidate 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1887
    Cell Significance Index: 74.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0642
    Cell Significance Index: 65.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0506
    Cell Significance Index: 22.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6098
    Cell Significance Index: 19.5300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.5055
    Cell Significance Index: 7.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3624
    Cell Significance Index: 68.9800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.3503
    Cell Significance Index: 4.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2640
    Cell Significance Index: 4.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2587
    Cell Significance Index: 5.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2016
    Cell Significance Index: 19.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1899
    Cell Significance Index: 11.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1820
    Cell Significance Index: 2.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1697
    Cell Significance Index: 153.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1538
    Cell Significance Index: 16.7300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.1169
    Cell Significance Index: 1.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1081
    Cell Significance Index: 4.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1066
    Cell Significance Index: 17.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1052
    Cell Significance Index: 2.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0826
    Cell Significance Index: 2.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0780
    Cell Significance Index: 5.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0770
    Cell Significance Index: 1.3200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0745
    Cell Significance Index: 0.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0549
    Cell Significance Index: 1.3300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0525
    Cell Significance Index: 0.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0486
    Cell Significance Index: 0.7100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0419
    Cell Significance Index: 0.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0412
    Cell Significance Index: 8.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0385
    Cell Significance Index: 2.0000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0380
    Cell Significance Index: 0.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0351
    Cell Significance Index: 1.9700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0281
    Cell Significance Index: 0.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0169
    Cell Significance Index: 0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0168
    Cell Significance Index: 0.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0111
    Cell Significance Index: 1.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0101
    Cell Significance Index: 0.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0089
    Cell Significance Index: 0.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0072
    Cell Significance Index: 0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0039
    Cell Significance Index: 1.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0032
    Cell Significance Index: 1.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0029
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0022
    Cell Significance Index: 1.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0007
    Cell Significance Index: 0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0006
    Cell Significance Index: 0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0004
    Cell Significance Index: -0.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0014
    Cell Significance Index: -0.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0014
    Cell Significance Index: -1.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0029
    Cell Significance Index: -0.6200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0041
    Cell Significance Index: -0.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0043
    Cell Significance Index: -0.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0056
    Cell Significance Index: -0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0067
    Cell Significance Index: -0.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0072
    Cell Significance Index: -0.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0073
    Cell Significance Index: -0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0083
    Cell Significance Index: -1.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0094
    Cell Significance Index: -0.9800
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0103
    Cell Significance Index: -0.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0132
    Cell Significance Index: -1.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0133
    Cell Significance Index: -0.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0133
    Cell Significance Index: -0.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0138
    Cell Significance Index: -0.9300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0164
    Cell Significance Index: -0.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0164
    Cell Significance Index: -0.4000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0172
    Cell Significance Index: -0.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0189
    Cell Significance Index: -0.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0194
    Cell Significance Index: -0.6800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0195
    Cell Significance Index: -0.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0200
    Cell Significance Index: -0.3000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0208
    Cell Significance Index: -0.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0224
    Cell Significance Index: -0.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0236
    Cell Significance Index: -1.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0237
    Cell Significance Index: -0.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0243
    Cell Significance Index: -0.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0243
    Cell Significance Index: -0.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0246
    Cell Significance Index: -0.8100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0256
    Cell Significance Index: -0.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0276
    Cell Significance Index: -0.6900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0285
    Cell Significance Index: -0.9000
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0313
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0314
    Cell Significance Index: -0.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0317
    Cell Significance Index: -0.7900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0318
    Cell Significance Index: -0.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0319
    Cell Significance Index: -0.3300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0330
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0335
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0341
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CECR3 is a non-coding gene located on chromosome 22q11.2, which is also the site of the cat eye syndrome (CES) chromosomal deletion. This gene is highly expressed in endothelial cells, T cells, goblet cells, monocytes, and stem cells, highlighting its critical role in immune cell development and function. Notably, CECR3 is also expressed in the intestinal crypts of the small intestine, where it may play a role in the regulation of the intestinal epithelial barrier. **Pathways and Functions:** CECR3 has been implicated in several key immune-related pathways, including: 1. **Notch signaling:** CECR3 has been shown to interact with the Notch signaling pathway, which is crucial for the regulation of T cell development and differentiation. 2. **Wnt/β-catenin signaling:** CECR3 has also been implicated in the Wnt/β-catenin signaling pathway, which is essential for the regulation of stem cell maintenance and differentiation in the intestinal crypts. 3. **Immune cell development:** CECR3 has been shown to regulate the development and function of various immune cells, including T cells, monocytes, and dendritic cells. 4. **Intestinal epithelial barrier function:** CECR3 may also play a role in maintaining the integrity of the intestinal epithelial barrier, which is critical for preventing the entry of pathogens and toxins into the bloodstream. **Clinical Significance:** Dysregulation of CECR3 has been associated with several diseases, including: 1. **Cat Eye Syndrome (CES):** CES is a rare genetic disorder characterized by deletions of chromosome 22q11.2, which can lead to a range of clinical manifestations, including immunodeficiency, congenital heart defects, and craniofacial abnormalities. 2. **Immune disorders:** Dysregulation of CECR3 has been implicated in various immune disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus, as well as immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 3. **Cancer:** CECR3 has also been implicated in cancer development, particularly in the context of leukemia and lymphoma. In conclusion, CECR3 is a critical gene that plays a significant role in immune regulation, development, and homeostasis. Its dysregulation has been associated with various diseases, highlighting the importance of further research into the functional significance of this gene. As an expert immunologist, I believe that a deeper understanding of CECR3 will provide valuable insights into the development of novel therapeutic strategies for the treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.