Details for: AMY1A

Gene ID: 276

Symbol: AMY1A

Ensembl ID: ENSG00000237763

Description: amylase alpha 1A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 9.57
    Marker Score: 97012.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8270
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.71
    Marker Score: 30367
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3170
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.65
    Marker Score: 1844
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.58
    Marker Score: 748.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.11
    Marker Score: 3805
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7301
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.04
    Marker Score: 2378
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1315
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 515
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.55
    Marker Score: 319
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.46
    Marker Score: 866
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.39
    Marker Score: 367
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.38
    Marker Score: 648
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.36
    Marker Score: 405
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 319
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.33
    Marker Score: 316
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.2
    Marker Score: 237
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.16
    Marker Score: 495
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.15
    Marker Score: 265
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 69
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 73
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.04
    Marker Score: 290
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.04
    Marker Score: 88
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 52
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.04
    Marker Score: 485
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.03
    Marker Score: 82
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.03
    Marker Score: 85
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.02
    Marker Score: 385
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.02
    Marker Score: 120
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.02
    Marker Score: 187
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 89
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.02
    Marker Score: 45
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 37
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.01
    Marker Score: 313

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Other Information

**Key characteristics:** - AMY1A is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a secreted protein that is found in the extracellular space. - It is involved in the hydrolysis of complex carbohydrates, including starch, dextrin, and lactose. **Pathways and functions:** - AMY1A is involved in the alpha-amylase activity pathway, which is responsible for breaking down complex carbohydrates into simpler ones. - It also plays a role in the calcium ion binding pathway, which is involved in regulating muscle contraction and neuronal signaling. - AMY1A is involved in the carbohydrate metabolic process, including the digestion and absorption of dietary carbohydrates. - It is also involved in the regulation of extracellular exosome production, which is a process that is important for intercellular communication. **Clinical significance:** - Mutations in the AMY1A gene have been linked to several human diseases, including amyloidosis, which is an autoimmune disease characterized by the deposition of a protein called amyloid-beta in the brain and other tissues. - AMY1A mutations can also cause lysosomal storage disorders, which are a group of genetic disorders characterized by the accumulation of lysosomes in cells. - Therefore, understanding the role of AMY1A in carbohydrate metabolism and cellular function may lead to the development of new therapies for amyloidosis and lysosomal storage disorders.

Genular Protein ID: 2769712456

Symbol: AMY1A_HUMAN

Name: Alpha-amylase 1A

UniProtKB Accession Codes:

P0DUB6 A6NJS5 A8K8H6 P04745 Q13763 Q5T083

Database IDs:

AGR 3 AlphaFoldDB 1 Bgee 1 BindingDB 1 CCDS 1 CDD 1 CTD 3 ChEBI 9 ChEMBL 1 EC 1 EMBL 24 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 InterPro 6 KEGG 3 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 13 PIR 1 PRINTS 1 PRO 1 Pfam 2 PhosphoSitePlus 1 Proteomes 1 Reactome 1 RefSeq 7 SMART 2 SMR 1 SUPFAM 2 UniProtKB 2 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2423416

Title: Primary structure of human salivary alpha-amylase gene.

PubMed ID: 2423416

DOI: 10.1016/0378-1119(86)90110-1

PubMed ID: 6610603

Title: Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases.

PubMed ID: 6610603

DOI: 10.1016/0378-1119(84)90265-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2452973

Title: Concerted evolution of human amylase genes.

PubMed ID: 2452973

DOI: 10.1128/mcb.8.3.1197-1205.1988

PubMed ID: 2442579

Title: Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1.

PubMed ID: 2442579

PubMed ID: 1710976

Title: Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase.

PubMed ID: 1710976

DOI: 10.1002/elps.1150120114

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 15299664

Title: Structure of human salivary alpha-amylase at 1.6-A resolution: implications for its role in the oral cavity.

PubMed ID: 15299664

DOI: 10.1107/s0907444995014119

PubMed ID: 12527308

Title: Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase.

PubMed ID: 12527308

DOI: 10.1016/s0022-2836(02)01326-8

Sequence Information:

  • Length: 511
  • Mass: 57768
  • Checksum: 7710BCAC83EBE8B2
  • Sequence:
    • MKLFWLLFTI GFCWAQYSSN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP 
NENVAIHNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN 
AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLSGL 
LDLALGKDYV RSKIAEYMNH LIDIGVAGFR IDASKHMWPG DIKAILDKLH NLNSNWFPEG 
SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG 
FMPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP 
RYFENGKDVN DWVGPPNDNG VTKEVTINPD TTCGNDWVCE HRWRQIRNMV NFRNVVDGQP 
FTNWYDNGSN QVAFGRGNRG FIVFNNDDWT FSLTLQTGLP AGTYCDVISG DKINGNCTGI 
KIYVSDDGKA HFSISNSAED PFIAIHAESK L

Genular Protein ID: 3897848192

Symbol: Q6NSB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NSB3

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 2 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 RuleBase 2 SAM 1 SMART 4 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 495
  • Mass: 56210
  • Checksum: 7BC87EAD21F1FFFB
  • Sequence:
    • MKLFWLLFTI GFCWAQYSSN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP 
NENVAIHNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN 
AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLSGL 
LDLALGKDYV RSKIAEYMNH LIDIGVAGFR IDASKHMWPG DIKAILDKLH NLNSNWFPEG 
SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG 
FMPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP 
RYFENGKDVN DWVGPPNDNG VTKEVTINPD TTCGNDWVCE HRWRQIRNMV NFRNVVDGQP 
FTNWYDNGSN QVAFGRGNRG FIVFNNDDWT FSLTLQTGLP AGTYCDVISG DKINGNCTGI 
KIYVSAKKKK KKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.