Details for: GNA11

Gene ID: 2767

Symbol: GNA11

Ensembl ID: ENSG00000088256

Description: G protein subunit alpha 11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.16
    Marker Score: 10353
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.06
    Marker Score: 6477
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.84
    Marker Score: 4030
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.75
    Marker Score: 2704
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.7
    Marker Score: 2815
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.67
    Marker Score: 863.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.52
    Marker Score: 5617.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.46
    Marker Score: 12822
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.44
    Marker Score: 12473
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.31
    Marker Score: 2756
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3
    Marker Score: 323
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.25
    Marker Score: 953
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.23
    Marker Score: 4213
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.21
    Marker Score: 7704.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.18
    Marker Score: 443
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.17
    Marker Score: 1126
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.16
    Marker Score: 1599
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.13
    Marker Score: 637
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.12
    Marker Score: 271
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.1
    Marker Score: 2611
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1
    Marker Score: 1093
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.09
    Marker Score: 770.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.08
    Marker Score: 2048
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.08
    Marker Score: 2716
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16513
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.05
    Marker Score: 718
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.04
    Marker Score: 2451
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.02
    Marker Score: 1061.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.02
    Marker Score: 2326
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.02
    Marker Score: 881
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.02
    Marker Score: 1430
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.02
    Marker Score: 318
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1
    Marker Score: 2458
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71759
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1980
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 497.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.96
    Marker Score: 33389
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.96
    Marker Score: 2579
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.96
    Marker Score: 220
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1006
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1523
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.93
    Marker Score: 3798
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.93
    Marker Score: 237
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.93
    Marker Score: 1370
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5293
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.93
    Marker Score: 568
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.92
    Marker Score: 3829.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.92
    Marker Score: 612
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.91
    Marker Score: 1047
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.88
    Marker Score: 843
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.88
    Marker Score: 411
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.87
    Marker Score: 326
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.87
    Marker Score: 252
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5260
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.86
    Marker Score: 52614
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.84
    Marker Score: 441
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.84
    Marker Score: 3232
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.83
    Marker Score: 3861
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.83
    Marker Score: 381
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.82
    Marker Score: 7042
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.82
    Marker Score: 27887
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.81
    Marker Score: 979.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.81
    Marker Score: 8379
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.8
    Marker Score: 3949.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.8
    Marker Score: 395
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.8
    Marker Score: 180
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.8
    Marker Score: 192
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.8
    Marker Score: 30334
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.79
    Marker Score: 744
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.79
    Marker Score: 228
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.79
    Marker Score: 2803.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.78
    Marker Score: 7453.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.77
    Marker Score: 1185
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.75
    Marker Score: 809
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.75
    Marker Score: 4886
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.75
    Marker Score: 1697
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.75
    Marker Score: 797
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.75
    Marker Score: 4484
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.74
    Marker Score: 6987
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3088.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.73
    Marker Score: 657
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.72
    Marker Score: 10812
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.72
    Marker Score: 227.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.71
    Marker Score: 507
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.71
    Marker Score: 766
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.71
    Marker Score: 335
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 642
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.7
    Marker Score: 4172
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.7
    Marker Score: 843

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Other Information

## Summary The GNA11 gene encodes a G protein subunit alpha-11, a protein that is involved in the regulation of insulin secretion. It is expressed in a variety of cell types, including enterocytes, colon epithelial cells, ciliary muscle cells, enterocytes of colon, kidney collecting duct intercalated cell, endocrine cell, cortical thymic epithelial cell, lung endothelial cell, and ciliated columnar cell of tracheobronchial tree. ## Key characteristics * The GNA11 gene is located on chromosome 15q21.1. * It is a large gene, encoding a protein of 1,840 amino acids. * GNA11 is a member of the G protein family of proteins. * It is a ligand for the G protein-coupled receptor Gα(i) and Gα(q). * GNA11 is involved in the regulation of insulin secretion. ## Pathways and functions * GNA11 is involved in the regulation of insulin secretion. * It is a key regulator of insulin secretion in the pancreatic beta cells of the pancreas. * GNA11 is also involved in the regulation of insulin secretion in the cells of the gut. * It is a key regulator of the metabolic regulation of glucose. * GNA11 is also involved in the regulation of inflammation and cell migration. ## Clinical significance Mutations in the GNA11 gene have been linked to a variety of human diseases, including diabetes. In particular, mutations in GNA11 have been linked to type 2 diabetes, a chronic disease characterized by high blood sugar levels. GNA11 is a promising target for the treatment of type 2 diabetes. Small molecule drugs that block GNA11 have been shown to be effective in improving insulin secretion and reducing blood sugar levels in animal models of diabetes.

Genular Protein ID: 928700668

Symbol: GNA11_HUMAN

Name: Guanine nucleotide-binding protein subunit alpha-11

UniProtKB Accession Codes:

P29992 O15109 Q14350 Q6IB00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1902575

Title: Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.

PubMed ID: 1902575

DOI: 10.1073/pnas.88.9.3907

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7492305

Title: Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.

PubMed ID: 7492305

DOI: 10.1042/bj3120151

PubMed ID: 18703424

Title: RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.

PubMed ID: 18703424

DOI: 10.1095/biolreprod.107.067504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21725197

Title: Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains.

PubMed ID: 21725197

DOI: 10.4161/cbt.12.5.15984

PubMed ID: 21044946

Title: Site-specific analysis of protein S-acylation by resin-assisted capture.

PubMed ID: 21044946

DOI: 10.1194/jlr.d011106

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 27852822

Title: Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.

PubMed ID: 27852822

DOI: 10.1074/jbc.m116.754887

PubMed ID: 23782177

Title: A rude awakening--the perioperative sleep apnea epidemic.

PubMed ID: 23782177

DOI: 10.1056/nejmp1302941

PubMed ID: 23802516

Title: Mutations affecting G-protein subunit alpha11 in hypercalcemia and hypocalcemia.

PubMed ID: 23802516

DOI: 10.1056/nejmoa1300253

PubMed ID: 31073061

Title: Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.

PubMed ID: 31073061

DOI: 10.1126/science.aaw5188

PubMed ID: 35061538

Title: Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.

PubMed ID: 35061538

DOI: 10.1126/sciadv.abl5442

Sequence Information:

  • Length: 359
  • Mass: 42123
  • Checksum: DD37176589E66046
  • Sequence:
    • MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR 
IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM IRAMETLKIL YKYEQNKANA LLIREVDVEK 
VTTFEHQYVS AIKTLWEDPG IQECYDRRRE YQLSDSAKYY LTDVDRIATL GYLPTQQDVL 
RVRVPTTGII EYPFDLENII FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV 
ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILYSHLVD YFPEFDGPQR 
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.