Details for: GNG10

Gene ID: 2790

Symbol: GNG10

Ensembl ID: ENSG00000242616

Description: G protein subunit gamma 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 4.11
    Marker Score: 11592.5
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.79
    Marker Score: 3035
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.97
    Marker Score: 1801
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.64
    Marker Score: 1861
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.11
    Marker Score: 71955
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.01
    Marker Score: 2022.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.74
    Marker Score: 11127
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.67
    Marker Score: 695
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.61
    Marker Score: 7888
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.58
    Marker Score: 637
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.54
    Marker Score: 1312
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.41
    Marker Score: 3837
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.36
    Marker Score: 2383
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.33
    Marker Score: 427
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.31
    Marker Score: 467
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.28
    Marker Score: 704
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.25
    Marker Score: 1268.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.17
    Marker Score: 7136
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.17
    Marker Score: 13574
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.13
    Marker Score: 1220
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.13
    Marker Score: 2205
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.13
    Marker Score: 818
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.13
    Marker Score: 8398
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1
    Marker Score: 7164
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.09
    Marker Score: 270
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.04
    Marker Score: 58125
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.02
    Marker Score: 4251
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.01
    Marker Score: 931
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1
    Marker Score: 10079.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48001
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.99
    Marker Score: 1057
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.98
    Marker Score: 2908
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.97
    Marker Score: 454.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.96
    Marker Score: 317
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5206
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.88
    Marker Score: 7548
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.88
    Marker Score: 596
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.87
    Marker Score: 247
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.87
    Marker Score: 5162
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5270
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.85
    Marker Score: 203
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.84
    Marker Score: 415
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.84
    Marker Score: 1380.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.84
    Marker Score: 418
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.84
    Marker Score: 203
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.82
    Marker Score: 433
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8
    Marker Score: 49185
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.8
    Marker Score: 7587
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.79
    Marker Score: 10678
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.79
    Marker Score: 253
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 598
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.78
    Marker Score: 274
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.77
    Marker Score: 473
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1250
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.76
    Marker Score: 439
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.76
    Marker Score: 1172
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.74
    Marker Score: 655
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.74
    Marker Score: 9759
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3042.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.72
    Marker Score: 517
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.72
    Marker Score: 1278
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.71
    Marker Score: 336
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.69
    Marker Score: 410
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.69
    Marker Score: 253
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.69
    Marker Score: 456
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.68
    Marker Score: 562
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.67
    Marker Score: 451
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.67
    Marker Score: 739
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.67
    Marker Score: 486
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.66
    Marker Score: 412
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.65
    Marker Score: 220
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.64
    Marker Score: 911
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.64
    Marker Score: 6028
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.64
    Marker Score: 1659
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.64
    Marker Score: 569
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.63
    Marker Score: 1531
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.63
    Marker Score: 261
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.63
    Marker Score: 1225
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.62
    Marker Score: 521.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.62
    Marker Score: 1059
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 773
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.6
    Marker Score: 368
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.6
    Marker Score: 1504
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.6
    Marker Score: 866
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.6
    Marker Score: 275
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.6
    Marker Score: 3138
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6
    Marker Score: 2304
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.6
    Marker Score: 260
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.59
    Marker Score: 1653

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Other Information

## Summary GNG10 is a G protein subunit that is expressed in a variety of cell types, including epithelial cells, immune cells, and cancer cells. It is involved in a variety of cellular processes, including water transport, inflammation, and cell signaling. ## Key characteristics * GNG10 is a transmembrane protein that is expressed in the plasma membrane of cells. * It is a member of the G protein family of proteins. * It is a heterotrimer, meaning that it consists of three subunits that come together to form a functional protein. * Each subunit of GNG10 is responsible for a specific signaling pathway. ## Pathways and functions * **Water transport:** GNG10 is involved in the regulation of water transport across cell membranes. It is a key regulator of water balance in cells, and it is also involved in the regulation of cell migration and invasion. * **Inflammation:** GNG10 is also involved in the regulation of inflammation. It is a key regulator of the inflammatory response, and it is expressed in a variety of inflammatory cells. * **Cell signaling:** GNG10 is involved in a variety of cellular signaling pathways. It is a key regulator of cell growth, differentiation, and migration. It is also involved in the regulation of cell death. ## Clinical significance GNG10 is a potential therapeutic target for a variety of diseases. For example, GNG10 inhibitors are being investigated as a treatment for cancer, rheumatoid arthritis, and inflammatory bowel disease. ## Additional information * GNG10 is a relatively new protein, and there is still much that is unknown about its function. * However, it is clear that GNG10 is a critical molecule for a variety of cellular processes. * GNG10 inhibitors are a promising new class of drugs for a variety of diseases.

Genular Protein ID: 1936835480

Symbol: GBG10_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

UniProtKB Accession Codes:

P50151 Q3B7K2 Q4VC27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 28 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7665596

Title: Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.

PubMed ID: 7665596

DOI: 10.1074/jbc.270.37.21765

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 68
  • Mass: 7205
  • Checksum: E3EC3CEA0EB0BD5A
  • Sequence:
    • MSSGASASAL QRLVEQLKLE AGVERIKVSQ AAAELQQYCM QNACKDALLV GVPAGSNPFR 
EPRSCALL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.