Details for: XCR1

Gene ID: 2829

Symbol: XCR1

Ensembl ID: ENSG00000173578

Description: X-C motif chemokine receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.82
    Marker Score: 3705
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.6
    Marker Score: 3029
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.57
    Marker Score: 941
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19273
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2499
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 326
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 438.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 494
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.57
    Marker Score: 328
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.5
    Marker Score: 294.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 212
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.27
    Marker Score: 183
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.17
    Marker Score: 117
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.15
    Marker Score: 186
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 81
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 125
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 125
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 206.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.09
    Marker Score: 89
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.09
    Marker Score: 117
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.08
    Marker Score: 67
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 71
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.05
    Marker Score: 42
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.05
    Marker Score: 80
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 144
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 92
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 9.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 61
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.02
    Marker Score: 86
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.02
    Marker Score: 1155
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 46
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.02
    Marker Score: 12

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * XCR1 is a single-pass membrane protein with a molecular weight of approximately 140 kDa. * It is expressed on the surface of immune cells, including macrophages, dendritic cells, neutrophils, and eosinophils. * XCR1 is also expressed on endothelial cells, where it is involved in the regulation of inflammation and blood-brain barrier function. * It is a ligand for the chemokine CXCR3. **Pathways and functions:** * XCR1 is a key regulator of inflammation and immune responses. * It is expressed on immune cells, where it is involved in the regulation of inflammation and cell migration. * XCR1 is also expressed on endothelial cells, where it is involved in the regulation of blood-brain barrier function. * It is a ligand for the chemokine CXCR3, which is expressed on activated macrophages and dendritic cells. * When XCR1 binds to CXCR3, it recruits CXCR3 to the cell surface, which leads to the activation of downstream signaling pathways. **Clinical significance:** * Mutations in XCR1 have been linked to a number of human diseases, including asthma, inflammatory bowel disease, and cancer. * XCR1 is a potential therapeutic target for these diseases. * Inhibition of XCR1 has been shown to reduce inflammation and improve disease symptoms. **Additional information:** * XCR1 is a member of the chemokine receptor family, which is a large family of cell surface receptors that are involved in the regulation of inflammation and immune responses. * XCR1 is a member of the G protein-coupled receptor (GPCR) superfamily. * XCR1 is a highly conserved protein, with similar sequences found in mammals, birds, and fish.

Genular Protein ID: 1222312696

Symbol: XCR1_HUMAN

Name: Chemokine XC receptor 1

UniProtKB Accession Codes:

P46094

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7832990

Title: Isolation of three novel human genes encoding G protein-coupled receptors.

PubMed ID: 7832990

DOI: 10.1089/dna.1995.14.25

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632725

Title: Identification of single C motif-1/lymphotactin receptor XCR1.

PubMed ID: 9632725

DOI: 10.1074/jbc.273.26.16551

Sequence Information:

  • Length: 333
  • Mass: 38508
  • Checksum: C84E7A3EF919CFA5
  • Sequence:
    • MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE 
SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYSSIFFL 
TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL 
TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP 
YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH 
VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY

Genular Protein ID: 1496461535

Symbol: Q502V0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q502V0

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 333
  • Mass: 38477
  • Checksum: D557AEB6E4CD4EED
  • Sequence:
    • MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE 
SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYGSIFFL 
TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL 
TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP 
YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH 
VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY

Genular Protein ID: 4161276678

Symbol: Q689E2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q689E2

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PharmGKB 1 Proteomes 2 RefSeq 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15777643

Title: Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1.

PubMed ID: 15777643

DOI: 10.1016/j.gene.2004.10.017

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 36
  • Mass: 4064
  • Checksum: A3E7DBED401C8B0D
  • Sequence:
    • MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.