Details for: XCR1

Gene ID: 2829

Symbol: XCR1

Ensembl ID: ENSG00000173578

Description: X-C motif chemokine receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.0576
    Cell Significance Index: 49.8400
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.0470
    Cell Significance Index: 5.4000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.3291
    Cell Significance Index: 12.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7556
    Cell Significance Index: 11.6900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4422
    Cell Significance Index: 6.4200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3973
    Cell Significance Index: 4.7000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1711
    Cell Significance Index: 2.5600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0467
    Cell Significance Index: 0.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0181
    Cell Significance Index: 0.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0028
    Cell Significance Index: -1.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0035
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0038
    Cell Significance Index: -1.7300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0044
    Cell Significance Index: -0.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0054
    Cell Significance Index: -0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0056
    Cell Significance Index: -1.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0060
    Cell Significance Index: -1.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0068
    Cell Significance Index: -0.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0070
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0075
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0076
    Cell Significance Index: -1.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0086
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0096
    Cell Significance Index: -1.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0104
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0105
    Cell Significance Index: -1.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0117
    Cell Significance Index: -1.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0139
    Cell Significance Index: -0.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0150
    Cell Significance Index: -1.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0177
    Cell Significance Index: -2.4300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0182
    Cell Significance Index: -0.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0216
    Cell Significance Index: -0.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0224
    Cell Significance Index: -0.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0231
    Cell Significance Index: -1.5500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0240
    Cell Significance Index: -0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0244
    Cell Significance Index: -1.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0320
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0321
    Cell Significance Index: -0.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0371
    Cell Significance Index: -2.0800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0377
    Cell Significance Index: -1.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0401
    Cell Significance Index: -1.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0442
    Cell Significance Index: -1.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0448
    Cell Significance Index: -1.9800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0451
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0457
    Cell Significance Index: -1.5000
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0472
    Cell Significance Index: -0.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0487
    Cell Significance Index: -1.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0520
    Cell Significance Index: -1.9700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0547
    Cell Significance Index: -1.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0552
    Cell Significance Index: -1.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0554
    Cell Significance Index: -1.5800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0562
    Cell Significance Index: -0.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0570
    Cell Significance Index: -2.6800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0586
    Cell Significance Index: -0.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0593
    Cell Significance Index: -1.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0595
    Cell Significance Index: -1.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0629
    Cell Significance Index: -1.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0629
    Cell Significance Index: -2.3100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0637
    Cell Significance Index: -0.5900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0655
    Cell Significance Index: -1.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0699
    Cell Significance Index: -0.7600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0711
    Cell Significance Index: -0.8000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0722
    Cell Significance Index: -1.5600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0726
    Cell Significance Index: -1.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0726
    Cell Significance Index: -0.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0730
    Cell Significance Index: -1.5500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0738
    Cell Significance Index: -0.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0771
    Cell Significance Index: -1.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0775
    Cell Significance Index: -1.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0782
    Cell Significance Index: -1.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0789
    Cell Significance Index: -1.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0791
    Cell Significance Index: -1.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0793
    Cell Significance Index: -1.6600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0796
    Cell Significance Index: -1.1400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0829
    Cell Significance Index: -0.9800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0857
    Cell Significance Index: -1.0600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0894
    Cell Significance Index: -1.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0904
    Cell Significance Index: -1.9800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0923
    Cell Significance Index: -2.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0926
    Cell Significance Index: -1.5600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0929
    Cell Significance Index: -1.1300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0942
    Cell Significance Index: -1.2300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0966
    Cell Significance Index: -1.1500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0968
    Cell Significance Index: -1.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0969
    Cell Significance Index: -2.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0970
    Cell Significance Index: -2.7800
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0976
    Cell Significance Index: -1.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0983
    Cell Significance Index: -2.2700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1019
    Cell Significance Index: -1.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1025
    Cell Significance Index: -1.2100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1053
    Cell Significance Index: -1.2700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1054
    Cell Significance Index: -1.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1061
    Cell Significance Index: -0.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** XCR1 is a seven-transmembrane GPCR with a characteristic C-C chemokine motif. It belongs to the class A/1 (rhodopsin-like receptors) and exhibits a high degree of homology with other chemokine receptors, such as CCR1 and CCR5. The receptor's ligand-binding properties and signaling cascades are characterized by the activation of Gαq proteins, leading to the release of sequestered calcium ions into the cytosol. This calcium influx is critical for various cellular processes, including cell chemotaxis, proliferation, and differentiation. **Pathways and Functions:** XCR1's involvement in immune responses is primarily mediated through its interaction with its ligands, such as CXCL4 and CXCL5. The binding of these chemokines to XCR1 triggers a GPCR signaling cascade, leading to the activation of various downstream pathways. These include: 1. Calcium-mediated signaling: The release of sequestered calcium ions into the cytosol modulates cellular processes, including cell adhesion, migration, and proliferation. 2. Chemokine-mediated signaling pathway: The activation of XCR1 by chemokines leads to the phosphorylation and activation of downstream kinases, such as PI3K and MAPK, resulting in the regulation of gene expression and cellular responses. 3. Cell chemotaxis: The chemotactic response mediated by XCR1 plays a crucial role in the migration of immune cells, including immature innate lymphoid cells and lymphoid lineage-restricted progenitor cells, towards chemokine gradients. 4. Immune response: XCR1's expression in various immune cells, including cardiac endothelial cells and goblet cells, highlights its role in modulating immune responses and tissue homeostasis. **Clinical Significance:** XCR1's involvement in immune responses and its expression in various cell types make it an attractive target for therapeutic interventions in diseases characterized by immune dysregulation. Some potential applications of XCR1 include: 1. Cancer immunotherapy: Targeting XCR1 could enhance the anti-tumor immune response by modulating the activity of immune cells, such as natural killer cells and T cells. 2. Autoimmune diseases: XCR1's role in modulating immune responses makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. Cardiovascular diseases: The expression of XCR1 in cardiac endothelial cells highlights its potential role in cardiovascular diseases, such as atherosclerosis and cardiac hypertrophy. In conclusion, XCR1 is a multifaceted receptor with a wide range of functions in immune responses and beyond. Its involvement in cell chemotaxis, calcium-mediated signaling, and chemokine-mediated signaling pathways underscores its importance in modulating immune cell development and function. Further research is needed to fully elucidate the clinical significance of XCR1 and its potential applications in therapeutic interventions.

Genular Protein ID: 1222312696

Symbol: XCR1_HUMAN

Name: Chemokine XC receptor 1

UniProtKB Accession Codes:

P46094

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7832990

Title: Isolation of three novel human genes encoding G protein-coupled receptors.

PubMed ID: 7832990

DOI: 10.1089/dna.1995.14.25

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632725

Title: Identification of single C motif-1/lymphotactin receptor XCR1.

PubMed ID: 9632725

DOI: 10.1074/jbc.273.26.16551

Sequence Information:

  • Length: 333
  • Mass: 38508
  • Checksum: C84E7A3EF919CFA5
  • Sequence:
    • MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE 
SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYSSIFFL 
TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL 
TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP 
YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH 
VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY

Genular Protein ID: 4161276678

Symbol: Q689E2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q689E2

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 HOGENOM 1 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PharmGKB 1 Proteomes 2 RefSeq 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15777643

Title: Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1.

PubMed ID: 15777643

DOI: 10.1016/j.gene.2004.10.017

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 36
  • Mass: 4064
  • Checksum: A3E7DBED401C8B0D
  • Sequence:
    • MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTV

Genular Protein ID: 1496461535

Symbol: Q502V0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q502V0

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 333
  • Mass: 38477
  • Checksum: D557AEB6E4CD4EED
  • Sequence:
    • MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE 
SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYGSIFFL 
TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL 
TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP 
YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH 
VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.