Details for: GPR26

Gene ID: 2849

Symbol: GPR26

Ensembl ID: ENSG00000154478

Description: G protein-coupled receptor 26

Associated with

  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • G protein-coupled receptor activity
    (GO:0004930)
  • Plasma membrane
    (GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.9684
    Cell Significance Index: 43.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8191
    Cell Significance Index: 19.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2538
    Cell Significance Index: 3.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1866
    Cell Significance Index: 37.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1445
    Cell Significance Index: 4.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0681
    Cell Significance Index: 4.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0603
    Cell Significance Index: 21.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0139
    Cell Significance Index: 9.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0055
    Cell Significance Index: 10.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0042
    Cell Significance Index: -1.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0048
    Cell Significance Index: -0.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0075
    Cell Significance Index: -4.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0083
    Cell Significance Index: -4.6900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0251
    Cell Significance Index: -4.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0277
    Cell Significance Index: -2.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0382
    Cell Significance Index: -2.3500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0399
    Cell Significance Index: -0.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0404
    Cell Significance Index: -2.1200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0435
    Cell Significance Index: -0.5800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0454
    Cell Significance Index: -0.5300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0506
    Cell Significance Index: -0.5200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0521
    Cell Significance Index: -0.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0528
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0558
    Cell Significance Index: -6.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0587
    Cell Significance Index: -0.6400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0693
    Cell Significance Index: -1.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0695
    Cell Significance Index: -2.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.0708
    Cell Significance Index: -0.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0714
    Cell Significance Index: -3.3300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0719
    Cell Significance Index: -1.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0747
    Cell Significance Index: -4.1900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0766
    Cell Significance Index: -0.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0819
    Cell Significance Index: -1.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0865
    Cell Significance Index: -3.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0881
    Cell Significance Index: -4.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0914
    Cell Significance Index: -2.9100
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0926
    Cell Significance Index: -1.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0936
    Cell Significance Index: -2.3400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0960
    Cell Significance Index: -1.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0967
    Cell Significance Index: -2.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0971
    Cell Significance Index: -3.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0986
    Cell Significance Index: -3.7400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1076
    Cell Significance Index: -1.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1082
    Cell Significance Index: -2.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1166
    Cell Significance Index: -2.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1268
    Cell Significance Index: -4.0100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1351
    Cell Significance Index: -2.7500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1371
    Cell Significance Index: -1.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1381
    Cell Significance Index: -3.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1389
    Cell Significance Index: -3.7100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1426
    Cell Significance Index: -3.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1435
    Cell Significance Index: -2.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1451
    Cell Significance Index: -3.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1459
    Cell Significance Index: -3.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1553
    Cell Significance Index: -3.3200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1680
    Cell Significance Index: -3.3500
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.1684
    Cell Significance Index: -1.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1715
    Cell Significance Index: -4.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1774
    Cell Significance Index: -4.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1781
    Cell Significance Index: -3.0000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1803
    Cell Significance Index: -1.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1816
    Cell Significance Index: -4.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1842
    Cell Significance Index: -2.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1885
    Cell Significance Index: -3.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1913
    Cell Significance Index: -9.6700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1967
    Cell Significance Index: -2.8000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2051
    Cell Significance Index: -4.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2133
    Cell Significance Index: -2.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2137
    Cell Significance Index: -4.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2170
    Cell Significance Index: -2.9600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2208
    Cell Significance Index: -2.3800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2233
    Cell Significance Index: -3.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2236
    Cell Significance Index: -2.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2272
    Cell Significance Index: -4.2000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2315
    Cell Significance Index: -3.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2322
    Cell Significance Index: -3.9800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2393
    Cell Significance Index: -4.0300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2464
    Cell Significance Index: -1.6700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2507
    Cell Significance Index: -3.1400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2545
    Cell Significance Index: -3.3000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2575
    Cell Significance Index: -3.2500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2632
    Cell Significance Index: -3.6800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2650
    Cell Significance Index: -3.4600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2702
    Cell Significance Index: -4.1100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2711
    Cell Significance Index: -2.4800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2715
    Cell Significance Index: -3.4100
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.2727
    Cell Significance Index: -2.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2778
    Cell Significance Index: -4.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2814
    Cell Significance Index: -5.8900
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.2842
    Cell Significance Index: -2.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2852
    Cell Significance Index: -4.2100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2870
    Cell Significance Index: -2.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** GPR26 belongs to the class B GPCR family, which consists of seven transmembrane alpha-helices. The receptor's extracellular domain contains a conserved sequence motif, while its intracellular domain is characterized by a G-protein coupled receptor activity domain. 2. **Signal Transduction:** Upon ligand binding, GPR26 activates adenylate cyclase, a key enzyme involved in the production of cAMP. This secondary messenger molecule triggers a cascade of downstream signaling events, including the activation of protein kinase A (PKA) and the regulation of gene expression. 3. **Expression Pattern:** GPR26 is widely expressed in various tissues, including the brain, heart, lungs, and gastrointestinal tract. Its expression is observed in progenitor cells, endothelial cells, plasma cells, and neurons, highlighting its involvement in tissue development, immune responses, and neural function. **Pathways and Functions:** 1. **Adenylate Cyclase-Activating GPCR Signaling Pathway:** GPR26 activates adenylate cyclase, leading to the production of cAMP and the stimulation of downstream signaling events, including the activation of PKA. 2. **G Protein-Coupled Receptor Activity:** GPR26 exhibits G-protein coupled receptor activity, which involves the activation of G-proteins and the regulation of adenylate cyclase activity. 3. **Cellular Signaling:** GPR26 is involved in various cellular signaling pathways, including the regulation of gene expression, cell proliferation, and differentiation. **Clinical Significance:** 1. **Immune Response:** GPR26 plays a crucial role in the regulation of immune responses, particularly in the production of antibodies by plasma cells. Alterations in GPR26 expression or function may contribute to the development of autoimmune diseases. 2. **Neurological Disorders:** GPR26 is expressed in neurons and has been implicated in the regulation of neural function and behavior. Dysregulation of GPR26 may contribute to the development of neurological disorders, such as anxiety and depression. 3. **Cancer:** GPR26 has been identified as a potential target for cancer therapy, as its expression is altered in various types of cancer. Inhibition of GPR26 may disrupt cancer cell proliferation and survival. 4. **Cardiovascular Disease:** GPR26 is involved in the regulation of cardiovascular function, particularly in the production of cAMP. Alterations in GPR26 expression or function may contribute to the development of cardiovascular disease. In conclusion, GPR26 is a multifunctional GPCR that plays a critical role in various physiological processes, including immune responses, neural function, and tissue development. Further research is necessary to fully elucidate the function and significance of GPR26 in human health and disease.

Genular Protein ID: 3286913403

Symbol: GPR26_HUMAN

Name: G-protein coupled receptor 26

UniProtKB Accession Codes:

Q8NDV2 Q2M2E2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17363172

Title: Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78.

PubMed ID: 17363172

DOI: 10.1016/j.bbagen.2007.01.013

PubMed ID: 18037267

Title: GPR26: a marker for primary glioblastoma?

PubMed ID: 18037267

DOI: 10.1016/j.mcp.2007.10.002

Sequence Information:

  • Length: 337
  • Mass: 37604
  • Checksum: 4E04D371505F6D01
  • Sequence:
    • MNSWDAGLAG LLVGTMGVSL LSNALVLLCL LHSADIRRQA PALFTLNLTC GNLLCTVVNM 
PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL SIDRWVAVVF PLSYRAKMRL 
RDAALMVAYT WLHALTFPAA ALALSWLGFH QLYASCTLCS RRPDERLRFA VFTGAFHALS 
FLLSFVVLCC TYLKVLKVAR FHCKRIDVIT MQTLVLLVDL HPSVRERCLE EQKRRRQRAT 
KKISTFIGTF LVCFAPYVIT RLVELFSTVP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ 
YRKSCKEILN RLLHRRSIHS SGLTGDSHSQ NILPVSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.