Details for: GPR26

Gene ID: 2849

Symbol: GPR26

Ensembl ID: ENSG00000154478

Description: G protein-coupled receptor 26

Associated with

  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • G protein-coupled receptor activity
    (GO:0004930)
  • Plasma membrane
    (GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30402
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.32
    Marker Score: 2331
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2221
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.2
    Marker Score: 1147
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.05
    Marker Score: 1988
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.85
    Marker Score: 8753
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1191
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1490.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.7
    Marker Score: 1112.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.66
    Marker Score: 383
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 520
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9371
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 269
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.44
    Marker Score: 759
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.42
    Marker Score: 523
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.41
    Marker Score: 244.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.39
    Marker Score: 1573
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 177
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 125.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.33
    Marker Score: 135
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.26
    Marker Score: 8795
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.26
    Marker Score: 1068
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 230
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.26
    Marker Score: 1957
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.24
    Marker Score: 233
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.23
    Marker Score: 470.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.2
    Marker Score: 567
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.19
    Marker Score: 381.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.18
    Marker Score: 695
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.18
    Marker Score: 747
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 139
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 83
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.16
    Marker Score: 652
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.15
    Marker Score: 96
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.15
    Marker Score: 244
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.12
    Marker Score: 553
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.12
    Marker Score: 29.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.11
    Marker Score: 31.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1
    Marker Score: 30.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.1
    Marker Score: 28.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.1
    Marker Score: 29.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.1
    Marker Score: 240
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1
    Marker Score: 175
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.09
    Marker Score: 886
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 107
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.09
    Marker Score: 31.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 542
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.09
    Marker Score: 159
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.09
    Marker Score: 138
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 31.5
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.08
    Marker Score: 25.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.08
    Marker Score: 28.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.08
    Marker Score: 29.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.08
    Marker Score: 22.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.08
    Marker Score: 31.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.07
    Marker Score: 705
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 31.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.07
    Marker Score: 149
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.07
    Marker Score: 2477
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.06
    Marker Score: 30.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 28.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.06
    Marker Score: 165
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 96
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 102
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 17.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.05
    Marker Score: 30.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.05
    Marker Score: 180
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 125
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.05
    Marker Score: 31.5

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Other Information

**Key characteristics:** * G protein-coupled receptor 26 (GPR26) is a type of GPCR that is expressed in the plasma membrane. * It is a single-pass transmembrane protein with seven transmembrane domains. * It is a member of the GPCR superfamily, which is a large family of GPCRs that are involved in a variety of cellular processes. **Pathways and functions:** * GPR26 is a key regulator of the adenylate cyclase-activating G protein-coupled receptor signaling pathway. * This pathway is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. * Activation of GPR26 leads to the activation of the adenylate cyclase, which is a protein that is involved in the production of cyclic GMP (cGMP). * cGMP is a second messenger that can regulate a variety of cellular processes, including cell migration and proliferation. **Clinical significance:** * Mutations in GPR26 have been linked to a number of human diseases, including autism, schizophrenia, and cancer. * These mutations can disrupt the function of GPR26, leading to the development of these diseases. * Therefore, GPR26 is a promising target for the treatment of these diseases. **Additional information:** * The gene encoding GPR26 is located on chromosome 15q21.1. * The protein encoded by GPR26 is a type I transmembrane protein. * It is a member of the GPCR superfamily, which is a large family of GPCRs that are involved in a variety of cellular processes. * GPR26 is a key regulator of the adenylate cyclase-activating G protein-coupled receptor signaling pathway. * Activation of GPR26 leads to the activation of the adenylate cyclase, which is a protein that is involved in the production of cyclic GMP (cGMP). * cGMP is a second messenger that can regulate a variety of cellular processes, including cell migration and proliferation.

Genular Protein ID: 3286913403

Symbol: GPR26_HUMAN

Name: G-protein coupled receptor 26

UniProtKB Accession Codes:

Q8NDV2 Q2M2E2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17363172

Title: Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78.

PubMed ID: 17363172

DOI: 10.1016/j.bbagen.2007.01.013

PubMed ID: 18037267

Title: GPR26: a marker for primary glioblastoma?

PubMed ID: 18037267

DOI: 10.1016/j.mcp.2007.10.002

Sequence Information:

  • Length: 337
  • Mass: 37604
  • Checksum: 4E04D371505F6D01
  • Sequence:
    • MNSWDAGLAG LLVGTMGVSL LSNALVLLCL LHSADIRRQA PALFTLNLTC GNLLCTVVNM 
PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL SIDRWVAVVF PLSYRAKMRL 
RDAALMVAYT WLHALTFPAA ALALSWLGFH QLYASCTLCS RRPDERLRFA VFTGAFHALS 
FLLSFVVLCC TYLKVLKVAR FHCKRIDVIT MQTLVLLVDL HPSVRERCLE EQKRRRQRAT 
KKISTFIGTF LVCFAPYVIT RLVELFSTVP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ 
YRKSCKEILN RLLHRRSIHS SGLTGDSHSQ NILPVSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.