Details for: TRDV1

Gene ID: 28518

Symbol: TRDV1

Ensembl ID: ENSG00000211804

Description: T cell receptor delta variable 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3509
    Cell Significance Index: 0.9400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1834
    Cell Significance Index: 1.0000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0106
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0176
    Cell Significance Index: -3.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0244
    Cell Significance Index: -3.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0277
    Cell Significance Index: -0.4700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0371
    Cell Significance Index: -0.3700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0426
    Cell Significance Index: -0.5800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0452
    Cell Significance Index: -0.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0464
    Cell Significance Index: -1.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0559
    Cell Significance Index: -0.6600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0559
    Cell Significance Index: -0.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0567
    Cell Significance Index: -1.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0594
    Cell Significance Index: -1.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0633
    Cell Significance Index: -3.2900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0640
    Cell Significance Index: -0.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0671
    Cell Significance Index: -3.1300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0744
    Cell Significance Index: -0.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0747
    Cell Significance Index: -3.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0752
    Cell Significance Index: -1.9200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0801
    Cell Significance Index: -2.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0822
    Cell Significance Index: -1.9000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0824
    Cell Significance Index: -1.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0852
    Cell Significance Index: -1.3800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0862
    Cell Significance Index: -0.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0896
    Cell Significance Index: -1.5100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0904
    Cell Significance Index: -0.7700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0939
    Cell Significance Index: -0.7600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0949
    Cell Significance Index: -0.9000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1038
    Cell Significance Index: -1.7900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1067
    Cell Significance Index: -1.0400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1124
    Cell Significance Index: -1.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1142
    Cell Significance Index: -2.2300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1159
    Cell Significance Index: -1.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1170
    Cell Significance Index: -2.0000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1190
    Cell Significance Index: -0.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1199
    Cell Significance Index: -1.7700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1203
    Cell Significance Index: -1.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1212
    Cell Significance Index: -2.2400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1229
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1330
    Cell Significance Index: -1.9100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1363
    Cell Significance Index: -1.8900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1386
    Cell Significance Index: -1.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1386
    Cell Significance Index: -1.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1403
    Cell Significance Index: -3.5000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1409
    Cell Significance Index: -2.1400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1416
    Cell Significance Index: -1.4300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1425
    Cell Significance Index: -1.7800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1460
    Cell Significance Index: -1.9100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1464
    Cell Significance Index: -1.6500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1467
    Cell Significance Index: -1.9300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1475
    Cell Significance Index: -1.9000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1482
    Cell Significance Index: -2.1600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1488
    Cell Significance Index: -1.6000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1490
    Cell Significance Index: -1.9100
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1492
    Cell Significance Index: -1.6500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1494
    Cell Significance Index: -1.6200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1505
    Cell Significance Index: -2.1100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1506
    Cell Significance Index: -2.1400
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.1516
    Cell Significance Index: -1.1700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1532
    Cell Significance Index: -2.0100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1532
    Cell Significance Index: -1.7800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1543
    Cell Significance Index: -1.8200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1570
    Cell Significance Index: -1.9100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1584
    Cell Significance Index: -1.9000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1586
    Cell Significance Index: -1.9500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1591
    Cell Significance Index: -1.8800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1598
    Cell Significance Index: -1.9000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1605
    Cell Significance Index: -1.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1610
    Cell Significance Index: -1.6700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1614
    Cell Significance Index: -1.5100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1616
    Cell Significance Index: -1.7900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1617
    Cell Significance Index: -2.2200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1638
    Cell Significance Index: -1.9000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1660
    Cell Significance Index: -1.9100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1667
    Cell Significance Index: -1.9700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1669
    Cell Significance Index: -1.7700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1674
    Cell Significance Index: -2.1900
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.1674
    Cell Significance Index: -1.1600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1681
    Cell Significance Index: -1.8200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1682
    Cell Significance Index: -1.8400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1693
    Cell Significance Index: -1.7300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1697
    Cell Significance Index: -1.3200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1708
    Cell Significance Index: -1.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1709
    Cell Significance Index: -3.3800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1711
    Cell Significance Index: -1.8800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1711
    Cell Significance Index: -1.9000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1715
    Cell Significance Index: -1.9500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1717
    Cell Significance Index: -1.8100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1721
    Cell Significance Index: -1.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1722
    Cell Significance Index: -1.6600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1739
    Cell Significance Index: -2.0200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1744
    Cell Significance Index: -1.9000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1747
    Cell Significance Index: -2.0100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1755
    Cell Significance Index: -1.9000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1777
    Cell Significance Index: -1.7900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1777
    Cell Significance Index: -2.1000
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1795
    Cell Significance Index: -1.5000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1796
    Cell Significance Index: -2.0700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1817
    Cell Significance Index: -1.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRDV1 is a member of the TCR family, specifically belonging to the delta (δ) subfamily. It is characterized by its unique structure, which consists of two immunoglobulin-like domains and a variable region. This structure allows TRDV1 to recognize and bind to specific antigens, facilitating the activation of T cells. TRDV1 is significantly expressed in various cell types, including goblet cells, granulocyte-monocyte progenitor cells, and hematopoietic cells, highlighting its widespread role in immune regulation. **Pathways and Functions:** TRDV1 is involved in the adaptive immune response, which is mediated by T cells. The TCR complex, comprising TRDV1, is responsible for recognizing antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). Upon antigen recognition, the TCR complex triggers a signaling cascade that activates T cells, leading to their proliferation, differentiation, and effector functions. TRDV1 is also implicated in the regulation of innate immune responses, particularly in the context of innate-like T cells. **Clinical Significance:** The dysregulation of TRDV1 has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Additionally, TRDV1 has been linked to cancer, with aberrant expression found in neoplastic cells. The identification of TRDV1 as a potential therapeutic target has sparked interest in the development of novel immunotherapies. Furthermore, the understanding of TRDV1's role in immune regulation has significant implications for the treatment of infectious diseases, where dysregulated immune responses can lead to severe outcomes. In conclusion, TRDV1 is a crucial component of the adaptive immune system, playing a pivotal role in the regulation of immune responses. Its significant expression in various cell types and involvement in both adaptive and innate immune responses make it an attractive target for the development of novel immunotherapies. Further research is needed to fully elucidate the mechanisms of TRDV1 and its clinical significance, but its potential as a therapeutic target holds great promise for the treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.