Details for: TRBV27

Gene ID: 28560

Symbol: TRBV27

Ensembl ID: ENSG00000211752

Description: T cell receptor beta variable 27

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7601
    Cell Significance Index: 8.5000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.5410
    Cell Significance Index: 2.9500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.2655
    Cell Significance Index: 2.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1174
    Cell Significance Index: 1.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0310
    Cell Significance Index: -5.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0327
    Cell Significance Index: -6.5600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0331
    Cell Significance Index: -0.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0406
    Cell Significance Index: -0.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0421
    Cell Significance Index: -1.1300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0482
    Cell Significance Index: -0.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0495
    Cell Significance Index: -2.1900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0554
    Cell Significance Index: -0.8100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0573
    Cell Significance Index: -2.1700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0651
    Cell Significance Index: -0.8100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0775
    Cell Significance Index: -0.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0810
    Cell Significance Index: -2.0700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0833
    Cell Significance Index: -0.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0842
    Cell Significance Index: -2.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0854
    Cell Significance Index: -2.4600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0857
    Cell Significance Index: -1.0700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0877
    Cell Significance Index: -0.7100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0881
    Cell Significance Index: -0.8900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0988
    Cell Significance Index: -0.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1021
    Cell Significance Index: -4.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1166
    Cell Significance Index: -2.9700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1183
    Cell Significance Index: -1.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1352
    Cell Significance Index: -1.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1357
    Cell Significance Index: -1.7200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1391
    Cell Significance Index: -2.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1534
    Cell Significance Index: -2.0700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1556
    Cell Significance Index: -2.5200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1577
    Cell Significance Index: -1.4800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1586
    Cell Significance Index: -1.5900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1606
    Cell Significance Index: -1.8900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1606
    Cell Significance Index: -2.0400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1607
    Cell Significance Index: -1.1100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1620
    Cell Significance Index: -2.7700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1620
    Cell Significance Index: -1.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1624
    Cell Significance Index: -2.8000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1673
    Cell Significance Index: -2.0200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1717
    Cell Significance Index: -1.7300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1746
    Cell Significance Index: -1.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1764
    Cell Significance Index: -3.2600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1828
    Cell Significance Index: -2.0000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1854
    Cell Significance Index: -1.5800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1862
    Cell Significance Index: -3.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1935
    Cell Significance Index: -1.8600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1950
    Cell Significance Index: -1.9800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1955
    Cell Significance Index: -2.3100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1962
    Cell Significance Index: -2.1100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1976
    Cell Significance Index: -2.6000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.2069
    Cell Significance Index: -2.2100
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.2147
    Cell Significance Index: -2.1800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2157
    Cell Significance Index: -2.2000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2171
    Cell Significance Index: -2.5800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2184
    Cell Significance Index: -1.8300
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.2221
    Cell Significance Index: -2.1700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.2230
    Cell Significance Index: -2.2000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2249
    Cell Significance Index: -1.7500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2253
    Cell Significance Index: -2.1800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2281
    Cell Significance Index: -2.6500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2302
    Cell Significance Index: -2.6700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2304
    Cell Significance Index: -2.5100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2306
    Cell Significance Index: -3.0100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2309
    Cell Significance Index: -2.5300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2310
    Cell Significance Index: -2.4900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2318
    Cell Significance Index: -2.2600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2322
    Cell Significance Index: -2.5300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2357
    Cell Significance Index: -2.3900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2358
    Cell Significance Index: -2.5000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2368
    Cell Significance Index: -2.8800
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.2393
    Cell Significance Index: -2.3600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2399
    Cell Significance Index: -2.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2405
    Cell Significance Index: -3.5100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2421
    Cell Significance Index: -3.1100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2431
    Cell Significance Index: -3.1900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2453
    Cell Significance Index: -2.0700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2455
    Cell Significance Index: -2.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2464
    Cell Significance Index: -4.1500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2468
    Cell Significance Index: -2.8400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2482
    Cell Significance Index: -2.2800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2521
    Cell Significance Index: -2.8000
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.2525
    Cell Significance Index: -2.4900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2529
    Cell Significance Index: -2.6200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2537
    Cell Significance Index: -2.5100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2590
    Cell Significance Index: -2.0700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2590
    Cell Significance Index: -2.8800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2605
    Cell Significance Index: -2.8300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2644
    Cell Significance Index: -2.9800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2649
    Cell Significance Index: -3.5200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2653
    Cell Significance Index: -3.1400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2657
    Cell Significance Index: -3.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2677
    Cell Significance Index: -3.2900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2681
    Cell Significance Index: -2.4800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2683
    Cell Significance Index: -2.8300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2690
    Cell Significance Index: -2.5500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2746
    Cell Significance Index: -3.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV27 is a member of the TCR beta variable (TRBV) family, which comprises a diverse array of genes that encode the variable regions of the TCR beta chain. The TCR beta chain is a critical component of the TCR complex, which recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. TRBV27 is specifically expressed in various subsets of alpha-beta T cells, including effector CD8-positive, central memory CD4-positive, and cytotoxic T cells. **Pathways and Functions:** TRBV27 is integral to the adaptive immune response, participating in the signaling pathways that regulate T cell activation, proliferation, and differentiation. The TCR complex, including TRBV27, interacts with MHC molecules on the surface of antigen-presenting cells, triggering a series of downstream signaling events that activate the T cell receptor signaling pathway. This pathway involves the activation of various kinases, including ZAP-70 and LCK, which phosphorylate and activate downstream transcription factors, such as NF-AT and NF-κB. The subsequent transcriptional response regulates the expression of genes involved in T cell activation, proliferation, and effector functions. TRBV27 also plays a role in the regulation of T cell receptor signaling, influencing the affinity and specificity of the TCR for antigens. Variations in TRBV27 can affect the binding affinity of the TCR for MHC molecules, influencing the strength and duration of T cell activation. Furthermore, TRBV27 has been implicated in the regulation of T cell exhaustion, a state of functional attenuation characterized by reduced T cell activation and proliferation in response to chronic antigen exposure. **Clinical Significance:** The dysregulation of TRBV27 has been implicated in various autoimmune and immune-related disorders, including rheumatoid arthritis, multiple sclerosis, and cancer. Aberrant expression or function of TRBV27 can contribute to the development of immune dysregulation, leading to the activation of autoreactive T cells and the induction of autoimmune responses. In addition, TRBV27 has been identified as a potential biomarker for immune-related disorders, with its expression levels correlating with disease activity and response to therapy. Furthermore, TRBV27 has been explored as a target for immunotherapy, with its manipulation potentially enhancing T cell activation and proliferation in response to cancer antigens. In conclusion, TRBV27 plays a critical role in the adaptive immune response, participating in the signaling pathways that regulate T cell activation, proliferation, and differentiation. Its dysregulation has been implicated in various immune-related disorders, highlighting its potential as a therapeutic target and biomarker for immune-related diseases. Further research into the function and significance of TRBV27 is necessary to fully elucidate its role in the adaptive immune response and to explore its potential applications in immunotherapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.