Details for: TRBV23 1

Gene ID: 28564

Symbol: TRBV23 1

Ensembl ID: ENSG00000211749

Description: T cell receptor beta variable 23-1 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 5.28
    Marker Score: 5,870
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.9
    Marker Score: 1,264
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,810
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,575
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,653
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,727
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,343
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.81
    Marker Score: 464
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 736
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.43
    Marker Score: 217
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.25
    Marker Score: 267
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.15
    Marker Score: 196
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.13
    Marker Score: 174
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.12
    Marker Score: 210
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.1
    Marker Score: 204
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.08
    Marker Score: 90
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.08
    Marker Score: 145
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 203
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.06
    Marker Score: 66
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 89
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 102
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.04
    Marker Score: 2,118
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 55
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.02
    Marker Score: 56
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.02
    Marker Score: 62
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.02
    Marker Score: 80
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.01
    Marker Score: 112
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 40
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 23

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBV23-1 gene exhibits several key characteristics that warrant further investigation. Firstly, its non-functional status implies that it may not be capable of participating in the T cell receptor complex, which is essential for recognizing and responding to antigens. The gene's significant expression in various cell types, including those that are not typically associated with the adaptive immune response, further underscores its potential for functional redundancy or compensation. **Pathways and Functions:** The TRBV23-1 gene is involved in several signaling pathways, including the adaptive immune response, cell surface receptor signaling pathway, and plasma membrane signaling. However, its non-functional status suggests that these pathways may not be directly influenced by the gene. Instead, the gene's expression may serve as a "decoy" or a "placeholder" for other genes that can participate in these pathways. Additionally, the gene's expression in cells that are not typically associated with the adaptive immune response may indicate a role for TRBV23-1 in non-immunological processes, such as cell proliferation, differentiation, or survival. **Clinical Significance:** The TRBV23-1 gene's non-functional status and significant expression in various cell types raise several questions about its clinical significance. Firstly, the gene's expression in neoplastic cells and abnormal cells may indicate a role for TRBV23-1 in cancer development or progression. Further studies are needed to investigate the potential mechanisms by which TRBV23-1 contributes to tumorigenesis. Additionally, the gene's expression in goblet cells and intestinal crypt stem cells may suggest a role for TRBV23-1 in gastrointestinal health and disease. For example, the gene's expression in goblet cells may be involved in the regulation of mucin production or the maintenance of intestinal barrier function. In conclusion, the TRBV23-1 gene's non-functional status and significant expression in various cell types warrant further investigation into its role in the adaptive immune response and non-immunological processes. Further studies are needed to elucidate the clinical significance of TRBV23-1 and its potential implications for human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.