Details for: TRBV23 1

Gene ID: 28564

Symbol: TRBV23 1

Ensembl ID: ENSG00000211749

Description: T cell receptor beta variable 23-1 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4123
    Cell Significance Index: 34.2100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.8425
    Cell Significance Index: 2.2600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1642
    Cell Significance Index: 1.8400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1204
    Cell Significance Index: 1.3000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1192
    Cell Significance Index: 0.6500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.0836
    Cell Significance Index: 0.8700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0834
    Cell Significance Index: 1.1700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.0394
    Cell Significance Index: 0.4000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0237
    Cell Significance Index: 0.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0010
    Cell Significance Index: -0.7700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0034
    Cell Significance Index: -0.1000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0059
    Cell Significance Index: -0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0064
    Cell Significance Index: -0.3000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0069
    Cell Significance Index: -0.1000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0082
    Cell Significance Index: -0.1400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0096
    Cell Significance Index: -0.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0103
    Cell Significance Index: -0.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0110
    Cell Significance Index: -0.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0125
    Cell Significance Index: -0.5600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0125
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0136
    Cell Significance Index: -0.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0143
    Cell Significance Index: -0.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0155
    Cell Significance Index: -0.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0164
    Cell Significance Index: -0.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0169
    Cell Significance Index: -0.2000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0179
    Cell Significance Index: -0.4800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0190
    Cell Significance Index: -0.2600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0215
    Cell Significance Index: -0.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0216
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0222
    Cell Significance Index: -0.2300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0228
    Cell Significance Index: -0.2700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0229
    Cell Significance Index: -0.3000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0229
    Cell Significance Index: -0.3000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0256
    Cell Significance Index: -0.2200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0258
    Cell Significance Index: -0.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0258
    Cell Significance Index: -0.5100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0261
    Cell Significance Index: -0.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0264
    Cell Significance Index: -0.5600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0265
    Cell Significance Index: -0.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0271
    Cell Significance Index: -0.5400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0310
    Cell Significance Index: -0.4300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0315
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0317
    Cell Significance Index: -0.3200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0319
    Cell Significance Index: -0.3600
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: -0.0321
    Cell Significance Index: -0.2400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0335
    Cell Significance Index: -0.3500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0340
    Cell Significance Index: -0.8700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0340
    Cell Significance Index: -0.5500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0348
    Cell Significance Index: -0.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0365
    Cell Significance Index: -0.4600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0378
    Cell Significance Index: -0.5100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0385
    Cell Significance Index: -0.3600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0387
    Cell Significance Index: -0.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0400
    Cell Significance Index: -0.5900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0404
    Cell Significance Index: -0.3400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0412
    Cell Significance Index: -0.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0413
    Cell Significance Index: -0.4500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0432
    Cell Significance Index: -0.3400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0433
    Cell Significance Index: -0.5700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0435
    Cell Significance Index: -0.4000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0442
    Cell Significance Index: -0.5000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0442
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0443
    Cell Significance Index: -0.4500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0444
    Cell Significance Index: -0.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0447
    Cell Significance Index: -0.4300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0452
    Cell Significance Index: -0.6000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0454
    Cell Significance Index: -0.5800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0459
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0464
    Cell Significance Index: -0.4400
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0467
    Cell Significance Index: -0.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0468
    Cell Significance Index: -0.5800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0470
    Cell Significance Index: -0.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0470
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0472
    Cell Significance Index: -0.5800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0475
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0476
    Cell Significance Index: -0.8800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0477
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0483
    Cell Significance Index: -0.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0485
    Cell Significance Index: -0.5800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0490
    Cell Significance Index: -0.5300
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0495
    Cell Significance Index: -0.4400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0499
    Cell Significance Index: -0.5800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0506
    Cell Significance Index: -0.5400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0513
    Cell Significance Index: -0.5200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0515
    Cell Significance Index: -0.5300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0517
    Cell Significance Index: -0.6200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0518
    Cell Significance Index: -0.5500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0519
    Cell Significance Index: -0.5500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0526
    Cell Significance Index: -0.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0530
    Cell Significance Index: -0.5000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0536
    Cell Significance Index: -0.6700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0539
    Cell Significance Index: -0.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0542
    Cell Significance Index: -0.7700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0549
    Cell Significance Index: -0.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0553
    Cell Significance Index: -0.6000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0559
    Cell Significance Index: -0.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBV23-1 gene exhibits several key characteristics that warrant further investigation. Firstly, its non-functional status implies that it may not be capable of participating in the T cell receptor complex, which is essential for recognizing and responding to antigens. The gene's significant expression in various cell types, including those that are not typically associated with the adaptive immune response, further underscores its potential for functional redundancy or compensation. **Pathways and Functions:** The TRBV23-1 gene is involved in several signaling pathways, including the adaptive immune response, cell surface receptor signaling pathway, and plasma membrane signaling. However, its non-functional status suggests that these pathways may not be directly influenced by the gene. Instead, the gene's expression may serve as a "decoy" or a "placeholder" for other genes that can participate in these pathways. Additionally, the gene's expression in cells that are not typically associated with the adaptive immune response may indicate a role for TRBV23-1 in non-immunological processes, such as cell proliferation, differentiation, or survival. **Clinical Significance:** The TRBV23-1 gene's non-functional status and significant expression in various cell types raise several questions about its clinical significance. Firstly, the gene's expression in neoplastic cells and abnormal cells may indicate a role for TRBV23-1 in cancer development or progression. Further studies are needed to investigate the potential mechanisms by which TRBV23-1 contributes to tumorigenesis. Additionally, the gene's expression in goblet cells and intestinal crypt stem cells may suggest a role for TRBV23-1 in gastrointestinal health and disease. For example, the gene's expression in goblet cells may be involved in the regulation of mucin production or the maintenance of intestinal barrier function. In conclusion, the TRBV23-1 gene's non-functional status and significant expression in various cell types warrant further investigation into its role in the adaptive immune response and non-immunological processes. Further studies are needed to elucidate the clinical significance of TRBV23-1 and its potential implications for human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.