Details for: TRBV14

Gene ID: 28573

Symbol: TRBV14

Ensembl ID: ENSG00000275743

Description: T cell receptor beta variable 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4796
    Cell Significance Index: 7.4200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.3980
    Cell Significance Index: 3.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0096
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0118
    Cell Significance Index: -1.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0177
    Cell Significance Index: -5.1000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0189
    Cell Significance Index: -0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0267
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0363
    Cell Significance Index: -6.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0466
    Cell Significance Index: -4.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0604
    Cell Significance Index: -27.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0772
    Cell Significance Index: -1.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1219
    Cell Significance Index: -5.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1423
    Cell Significance Index: -5.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1659
    Cell Significance Index: -6.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1695
    Cell Significance Index: -4.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1852
    Cell Significance Index: -4.7300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1870
    Cell Significance Index: -4.7700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2235
    Cell Significance Index: -4.3700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2245
    Cell Significance Index: -2.4800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2309
    Cell Significance Index: -3.7400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2442
    Cell Significance Index: -4.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2500
    Cell Significance Index: -4.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2547
    Cell Significance Index: -5.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2555
    Cell Significance Index: -3.6300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2557
    Cell Significance Index: -1.8400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2921
    Cell Significance Index: -3.2700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2932
    Cell Significance Index: -2.9400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2989
    Cell Significance Index: -1.6300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2998
    Cell Significance Index: -3.4500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3030
    Cell Significance Index: -5.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3136
    Cell Significance Index: -4.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3164
    Cell Significance Index: -7.7200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3184
    Cell Significance Index: -4.1200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3269
    Cell Significance Index: -4.1300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3336
    Cell Significance Index: -3.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3336
    Cell Significance Index: -3.4600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.3391
    Cell Significance Index: -2.7100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3435
    Cell Significance Index: -4.0600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3438
    Cell Significance Index: -4.1500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3624
    Cell Significance Index: -4.7400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3628
    Cell Significance Index: -3.6600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3678
    Cell Significance Index: -4.5500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3706
    Cell Significance Index: -4.6500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3722
    Cell Significance Index: -5.4300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3761
    Cell Significance Index: -4.4300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3822
    Cell Significance Index: -3.8800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3905
    Cell Significance Index: -5.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3974
    Cell Significance Index: -3.8200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3976
    Cell Significance Index: -5.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3983
    Cell Significance Index: -18.7200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4011
    Cell Significance Index: -3.9100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4075
    Cell Significance Index: -4.6900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4089
    Cell Significance Index: -4.2400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4110
    Cell Significance Index: -4.1700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4122
    Cell Significance Index: -5.3800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4133
    Cell Significance Index: -5.0800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4154
    Cell Significance Index: -4.4200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.4160
    Cell Significance Index: -3.5900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4162
    Cell Significance Index: -5.5300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4182
    Cell Significance Index: -4.6300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4200
    Cell Significance Index: -5.3000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4202
    Cell Significance Index: -3.9500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4204
    Cell Significance Index: -4.3300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4243
    Cell Significance Index: -5.3000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4264
    Cell Significance Index: -5.6000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4278
    Cell Significance Index: -5.4000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4287
    Cell Significance Index: -3.7500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4287
    Cell Significance Index: -4.6100
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.4317
    Cell Significance Index: -4.7600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.4327
    Cell Significance Index: -4.5600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4349
    Cell Significance Index: -4.6200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.4350
    Cell Significance Index: -4.6900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4355
    Cell Significance Index: -5.4300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.4360
    Cell Significance Index: -5.3000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4394
    Cell Significance Index: -4.7400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.4397
    Cell Significance Index: -4.6200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4400
    Cell Significance Index: -5.2000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4407
    Cell Significance Index: -4.8200
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.4409
    Cell Significance Index: -4.7600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4419
    Cell Significance Index: -5.3300
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.4430
    Cell Significance Index: -4.6600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4459
    Cell Significance Index: -5.3000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4479
    Cell Significance Index: -5.2000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4482
    Cell Significance Index: -4.7600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.4483
    Cell Significance Index: -4.7900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.4484
    Cell Significance Index: -4.2000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.4487
    Cell Significance Index: -4.1500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.4491
    Cell Significance Index: -4.0400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4494
    Cell Significance Index: -5.3000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4495
    Cell Significance Index: -5.2900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4527
    Cell Significance Index: -5.3500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4554
    Cell Significance Index: -5.9500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.4586
    Cell Significance Index: -4.6500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4606
    Cell Significance Index: -3.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4612
    Cell Significance Index: -6.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4619
    Cell Significance Index: -3.5600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.4640
    Cell Significance Index: -5.3000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4650
    Cell Significance Index: -5.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** TRBV14 is located on chromosome 14, and its gene structure consists of a variable region (V) and a constant region (C), which are essential for the assembly and function of the TCR. 2. **Expression Patterns:** TRBV14 is expressed in a range of cell types, including endothelial cells, granulocytes, T cells, and precursor cells of the myeloid and lymphoid lineages. 3. **Cellular Distribution:** TRBV14 is found on the surface of cells, where it interacts with MHC class I molecules to initiate antigen recognition and signal transduction. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBV14 plays a critical role in the adaptive immune response by recognizing and binding to specific antigens presented by MHC class I molecules. This interaction triggers the activation of T cells, which then undergo clonal expansion, differentiation, and effector function. 2. **Cell Surface Receptor Signaling Pathway:** TRBV14 is part of the TCR complex, which is a surface receptor that recognizes and responds to antigens. The interaction between TRBV14 and MHC class I molecules activates a signaling cascade that regulates T cell activation, proliferation, and differentiation. 3. **Plasma Membrane and T Cell Receptor Complex:** TRBV14 is embedded in the plasma membrane and is part of the TCR complex, which is essential for the recognition and response to antigens. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in TRBV14 expression or function have been implicated in various autoimmune diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. These conditions result from the inappropriate activation of autoreactive T cells, which recognize self-antigens and mount an immune response against the body's own tissues. 2. **Cancer Immunotherapy:** TRBV14 has been recognized as a potential target for cancer immunotherapy. The expression of TRBV14 on tumor cells and the activation of T cells by TRBV14-MHC class I interactions offer a promising approach for the development of novel cancer therapies. 3. **Immunodeficiency Disorders:** Mutations or deletions in the TRBV14 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). These conditions result from the impaired function or absence of T cells, which are essential for the adaptive immune response. In conclusion, the TRBV14 gene plays a critical role in the adaptive immune response, and its dysregulation has been implicated in various autoimmune diseases and immunodeficiency disorders. Further research on the function and clinical significance of TRBV14 is essential for the development of novel therapeutic strategies for these conditions.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.