Details for: TRBV3 1

Gene ID: 28619

Symbol: TRBV3 1

Ensembl ID: ENSG00000237702

Description: T cell receptor beta variable 3-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7519
    Cell Significance Index: 4.1000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1739
    Cell Significance Index: 0.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0140
    Cell Significance Index: -0.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0148
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0171
    Cell Significance Index: -2.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0183
    Cell Significance Index: -0.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0238
    Cell Significance Index: -2.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0247
    Cell Significance Index: -4.9500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0287
    Cell Significance Index: -0.3900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0362
    Cell Significance Index: -0.5300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0373
    Cell Significance Index: -0.4400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0399
    Cell Significance Index: -0.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0412
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0493
    Cell Significance Index: -0.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0601
    Cell Significance Index: -2.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0621
    Cell Significance Index: -1.6600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0762
    Cell Significance Index: -0.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0775
    Cell Significance Index: -1.9800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0855
    Cell Significance Index: -0.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0870
    Cell Significance Index: -4.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0926
    Cell Significance Index: -0.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0934
    Cell Significance Index: -2.3800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0954
    Cell Significance Index: -0.8200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0974
    Cell Significance Index: -0.6700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1079
    Cell Significance Index: -1.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1108
    Cell Significance Index: -2.6900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1108
    Cell Significance Index: -1.0800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1142
    Cell Significance Index: -0.9900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1217
    Cell Significance Index: -2.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1228
    Cell Significance Index: -2.2700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1255
    Cell Significance Index: -1.0700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1285
    Cell Significance Index: -1.5900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1308
    Cell Significance Index: -1.2400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1312
    Cell Significance Index: -1.5500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1324
    Cell Significance Index: -1.0100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1334
    Cell Significance Index: -1.8300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1346
    Cell Significance Index: -2.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1348
    Cell Significance Index: -2.2700
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1363
    Cell Significance Index: -1.1300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1364
    Cell Significance Index: -1.9800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1405
    Cell Significance Index: -1.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1408
    Cell Significance Index: -1.4600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1420
    Cell Significance Index: -1.1500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1422
    Cell Significance Index: -2.4300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1448
    Cell Significance Index: -1.3400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1459
    Cell Significance Index: -1.4700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1482
    Cell Significance Index: -2.1600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1482
    Cell Significance Index: -1.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1529
    Cell Significance Index: -4.1600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1536
    Cell Significance Index: -1.2000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1558
    Cell Significance Index: -1.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1561
    Cell Significance Index: -2.0200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1601
    Cell Significance Index: -1.4000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1604
    Cell Significance Index: -1.8600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1606
    Cell Significance Index: -1.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1612
    Cell Significance Index: -2.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1689
    Cell Significance Index: -2.1100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1694
    Cell Significance Index: -2.0600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1704
    Cell Significance Index: -1.9800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1707
    Cell Significance Index: -1.9700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1717
    Cell Significance Index: -1.7800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1730
    Cell Significance Index: -2.2700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1731
    Cell Significance Index: -2.0900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1736
    Cell Significance Index: -2.1100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1747
    Cell Significance Index: -2.2800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1751
    Cell Significance Index: -1.6200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1774
    Cell Significance Index: -1.9400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1775
    Cell Significance Index: -2.2800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1776
    Cell Significance Index: -2.0900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1799
    Cell Significance Index: -2.1900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1831
    Cell Significance Index: -2.2500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1831
    Cell Significance Index: -2.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1865
    Cell Significance Index: -2.6500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1866
    Cell Significance Index: -2.2700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1872
    Cell Significance Index: -2.0400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1891
    Cell Significance Index: -1.5800
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.1893
    Cell Significance Index: -2.0200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1895
    Cell Significance Index: -2.1800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1896
    Cell Significance Index: -2.2400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1896
    Cell Significance Index: -2.0600
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1916
    Cell Significance Index: -1.8700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1921
    Cell Significance Index: -2.0400
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.1937
    Cell Significance Index: -2.0700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1957
    Cell Significance Index: -2.6000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1961
    Cell Significance Index: -2.0000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1965
    Cell Significance Index: -2.0600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1969
    Cell Significance Index: -2.2000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1976
    Cell Significance Index: -2.3700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1986
    Cell Significance Index: -2.2000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1996
    Cell Significance Index: -2.5700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1998
    Cell Significance Index: -2.4100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2001
    Cell Significance Index: -2.1700
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.2001
    Cell Significance Index: -2.0600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2003
    Cell Significance Index: -1.4900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2004
    Cell Significance Index: -2.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure:** The TRBV3-1 gene is a member of the T cell receptor beta (TRB) gene family, which consists of 43 variable region (V) genes. Each V gene encodes for a unique sequence of amino acids that forms the antigen-binding site of the T cell receptor. 2. **Expression Patterns:** The TRBV3-1 gene is expressed in various cell types, including goblet cells, granulocyte monocyte progenitor cells, neoplastic cells, and intestinal epithelial cells. This widespread expression suggests a role in immune surveillance and tissue homeostasis. 3. **Cellular Specificity:** The TRBV3-1 gene is specifically expressed in early T lineage precursors, intestinal crypt stem cells, and transit amplifying cells, indicating a role in the development and maintenance of the immune system. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBV3-1 gene plays a critical role in the adaptive immune response by encoding for a unique antigen-binding site on the T cell receptor. This allows T cells to recognize and respond to specific antigens, thereby protecting against infection and disease. 2. **Cell Surface Receptor Signaling Pathway:** The TRBV3-1 gene is part of the T cell receptor complex, which is a key player in cell surface receptor signaling pathways. The complex interacts with the T cell receptor, activating downstream signaling pathways that regulate T cell activation, proliferation, and differentiation. 3. **Plasma Membrane and T Cell Receptor Complex:** The TRBV3-1 gene is localized to the plasma membrane, where it interacts with other components of the T cell receptor complex to form a functional antigen receptor. **Clinical Significance:** The TRBV3-1 gene has significant implications for our understanding of immune-related diseases and disorders. Mutations or alterations in the TRBV3-1 gene have been associated with various conditions, including: 1. **Autoimmune Diseases:** Dysregulation of the TRBV3-1 gene has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where the immune system mistakenly attacks healthy tissues. 2. **Cancer:** Alterations in the TRBV3-1 gene have been observed in various types of cancer, including leukemia and lymphoma, where the immune system is compromised. 3. **Infectious Diseases:** The TRBV3-1 gene plays a critical role in recognizing and responding to pathogens, and dysregulation of this gene has been associated with increased susceptibility to infectious diseases. In conclusion, the TRBV3-1 gene is a critical component of the adaptive immune response, and its dysregulation has significant implications for our understanding of immune-related diseases and disorders. Further research is needed to fully elucidate the role of the TRBV3-1 gene in immune surveillance and tissue homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.