Details for: TRAV30

Gene ID: 28652

Symbol: TRAV30

Ensembl ID: ENSG00000259092

Description: T cell receptor alpha variable 30

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0133
    Cell Significance Index: 1.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0106
    Cell Significance Index: 0.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0056
    Cell Significance Index: -3.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0091
    Cell Significance Index: -1.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0154
    Cell Significance Index: -2.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0296
    Cell Significance Index: -1.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0321
    Cell Significance Index: -4.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0348
    Cell Significance Index: -4.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0366
    Cell Significance Index: -1.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0446
    Cell Significance Index: -1.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0558
    Cell Significance Index: -1.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0578
    Cell Significance Index: -1.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0736
    Cell Significance Index: -1.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0782
    Cell Significance Index: -1.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0822
    Cell Significance Index: -1.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0825
    Cell Significance Index: -1.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0825
    Cell Significance Index: -1.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0837
    Cell Significance Index: -1.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1108
    Cell Significance Index: -3.2700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1162
    Cell Significance Index: -1.2600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1184
    Cell Significance Index: -1.4400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1253
    Cell Significance Index: -1.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1275
    Cell Significance Index: -4.6800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1278
    Cell Significance Index: -2.1700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1287
    Cell Significance Index: -1.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1317
    Cell Significance Index: -3.3600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1409
    Cell Significance Index: -1.3800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1433
    Cell Significance Index: -1.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1568
    Cell Significance Index: -4.2000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1712
    Cell Significance Index: -1.7900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1850
    Cell Significance Index: -2.2100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1877
    Cell Significance Index: -1.7100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1904
    Cell Significance Index: -1.9700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1924
    Cell Significance Index: -1.9600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1938
    Cell Significance Index: -2.2900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1967
    Cell Significance Index: -1.8000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2041
    Cell Significance Index: -3.9900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2102
    Cell Significance Index: -3.3800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2135
    Cell Significance Index: -3.6800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2148
    Cell Significance Index: -2.7600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2204
    Cell Significance Index: -3.5700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2277
    Cell Significance Index: -3.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2337
    Cell Significance Index: -4.3200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2433
    Cell Significance Index: -2.8000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2443
    Cell Significance Index: -3.5600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2478
    Cell Significance Index: -2.8800
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.2499
    Cell Significance Index: -1.8500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2584
    Cell Significance Index: -1.6800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2596
    Cell Significance Index: -1.8000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2629
    Cell Significance Index: -0.9900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2630
    Cell Significance Index: -3.5000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2678
    Cell Significance Index: -3.1700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2740
    Cell Significance Index: -1.7200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2819
    Cell Significance Index: -3.6800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2884
    Cell Significance Index: -4.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2911
    Cell Significance Index: -3.8200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2931
    Cell Significance Index: -3.0400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2932
    Cell Significance Index: -1.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3069
    Cell Significance Index: -7.0900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3115
    Cell Significance Index: -3.1800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3169
    Cell Significance Index: -3.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3193
    Cell Significance Index: -2.9400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.3197
    Cell Significance Index: -2.6500
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.3207
    Cell Significance Index: -3.5100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3225
    Cell Significance Index: -3.9200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3242
    Cell Significance Index: -4.0100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.3268
    Cell Significance Index: -2.8100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3286
    Cell Significance Index: -3.3200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.3306
    Cell Significance Index: -3.5700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3343
    Cell Significance Index: -3.5500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3348
    Cell Significance Index: -2.8300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3351
    Cell Significance Index: -3.5600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3354
    Cell Significance Index: -3.8900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3364
    Cell Significance Index: -4.2500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3371
    Cell Significance Index: -4.6300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3378
    Cell Significance Index: -4.0100
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3388
    Cell Significance Index: -3.5600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3427
    Cell Significance Index: -3.2900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3428
    Cell Significance Index: -4.1400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3436
    Cell Significance Index: -3.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3493
    Cell Significance Index: -3.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3498
    Cell Significance Index: -4.4800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3571
    Cell Significance Index: -4.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3579
    Cell Significance Index: -4.2300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3613
    Cell Significance Index: -4.0000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3676
    Cell Significance Index: -4.9000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3685
    Cell Significance Index: -4.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3686
    Cell Significance Index: -3.7400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3701
    Cell Significance Index: -4.8700
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.3712
    Cell Significance Index: -3.4600
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.3746
    Cell Significance Index: -4.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3777
    Cell Significance Index: -3.9100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3803
    Cell Significance Index: -3.5700
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3810
    Cell Significance Index: -3.9200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3816
    Cell Significance Index: -3.7200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3821
    Cell Significance Index: -5.2400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3828
    Cell Significance Index: -3.2300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3839
    Cell Significance Index: -3.9800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3860
    Cell Significance Index: -3.6600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3874
    Cell Significance Index: -5.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** TRAV30 is located on chromosome 7 and is expressed in a wide range of cell types, including glutamatergic neurons, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, plasma cells, granulocyte monocyte progenitor cells, goblet cells, early T lineage precursors, effector CD8-positive alpha-beta T cells, and cerebral cortex GABAergic interneurons. 2. **Gene Family:** TRAV30 belongs to the TRAV gene family, which is a group of genes that encode the variable regions of the T cell receptor alpha chain. These genes are responsible for generating the diversity of the T cell receptor repertoire, allowing for the recognition of a vast array of antigens. 3. **Function:** TRAV30 is involved in the development and function of T cells, which are critical for the adaptive immune response. The gene is likely to play a role in the recognition of bacterial antigens and the regulation of the immune response. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV30 is involved in the adaptive immune response, which is a specific and targeted response to pathogens. The gene is likely to play a role in the recognition of bacterial antigens and the activation of T cells. 2. **Response to Bacterium:** TRAV30 is significantly expressed in response to bacterial infections, suggesting that the gene plays a role in the immune response to these pathogens. 3. **T Cell Receptor Complex:** TRAV30 is part of the T cell receptor complex, which is responsible for recognizing and binding to antigens. The gene is likely to contribute to the diversity and specificity of the T cell receptor repertoire. **Clinical Significance:** The TRAV30 gene has significant clinical implications, particularly in the context of immune-related disorders. Mutations or variations in this gene may lead to impaired T cell function, increased susceptibility to infections, or the development of autoimmune diseases. Furthermore, TRAV30 may play a role in the regulation of the immune response to cancer, with potential implications for cancer immunotherapy. In conclusion, the TRAV30 gene is a critical component of the adaptive immune response, and its dysregulation may have significant clinical implications. Further research is needed to fully understand the function and clinical significance of this gene, but its importance in the immune system is clear.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.