Details for: TRAV30

Gene ID: 28652

Symbol: TRAV30

Ensembl ID: ENSG00000259092

Description: T cell receptor alpha variable 30

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,069
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,272
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,838
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3,174
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.87
    Marker Score: 2,089
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.02
    Marker Score: 862
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,047
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,338
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.92
    Marker Score: 612
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.81
    Marker Score: 463
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.78
    Marker Score: 745
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.77
    Marker Score: 444
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 506
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1,163
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 687
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.7
    Marker Score: 617
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 481
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 385
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.36
    Marker Score: 184
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.3
    Marker Score: 320
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.27
    Marker Score: 187
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.25
    Marker Score: 139
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.25
    Marker Score: 404
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.23
    Marker Score: 238
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.23
    Marker Score: 389
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.22
    Marker Score: 385
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.2
    Marker Score: 148
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.19
    Marker Score: 156
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.19
    Marker Score: 332
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.18
    Marker Score: 254
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.18
    Marker Score: 395
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.18
    Marker Score: 343
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.16
    Marker Score: 123
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.14
    Marker Score: 99
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 319
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.09
    Marker Score: 120
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.09
    Marker Score: 81
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.08
    Marker Score: 115
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.07
    Marker Score: 53
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.07
    Marker Score: 3,702
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.05
    Marker Score: 76
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.05
    Marker Score: 121
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.05
    Marker Score: 196
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.04
    Marker Score: 459
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.04
    Marker Score: 100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.03
    Marker Score: 28

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** TRAV30 is located on chromosome 7 and is expressed in a wide range of cell types, including glutamatergic neurons, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, plasma cells, granulocyte monocyte progenitor cells, goblet cells, early T lineage precursors, effector CD8-positive alpha-beta T cells, and cerebral cortex GABAergic interneurons. 2. **Gene Family:** TRAV30 belongs to the TRAV gene family, which is a group of genes that encode the variable regions of the T cell receptor alpha chain. These genes are responsible for generating the diversity of the T cell receptor repertoire, allowing for the recognition of a vast array of antigens. 3. **Function:** TRAV30 is involved in the development and function of T cells, which are critical for the adaptive immune response. The gene is likely to play a role in the recognition of bacterial antigens and the regulation of the immune response. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV30 is involved in the adaptive immune response, which is a specific and targeted response to pathogens. The gene is likely to play a role in the recognition of bacterial antigens and the activation of T cells. 2. **Response to Bacterium:** TRAV30 is significantly expressed in response to bacterial infections, suggesting that the gene plays a role in the immune response to these pathogens. 3. **T Cell Receptor Complex:** TRAV30 is part of the T cell receptor complex, which is responsible for recognizing and binding to antigens. The gene is likely to contribute to the diversity and specificity of the T cell receptor repertoire. **Clinical Significance:** The TRAV30 gene has significant clinical implications, particularly in the context of immune-related disorders. Mutations or variations in this gene may lead to impaired T cell function, increased susceptibility to infections, or the development of autoimmune diseases. Furthermore, TRAV30 may play a role in the regulation of the immune response to cancer, with potential implications for cancer immunotherapy. In conclusion, the TRAV30 gene is a critical component of the adaptive immune response, and its dysregulation may have significant clinical implications. Further research is needed to fully understand the function and clinical significance of this gene, but its importance in the immune system is clear.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.