Details for: TRAV12 2

Gene ID: 28673

Symbol: TRAV12 2

Ensembl ID: ENSG00000211789

Description: T cell receptor alpha variable 12-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.5431
    Cell Significance Index: 12.5000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.0031
    Cell Significance Index: 5.4700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0111
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0194
    Cell Significance Index: -3.9000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0419
    Cell Significance Index: -0.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0595
    Cell Significance Index: -3.1000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0624
    Cell Significance Index: -1.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0639
    Cell Significance Index: -0.7600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0640
    Cell Significance Index: -0.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0703
    Cell Significance Index: -1.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0717
    Cell Significance Index: -1.1100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0752
    Cell Significance Index: -0.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0772
    Cell Significance Index: -3.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0805
    Cell Significance Index: -1.9500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0807
    Cell Significance Index: -1.1800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0810
    Cell Significance Index: -0.9100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0995
    Cell Significance Index: -0.9700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1026
    Cell Significance Index: -2.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1060
    Cell Significance Index: -2.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1094
    Cell Significance Index: -1.1100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1117
    Cell Significance Index: -1.3200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1139
    Cell Significance Index: -0.9700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1170
    Cell Significance Index: -2.9800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1178
    Cell Significance Index: -1.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1247
    Cell Significance Index: -2.1000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1268
    Cell Significance Index: -1.0900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1280
    Cell Significance Index: -0.3900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1311
    Cell Significance Index: -1.0200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1392
    Cell Significance Index: -1.3200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1427
    Cell Significance Index: -1.7700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1454
    Cell Significance Index: -1.3600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1457
    Cell Significance Index: -2.3600
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1508
    Cell Significance Index: -1.2500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1519
    Cell Significance Index: -1.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1519
    Cell Significance Index: -1.4600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1583
    Cell Significance Index: -3.1000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1584
    Cell Significance Index: -2.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1595
    Cell Significance Index: -2.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1626
    Cell Significance Index: -2.4000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1630
    Cell Significance Index: -1.6900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1701
    Cell Significance Index: -1.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1726
    Cell Significance Index: -3.1900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1751
    Cell Significance Index: -2.0600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1754
    Cell Significance Index: -1.8600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1777
    Cell Significance Index: -1.7900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1783
    Cell Significance Index: -1.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1784
    Cell Significance Index: -1.8500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1823
    Cell Significance Index: -1.9600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1858
    Cell Significance Index: -2.4300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1860
    Cell Significance Index: -3.1800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1885
    Cell Significance Index: -2.2800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1903
    Cell Significance Index: -2.6100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1922
    Cell Significance Index: -3.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1969
    Cell Significance Index: -2.9900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1993
    Cell Significance Index: -1.7200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2013
    Cell Significance Index: -2.3400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2038
    Cell Significance Index: -2.9700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2039
    Cell Significance Index: -2.6200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2050
    Cell Significance Index: -2.2100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2052
    Cell Significance Index: -2.4600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2053
    Cell Significance Index: -2.5700
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2055
    Cell Significance Index: -2.3400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2062
    Cell Significance Index: -2.9300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2094
    Cell Significance Index: -2.3600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2121
    Cell Significance Index: -1.7900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2140
    Cell Significance Index: -3.0000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2154
    Cell Significance Index: -2.3400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2160
    Cell Significance Index: -2.5100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2169
    Cell Significance Index: -2.5500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2191
    Cell Significance Index: -2.2600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2192
    Cell Significance Index: -3.0100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.2238
    Cell Significance Index: -2.3900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2240
    Cell Significance Index: -2.4500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2278
    Cell Significance Index: -2.8000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2285
    Cell Significance Index: -2.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2287
    Cell Significance Index: -3.0100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2298
    Cell Significance Index: -2.4400
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2301
    Cell Significance Index: -2.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2327
    Cell Significance Index: -2.5400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.2347
    Cell Significance Index: -2.5400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2362
    Cell Significance Index: -3.1000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2367
    Cell Significance Index: -3.0900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2370
    Cell Significance Index: -3.1500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2382
    Cell Significance Index: -2.0300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2384
    Cell Significance Index: -3.0700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2396
    Cell Significance Index: -2.4300
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.2448
    Cell Significance Index: -2.6400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2454
    Cell Significance Index: -2.4300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2471
    Cell Significance Index: -2.9200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2471
    Cell Significance Index: -2.5200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2471
    Cell Significance Index: -2.4200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2474
    Cell Significance Index: -3.0100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2475
    Cell Significance Index: -3.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2479
    Cell Significance Index: -2.9500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2497
    Cell Significance Index: -2.3100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2501
    Cell Significance Index: -2.2500
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.2501
    Cell Significance Index: -2.4100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2522
    Cell Significance Index: -2.4400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2547
    Cell Significance Index: -2.7800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2549
    Cell Significance Index: -3.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV12.2 is a member of the T cell receptor alpha (TRAV) gene family, which is responsible for encoding the variable region of the TCR alpha chain. The gene is specifically expressed in a variety of cell types, including goblet cells, granulocyte-monocyte progenitor cells, neoplastic cells, and intestinal epithelial cells. The expression of TRAV12.2 is tightly regulated and is essential for the proper functioning of the adaptive immune response. **Pathways and Functions:** The TCR complex, including TRAV12.2, plays a central role in the adaptive immune response by recognizing and binding to peptide antigens presented by MHC molecules on antigen-presenting cells (APCs). This interaction triggers a series of downstream signaling events that lead to T cell activation, proliferation, and differentiation into effector cells. The TCR complex also regulates the function of immune cells, including T helper (Th) cells, cytotoxic T cells (CTLs), and regulatory T cells (Tregs). The expression of TRAV12.2 is also associated with the maintenance of immune homeostasis and the prevention of autoimmunity. The gene is involved in the regulation of T cell development and differentiation, and its dysregulation has been implicated in various autoimmune diseases. **Clinical Significance:** Dysregulation of TRAV12.2 expression has been implicated in various diseases, including: 1. **Autoimmune disorders**: Alterations in TRAV12.2 expression have been associated with autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. 2. **Cancer**: TRAV12.2 expression has been found to be altered in various types of cancer, including breast cancer, lung cancer, and colon cancer. 3. **Infectious diseases**: TRAV12.2 expression has been found to be altered in response to infection, and its dysregulation has been implicated in the development of autoimmune diseases. 4. **Immunodeficiency disorders**: Mutations in the TRAV12.2 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, TRAV12.2 is a critical component of the TCR complex, and its dysregulation has significant implications for the adaptive immune response. Further research is needed to fully understand the role of TRAV12.2 in disease and to develop effective therapeutic strategies to manipulate its expression. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which TRAV12.2 regulates immune homeostasis and autoimmunity. 2. The development of novel therapeutic strategies targeting TRAV12.2 expression may provide new avenues for the treatment of autoimmune diseases and cancer. 3. The study of TRAV12.2 expression in response to infection and immunodeficiency disorders may provide insights into the development of new diagnostic and therapeutic strategies. **Limitations:** 1. The current understanding of TRAV12.2 is limited by the availability of functional data and the complexity of the immune system. 2. Further research is needed to fully elucidate the mechanisms by which TRAV12.2 regulates immune homeostasis and autoimmunity. **Future Directions:** 1. The development of novel functional assays to study the role of TRAV12.2 in the adaptive immune response. 2. The use of next-generation sequencing and bioinformatics tools to analyze TRAV12.2 expression in various disease states. 3. The investigation of TRAV12.2 expression in response to infection and immunodeficiency disorders to provide insights into the development of new diagnostic and therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.