Details for: TRAV8 6

Gene ID: 28680

Symbol: TRAV8 6

Ensembl ID: ENSG00000211795

Description: T cell receptor alpha variable 8-6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0698
    Cell Significance Index: -3.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0877
    Cell Significance Index: -4.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0912
    Cell Significance Index: -9.3200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1457
    Cell Significance Index: -2.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2196
    Cell Significance Index: -5.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2199
    Cell Significance Index: -3.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2462
    Cell Significance Index: -6.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2672
    Cell Significance Index: -3.9400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2689
    Cell Significance Index: -3.7300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2769
    Cell Significance Index: -3.3200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.3533
    Cell Significance Index: -3.4600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3599
    Cell Significance Index: -4.2300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3714
    Cell Significance Index: -3.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3937
    Cell Significance Index: -10.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4107
    Cell Significance Index: -10.9900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.4166
    Cell Significance Index: -4.3100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4171
    Cell Significance Index: -5.0700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.4195
    Cell Significance Index: -3.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4619
    Cell Significance Index: -11.8000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.4899
    Cell Significance Index: -3.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5364
    Cell Significance Index: -15.8000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.5436
    Cell Significance Index: -8.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5456
    Cell Significance Index: -15.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5713
    Cell Significance Index: -10.5600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.5716
    Cell Significance Index: -7.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5841
    Cell Significance Index: -11.4200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5896
    Cell Significance Index: -5.5900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.6189
    Cell Significance Index: -9.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.6762
    Cell Significance Index: -7.9900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.7140
    Cell Significance Index: -7.9800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.7177
    Cell Significance Index: -9.2200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7216
    Cell Significance Index: -10.9600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7306
    Cell Significance Index: -10.2400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.7478
    Cell Significance Index: -10.2600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.7483
    Cell Significance Index: -9.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.7502
    Cell Significance Index: -7.7800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.7578
    Cell Significance Index: -10.0700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.7605
    Cell Significance Index: -9.9800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.7606
    Cell Significance Index: -8.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7631
    Cell Significance Index: -13.1600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.8053
    Cell Significance Index: -10.0600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.8125
    Cell Significance Index: -7.9200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.8305
    Cell Significance Index: -10.1100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.8332
    Cell Significance Index: -13.5000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.8585
    Cell Significance Index: -8.0600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.8600
    Cell Significance Index: -10.2100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.8832
    Cell Significance Index: -10.9300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.8941
    Cell Significance Index: -11.4500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.8970
    Cell Significance Index: -8.6100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.8993
    Cell Significance Index: -9.0900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.9016
    Cell Significance Index: -9.0400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.9086
    Cell Significance Index: -7.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.9089
    Cell Significance Index: -6.5300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.9109
    Cell Significance Index: -9.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.9177
    Cell Significance Index: -10.5600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.9215
    Cell Significance Index: -5.0300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.9228
    Cell Significance Index: -10.2200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.9269
    Cell Significance Index: -12.1000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.9364
    Cell Significance Index: -11.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.9380
    Cell Significance Index: -10.8800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.9414
    Cell Significance Index: -10.3800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.9591
    Cell Significance Index: -11.4000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.9635
    Cell Significance Index: -12.6800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.9639
    Cell Significance Index: -11.4700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.9662
    Cell Significance Index: -16.4100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.9662
    Cell Significance Index: -9.9400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.9718
    Cell Significance Index: -3.6600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.9737
    Cell Significance Index: -8.7600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.9833
    Cell Significance Index: -11.6200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.9867
    Cell Significance Index: -8.6300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.9962
    Cell Significance Index: -7.7500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.9963
    Cell Significance Index: -10.5000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -1.0017
    Cell Significance Index: -10.8000
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -1.0036
    Cell Significance Index: -9.8000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -1.0080
    Cell Significance Index: -11.1600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -1.0141
    Cell Significance Index: -11.6700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -1.0147
    Cell Significance Index: -12.3500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -1.0153
    Cell Significance Index: -10.2300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -1.0155
    Cell Significance Index: -11.0100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -1.0167
    Cell Significance Index: -9.6200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -1.0176
    Cell Significance Index: -11.5600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -1.0203
    Cell Significance Index: -8.6100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -1.0215
    Cell Significance Index: -9.3100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -1.0238
    Cell Significance Index: -10.4600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -1.0258
    Cell Significance Index: -12.4700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -1.0279
    Cell Significance Index: -9.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -1.0301
    Cell Significance Index: -10.4500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -1.0351
    Cell Significance Index: -11.1300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -1.0405
    Cell Significance Index: -11.6500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -1.0410
    Cell Significance Index: -9.8700
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -1.0529
    Cell Significance Index: -9.7100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -1.0546
    Cell Significance Index: -9.1000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -1.0565
    Cell Significance Index: -9.0100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -1.0571
    Cell Significance Index: -9.0900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -1.0606
    Cell Significance Index: -11.7800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -1.0620
    Cell Significance Index: -10.6000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -1.0622
    Cell Significance Index: -9.4900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -1.0649
    Cell Significance Index: -9.8500
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -1.0659
    Cell Significance Index: -9.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV8-6 exhibits several distinct characteristics that underscore its importance in the immune response. Firstly, its expression is significantly elevated in cells of the myeloid lineage, including granulocytes and monocytes. This suggests that TRAV8-6 may play a role in the regulation of myeloid cell function and development. Additionally, its expression is also observed in early T lineage precursors, which implies that TRAV8-6 may contribute to the development and maturation of T cells. **Pathways and Functions:** The TRAV8-6 gene is embedded within the T cell receptor (TCR) complex, a critical component of the adaptive immune response. The TCR complex is responsible for recognizing and binding to specific antigens, triggering a cascade of signaling events that ultimately lead to T cell activation and proliferation. TRAV8-6 is thought to participate in this process by contributing to the development and maturation of alpha-beta cytotoxic T cells, which are essential for eliminating infected cells and tumor cells. Furthermore, TRAV8-6 has been implicated in the regulation of immune cell function and development. Its expression has been shown to influence the differentiation and proliferation of T cells, as well as the maturation of B cells. This suggests that TRAV8-6 may play a broader role in the regulation of the immune system, potentially influencing the balance between different immune cell populations. **Clinical Significance:** The clinical significance of TRAV8-6 is an area of active research, with potential implications for the diagnosis and treatment of immune-related disorders. One area of interest is the potential role of TRAV8-6 in autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Mutations in TRAV8-6 have been associated with these diseases, suggesting that alterations in TRAV8-6 expression may contribute to the development of autoimmune responses. Furthermore, TRAV8-6 may also play a role in the regulation of cancer immunity. Its expression has been observed in various types of cancer, including melanoma and lung cancer, suggesting that TRAV8-6 may contribute to the development of anti-tumor immune responses. In conclusion, the TRAV8-6 gene is a critical component of the adaptive immune response, with a broad range of functions and clinical significance. Further research is needed to fully elucidate the mechanisms by which TRAV8-6 regulates immune cell function and development, as well as its role in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.