IGLV6 57 | ENSG00000211640 | NCBI 28778

Details for: IGLV6 57

Gene ID: 28778

Symbol: IGLV6 57

Ensembl ID: ENSG00000211640

Description: immunoglobulin lambda variable 6-57

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 10.2516
Cell Significance Index: -4.8400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 8.7365
Cell Significance Index: 306.9900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 4.9226
Cell Significance Index: 141.8300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 4.3809
Cell Significance Index: 109.5100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 3.6933
Cell Significance Index: 76.6200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.2874
Cell Significance Index: 49.5600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.7725
Cell Significance Index: 56.7700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4263
Cell Significance Index: 64.6500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.0649
Cell Significance Index: 16.0500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0644
Cell Significance Index: 202.5600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7417
Cell Significance Index: 73.3800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6389
Cell Significance Index: 576.8900
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.6030
Cell Significance Index: 8.7600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4491
Cell Significance Index: 9.5700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3946
Cell Significance Index: 64.1900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3368
Cell Significance Index: 36.6400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2056
Cell Significance Index: 14.2200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1430
Cell Significance Index: 8.5900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0006
Cell Significance Index: -0.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0006
Cell Significance Index: -0.4800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0011
Cell Significance Index: -0.6200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0025
Cell Significance Index: -0.5300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0055
Cell Significance Index: -0.7100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0062
Cell Significance Index: -4.6800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0112
Cell Significance Index: -1.1400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0155
Cell Significance Index: -11.3300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0389
Cell Significance Index: -2.3900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0516
Cell Significance Index: -1.3800
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0631
Cell Significance Index: -0.7800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0655
Cell Significance Index: -1.6400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0990
Cell Significance Index: -5.2000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1041
Cell Significance Index: -5.4100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1163
Cell Significance Index: -15.0300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1180
Cell Significance Index: -5.5000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1230
Cell Significance Index: -1.4000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1349
Cell Significance Index: -27.0600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1446
Cell Significance Index: -19.8600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1584
Cell Significance Index: -10.2200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1918
Cell Significance Index: -4.9000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1997
Cell Significance Index: -14.8800
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.2072
Cell Significance Index: -1.7100
Cell Name: mural cell (CL0008034)
Fold Change: -0.2099
Cell Significance Index: -2.5600
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.2156
Cell Significance Index: -2.4100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2160
Cell Significance Index: -7.9300
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2202
Cell Significance Index: -2.4600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2282
Cell Significance Index: -7.9300
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2315
Cell Significance Index: -3.1500
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.2405
Cell Significance Index: -2.8300
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2753
Cell Significance Index: -3.6000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2779
Cell Significance Index: -7.0800
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2798
Cell Significance Index: -2.3500
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2851
Cell Significance Index: -4.1700
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2882
Cell Significance Index: -4.1300
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2943
Cell Significance Index: -1.9600
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3082
Cell Significance Index: -3.9100
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3188
Cell Significance Index: -3.3000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3215
Cell Significance Index: -9.4700
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.3421
Cell Significance Index: -4.1300
Cell Name: retina horizontal cell (CL0000745)
Fold Change: -0.3666
Cell Significance Index: -4.6000
Cell Name: thymocyte (CL0000893)
Fold Change: -0.3696
Cell Significance Index: -4.6700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3698
Cell Significance Index: -5.9900
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3716
Cell Significance Index: -9.0000
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.3816
Cell Significance Index: -4.5100
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3913
Cell Significance Index: -4.4300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3937
Cell Significance Index: -6.7300
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3937
Cell Significance Index: -3.2100
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.3942
Cell Significance Index: -4.6800
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3951
Cell Significance Index: -4.7100
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.3995
Cell Significance Index: -5.0600
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.4136
Cell Significance Index: -4.5600
Cell Name: myelocyte (CL0002193)
Fold Change: -0.4137
Cell Significance Index: -4.4200
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.4203
Cell Significance Index: -5.3900
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4309
Cell Significance Index: -4.7000
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.4336
Cell Significance Index: -5.4300
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4386
Cell Significance Index: -5.4400
Cell Name: promonocyte (CL0000559)
Fold Change: -0.4391
Cell Significance Index: -4.6900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4409
Cell Significance Index: -8.6200
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.4421
Cell Significance Index: -4.6000
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.4445
Cell Significance Index: -4.5100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4446
Cell Significance Index: -7.4400
Cell Name: plasmablast (CL0000980)
Fold Change: -0.4450
Cell Significance Index: -4.1300
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.4461
Cell Significance Index: -5.0600
Cell Name: monocyte (CL0000576)
Fold Change: -0.4502
Cell Significance Index: -5.1800
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.4525
Cell Significance Index: -4.9500
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.4541
Cell Significance Index: -5.1300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4556
Cell Significance Index: -8.4200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.4648
Cell Significance Index: -7.8300
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4663
Cell Significance Index: -5.9900
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4745
Cell Significance Index: -6.1400
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.4776
Cell Significance Index: -6.5500
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: -0.4837
Cell Significance Index: -5.2000
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.4855
Cell Significance Index: -4.7900
Cell Name: helper T cell (CL0000912)
Fold Change: -0.4870
Cell Significance Index: -6.9200
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.4892
Cell Significance Index: -5.4400
Cell Name: leukocyte (CL0000738)
Fold Change: -0.4952
Cell Significance Index: -8.4100
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5074
Cell Significance Index: -5.3900
Cell Name: club cell (CL0000158)
Fold Change: -0.5103
Cell Significance Index: -5.5600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5186
Cell Significance Index: -14.8700
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.5227
Cell Significance Index: -7.2500
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.5380
Cell Significance Index: -6.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Immunoglobulin Lambda Variable Gene**: The IGLV6-57 gene is a member of the immunoglobulin lambda variable (IGLV) gene family, which plays a critical role in the production of antibodies. 2. **High Expression in Immune Cells**: The IGLV6-57 gene is highly expressed in various immune cells, including B cells, natural killer cells, and granulocytes, indicating its importance in regulating immune responses. 3. **Multiple Signaling Pathways**: The IGLV6-57 gene is involved in multiple signaling pathways, including the activation of the B cell receptor (BCR), the regulation of complement cascade, and the modulation of calcium mobilization. 4. **Leishmania Infection**: The IGLV6-57 gene has been implicated in the regulation of immune responses against Leishmania parasites, suggesting its potential role in the development of novel therapeutic strategies. **Pathways and Functions:** 1. **Adaptive Immune Response**: The IGLV6-57 gene plays a critical role in the adaptive immune response, regulating the activation of B cells and the production of antibodies. 2. **Complement Cascade**: The IGLV6-57 gene is involved in the regulation of the complement cascade, a critical component of the innate immune response. 3. **Calcium Mobilization**: The IGLV6-57 gene modulates calcium mobilization, which is essential for various cellular processes, including cell signaling and phagocytosis. 4. **Antigen Binding**: The IGLV6-57 gene is involved in the binding of antigens to the B cell receptor (BCR), leading to the activation of B cells and the production of antibodies. 5. **Regulation of Actin Dynamics**: The IGLV6-57 gene regulates actin dynamics, which is essential for phagocytic cup formation and the clearance of pathogens. **Clinical Significance:** 1. **Leishmania Infection**: The IGLV6-57 gene has been implicated in the regulation of immune responses against Leishmania parasites, suggesting its potential role in the development of novel therapeutic strategies. 2. **Immunodeficiency Disorders**: The IGLV6-57 gene may play a critical role in the development of immunodeficiency disorders, such as agammaglobulinemia, which is characterized by a lack of antibodies. 3. **Cancer Immunotherapy**: The IGLV6-57 gene may be involved in the regulation of immune responses against cancer cells, suggesting its potential role in the development of novel cancer immunotherapies. 4. **Viral Infections**: The IGLV6-57 gene may play a critical role in the regulation of immune responses against viral infections, such as SARS-CoV, suggesting its potential role in the development of novel therapeutic strategies. In conclusion, the IGLV6-57 gene is a critical component of the immune system, playing a vital role in the adaptive immune response against various pathogens, including Leishmania parasites. Understanding the function and significance of this gene is essential for developing novel therapeutic strategies against Leishmania infection and other immune-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.