IGKV1 12 | ENSG00000243290 | NCBI 28940

Details for: IGKV1 12

Gene ID: 28940

Symbol: IGKV1 12

Ensembl ID: ENSG00000243290

Description: immunoglobulin kappa variable 1-12

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1028
Cell Significance Index: 1.5900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0058
Cell Significance Index: -4.4200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0322
Cell Significance Index: -3.2900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0829
Cell Significance Index: -5.0800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1137
Cell Significance Index: -2.7600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1172
Cell Significance Index: -16.1000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1267
Cell Significance Index: -3.3900
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1610
Cell Significance Index: -2.0400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1628
Cell Significance Index: -4.1600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1739
Cell Significance Index: -4.4300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1841
Cell Significance Index: -6.7600
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1887
Cell Significance Index: -2.2300
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2207
Cell Significance Index: -1.4700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2336
Cell Significance Index: -2.6100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2401
Cell Significance Index: -4.7000
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.2514
Cell Significance Index: -2.8100
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.2568
Cell Significance Index: -3.1000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2662
Cell Significance Index: -4.9200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2715
Cell Significance Index: -7.1400
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2787
Cell Significance Index: -3.6500
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2881
Cell Significance Index: -3.9200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2962
Cell Significance Index: -4.3000
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2966
Cell Significance Index: -5.0700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3124
Cell Significance Index: -5.0600
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3154
Cell Significance Index: -4.3300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3176
Cell Significance Index: -14.8100
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.3177
Cell Significance Index: -3.9300
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3298
Cell Significance Index: -3.3700
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3343
Cell Significance Index: -3.5200
Cell Name: thymocyte (CL0000893)
Fold Change: -0.3463
Cell Significance Index: -4.3800
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3542
Cell Significance Index: -3.4000
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.3569
Cell Significance Index: -5.2200
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.3587
Cell Significance Index: -4.2200
Cell Name: promonocyte (CL0000559)
Fold Change: -0.3680
Cell Significance Index: -3.9300
Cell Name: peg cell (CL4033014)
Fold Change: -0.3735
Cell Significance Index: -8.6300
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.3778
Cell Significance Index: -3.3700
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3792
Cell Significance Index: -3.8500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3796
Cell Significance Index: -7.6200
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.3799
Cell Significance Index: -4.5100
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3828
Cell Significance Index: -3.1600
Cell Name: glial cell (CL0000125)
Fold Change: -0.3843
Cell Significance Index: -4.2100
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3860
Cell Significance Index: -4.3700
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.3868
Cell Significance Index: -4.2700
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.3885
Cell Significance Index: -3.8400
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.3905
Cell Significance Index: -5.1300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.3918
Cell Significance Index: -5.0700
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3948
Cell Significance Index: -3.6100
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3954
Cell Significance Index: -4.9400
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3959
Cell Significance Index: -4.3300
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.4011
Cell Significance Index: -3.9100
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.4016
Cell Significance Index: -4.2700
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: -0.4034
Cell Significance Index: -4.2700
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.4038
Cell Significance Index: -4.2900
Cell Name: plasmablast (CL0000980)
Fold Change: -0.4127
Cell Significance Index: -3.8300
Cell Name: myelocyte (CL0002193)
Fold Change: -0.4137
Cell Significance Index: -4.4200
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.4161
Cell Significance Index: -4.3300
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -0.4168
Cell Significance Index: -3.2000
Cell Name: osteoclast (CL0000092)
Fold Change: -0.4202
Cell Significance Index: -4.2900
Cell Name: acinar cell (CL0000622)
Fold Change: -0.4212
Cell Significance Index: -5.2900
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4239
Cell Significance Index: -4.5100
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.4295
Cell Significance Index: -4.8400
Cell Name: monocyte (CL0000576)
Fold Change: -0.4345
Cell Significance Index: -5.0000
Cell Name: B cell (CL0000236)
Fold Change: -0.4350
Cell Significance Index: -5.1400
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.4366
Cell Significance Index: -6.0600
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.4372
Cell Significance Index: -2.4300
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -0.4469
Cell Significance Index: -3.8500
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.4560
Cell Significance Index: -5.4200
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.4562
Cell Significance Index: -5.3000
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: -0.4568
Cell Significance Index: -4.3500
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4661
Cell Significance Index: -5.1600
Cell Name: muscle cell (CL0000187)
Fold Change: -0.4662
Cell Significance Index: -4.4600
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.4663
Cell Significance Index: -4.2500
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.4666
Cell Significance Index: -3.7500
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.4673
Cell Significance Index: -5.0600
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.4673
Cell Significance Index: -5.6800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.4702
Cell Significance Index: -7.9200
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.4719
Cell Significance Index: -5.1800
Cell Name: platelet (CL0000233)
Fold Change: -0.4724
Cell Significance Index: -4.8600
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.4757
Cell Significance Index: -4.2500
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.4766
Cell Significance Index: -5.3000
Cell Name: basophil (CL0000767)
Fold Change: -0.4825
Cell Significance Index: -4.4400
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4842
Cell Significance Index: -5.2200
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.4862
Cell Significance Index: -4.5300
Cell Name: club cell (CL0000158)
Fold Change: -0.4883
Cell Significance Index: -5.3200
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.4892
Cell Significance Index: -5.1600
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.4925
Cell Significance Index: -5.1900
Cell Name: fibroblast (CL0000057)
Fold Change: -0.4937
Cell Significance Index: -4.6400
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.4962
Cell Significance Index: -5.4200
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.4971
Cell Significance Index: -5.3900
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.4984
Cell Significance Index: -4.9800
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.5007
Cell Significance Index: -5.4200
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.5023
Cell Significance Index: -5.7800
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.5029
Cell Significance Index: -4.9600
Cell Name: blood cell (CL0000081)
Fold Change: -0.5045
Cell Significance Index: -4.3000
Cell Name: T cell (CL0000084)
Fold Change: -0.5065
Cell Significance Index: -5.9800
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.5068
Cell Significance Index: -6.7400
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.5088
Cell Significance Index: -4.4700
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.5114
Cell Significance Index: -5.3600
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.5146
Cell Significance Index: -6.2600
Cell Name: alveolar adventitial fibroblast (CL4028006)
Fold Change: -0.5150
Cell Significance Index: -5.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGKV1-12 is a member of the immunoglobulin family, which consists of genes that encode for the variable region of immunoglobulins (Ig). The IGKV1-12 gene is unique in that it encodes for a kappa light chain variable region, which is a critical component of the antibody structure. This gene is expressed in a wide range of cell types, including: * Immune cells: B cells, natural killer cells, and dendritic cells * Endothelial cells: Blood vessel endothelial cells * Non-immune cells: Glutamatergic neurons, oligodendrocyte precursor cells, goblet cells, and others **Pathways and Functions:** IGKV1-12 is involved in various cellular interactions and signaling pathways, including: 1. **Adaptive Immune Response**: IGKV1-12 plays a crucial role in the adaptive immune response, particularly in the activation of B cells and the production of antibodies. 2. **Anti-inflammatory Response**: IGKV1-12 is involved in the anti-inflammatory response, particularly in the regulation of immune responses against pathogens like Leishmania parasites. 3. **Cell Surface Interactions**: IGKV1-12 mediates cell surface interactions, including binding and uptake of ligands by scavenger receptors, Cd22-mediated BCR regulation, and FcεRI signaling. 4. **Complement Activation**: IGKV1-12 is involved in the classical antibody-mediated complement activation pathway, which is crucial for the elimination of pathogens. 5. **Innate Immune Response**: IGKV1-12 also plays a role in the innate immune response, particularly in the recognition and elimination of pathogens. **Clinical Significance:** The IGKV1-12 gene has significant implications for various diseases, including: 1. **Leishmania Infections**: IGKV1-12 is involved in the regulation of immune responses against Leishmania parasites, making it a potential target for therapeutic interventions. 2. **Infectious Diseases**: IGKV1-12 plays a crucial role in the recognition and elimination of pathogens, making it a potential target for the development of novel therapeutic agents. 3. **Autoimmune Diseases**: IGKV1-12 may also contribute to the development of autoimmune diseases by modulating immune responses and promoting inflammation. 4. **Cancer**: IGKV1-12 may also play a role in cancer development and progression, particularly in the regulation of immune responses and the promotion of tumor growth. In conclusion, the IGKV1-12 gene is a complex and multifaceted gene that plays a crucial role in the immune system. Its involvement in various cellular interactions and signaling pathways highlights its importance in regulating immune responses and modulating disease outcomes. Further research is needed to fully elucidate the functions of IGKV1-12 and its potential implications for human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.