Details for: IGKV1 9

Gene ID: 28941

Symbol: IGKV1 9

Ensembl ID: ENSG00000241755

Description: immunoglobulin kappa variable 1-9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0922
    Cell Significance Index: 1.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0125
    Cell Significance Index: 1.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0084
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0255
    Cell Significance Index: -5.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0359
    Cell Significance Index: -3.6700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0568
    Cell Significance Index: -0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0649
    Cell Significance Index: -3.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0955
    Cell Significance Index: -2.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0957
    Cell Significance Index: -2.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1083
    Cell Significance Index: -4.9100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1147
    Cell Significance Index: -1.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1297
    Cell Significance Index: -4.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1327
    Cell Significance Index: -3.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1441
    Cell Significance Index: -1.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1489
    Cell Significance Index: -4.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1542
    Cell Significance Index: -5.4200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1548
    Cell Significance Index: -1.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1647
    Cell Significance Index: -3.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1723
    Cell Significance Index: -4.3900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1857
    Cell Significance Index: -3.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1899
    Cell Significance Index: -5.4700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1931
    Cell Significance Index: -3.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1945
    Cell Significance Index: -3.1500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1997
    Cell Significance Index: -2.4700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2006
    Cell Significance Index: -2.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2029
    Cell Significance Index: -3.7500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.2140
    Cell Significance Index: -1.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2190
    Cell Significance Index: -10.2100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2282
    Cell Significance Index: -1.5200
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2471
    Cell Significance Index: -2.0400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2521
    Cell Significance Index: -4.3100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2535
    Cell Significance Index: -4.2700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2592
    Cell Significance Index: -3.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2614
    Cell Significance Index: -6.0400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2705
    Cell Significance Index: -2.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2785
    Cell Significance Index: -4.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2826
    Cell Significance Index: -3.8800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2836
    Cell Significance Index: -3.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2850
    Cell Significance Index: -3.2400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2925
    Cell Significance Index: -3.0800
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3011
    Cell Significance Index: -2.8900
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3040
    Cell Significance Index: -2.3200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3049
    Cell Significance Index: -2.7200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3080
    Cell Significance Index: -3.6400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3083
    Cell Significance Index: -3.1800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3102
    Cell Significance Index: -3.3000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3185
    Cell Significance Index: -2.7200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3186
    Cell Significance Index: -3.9800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3254
    Cell Significance Index: -4.2100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3311
    Cell Significance Index: -4.3300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3349
    Cell Significance Index: -4.0400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3361
    Cell Significance Index: -3.0400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3514
    Cell Significance Index: -3.8900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3523
    Cell Significance Index: -3.8600
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.3526
    Cell Significance Index: -2.3000
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.3554
    Cell Significance Index: -3.2500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3577
    Cell Significance Index: -3.8000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3581
    Cell Significance Index: -4.2700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3583
    Cell Significance Index: -4.5000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3587
    Cell Significance Index: -4.9800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3633
    Cell Significance Index: -4.1800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3646
    Cell Significance Index: -3.9200
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.3661
    Cell Significance Index: -3.0500
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.3689
    Cell Significance Index: -2.6000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3698
    Cell Significance Index: -4.3000
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.3782
    Cell Significance Index: -3.7300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3782
    Cell Significance Index: -4.1700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3800
    Cell Significance Index: -4.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3812
    Cell Significance Index: -3.8700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.3815
    Cell Significance Index: -3.6100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.3823
    Cell Significance Index: -2.6900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3847
    Cell Significance Index: -3.7500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3858
    Cell Significance Index: -4.6900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3884
    Cell Significance Index: -5.6800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3886
    Cell Significance Index: -4.1200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3888
    Cell Significance Index: -4.0000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.3927
    Cell Significance Index: -3.9300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3936
    Cell Significance Index: -5.1700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3940
    Cell Significance Index: -5.1900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3958
    Cell Significance Index: -4.4600
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.3973
    Cell Significance Index: -4.2500
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.3987
    Cell Significance Index: -3.7000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3989
    Cell Significance Index: -4.7100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3990
    Cell Significance Index: -3.4900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3994
    Cell Significance Index: -3.9400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4002
    Cell Significance Index: -4.6500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4014
    Cell Significance Index: -5.2400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4016
    Cell Significance Index: -4.3300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4018
    Cell Significance Index: -4.4500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4026
    Cell Significance Index: -4.6700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4037
    Cell Significance Index: -4.4900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4041
    Cell Significance Index: -5.3700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.4074
    Cell Significance Index: -4.4100
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4096
    Cell Significance Index: -4.5500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.4143
    Cell Significance Index: -4.1400
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.4157
    Cell Significance Index: -4.5400
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.4158
    Cell Significance Index: -4.0600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4169
    Cell Significance Index: -4.9600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.4178
    Cell Significance Index: -4.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin kappa variable**: IGKV1-9 is a member of the immunoglobulin superfamily, which comprises proteins that recognize and bind to specific antigens. 2. **Variable region**: The kappa variable region of IGKV1-9 is responsible for recognizing and binding to antigens, a process essential for the activation of the adaptive immune response. 3. **Cellular expression**: IGKV1-9 is expressed in a wide range of cell types, including CD16-positive natural killer cells, early T lineage precursors, and epithelial cells of the fallopian tube and intestine. 4. **Pathway involvement**: IGKV1-9 is involved in various signaling pathways, including the adaptive immune response, extracellular space, and immune response. **Pathways and Functions:** 1. **Adaptive immune response**: IGKV1-9 plays a crucial role in the adaptive immune response by producing kappa light chains, which are essential for the recognition and neutralization of pathogens. 2. **Extracellular space**: IGKV1-9 is involved in the regulation of the extracellular space by modulating the expression of immune-related genes. 3. **Immune response**: IGKV1-9 is a key player in the immune response by regulating the production of antibodies and the activation of immune cells. 4. **Immunoglobulin complex**: IGKV1-9 is part of the immunoglobulin complex, which is responsible for the recognition and binding to antigens. 5. **Immunoglobulin production**: IGKV1-9 is involved in the production of immunoglobulins, which are essential for the neutralization of pathogens. **Clinical Significance:** 1. **Immunodeficiency disorders**: Abnormal expression or mutation of IGKV1-9 has been linked to immunodeficiency disorders, such as X-linked hyper-IgM syndrome. 2. **Cancer**: IGKV1-9 has been implicated in the development and progression of various cancers, including lymphoma and leukemia. 3. **Autoimmune diseases**: IGKV1-9 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system attacks healthy tissues. 4. **Infectious diseases**: IGKV1-9 plays a crucial role in the immune response to infectious diseases, such as HIV and tuberculosis. In conclusion, IGKV1-9 is a complex gene that plays a pivotal role in the adaptive immune response. Its involvement in various signaling pathways and cellular expression patterns highlights its importance in maintaining immune homeostasis. Further research is necessary to fully elucidate the clinical significance of IGKV1-9 and its potential applications in the treatment of immunodeficiency disorders and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.