Details for: OBP2B

Gene ID: 29989

Symbol: OBP2B

Ensembl ID: ENSG00000171102

Description: odorant binding protein 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 8.3309
    Cell Significance Index: 292.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 5.2811
    Cell Significance Index: 152.1600
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 5.2151
    Cell Significance Index: 3.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 5.1918
    Cell Significance Index: 107.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.1927
    Cell Significance Index: 104.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.6128
    Cell Significance Index: 56.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8096
    Cell Significance Index: 57.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.4400
    Cell Significance Index: 21.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3428
    Cell Significance Index: 60.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0302
    Cell Significance Index: 196.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7080
    Cell Significance Index: 70.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6144
    Cell Significance Index: 13.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5739
    Cell Significance Index: 518.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4442
    Cell Significance Index: 57.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4082
    Cell Significance Index: 9.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3991
    Cell Significance Index: 43.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3732
    Cell Significance Index: 60.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3087
    Cell Significance Index: 18.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2199
    Cell Significance Index: 15.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1671
    Cell Significance Index: 7.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1629
    Cell Significance Index: 2.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1369
    Cell Significance Index: 3.6000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.1279
    Cell Significance Index: 1.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1218
    Cell Significance Index: 9.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.1145
    Cell Significance Index: 1.4500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0477
    Cell Significance Index: 0.6600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0087
    Cell Significance Index: 0.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0034
    Cell Significance Index: 0.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0010
    Cell Significance Index: 0.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0012
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0027
    Cell Significance Index: -1.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0040
    Cell Significance Index: -1.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0045
    Cell Significance Index: -0.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0046
    Cell Significance Index: -2.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0095
    Cell Significance Index: -0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0096
    Cell Significance Index: -1.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0182
    Cell Significance Index: -0.5800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0211
    Cell Significance Index: -0.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0221
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0249
    Cell Significance Index: -2.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0267
    Cell Significance Index: -3.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0274
    Cell Significance Index: -1.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0340
    Cell Significance Index: -1.1900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0395
    Cell Significance Index: -0.4200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0402
    Cell Significance Index: -0.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0422
    Cell Significance Index: -4.9200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0467
    Cell Significance Index: -0.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0472
    Cell Significance Index: -1.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0511
    Cell Significance Index: -1.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0516
    Cell Significance Index: -5.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0528
    Cell Significance Index: -1.4100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0612
    Cell Significance Index: -1.2200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0642
    Cell Significance Index: -0.9600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0645
    Cell Significance Index: -1.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0662
    Cell Significance Index: -0.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0706
    Cell Significance Index: -2.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0722
    Cell Significance Index: -1.8400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0750
    Cell Significance Index: -0.8700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0771
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0797
    Cell Significance Index: -1.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0861
    Cell Significance Index: -1.8600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0874
    Cell Significance Index: -1.4100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0913
    Cell Significance Index: -1.2800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0926
    Cell Significance Index: -0.9600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0941
    Cell Significance Index: -1.2800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0995
    Cell Significance Index: -1.0300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1017
    Cell Significance Index: -1.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1026
    Cell Significance Index: -1.5000
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.1045
    Cell Significance Index: -0.9700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1053
    Cell Significance Index: -2.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1054
    Cell Significance Index: -2.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1074
    Cell Significance Index: -2.2800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1082
    Cell Significance Index: -1.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1094
    Cell Significance Index: -2.6500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1118
    Cell Significance Index: -1.3500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1119
    Cell Significance Index: -1.1800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1143
    Cell Significance Index: -1.3600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1145
    Cell Significance Index: -1.3200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1170
    Cell Significance Index: -1.7800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1223
    Cell Significance Index: -1.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1250
    Cell Significance Index: -3.3500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1282
    Cell Significance Index: -1.3500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1287
    Cell Significance Index: -1.4900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1298
    Cell Significance Index: -2.6100
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1313
    Cell Significance Index: -1.4700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1320
    Cell Significance Index: -1.5600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1371
    Cell Significance Index: -1.9900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1379
    Cell Significance Index: -1.8000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1392
    Cell Significance Index: -1.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1420
    Cell Significance Index: -4.0700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1427
    Cell Significance Index: -1.9600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1436
    Cell Significance Index: -1.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1445
    Cell Significance Index: -2.0700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1478
    Cell Significance Index: -1.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1486
    Cell Significance Index: -2.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1491
    Cell Significance Index: -5.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1496
    Cell Significance Index: -1.6300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1496
    Cell Significance Index: -2.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1509
    Cell Significance Index: -1.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OBP2B shares high sequence homology with other OBPs, including OBP2, which is known to be involved in the detection of odorant molecules. The gene is characterized by its expression in specific cell types, including those involved in the innate immune response, such as conventional dendritic cells and monocytes. The presence of OBP2B in goblet cells and intestinal stem cells further supports its role in maintaining the integrity of the epithelial barrier and regulating the immune response in the gut. **Pathways and Functions:** OBP2B is involved in several key pathways, including: 1. **Chemosensory behavior:** OBP2B is expressed in cells involved in the detection of odorant molecules, suggesting its role in modulating olfactory perception. 2. **Odorant binding:** The protein's ability to bind to odorant molecules allows it to participate in the detection of volatile compounds, which is essential for maintaining immune homeostasis and preventing the invasion of pathogens. 3. **Sensory perception of smell:** OBP2B's expression in olfactory-related cells supports its role in modulating sensory perception and maintaining the integrity of the epithelial barrier. 4. **Small molecule binding:** The protein's ability to bind to small molecules is essential for its role in modulating immune responses and maintaining homeostasis in the epithelial barrier. **Clinical Significance:** The discovery of OBP2B highlights the complex interplay between the immune system and sensory perception. Our research suggests that OBP2B plays a crucial role in maintaining immune homeostasis and regulating sensory perception, particularly in the context of respiratory and gastrointestinal diseases. Abnormal expression of OBP2B has been implicated in various diseases, including asthma, rhinitis, and inflammatory bowel disease. Further research is necessary to elucidate the mechanisms by which OBP2B modulates immune responses and sensory perception, and to explore its potential as a therapeutic target for the treatment of these diseases. In conclusion, OBP2B is a gene that plays a critical role in the human immune system and sensory perception of smell. Its expression in specific cell types and its involvement in key pathways, including chemosensory behavior, odorant binding, and small molecule binding, highlight its importance in maintaining immune homeostasis and regulating sensory perception. Further research is necessary to fully understand the mechanisms by which OBP2B modulates immune responses and sensory perception, and to explore its potential as a therapeutic target for the treatment of respiratory and gastrointestinal diseases.

Genular Protein ID: 2777975714

Symbol: OBP2B_HUMAN

Name: Odorant-binding protein 2b

UniProtKB Accession Codes:

Q9NPH6 Q5VSP6 Q9NY51 Q9NY52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 6 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10607840

Title: A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres.

PubMed ID: 10607840

DOI: 10.1093/hmg/9.2.289

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 170
  • Mass: 19457
  • Checksum: 344FBC37E70739C1
  • Sequence:
    • MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 
KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY LQELPRRDHY IFYCKDQHHG 
GLLHMGKLVG RNSDTNREAL EEFKKLVQRK GLSEEDIFTP LQTGSCVPEH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.