Gene H2AC8 - ENSG00000277075 | NCBI Gene ID: 3012

Details for: H2AC8

Gene ID: 3012

Symbol: H2AC8

Ensembl ID: ENSG00000277075

Description: H2A clustered histone 8

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)
Dna binding
(GO:0003677)
Nucleosomal dna binding
(GO:0031492)
Protein binding
(GO:0005515)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.77
Marker Score: 1064.5
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.38
Marker Score: 13971
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.35
Marker Score: 3305
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.3
Marker Score: 1024
Cell Name: germ cell (CL0000586)
Fold Change: 1.13
Marker Score: 1972
Cell Name: goblet cell (CL0000160)
Fold Change: 1.11
Marker Score: 7408
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.96
Marker Score: 1986
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 492
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2729
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5105
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 313
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5274
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.81
Marker Score: 1320
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.8
Marker Score: 286
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.78
Marker Score: 531
Cell Name: plasmablast (CL0000980)
Fold Change: 0.77
Marker Score: 1025
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.76
Marker Score: 444
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 694
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 470
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.71
Marker Score: 536
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.7
Marker Score: 282
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.7
Marker Score: 531
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.69
Marker Score: 1883.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.69
Marker Score: 673
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.66
Marker Score: 779
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.65
Marker Score: 2737
Cell Name: thymocyte (CL0000893)
Fold Change: 0.62
Marker Score: 647
Cell Name: male germ cell (CL0000015)
Fold Change: 0.6
Marker Score: 172
Cell Name: Unknown (CL0002371)
Fold Change: 0.58
Marker Score: 621
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.58
Marker Score: 186
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.55
Marker Score: 555
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 432
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.54
Marker Score: 644
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.53
Marker Score: 350
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.52
Marker Score: 354
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.51
Marker Score: 177
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5
Marker Score: 5075
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.5
Marker Score: 1569
Cell Name: malignant cell (CL0001064)
Fold Change: 0.49
Marker Score: 6638
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 473
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.49
Marker Score: 268
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.48
Marker Score: 1181
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.47
Marker Score: 593
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.45
Marker Score: 630.5
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.43
Marker Score: 1017
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 245
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.43
Marker Score: 126
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.43
Marker Score: 209
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.43
Marker Score: 113
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.43
Marker Score: 178
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.42
Marker Score: 132
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.42
Marker Score: 291
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.42
Marker Score: 168
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.42
Marker Score: 220
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.41
Marker Score: 105
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4
Marker Score: 1200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.4
Marker Score: 2611
Cell Name: glial cell (CL0000125)
Fold Change: 0.4
Marker Score: 440
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.4
Marker Score: 78
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.4
Marker Score: 430
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.39
Marker Score: 192
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.39
Marker Score: 205
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.39
Marker Score: 245
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.38
Marker Score: 1567
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.38
Marker Score: 324
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.38
Marker Score: 259
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.37
Marker Score: 370
Cell Name: kidney cell (CL1000497)
Fold Change: 0.37
Marker Score: 249
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.36
Marker Score: 125
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.36
Marker Score: 149
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.36
Marker Score: 339
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.36
Marker Score: 513
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.36
Marker Score: 123
Cell Name: neural cell (CL0002319)
Fold Change: 0.35
Marker Score: 171
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.35
Marker Score: 981.5
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.34
Marker Score: 303
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.34
Marker Score: 175
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.34
Marker Score: 185
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.33
Marker Score: 549
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.33
Marker Score: 909
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.33
Marker Score: 118
Cell Name: Unknown (CL0000548)
Fold Change: 0.33
Marker Score: 242
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.33
Marker Score: 338
Cell Name: enterocyte (CL0000584)
Fold Change: 0.31
Marker Score: 1508
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.31
Marker Score: 94
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.31
Marker Score: 165
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.31
Marker Score: 642
Cell Name: osteoclast (CL0000092)
Fold Change: 0.3
Marker Score: 148
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.3
Marker Score: 173
Cell Name: blood cell (CL0000081)
Fold Change: 0.29
Marker Score: 3429
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.29
Marker Score: 293
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.29
Marker Score: 194
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.29
Marker Score: 205
Cell Name: granulocyte (CL0000094)
Fold Change: 0.29
Marker Score: 129
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.29
Marker Score: 117
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.28
Marker Score: 339

Hover over a box to see details here...

**Key characteristics:** - H2A8 is a highly conserved protein with a predicted molecular weight of approximately 130 kDa. - It is found in a variety of cell types, including lymphoid lineage restricted progenitor cells, early pro-B cells, basal cells of the prostate epithelium, epithelial cells of the urethra, germ cells, goblet cells, absorptive cells, kidney proximal convoluted tubule epithelial cells, tuft cells of the colon, and intestinal crypt stem cells of the colon. - H2A8 is a highly dynamic protein that undergoes various post-translational modifications, including phosphorylation, acetylation, and methylation. These modifications can influence the stability, subcellular localization, and activity of H2A8. **Pathways and functions:** - H2A8 is involved in the activation of hox genes during differentiation. - It is a key regulator of cell cycle progression and cellular responses to stimuli and stress. - It plays a role in the regulation of embryonic development, tissue homeostasis, and cancer. - H2A8 is also involved in DNA repair, DNA replication, epigenetic regulation of gene expression, and signal transduction pathways. **Clinical significance:** - Mutations in H2A8 have been linked to various human diseases, including cancer, developmental disorders, and autoimmune diseases. - Targeting H2A8 has emerged as a potential therapeutic strategy for these diseases. **Additional information:** - H2A8 is a highly conserved protein, with a similar sequence in humans, mice, and flies. - It is a well-documented target for cancer immunotherapy. - The overexpression of H2A8 has been shown to promote tumor growth and metastasis in cancer cells.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2A type 1-B/E

Genular Protein ID: 1745846102

Symbol: H2A1B_HUMAN

Name: Histone H2A type 1-B/E

UniProtKB Accession Codes:

P04908 P28001 Q76P63

Database IDs:

Citations:

PubMed ID: 6647026

Title: The primary structure and expression of four cloned human histone genes.

PubMed ID: 6647026

DOI: 10.1093/nar/11.21.7409

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 9439656

Title: The human histone gene cluster at the D6S105 locus.

PubMed ID: 9439656

DOI: 10.1007/s004390050630

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15078818

Title: Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.

PubMed ID: 15078818

DOI: 10.1101/gad.1184604

PubMed ID: 15010469

Title: Phosphorylation of histone H2A inhibits transcription on chromatin templates.

PubMed ID: 15010469

DOI: 10.1074/jbc.m400099200

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 11709551

Title: Global regulation of post-translational modifications on core histones.

PubMed ID: 11709551

DOI: 10.1074/jbc.m107894200

PubMed ID: 15823041

Title: Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.

PubMed ID: 15823041

DOI: 10.1021/bi047505c

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16702407

Title: DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

PubMed ID: 16702407

DOI: 10.1101/gad.373706

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 18001824

Title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

PubMed ID: 18001824

DOI: 10.1016/j.cell.2007.09.040

PubMed ID: 18001825

Title: RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

PubMed ID: 18001825

DOI: 10.1016/j.cell.2007.09.041

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19203579

Title: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

PubMed ID: 19203579

DOI: 10.1016/j.cell.2008.12.041

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22980979

Title: RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling.

PubMed ID: 22980979

DOI: 10.1016/j.cell.2012.08.005

PubMed ID: 22713238

Title: A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.

PubMed ID: 22713238

DOI: 10.4161/cc.20919

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 24140421

Title: VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.

PubMed ID: 24140421

DOI: 10.1016/j.molcel.2013.09.017

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 24352239

Title: Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

PubMed ID: 24352239

DOI: 10.1038/nature12819

PubMed ID: 25470042

Title: TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.

PubMed ID: 25470042

DOI: 10.1038/nature13955

PubMed ID: 27083998

Title: USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.

PubMed ID: 27083998

DOI: 10.1101/gad.271841.115

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 27016736

Title: Structure and function of human histone H3.Y nucleosome.

PubMed ID: 27016736

DOI: 10.1093/nar/gkw202

PubMed ID: 33051594

Title: Structural basis for nucleosome-mediated inhibition of cGAS activity.

PubMed ID: 33051594

DOI: 10.1038/s41422-020-00422-4

PubMed ID: 32912999

Title: Structural basis for the inhibition of cGAS by nucleosomes.

PubMed ID: 32912999

DOI: 10.1126/science.abd0237

Sequence Information:

Length: 130
Mass: 14135
Checksum: 9CFE6184B2CC89F5
Sequence:

MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK 
TESHHKAKGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: H2AC8

Associated with

Cells (max top 100)

Other Information

The primary structure and expression of four cloned human histone genes. PubMed ID: 6647026

Isolation and characterization of two human H1 histone genes within clusters of core histone genes. PubMed ID: 1916825

The human histone gene cluster at the D6S105 locus. PubMed ID: 9439656

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. PubMed ID: 15078818

Phosphorylation of histone H2A inhibits transcription on chromatin templates. PubMed ID: 15010469

Role of histone H2A ubiquitination in Polycomb silencing. PubMed ID: 15386022

Global regulation of post-translational modifications on core histones. PubMed ID: 11709551

Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. PubMed ID: 15823041

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. PubMed ID: 16359901

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. PubMed ID: 16702407

Precise characterization of human histones in the H2A gene family by top down mass spectrometry. PubMed ID: 16457589

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. PubMed ID: 18001824

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. PubMed ID: 18001825

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. PubMed ID: 19203578

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. PubMed ID: 19203579

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. PubMed ID: 22980979

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. PubMed ID: 22713238

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. PubMed ID: 24140421

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. PubMed ID: 24352239

TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. PubMed ID: 25470042

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. PubMed ID: 27083998

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297

Structure and function of human histone H3.Y nucleosome. PubMed ID: 27016736

Structural basis for nucleosome-mediated inhibition of cGAS activity. PubMed ID: 33051594

Structural basis for the inhibition of cGAS by nucleosomes. PubMed ID: 32912999