Details for: HCRTR1

Gene ID: 3061

Symbol: HCRTR1

Ensembl ID: ENSG00000121764

Description: hypocretin receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.71
    Marker Score: 2612
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1510.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.17
    Marker Score: 2182
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 2.14
    Marker Score: 6858
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.88
    Marker Score: 2095
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.78
    Marker Score: 3366
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.67
    Marker Score: 2298
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.58
    Marker Score: 1516
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.55
    Marker Score: 883
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.45
    Marker Score: 763
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.38
    Marker Score: 4096.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.23
    Marker Score: 3592
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17760
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7408
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 647
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.77
    Marker Score: 965
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.67
    Marker Score: 5651
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.65
    Marker Score: 340
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.62
    Marker Score: 260
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.61
    Marker Score: 1271
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.61
    Marker Score: 1746
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.56
    Marker Score: 342.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1104
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 250
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 323
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.48
    Marker Score: 278.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.44
    Marker Score: 339
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 186
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.3
    Marker Score: 487.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 95
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.3
    Marker Score: 332
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 151
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 126
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.22
    Marker Score: 97
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 189
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 87
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 105
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.19
    Marker Score: 69
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.19
    Marker Score: 531
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 56
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 370
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.15
    Marker Score: 52
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.15
    Marker Score: 1130
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.14
    Marker Score: 587
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.13
    Marker Score: 316
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.11
    Marker Score: 105
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.11
    Marker Score: 92
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 189.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 106
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1
    Marker Score: 1299
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.09
    Marker Score: 101
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.09
    Marker Score: 370
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.09
    Marker Score: 356
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 72.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary The HCRTR1 gene encodes for a protein called HCRTR1, a G protein-coupled receptor (GPCR) that is expressed in a variety of cell types. The protein is involved in a variety of cellular processes, including cellular response to hormone stimulus, chemical synaptic transmission, feeding behavior, and G alpha (q) signaling events. ## Key characteristics * HCRTR1 is a member of the GPCR superfamily, which is a large family of cell surface receptors that are involved in a variety of cellular processes, including cell adhesion, migration, and differentiation. * HCRTR1 is a G protein-coupled receptor, which means that it is a protein that binds to a G protein and activates it. * HCRTR1 is expressed in a variety of cell types, including erythrocyte, conventional dendritic cell, blood vessel endothelial cell, amacrine cell, plasma cell, cardiac endothelial cell, double negative thymocyte, retina horizontal cell, megakaryocyte, and hematopoietic stem cell. * HCRTR1 is a key regulator of cellular processes such as cellular response to hormone stimulus, chemical synaptic transmission, and feeding behavior. ## Pathways and functions * HCRTR1 is involved in the cellular response to hormone stimulus. When HCRTR1 is stimulated by a hormone, it activates the G protein Gα(q). Gα(q) then activates the downstream signaling pathway, which leads to the activation of various downstream targets, including the transcription factor CREB. CREB then regulates the expression of genes that are involved in cellular response to hormone stimulus. * HCRTR1 is also involved in chemical synaptic transmission. When HCRTR1 is expressed on the surface of a neuron, it can bind to a variety of ligands, including orexin and neuropeptides. When HCRTR1 binds to an orexin or neuropeptide, it activates the G protein Gα(q). Gα(q) then activates the downstream signaling pathway, which leads to the activation of various downstream targets, including the release of neurotransmitters from the presynaptic terminal. * HCRTR1 is also involved in feeding behavior. When HCRTR1 is expressed on the surface of a food-seeking neuron, it can bind to a variety of neuropeptides, including orexin and neuropeptide FF. When HCRTR1 binds to an orexin or neuropeptide FF, it activates the G protein Gα(q). Gα(q) then activates the downstream signaling pathway, which leads to the activation of various downstream targets, including the inhibition of the release of satiety hormones from the hypothalamus. ## Clinical significance HCRTR1 is a potential therapeutic target for a variety of diseases, including obesity, diabetes, and psychiatric disorders. In obesity, HCRTR1 is expressed in the brain and is involved in the regulation of food intake and body weight. In diabetes, HCRTR1 is expressed in the pancreas and is involved in the regulation of insulin secretion. In psychiatric disorders, HCRTR1 is expressed in the brain and is involved in the regulation of mood and behavior.

Genular Protein ID: 4036064441

Symbol: OX1R_HUMAN

Name: N/A

UniProtKB Accession Codes:

O43613 A8K3A6 Q9HBV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 14 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9491897

Title: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

PubMed ID: 9491897

DOI: 10.1016/s0092-8674(00)80949-6

PubMed ID: 10973318

Title: A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.

PubMed ID: 10973318

DOI: 10.1038/79690

PubMed ID: 11723285

Title: Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.

PubMed ID: 11723285

DOI: 10.1212/wnl.57.10.1896

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11340621

Title: Hypocretin/orexin, sleep and narcolepsy.

PubMed ID: 11340621

DOI: 10.1002/bies.1058

PubMed ID: 11283317

Title: To eat or to sleep? Orexin in the regulation of feeding and wakefulness.

PubMed ID: 11283317

DOI: 10.1146/annurev.neuro.24.1.429

PubMed ID: 26950369

Title: Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.

PubMed ID: 26950369

DOI: 10.1038/nsmb.3183

Sequence Information:

  • Length: 425
  • Mass: 47536
  • Checksum: B650B37F3A2CA096
  • Sequence:
    • MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFVVA 
LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK 
VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAIMVPQA 
AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR 
KLWGRQIPGT TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML 
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF 
LSGKFREQFK AAFSCCLPGL GPCGSLKAPS PRSSASHKSL SLQSRCSISK ISEHVVLTSV 
TTVLP

Genular Protein ID: 1345760348

Symbol: A6NMV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NMV7

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 389
  • Mass: 43613
  • Checksum: 36DB58EF470D7B13
  • Sequence:
    • MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFVVA 
LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK 
VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAIMVPQA 
AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR 
KLWGRQIPGT TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML 
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF 
LSGCKEKSLA LSCPSCPGHD PHLAAALCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.