Details for: HCRTR1

Gene ID: 3061

Symbol: HCRTR1

Ensembl ID: ENSG00000121764

Description: hypocretin receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.3166
    Cell Significance Index: 39.6000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4729
    Cell Significance Index: 5.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2787
    Cell Significance Index: 6.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2688
    Cell Significance Index: 3.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1662
    Cell Significance Index: 3.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1084
    Cell Significance Index: 1.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0668
    Cell Significance Index: 1.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0463
    Cell Significance Index: 8.3500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0440
    Cell Significance Index: 0.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0408
    Cell Significance Index: 5.9300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0269
    Cell Significance Index: 0.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0250
    Cell Significance Index: 0.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0226
    Cell Significance Index: 8.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0174
    Cell Significance Index: 0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0165
    Cell Significance Index: 3.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0068
    Cell Significance Index: 0.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0067
    Cell Significance Index: 1.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0035
    Cell Significance Index: 6.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0014
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0035
    Cell Significance Index: -1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0038
    Cell Significance Index: -1.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0067
    Cell Significance Index: -0.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0088
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0090
    Cell Significance Index: -1.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0093
    Cell Significance Index: -0.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0119
    Cell Significance Index: -1.6400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0126
    Cell Significance Index: -1.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0126
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0147
    Cell Significance Index: -0.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0159
    Cell Significance Index: -1.6600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0202
    Cell Significance Index: -0.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0205
    Cell Significance Index: -0.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0206
    Cell Significance Index: -1.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0226
    Cell Significance Index: -0.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0265
    Cell Significance Index: -1.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0268
    Cell Significance Index: -0.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0271
    Cell Significance Index: -1.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0276
    Cell Significance Index: -1.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0294
    Cell Significance Index: -1.3000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0303
    Cell Significance Index: -0.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0312
    Cell Significance Index: -0.8500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0314
    Cell Significance Index: -0.4300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0328
    Cell Significance Index: -0.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0329
    Cell Significance Index: -0.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0333
    Cell Significance Index: -1.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0356
    Cell Significance Index: -0.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0357
    Cell Significance Index: -1.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0363
    Cell Significance Index: -1.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0365
    Cell Significance Index: -0.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0371
    Cell Significance Index: -0.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0378
    Cell Significance Index: -1.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0398
    Cell Significance Index: -1.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0406
    Cell Significance Index: -0.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0411
    Cell Significance Index: -1.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0434
    Cell Significance Index: -0.4500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0435
    Cell Significance Index: -0.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0452
    Cell Significance Index: -1.2100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0461
    Cell Significance Index: -0.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0462
    Cell Significance Index: -0.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0469
    Cell Significance Index: -1.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0473
    Cell Significance Index: -0.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0475
    Cell Significance Index: -1.1600
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0486
    Cell Significance Index: -0.5000
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0487
    Cell Significance Index: -0.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0489
    Cell Significance Index: -1.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0501
    Cell Significance Index: -1.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0503
    Cell Significance Index: -1.0100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0507
    Cell Significance Index: -0.6500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0525
    Cell Significance Index: -0.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0530
    Cell Significance Index: -1.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0546
    Cell Significance Index: -1.3900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0550
    Cell Significance Index: -1.1200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0563
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0566
    Cell Significance Index: -1.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0572
    Cell Significance Index: -1.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0580
    Cell Significance Index: -0.9300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0593
    Cell Significance Index: -0.7900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0597
    Cell Significance Index: -0.7500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0600
    Cell Significance Index: -1.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0605
    Cell Significance Index: -0.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0608
    Cell Significance Index: -1.2900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0609
    Cell Significance Index: -0.9800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0611
    Cell Significance Index: -0.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0612
    Cell Significance Index: -0.8800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0621
    Cell Significance Index: -0.7200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0625
    Cell Significance Index: -0.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0627
    Cell Significance Index: -1.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0636
    Cell Significance Index: -2.0100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0643
    Cell Significance Index: -0.8800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0651
    Cell Significance Index: -0.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Highly expressed in immune cells:** HCRTR1 is significantly expressed in various immune cells, including erythrocytes, conventional dendritic cells, plasma cells, and hematopoietic stem cells, suggesting its potential role in immune regulation. 2. **Orexin and neuropeptide signaling:** HCRTR1 is part of the orexin signaling pathway, which is activated by the binding of orexin (hypocretin) and other neuropeptides to their respective receptors. This interaction triggers a cascade of downstream signaling events that regulate various physiological processes. 3. **G protein-coupled receptor activity:** HCRTR1 exhibits G protein-coupled receptor activity, which enables it to modulate the activity of G proteins and influence signaling pathways that impact cellular behavior. **Pathways and Functions:** 1. **Cellular response to hormone stimulus:** HCRTR1 plays a crucial role in regulating the cellular response to hormone stimuli, particularly orexin and other neuropeptides. 2. **Chemical synaptic transmission:** HCRTR1 is involved in modulating chemical synaptic transmission, which is essential for the transmission of signals between neurons and other cells. 3. **Feeding behavior:** The orexin signaling pathway, in which HCRTR1 is involved, regulates feeding behavior by modulating the activity of neurons in the hypothalamus and brainstem. 4. **G alpha (q) signaling events:** HCRTR1 is activated by the binding of orexin and other neuropeptides to its receptor, triggering G alpha (q) signaling events that regulate cellular behavior. 5. **Regulation of cytosolic calcium ion concentration:** HCRTR1 influences the regulation of cytosolic calcium ion concentration, which is essential for various cellular processes, including signaling and cellular differentiation. **Clinical Significance:** 1. **Sleep disorders:** HCRTR1 has been implicated in the regulation of sleep-wake cycles, and alterations in its expression or function have been associated with sleep disorders, such as narcolepsy. 2. **Autoimmune diseases:** The orexin signaling pathway, in which HCRTR1 is involved, has been shown to play a role in regulating immune responses and modulating the activity of immune cells. 3. **Cancer:** HCRTR1 has been identified as a potential target for cancer therapy, as its expression is altered in various types of cancer, including breast and lung cancer. 4. **Neurodegenerative diseases:** The orexin signaling pathway has been implicated in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, HCRTR1 is a critical component of the orexin signaling pathway, which regulates various physiological processes, including feeding behavior, sleep-wake cycles, and immune responses. Further research is necessary to fully elucidate the role of HCRTR1 in immune regulation and disease, but its involvement in various pathological conditions highlights its potential as a therapeutic target.

Genular Protein ID: 4036064441

Symbol: OX1R_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9491897

Title: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

PubMed ID: 9491897

DOI: 10.1016/s0092-8674(00)80949-6

PubMed ID: 10973318

Title: A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.

PubMed ID: 10973318

DOI: 10.1038/79690

PubMed ID: 11723285

Title: Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.

PubMed ID: 11723285

DOI: 10.1212/wnl.57.10.1896

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11340621

Title: Hypocretin/orexin, sleep and narcolepsy.

PubMed ID: 11340621

DOI: 10.1002/bies.1058

PubMed ID: 11283317

Title: To eat or to sleep? Orexin in the regulation of feeding and wakefulness.

PubMed ID: 11283317

DOI: 10.1146/annurev.neuro.24.1.429

PubMed ID: 26950369

Title: Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.

PubMed ID: 26950369

DOI: 10.1038/nsmb.3183

Sequence Information:

  • Length: 425
  • Mass: 47536
  • Checksum: B650B37F3A2CA096
  • Sequence:
  • MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFVVA 
    LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK 
    VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAIMVPQA 
    AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR 
    KLWGRQIPGT TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML 
    MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF 
    LSGKFREQFK AAFSCCLPGL GPCGSLKAPS PRSSASHKSL SLQSRCSISK ISEHVVLTSV 
    TTVLP

Genular Protein ID: 1345760348

Symbol: A6NMV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 389
  • Mass: 43613
  • Checksum: 36DB58EF470D7B13
  • Sequence:
  • MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFVVA 
    LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK 
    VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAIMVPQA 
    AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR 
    KLWGRQIPGT TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML 
    MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF 
    LSGCKEKSLA LSCPSCPGHD PHLAAALCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.