Details for: TLX1

Gene ID: 3195

Symbol: TLX1

Ensembl ID: ENSG00000107807

Description: T cell leukemia homeobox 1

Associated with

  • Animal organ development
    (GO:0048513)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.11
    Marker Score: 5085
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.42
    Marker Score: 1897
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.75
    Marker Score: 1561.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.41
    Marker Score: 4154
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.34
    Marker Score: 4258.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2234
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.68
    Marker Score: 1872
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.58
    Marker Score: 834
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.41
    Marker Score: 2032
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.24
    Marker Score: 1183
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.18
    Marker Score: 492
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 508
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.1
    Marker Score: 457
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.89
    Marker Score: 517
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1164
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2912
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.67
    Marker Score: 645
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.66
    Marker Score: 4406
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 502
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 408
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.56
    Marker Score: 1070
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8460
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1028
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.48
    Marker Score: 477
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.44
    Marker Score: 181
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.37
    Marker Score: 243
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.34
    Marker Score: 364.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.34
    Marker Score: 517
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 192
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 532
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.25
    Marker Score: 224
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.22
    Marker Score: 222
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 240
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.18
    Marker Score: 83
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.18
    Marker Score: 368
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.16
    Marker Score: 254
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.14
    Marker Score: 383.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.13
    Marker Score: 304
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.11
    Marker Score: 84
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.09
    Marker Score: 1192
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.09
    Marker Score: 114
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 113
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 64
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 472
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.08
    Marker Score: 119
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.07
    Marker Score: 50
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.06
    Marker Score: 307
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 149

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Other Information

**Key characteristics**: - TLX1 is a member of the T cell leukemia homeobox (TLX) family of transcription factors. - It is a key regulator of T cell development and function. - It is involved in the regulation of T cell differentiation, survival, and migration. - It is also involved in the regulation of immune responses to viral infections. **Pathways and functions**: - TLX1 is an important regulator of T cell development. - It is required for the survival and differentiation of T cells in the thymus. - It also plays a role in the regulation of T cell activation and effector function. - TLX1 is involved in the regulation of immune responses to viral infections. - It is also involved in the development of autoimmune diseases. **Clinical significance**: - Mutations in TLX1 have been linked to the development of several human cancers, including leukemia. - Targeting TLX1 has been investigated as a therapeutic strategy for cancer immunotherapy. - In clinical trials of TLX1 inhibitors, there have been promising results in treating leukemia and other cancers.

Genular Protein ID: 1832898366

Symbol: TLX1_HUMAN

Name: T-cell leukemia homeobox protein 1

UniProtKB Accession Codes:

P31314 A1L4G3 O75699 Q5VXP2 Q9HCA0 Q9UD59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1717256

Title: The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein.

PubMed ID: 1717256

DOI: 10.1002/j.1460-2075.1991.tb07840.x

PubMed ID: 1681546

Title: HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

PubMed ID: 1681546

DOI: 10.1073/pnas.88.20.8900

PubMed ID: 1676542

Title: Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.

PubMed ID: 1676542

DOI: 10.1126/science.1676542

PubMed ID: 1352396

Title: Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells.

PubMed ID: 1352396

PubMed ID: 10393251

Title: Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line.

PubMed ID: 10393251

DOI: 10.1016/s0378-1119(99)00157-2

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9778044

Title: Multiple negative elements contribute to repression of the HOX11 proto-oncogene.

PubMed ID: 9778044

DOI: 10.1038/sj.onc.1202078

PubMed ID: 7518789

Title: Identification of homeobox genes expressed in human haemopoietic progenitor cells.

PubMed ID: 7518789

DOI: 10.1016/0378-1119(94)90380-8

PubMed ID: 17303350

Title: A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene.

PubMed ID: 17303350

DOI: 10.1016/j.gene.2006.12.034

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19559479

Title: MEIS proteins as partners of the TLX1/HOX11 oncoprotein.

PubMed ID: 19559479

DOI: 10.1016/j.leukres.2009.06.003

Sequence Information:

  • Length: 330
  • Mass: 34365
  • Checksum: 09A518FB5271F7ED
  • Sequence:
    • MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG 
GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS 
GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN 
RRYTKDRFTG HPYQNRTPPK KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM 
TDAQVKTWFQ NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN 
SSLFALQNLQ PWSDDSTKIT SVTSVASACE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.