Details for: TLX1

Gene ID: 3195

Symbol: TLX1

Ensembl ID: ENSG00000107807

Description: T cell leukemia homeobox 1

Associated with

  • Animal organ development
    (GO:0048513)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 7.2063
    Cell Significance Index: 61.2500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.5788
    Cell Significance Index: 37.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5968
    Cell Significance Index: 97.9000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.6982
    Cell Significance Index: 8.6700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.6842
    Cell Significance Index: 8.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4736
    Cell Significance Index: 90.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3124
    Cell Significance Index: 9.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3015
    Cell Significance Index: 29.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2592
    Cell Significance Index: 234.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2138
    Cell Significance Index: 9.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1582
    Cell Significance Index: 25.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1542
    Cell Significance Index: 16.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1264
    Cell Significance Index: 7.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0801
    Cell Significance Index: 5.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0597
    Cell Significance Index: 11.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0540
    Cell Significance Index: 1.1700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0264
    Cell Significance Index: 0.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0234
    Cell Significance Index: 1.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0207
    Cell Significance Index: 0.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0080
    Cell Significance Index: 0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0074
    Cell Significance Index: 0.2600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0047
    Cell Significance Index: -2.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0063
    Cell Significance Index: -0.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0072
    Cell Significance Index: -0.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0072
    Cell Significance Index: -0.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0083
    Cell Significance Index: -4.5500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.5000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.0126
    Cell Significance Index: -0.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0159
    Cell Significance Index: -0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0196
    Cell Significance Index: -3.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0199
    Cell Significance Index: -0.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0206
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0210
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0302
    Cell Significance Index: -5.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0337
    Cell Significance Index: -4.6300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0363
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0370
    Cell Significance Index: -4.2400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0535
    Cell Significance Index: -0.7400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0685
    Cell Significance Index: -1.1100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0715
    Cell Significance Index: -0.8700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0744
    Cell Significance Index: -1.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0765
    Cell Significance Index: -1.9100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0784
    Cell Significance Index: -0.6400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0820
    Cell Significance Index: -1.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0842
    Cell Significance Index: -2.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0847
    Cell Significance Index: -1.6900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0854
    Cell Significance Index: -1.4600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0929
    Cell Significance Index: -1.1300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0973
    Cell Significance Index: -1.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0978
    Cell Significance Index: -3.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1070
    Cell Significance Index: -2.2400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1208
    Cell Significance Index: -1.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1240
    Cell Significance Index: -1.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1319
    Cell Significance Index: -3.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1384
    Cell Significance Index: -1.4600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1387
    Cell Significance Index: -1.4500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1429
    Cell Significance Index: -1.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1452
    Cell Significance Index: -2.4300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1453
    Cell Significance Index: -1.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1454
    Cell Significance Index: -4.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1457
    Cell Significance Index: -3.9100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1608
    Cell Significance Index: -2.2300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1620
    Cell Significance Index: -2.1600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1632
    Cell Significance Index: -2.2200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1649
    Cell Significance Index: -2.0900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1649
    Cell Significance Index: -1.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1653
    Cell Significance Index: -4.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1691
    Cell Significance Index: -4.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1692
    Cell Significance Index: -4.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1777
    Cell Significance Index: -5.0700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1801
    Cell Significance Index: -3.0300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1832
    Cell Significance Index: -1.9700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1848
    Cell Significance Index: -2.1300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1851
    Cell Significance Index: -2.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1876
    Cell Significance Index: -2.0400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1896
    Cell Significance Index: -1.8400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1937
    Cell Significance Index: -2.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1941
    Cell Significance Index: -4.2500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1948
    Cell Significance Index: -2.2100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.2022
    Cell Significance Index: -2.1800
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.2044
    Cell Significance Index: -2.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2045
    Cell Significance Index: -2.3400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.2057
    Cell Significance Index: -2.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2065
    Cell Significance Index: -2.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2067
    Cell Significance Index: -2.1400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2160
    Cell Significance Index: -2.0900
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.2165
    Cell Significance Index: -2.3500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2237
    Cell Significance Index: -3.1400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2245
    Cell Significance Index: -2.7100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2277
    Cell Significance Index: -2.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2281
    Cell Significance Index: -4.4600
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.2323
    Cell Significance Index: -2.4600
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.2379
    Cell Significance Index: -2.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2388
    Cell Significance Index: -3.2800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.2418
    Cell Significance Index: -2.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TLX1 is a transcription factor that belongs to the T-box family of homeobox genes. It is characterized by its ability to bind to DNA and regulate the expression of target genes through interaction with RNA polymerase II. TLX1 is highly expressed in various cell types, including immune cells, hematopoietic stem cells, and progenitor cells, suggesting its importance in cellular development and differentiation. The protein structure of TLX1 consists of a T-box domain, which is responsible for DNA binding, and a homeodomain, which mediates transcriptional activation. **Pathways and Functions:** TLX1 is involved in several key pathways, including: 1. **Animal organ development**: TLX1 plays a crucial role in the development of various organs, including the nervous system, heart, and hematopoietic system. 2. **Chromatin**: TLX1 regulates chromatin structure and function, influencing the expression of target genes. 3. **RNA polymerase II-specific**: TLX1 interacts with RNA polymerase II to regulate transcriptional activity. 4. **DNA-binding transcription activator activity**: TLX1 acts as a transcription activator, stimulating the expression of target genes. 5. **RNA polymerase II-specific**: TLX1 regulates the expression of target genes by interacting with RNA polymerase II. TLX1 functions as a transcription factor by binding to specific DNA sequences and recruiting coactivators, such as histone acetyltransferases and RNA polymerase II. This interaction enhances the expression of target genes, leading to changes in cellular behavior, including proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of TLX1 has been implicated in various immunological and developmental disorders, including: 1. **Immunodeficiency diseases**: Mutations in TLX1 have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Leukemia**: TLX1 is overexpressed in certain types of leukemia, including T-cell leukemia. 3. **Neurological disorders**: TLX1 has been implicated in the development of neurological disorders, such as autism spectrum disorder and schizophrenia. 4. **Cancer**: TLX1 is involved in the regulation of cancer cell proliferation and survival, making it a potential target for cancer therapy. In conclusion, TLX1 is a critical transcription factor that plays a pivotal role in regulating immune cell development, hematopoiesis, and tissue homeostasis. Its dysregulation has been implicated in various immunological and developmental disorders, highlighting the importance of TLX1 in maintaining cellular balance and promoting health. Further research is necessary to fully elucidate the mechanisms of TLX1 and its role in disease pathogenesis.

Genular Protein ID: 1832898366

Symbol: TLX1_HUMAN

Name: T-cell leukemia homeobox protein 1

UniProtKB Accession Codes:

P31314 A1L4G3 O75699 Q5VXP2 Q9HCA0 Q9UD59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1717256

Title: The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein.

PubMed ID: 1717256

DOI: 10.1002/j.1460-2075.1991.tb07840.x

PubMed ID: 1681546

Title: HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

PubMed ID: 1681546

DOI: 10.1073/pnas.88.20.8900

PubMed ID: 1676542

Title: Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.

PubMed ID: 1676542

DOI: 10.1126/science.1676542

PubMed ID: 1352396

Title: Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells.

PubMed ID: 1352396

PubMed ID: 10393251

Title: Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line.

PubMed ID: 10393251

DOI: 10.1016/s0378-1119(99)00157-2

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9778044

Title: Multiple negative elements contribute to repression of the HOX11 proto-oncogene.

PubMed ID: 9778044

DOI: 10.1038/sj.onc.1202078

PubMed ID: 7518789

Title: Identification of homeobox genes expressed in human haemopoietic progenitor cells.

PubMed ID: 7518789

DOI: 10.1016/0378-1119(94)90380-8

PubMed ID: 17303350

Title: A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene.

PubMed ID: 17303350

DOI: 10.1016/j.gene.2006.12.034

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19559479

Title: MEIS proteins as partners of the TLX1/HOX11 oncoprotein.

PubMed ID: 19559479

DOI: 10.1016/j.leukres.2009.06.003

Sequence Information:

  • Length: 330
  • Mass: 34365
  • Checksum: 09A518FB5271F7ED
  • Sequence:
    • MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG 
GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS 
GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN 
RRYTKDRFTG HPYQNRTPPK KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM 
TDAQVKTWFQ NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN 
SSLFALQNLQ PWSDDSTKIT SVTSVASACE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.