Details for: IDI1

Gene ID: 3422

Symbol: IDI1

Ensembl ID: ENSG00000067064

Description: isopentenyl-diphosphate delta isomerase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.53
    Marker Score: 80373
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.74
    Marker Score: 3306
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.69
    Marker Score: 5464
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.45
    Marker Score: 2315
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.41
    Marker Score: 7882
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.36
    Marker Score: 23873
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.11
    Marker Score: 13722
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.05
    Marker Score: 7593
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.02
    Marker Score: 3242
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.96
    Marker Score: 2888
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.88
    Marker Score: 5260
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.85
    Marker Score: 1575
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.82
    Marker Score: 1535
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.78
    Marker Score: 631
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.78
    Marker Score: 1074
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.77
    Marker Score: 1205
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.74
    Marker Score: 1716
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.72
    Marker Score: 5017
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.72
    Marker Score: 4219.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.71
    Marker Score: 1839
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.65
    Marker Score: 1295
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.63
    Marker Score: 10411
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.63
    Marker Score: 1233
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.63
    Marker Score: 2245
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.62
    Marker Score: 698
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.61
    Marker Score: 1696
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.6
    Marker Score: 2549
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.6
    Marker Score: 761
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.58
    Marker Score: 789
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.57
    Marker Score: 1314
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.57
    Marker Score: 13547
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.56
    Marker Score: 54146.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.54
    Marker Score: 368
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.52
    Marker Score: 306
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.51
    Marker Score: 14969.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.51
    Marker Score: 1142
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.51
    Marker Score: 467
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.51
    Marker Score: 452
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.5
    Marker Score: 2083
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.49
    Marker Score: 11656
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.49
    Marker Score: 550
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.48
    Marker Score: 4659
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.48
    Marker Score: 935
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.46
    Marker Score: 422
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.46
    Marker Score: 504
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.46
    Marker Score: 8649
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.46
    Marker Score: 3963
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.45
    Marker Score: 585
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.45
    Marker Score: 5582
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.44
    Marker Score: 602
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.44
    Marker Score: 827
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.43
    Marker Score: 705
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.43
    Marker Score: 1275
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.41
    Marker Score: 586
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4
    Marker Score: 47688
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.4
    Marker Score: 3805
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.39
    Marker Score: 622
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.38
    Marker Score: 3809
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.38
    Marker Score: 357
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.37
    Marker Score: 757
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.36
    Marker Score: 1484
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.36
    Marker Score: 620
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.36
    Marker Score: 2852
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.36
    Marker Score: 6510
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.35
    Marker Score: 13607
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.35
    Marker Score: 1265
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.35
    Marker Score: 2353
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.35
    Marker Score: 2406
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.34
    Marker Score: 714
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.34
    Marker Score: 601
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.33
    Marker Score: 1603.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.33
    Marker Score: 3250
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.33
    Marker Score: 289
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.32
    Marker Score: 295
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.31
    Marker Score: 823
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.31
    Marker Score: 294
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.31
    Marker Score: 286
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.3
    Marker Score: 1526
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.3
    Marker Score: 449
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.3
    Marker Score: 949
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3
    Marker Score: 3863
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.3
    Marker Score: 320
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.3
    Marker Score: 369
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.3
    Marker Score: 529
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.3
    Marker Score: 1372
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.3
    Marker Score: 1251
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.3
    Marker Score: 343
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.29
    Marker Score: 630
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.29
    Marker Score: 8228
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.29
    Marker Score: 651
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.28
    Marker Score: 660
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.28
    Marker Score: 5371.5
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.28
    Marker Score: 319
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.28
    Marker Score: 1278
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.28
    Marker Score: 3015
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 1.28
    Marker Score: 377
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.27
    Marker Score: 1076
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 1.27
    Marker Score: 354
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.27
    Marker Score: 1406
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.26
    Marker Score: 512

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Other Information

**Key characteristics:** - IDI1 is a protein of the CYP family, which are enzymes that break down and build up molecules. - It is a transmembrane protein, with a single transmembrane domain that spans the cell membrane. - IDI1 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. **Pathways and functions:** - IDI1 is involved in the activation of gene expression by the srebp (srebp) transcription factor. - It is also involved in the regulation of cholesterol biosynthesis, the metabolism of lipids and steroids, and the regulation of peroxidation. **Clinical significance:** - Mutations in the IDI1 gene have been linked to a number of human diseases, including hypercholesterolemia, atherosclerosis, and hepatic steatosis. - IDI1 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** - IDI1 is a highly important protein in the human body. - It is involved in a wide range of cellular processes, including cholesterol biosynthesis, lipid metabolism, and inflammation. - IDI1 is a promising target for the treatment of a variety of human diseases.

Genular Protein ID: 1429766534

Symbol: IDI1_HUMAN

Name: Isopentenyl-diphosphate Delta-isomerase 1

UniProtKB Accession Codes:

Q13907 B4E155 Q32Q13 Q53GQ6 Q86U81 Q8WUX8 Q96IZ4 Q9BQ74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 19 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8020941

Title: A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase.

PubMed ID: 8020941

DOI: 10.1006/geno.1994.1139

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8806705

Title: Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.

PubMed ID: 8806705

DOI: 10.1006/abbi.1996.0312

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17250851

Title: The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis.

PubMed ID: 17250851

DOI: 10.1016/j.jmb.2006.12.055

Sequence Information:

  • Length: 227
  • Mass: 26319
  • Checksum: 1255ACC2C4D1E8D1
  • Sequence:
    • MPEINTNHLD KQQVQLLAEM CILIDENDNK IGAETKKNCH LNENIEKGLL HRAFSVFLFN 
TENKLLLQQR SDAKITFPGC FTNTCCSHPL SNPAELEESD ALGVRRAAQR RLKAELGIPL 
EEVPPEEINY LTRIHYKAQS DGIWGEHEID YILLVRKNVT LNPDPNEIKS YCYVSKEELK 
ELLKKAASGE IKITPWFKII AATFLFKWWD NLNHLNQFVD HEKIYRM

Genular Protein ID: 856957785

Symbol: A0A8Q3WKR8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3WKR8

Database IDs:

ARBA 22 CDD 1 CTD 1 ChEBI 3 EC 1 EMBL 3 EPD 1 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 KEGG 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PIRSF 1 PROSITE 2 Pfam 1 Proteomes 2 RefSeq 3 Rhea 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 228
  • Mass: 26450
  • Checksum: 6782F1AECEEEB4E1
  • Sequence:
    • MMPEINTNHL DKQQVQLLAE MCILIDENDN KIGAETKKNC HLNENIEKGL LHRAFSVFLF 
NTENKLLLQQ RSDAKITFPG CFTNTCCSHP LSNPAELEES DALGVRRAAQ RRLKAELGIP 
LEEVPPEEIN YLTRIHYKAQ SDGIWGEHEI DYILLVRKNV TLNPDPNEIK SYCYVSKEEL 
KELLKKAASG EIKITPWFKI IAATFLFKWW DNLNHLNQFV DHEKIYRM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.