Gene IFNA6 - ENSG00000120235 | NCBI Gene ID: 3443

Details for: IFNA6

Gene ID: 3443

Symbol: IFNA6

Ensembl ID: ENSG00000120235

Description: interferon alpha 6

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Disease
(R-HSA-1643685)
Evasion by rsv of host interferon responses
(R-HSA-9833109)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Regulation of ifna/ifnb signaling
(R-HSA-912694)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Traf6 mediated irf7 activation
(R-HSA-933541)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
Cellular response to virus
(GO:0098586)
Cellular_component
(GO:0005575)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Defense response to virus
(GO:0051607)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Humoral immune response
(GO:0006959)
Natural killer cell activation involved in immune response
(GO:0002323)
Positive regulation of peptidyl-serine phosphorylation of stat protein
(GO:0033141)
Protein binding
(GO:0005515)
Response to exogenous dsrna
(GO:0043330)
T cell activation involved in immune response
(GO:0002286)
Type i interferon-mediated signaling pathway
(GO:0060337)
Type i interferon receptor binding
(GO:0005132)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.25
Marker Score: 402
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7691
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30396
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.94
Marker Score: 1519
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5334
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: leukocyte (CL0000738)
Fold Change: 0.87
Marker Score: 499.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.79
Marker Score: 719
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.69
Marker Score: 547
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.63
Marker Score: 199.5
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.49
Marker Score: 198.5
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.43
Marker Score: 188.5
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.4
Marker Score: 200.5
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.37
Marker Score: 193
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.35
Marker Score: 167.5
Cell Name: astrocyte (CL0000127)
Fold Change: 0.34
Marker Score: 298.5
Cell Name: pericyte (CL0000669)
Fold Change: 0.33
Marker Score: 190
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.32
Marker Score: 198.5
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.29
Marker Score: 191.5
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.29
Marker Score: 197.5
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.26
Marker Score: 199
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.23
Marker Score: 476
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.22
Marker Score: 524
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.21
Marker Score: 399
Cell Name: B cell (CL0000236)
Fold Change: 0.21
Marker Score: 196.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.21
Marker Score: 184
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.2
Marker Score: 200.5
Cell Name: fibroblast (CL0000057)
Fold Change: 0.19
Marker Score: 188
Cell Name: macrophage (CL0000235)
Fold Change: 0.19
Marker Score: 208
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.18
Marker Score: 111
Cell Name: plasma cell (CL0000786)
Fold Change: 0.18
Marker Score: 196.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.17
Marker Score: 182.5
Cell Name: stromal cell (CL0000499)
Fold Change: 0.16
Marker Score: 184
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.14
Marker Score: 176
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.14
Marker Score: 182.5
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.14
Marker Score: 198.5
Cell Name: T cell (CL0000084)
Fold Change: 0.12
Marker Score: 198.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.11
Marker Score: 1743.5
Cell Name: neuron (CL0000540)
Fold Change: 0.11
Marker Score: 444
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1
Marker Score: 580
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.08
Marker Score: 292.5
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.08
Marker Score: 160.5
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.08
Marker Score: 179
Cell Name: secretory cell (CL0000151)
Fold Change: 0.06
Marker Score: 116.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.06
Marker Score: 160
Cell Name: Unknown (CL0000003)
Fold Change: 0.04
Marker Score: 115.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.02
Marker Score: 194.5
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.01
Marker Score: 142.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.01
Marker Score: 135.5
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.01
Marker Score: 200.5
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.01
Marker Score: 200.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.01
Marker Score: 199.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.01
Marker Score: 194.5
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.01
Marker Score: 195.5
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0
Marker Score: 211

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**Key characteristics:** - IFNA6 is a type I interferon, which are known for promoting inflammation and immune responses. - It is produced in response to various stimuli, including viral infections, bacterial infections, and cytokines. - It acts on various cell types, including immune cells and non-immune cells. - It is a key regulator of the innate immune response and plays a role in the regulation of inflammation and immune responses. **Pathways and functions:** - IFNA6 is involved in the regulation of innate immune responses. - It promotes the production of type I interferons, which are potent cytokines that activate various immune cells. - It also modulates the production of other cytokines and chemokines, which can influence the inflammatory response. - It plays a role in the regulation of inflammation and immune responses by promoting the recruitment of immune cells to sites of infection and the production of antimicrobial proteins. **Clinical significance:** - Mutations in IFNA6 have been linked to the pathogenesis of several human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - IFNA6 is a potential therapeutic target for the treatment of inflammatory diseases. - Blockade of IFNA6 signaling has been shown to inhibit inflammation and improve disease outcomes in animal models of inflammatory diseases. **Additional notes:** - IFNA6 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. - It is a key regulator of the immune response to viral infections. - It is involved in the regulation of the inflammatory response to respiratory syncytial virus (RSV) infection.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interferon alpha-6

Genular Protein ID: 2424922871

Symbol: IFNA6_HUMAN

Name: Interferon alpha-6

UniProtKB Accession Codes:

P05013 Q5VYQ1

Database IDs:

Citations:

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

Length: 189
Mass: 22141
Checksum: 8C7F3F90F12C562E
Sequence:

MALPFALLMA LVVLSCKSSC SLDCDLPQTH SLGHRRTMML LAQMRRISLF SCLKDRHDFR 
FPQEEFDGNQ FQKAEAISVL HEVIQQTFNL FSTKDSSVAW DERLLDKLYT ELYQQLNDLE 
ACVMQEVWVG GTPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSSSRN 
LQERLRRKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IFNA6

Associated with

Cells (max top 100)

Other Information

Structural relationship of human interferon alpha genes and pseudogenes. PubMed ID: 4057246

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Database document:

PubMed ID: 4057246

PubMed ID: 15164053

PubMed ID: 15489334

PubMed ID: 15340161