Details for: IFNA6

Gene ID: 3443

Symbol: IFNA6

Ensembl ID: ENSG00000120235

Description: interferon alpha 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.0898
    Cell Significance Index: 11.1400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1638
    Cell Significance Index: 0.9700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0252
    Cell Significance Index: 0.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0216
    Cell Significance Index: 0.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0011
    Cell Significance Index: 0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0017
    Cell Significance Index: -0.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0094
    Cell Significance Index: -0.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0121
    Cell Significance Index: -0.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0127
    Cell Significance Index: -0.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0143
    Cell Significance Index: -0.5400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0145
    Cell Significance Index: -0.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0178
    Cell Significance Index: -0.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0183
    Cell Significance Index: -0.6000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0186
    Cell Significance Index: -0.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0200
    Cell Significance Index: -0.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0208
    Cell Significance Index: -0.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0221
    Cell Significance Index: -0.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0255
    Cell Significance Index: -0.5500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0261
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0263
    Cell Significance Index: -0.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0283
    Cell Significance Index: -0.6000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0286
    Cell Significance Index: -0.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0293
    Cell Significance Index: -0.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0299
    Cell Significance Index: -0.6000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0311
    Cell Significance Index: -0.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0315
    Cell Significance Index: -0.5300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0334
    Cell Significance Index: -0.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0335
    Cell Significance Index: -0.5800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0337
    Cell Significance Index: -0.4300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0362
    Cell Significance Index: -0.1900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0363
    Cell Significance Index: -0.4800
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0367
    Cell Significance Index: -0.4400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0392
    Cell Significance Index: -0.5000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0397
    Cell Significance Index: -0.5100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0404
    Cell Significance Index: -0.5100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0404
    Cell Significance Index: -0.4900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0405
    Cell Significance Index: -0.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0415
    Cell Significance Index: -0.4900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0418
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0427
    Cell Significance Index: -0.4500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0429
    Cell Significance Index: -0.5600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0430
    Cell Significance Index: -0.5800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0435
    Cell Significance Index: -0.5200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0436
    Cell Significance Index: -0.4300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0437
    Cell Significance Index: -0.5200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0446
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0451
    Cell Significance Index: -0.6300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0451
    Cell Significance Index: -0.5000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0460
    Cell Significance Index: -0.5700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0460
    Cell Significance Index: -0.4700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0467
    Cell Significance Index: -0.5600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0468
    Cell Significance Index: -0.5100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0476
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0480
    Cell Significance Index: -0.5900
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0483
    Cell Significance Index: -0.5800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0485
    Cell Significance Index: -0.5700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0489
    Cell Significance Index: -0.5600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0491
    Cell Significance Index: -0.5000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0494
    Cell Significance Index: -0.5100
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0505
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0510
    Cell Significance Index: -0.5600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0513
    Cell Significance Index: -0.4800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0526
    Cell Significance Index: -0.6200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0533
    Cell Significance Index: -0.5100
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0534
    Cell Significance Index: -0.6400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0534
    Cell Significance Index: -0.4900
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0539
    Cell Significance Index: -0.6300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0546
    Cell Significance Index: -0.5800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0574
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0575
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0577
    Cell Significance Index: -0.5300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0578
    Cell Significance Index: -0.6400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0583
    Cell Significance Index: -0.4600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0617
    Cell Significance Index: -0.4800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0642
    Cell Significance Index: -0.5600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0662
    Cell Significance Index: -0.6300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0662
    Cell Significance Index: -0.4900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0666
    Cell Significance Index: -0.6200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0709
    Cell Significance Index: -0.5100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0715
    Cell Significance Index: -0.6300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0732
    Cell Significance Index: -0.6400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0788
    Cell Significance Index: -0.5000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.0815
    Cell Significance Index: -0.6300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0839
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0861
    Cell Significance Index: -0.5200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0878
    Cell Significance Index: -0.4700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0940
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** IFNA6 is a type I interferon, consisting of 146 amino acids, with a molecular weight of approximately 16 kDa. 2. **Expression:** IFNA6 is expressed in various cell types, including mononuclear cells, goblet cells, absorptive cells, intestinal crypt stem cells, and leukocytes. 3. **Function:** IFNA6 plays a key role in regulating immune responses, including cell differentiation, proliferation, and survival. 4. **Pathways:** IFNA6 is involved in multiple signaling pathways, including the interferon alpha/beta signaling pathway, cytokine-mediated signaling pathway, and Ddx58/ifih1-mediated induction of interferon-alpha/beta. **Pathways and Functions:** 1. **Adaptive Immune Response:** IFNA6 is involved in the regulation of B cell differentiation and proliferation, contributing to the humoral immune response. 2. **Innate Immune Response:** IFNA6 plays a crucial role in the defense against viral infections, particularly RSV and SARS-CoV-2, by modulating the host immune response. 3. **Cytokine Signaling:** IFNA6 is involved in cytokine-mediated signaling pathways, including the regulation of peptidyl-serine phosphorylation of stat protein. 4. **Natural Killer Cell Activation:** IFNA6 is required for the activation of natural killer cells, which are essential for the immune response against viral infections. **Clinical Significance:** 1. **Viral Infections:** IFNA6 is significantly expressed in response to RSV and SARS-CoV-2 infections, highlighting its importance in modulating the host immune response. 2. **Respiratory Syncytial Virus (RSV) Infection:** IFNA6 is involved in the regulation of RSV infection, contributing to the severity of the disease. 3. **SARS-CoV-2 Infection:** IFNA6 is required for the modulation of innate and adaptive immune responses against SARS-CoV-2, highlighting its potential as a therapeutic target. 4. **Cancer Immunotherapy:** IFNA6 may play a role in the regulation of immune responses in cancer, including the modulation of tumor cell proliferation and survival. In conclusion, IFNA6 is a critical component of the innate immune response, playing a pivotal role in the defense against viral infections. Its expression and function are significant in modulating the host immune response, and its dysregulation may contribute to the pathogenesis of various diseases. Further research is needed to fully understand the complex role of IFNA6 in the immune response and its potential as a therapeutic target.

Genular Protein ID: 2424922871

Symbol: IFNA6_HUMAN

Name: Interferon alpha-6

UniProtKB Accession Codes:

P05013 Q5VYQ1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 189
  • Mass: 22141
  • Checksum: 8C7F3F90F12C562E
  • Sequence:
    • MALPFALLMA LVVLSCKSSC SLDCDLPQTH SLGHRRTMML LAQMRRISLF SCLKDRHDFR 
FPQEEFDGNQ FQKAEAISVL HEVIQQTFNL FSTKDSSVAW DERLLDKLYT ELYQQLNDLE 
ACVMQEVWVG GTPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSSSRN 
LQERLRRKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.