Details for: IFNA13

Gene ID: 3447

Symbol: IFNA13

Ensembl ID: ENSG00000233816

Description: interferon alpha 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0085
    Cell Significance Index: 0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0034
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0049
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0098
    Cell Significance Index: -0.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0129
    Cell Significance Index: -0.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0162
    Cell Significance Index: -1.0900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0168
    Cell Significance Index: -0.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0187
    Cell Significance Index: -1.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0201
    Cell Significance Index: -0.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0209
    Cell Significance Index: -0.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0221
    Cell Significance Index: -0.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0238
    Cell Significance Index: -0.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0267
    Cell Significance Index: -0.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0281
    Cell Significance Index: -0.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0304
    Cell Significance Index: -0.9600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0317
    Cell Significance Index: -0.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0375
    Cell Significance Index: -0.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0375
    Cell Significance Index: -1.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0377
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0392
    Cell Significance Index: -1.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0410
    Cell Significance Index: -0.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0479
    Cell Significance Index: -0.8900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0501
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0514
    Cell Significance Index: -0.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0518
    Cell Significance Index: -1.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0534
    Cell Significance Index: -1.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0544
    Cell Significance Index: -1.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0565
    Cell Significance Index: -1.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0574
    Cell Significance Index: -1.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0607
    Cell Significance Index: -1.2000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0630
    Cell Significance Index: -0.7500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0654
    Cell Significance Index: -1.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0693
    Cell Significance Index: -0.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0702
    Cell Significance Index: -1.3700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0705
    Cell Significance Index: -0.8900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0714
    Cell Significance Index: -0.8900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0718
    Cell Significance Index: -1.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0723
    Cell Significance Index: -1.4100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0734
    Cell Significance Index: -0.9900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0740
    Cell Significance Index: -0.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0750
    Cell Significance Index: -1.0200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0755
    Cell Significance Index: -1.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0766
    Cell Significance Index: -0.9500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0773
    Cell Significance Index: -0.8900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0774
    Cell Significance Index: -1.0100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0782
    Cell Significance Index: -0.9200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0796
    Cell Significance Index: -0.8500
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0801
    Cell Significance Index: -0.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0808
    Cell Significance Index: -0.8800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0808
    Cell Significance Index: -1.1300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0830
    Cell Significance Index: -1.0100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0842
    Cell Significance Index: -1.0100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0871
    Cell Significance Index: -1.1300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0895
    Cell Significance Index: -1.0700
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0902
    Cell Significance Index: -0.9900
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0906
    Cell Significance Index: -1.1000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0945
    Cell Significance Index: -1.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0950
    Cell Significance Index: -0.9700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0952
    Cell Significance Index: -1.0900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0954
    Cell Significance Index: -1.2000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0960
    Cell Significance Index: -0.9500
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0969
    Cell Significance Index: -1.1500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0971
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1002
    Cell Significance Index: -0.6300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1006
    Cell Significance Index: -0.5300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1019
    Cell Significance Index: -1.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1022
    Cell Significance Index: -1.2900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1024
    Cell Significance Index: -1.3700
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1029
    Cell Significance Index: -1.1800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1029
    Cell Significance Index: -0.8800
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.1030
    Cell Significance Index: -1.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1033
    Cell Significance Index: -1.2200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1044
    Cell Significance Index: -0.9800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1049
    Cell Significance Index: -1.2600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1054
    Cell Significance Index: -0.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1060
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1071
    Cell Significance Index: -1.1300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1076
    Cell Significance Index: -1.2500
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1079
    Cell Significance Index: -1.2600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1096
    Cell Significance Index: -1.1600
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1097
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1153
    Cell Significance Index: -0.9100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1157
    Cell Significance Index: -1.2200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1166
    Cell Significance Index: -1.2800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1212
    Cell Significance Index: -1.0000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1218
    Cell Significance Index: -1.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1235
    Cell Significance Index: -1.3800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1237
    Cell Significance Index: -1.3700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1265
    Cell Significance Index: -1.3700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1300
    Cell Significance Index: -1.0000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1311
    Cell Significance Index: -1.3400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1321
    Cell Significance Index: -1.0100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1366
    Cell Significance Index: -1.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFNA13 is a member of the interferon alpha (IFN-α) family, which consists of six distinct types of interferons: IFN-α1 to IFN-α6. IFNA13 is primarily expressed in various cell types, including microglial cells, endothelial cells, and neurons, suggesting its widespread involvement in immune surveillance and tissue homeostasis. Its expression is induced in response to viral infections, particularly those caused by Respiratory Syncytial Virus (RSV) and SARS-CoV-2, underscoring its critical role in the innate immune response. **Pathways and Functions:** IFNA13 is involved in several key signaling pathways, including: 1. **Type I Interferon-Mediated Signaling Pathway:** IFNA13 acts as a ligand for the type I interferon receptor, triggering a signaling cascade that activates the transcription factors IRF3 and IRF7, leading to the production of antiviral proteins and cytokines. 2. **Cytokine-Mediated Signaling Pathway:** IFNA13 interacts with various cytokines, including IL-6 and TNF-α, modulating their activity and influencing immune cell function. 3. **Ddx58/IFih1-Mediated Induction of Interferon-Alpha/Beta:** IFNA13 is induced by the RNA helicase Ddx58, which is activated in response to viral infections, highlighting the interplay between IFNA13 and other components of the innate immune response. IFNA13's functional implications are far-reaching, including: 1. **Antiviral Activity:** IFNA13 exerts direct antiviral effects by inhibiting viral replication and promoting the production of antiviral proteins. 2. **Immune Cell Activation:** IFNA13 stimulates the activation of immune cells, including natural killer cells, macrophages, and dendritic cells, enhancing their ability to recognize and eliminate pathogens. 3. **Tissue Protection:** IFNA13 contributes to tissue homeostasis by regulating the expression of genes involved in inflammation, cell proliferation, and differentiation. **Clinical Significance:** The understanding of IFNA13's mechanisms and functions has significant implications for the treatment and prevention of viral infections, particularly those caused by RSV and SARS-CoV-2. Potential therapeutic strategies include: 1. **IFNA13-Based Vaccines:** Developing vaccines that target IFNA13 could provide enhanced protection against viral infections. 2. **IFNA13-Based Therapies:** Using IFNA13 as a therapeutic agent to modulate the immune response in patients with viral infections or autoimmune diseases. 3. **Understanding IFNA13 Expression and Function:** Elucidating the factors that regulate IFNA13 expression and its functional implications in different diseases could lead to the identification of novel therapeutic targets. In conclusion, IFNA13 is a critical component of the innate immune response, playing a pivotal role in the defense against viral infections and other pathogenic agents. Further research on the mechanisms and functions of IFNA13 will be essential for the development of novel therapeutic strategies and a deeper understanding of its role in human health and disease.

Genular Protein ID: 2935930828

Symbol: A0A087WWS6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WWS6

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PaxDb 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 190
  • Mass: 21828
  • Checksum: 822F244732033EB3
  • Sequence:
    • MMASPFALLM ALVVLSCKSS CSLGCDLPET HSLDNRRTLM LLAQMSRISP SSCLMDRHDF 
GFPQEEFDGN QFQKAPAISV LHELIQQIFN LFTTKDSSAA WDEDLLDKFC TELYQQLNDL 
EACVMQEERV GETPLMNADS ILAVKKYFRR ITLYLTEKKY SPCAWEVVRA EIMRSLSLST 
NLQERLRRKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.