Details for: INHBC

Gene ID: 3626

Symbol: INHBC

Ensembl ID: ENSG00000175189

Description: inhibin subunit beta C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6414
    Cell Significance Index: 39.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.1713
    Cell Significance Index: 19.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3103
    Cell Significance Index: 61.5900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2511
    Cell Significance Index: 5.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2454
    Cell Significance Index: 3.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2149
    Cell Significance Index: 3.6200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2102
    Cell Significance Index: 2.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1657
    Cell Significance Index: 4.8800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1540
    Cell Significance Index: 1.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1488
    Cell Significance Index: 1.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0934
    Cell Significance Index: 1.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0834
    Cell Significance Index: 15.0400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0459
    Cell Significance Index: 0.5200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0451
    Cell Significance Index: 0.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0381
    Cell Significance Index: 1.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0237
    Cell Significance Index: 0.5200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0232
    Cell Significance Index: 0.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0196
    Cell Significance Index: 0.5100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0183
    Cell Significance Index: 0.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0135
    Cell Significance Index: 0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0115
    Cell Significance Index: 2.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0096
    Cell Significance Index: 0.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0077
    Cell Significance Index: 2.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0053
    Cell Significance Index: 0.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0044
    Cell Significance Index: 0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0043
    Cell Significance Index: 0.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0041
    Cell Significance Index: 0.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0033
    Cell Significance Index: 0.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0008
    Cell Significance Index: 1.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0008
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0006
    Cell Significance Index: 0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.4900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0010
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0011
    Cell Significance Index: -0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0018
    Cell Significance Index: -1.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0019
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0052
    Cell Significance Index: -1.1000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0069
    Cell Significance Index: -0.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0073
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0078
    Cell Significance Index: -1.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0089
    Cell Significance Index: -1.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0093
    Cell Significance Index: -0.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0101
    Cell Significance Index: -1.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0107
    Cell Significance Index: -0.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0123
    Cell Significance Index: -0.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0146
    Cell Significance Index: -0.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0149
    Cell Significance Index: -0.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0163
    Cell Significance Index: -0.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0166
    Cell Significance Index: -1.0700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0174
    Cell Significance Index: -0.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0187
    Cell Significance Index: -0.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0190
    Cell Significance Index: -0.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0194
    Cell Significance Index: -0.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0197
    Cell Significance Index: -0.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0201
    Cell Significance Index: -0.6400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0210
    Cell Significance Index: -0.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0211
    Cell Significance Index: -0.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0225
    Cell Significance Index: -1.0500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0229
    Cell Significance Index: -0.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0253
    Cell Significance Index: -0.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0272
    Cell Significance Index: -0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0273
    Cell Significance Index: -0.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0287
    Cell Significance Index: -1.0100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0294
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0295
    Cell Significance Index: -0.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0298
    Cell Significance Index: -0.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0302
    Cell Significance Index: -0.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0309
    Cell Significance Index: -0.8400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0330
    Cell Significance Index: -0.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0357
    Cell Significance Index: -0.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0361
    Cell Significance Index: -0.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0364
    Cell Significance Index: -0.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0366
    Cell Significance Index: -0.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0369
    Cell Significance Index: -0.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0379
    Cell Significance Index: -0.7500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0379
    Cell Significance Index: -0.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0384
    Cell Significance Index: -0.4900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0386
    Cell Significance Index: -0.6300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0386
    Cell Significance Index: -0.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0390
    Cell Significance Index: -0.8200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0394
    Cell Significance Index: -0.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0400
    Cell Significance Index: -1.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0408
    Cell Significance Index: -1.1700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0432
    Cell Significance Index: -0.6200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0433
    Cell Significance Index: -0.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0442
    Cell Significance Index: -1.1300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0448
    Cell Significance Index: -0.6700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0450
    Cell Significance Index: -0.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** INHBC is a 164-amino acid protein that belongs to the inhibin family of glycoprotein hormones. It is characterized by its unique structure, which consists of a disulfide-linked homodimeric subunit. INHBC is primarily expressed in the placenta during pregnancy, but it is also found in various tissues and cells, including plasma cells, goblet cells, and neural cells. **Pathways and Functions:** INHBC plays a crucial role in several signaling pathways, including: 1. **Cytokine activity:** INHBC interacts with cytokines, such as transforming growth factor-beta (TGF-β), to regulate immune responses and inflammation. 2. **Glycoprotein hormone biosynthesis:** INHBC is involved in the synthesis of glycoprotein hormones, including inhibin, activin, and follicle-stimulating hormone (FSH). 3. **Signal transduction:** INHBC modulates signal transduction pathways, including the TGF-β pathway, to regulate cell growth, differentiation, and apoptosis. 4. **Metabolism of proteins:** INHBC is involved in the regulation of protein metabolism, including the degradation of proteins and the synthesis of new proteins. **Significance in the Immune System:** INHBC has been shown to play a critical role in the immune system, particularly in the regulation of immune responses and inflammation. Its expression is increased in response to immune stimuli, and it interacts with various immune cells, including plasma cells, macrophages, and dendritic cells. **Clinical Significance:** Dysregulation of INHBC has been implicated in several diseases, including: 1. **Autoimmune disorders:** Alterations in INHBC expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** INHBC has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders:** INHBC has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive disorders:** INHBC has been linked to reproductive disorders, including infertility and miscarriage. In conclusion, INHBC is a multifunctional protein that plays a critical role in the immune system and beyond. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of INHBC and its potential therapeutic applications.

Genular Protein ID: 1081245761

Symbol: INHBC_HUMAN

Name: Inhibin beta C chain

UniProtKB Accession Codes:

P55103 A1L3Y2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7826378

Title: Cloning of a new member of the TGF-beta family: a putative new activin beta C chain.

PubMed ID: 7826378

DOI: 10.1006/bbrc.1995.1086

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9428386

Title: Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.

PubMed ID: 9428386

DOI: 10.1002/(sici)1097-0045(19980101)34:1<34::aid-pros5>3.0.co;2-k

Sequence Information:

  • Length: 352
  • Mass: 38238
  • Checksum: 496476AD82562D3E
  • Sequence:
    • MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS ILDKLHLTQR 
PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS FAETGLSTIN QTRLDFHFSS 
DRTAGDREVQ QASLMFFVQL PSNTTWTLKV RVLVLGPHNT NLTLATQYLL EVDASGWHQL 
PLGPEAQAAC SQGHLTLELV LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC 
QGGSRMCCRQ EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN 
LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG CS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.