Details for: INHBC

Gene ID: 3626

Symbol: INHBC

Ensembl ID: ENSG00000175189

Description: inhibin subunit beta C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.94
    Marker Score: 2164
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7536
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1584
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.82
    Marker Score: 1707
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.82
    Marker Score: 913
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.74
    Marker Score: 427
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.71
    Marker Score: 11170
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1298
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.63
    Marker Score: 2736
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 479
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6
    Marker Score: 3858
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.51
    Marker Score: 2729
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 259
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 621
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.35
    Marker Score: 240.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 165
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.33
    Marker Score: 125
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.29
    Marker Score: 129
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 612
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2
    Marker Score: 218
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.17
    Marker Score: 168
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.16
    Marker Score: 34
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 102
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 94
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 66
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 58
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 143
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.07
    Marker Score: 653
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.06
    Marker Score: 210
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.06
    Marker Score: 85
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.06
    Marker Score: 173
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.06
    Marker Score: 29.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.06
    Marker Score: 28.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 65
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.05
    Marker Score: 72
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.05
    Marker Score: 112
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.05
    Marker Score: 72
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 25

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Other Information

**Key characteristics:** - Inhibin beta C is a glycoprotein with a molecular weight of approximately 110 kDa. - It is expressed in high levels in the plasma and cerebrospinal fluid. - It is a key regulator of the cytokine system, which is responsible for a variety of physiological and pathological processes. **Pathways and functions:** - Inhibin beta C binds to the cytokine receptor and inhibits its activity. - This prevents the cytokine from binding to its target receptors and triggering a cascade of intracellular events that lead to a variety of cellular responses, including inhibition of cell growth, differentiation, and migration. - Inhibin beta C also plays a role in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in the INHBC gene have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - Inhibin beta C is a potential therapeutic target for these diseases, as it could be used to inhibit the inflammatory response and promote tissue repair.

Genular Protein ID: 1081245761

Symbol: INHBC_HUMAN

Name: Inhibin beta C chain

UniProtKB Accession Codes:

P55103 A1L3Y2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7826378

Title: Cloning of a new member of the TGF-beta family: a putative new activin beta C chain.

PubMed ID: 7826378

DOI: 10.1006/bbrc.1995.1086

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9428386

Title: Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.

PubMed ID: 9428386

DOI: 10.1002/(sici)1097-0045(19980101)34:1<34::aid-pros5>3.0.co;2-k

Sequence Information:

  • Length: 352
  • Mass: 38238
  • Checksum: 496476AD82562D3E
  • Sequence:
    • MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS ILDKLHLTQR 
PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS FAETGLSTIN QTRLDFHFSS 
DRTAGDREVQ QASLMFFVQL PSNTTWTLKV RVLVLGPHNT NLTLATQYLL EVDASGWHQL 
PLGPEAQAAC SQGHLTLELV LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC 
QGGSRMCCRQ EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN 
LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG CS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.