Details for: KIR3DL1

Gene ID: 3811

Symbol: KIR3DL1

Ensembl ID: ENSG00000167633

Description: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8275
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.4
    Marker Score: 2413
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.73
    Marker Score: 1193
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.43
    Marker Score: 767
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.08
    Marker Score: 2997
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2473.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1388
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.8
    Marker Score: 1182
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.78
    Marker Score: 455
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 467
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.66
    Marker Score: 734
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 510
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.63
    Marker Score: 206
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.58
    Marker Score: 936
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.58
    Marker Score: 513
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.52
    Marker Score: 1526
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.51
    Marker Score: 256
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.49
    Marker Score: 647
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.47
    Marker Score: 455
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.41
    Marker Score: 390
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.39
    Marker Score: 178
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.39
    Marker Score: 1231
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.39
    Marker Score: 299
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 342
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.27
    Marker Score: 352
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.27
    Marker Score: 221
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.26
    Marker Score: 193
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.26
    Marker Score: 429
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.23
    Marker Score: 241.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.17
    Marker Score: 168
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 351
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.17
    Marker Score: 89
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.16
    Marker Score: 383
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.15
    Marker Score: 1769
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 456
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.14
    Marker Score: 153
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.14
    Marker Score: 233
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1
    Marker Score: 660
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.1
    Marker Score: 226
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.09
    Marker Score: 126
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.08
    Marker Score: 25.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.07
    Marker Score: 24.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.07
    Marker Score: 24.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 137
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.06
    Marker Score: 122
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 25.5
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.06
    Marker Score: 25.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.06
    Marker Score: 49
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.06
    Marker Score: 21.5
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.05
    Marker Score: 150
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.05
    Marker Score: 25.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 18.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 74
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.05
    Marker Score: 84.5
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.05
    Marker Score: 25.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 110
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 25.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.04
    Marker Score: 31

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Other Information

**Key characteristics:** - KIR3DL1 is a cell surface receptor that is expressed on various immune cells. - It is a type of killer cell immunoglobulin like receptor (KIR). - KIR3DL1 is a heterodimeric protein, consisting of two immunoglobulin heavy chains and two immunoglobulin light chains. **Pathways and functions:** - KIR3DL1 is expressed on activated NK cells and some other immune cells. - It is a receptor for the HLA-B complex, expressed on antigen-presenting cells. - KIR3DL1 binds to HLA-B-positive cells and triggers the activation of NK cells. - KIR3DL1 is also a ligand for CD94, expressed on activated T cells. - Upon binding to HLA-B, KIR3DL1-CD94 complex can inhibit T cell activation, suggesting a role in regulating immune responses. **Clinical significance:** - KIR3DL1 is a potential therapeutic target for cancer immunotherapy. - Antibodies targeting KIR3DL1 have been shown to be effective in killing cancer cells in preclinical models. - Clinical trials of KIR3DL1 inhibitors are currently underway in multiple cancer types.

Genular Protein ID: 377094829

Symbol: KI3L1_HUMAN

Name: CD158 antigen-like family member E

UniProtKB Accession Codes:

P43629 O43473 Q14946 Q16541

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 Ensembl 9 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7716543

Title: Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.

PubMed ID: 7716543

DOI: 10.1126/science.7716543

PubMed ID: 8777725

Title: Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer.

PubMed ID: 8777725

DOI: 10.1016/1074-7613(95)90069-1

PubMed ID: 8760804

Title: The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

PubMed ID: 8760804

DOI: 10.1084/jem.184.2.505

PubMed ID: 7650366

Title: Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.

PubMed ID: 7650366

PubMed ID: 9430221

Title: Human diversity in killer cell inhibitory receptor genes.

PubMed ID: 9430221

DOI: 10.1016/s1074-7613(00)80394-5

PubMed ID: 8662091

Title: Alternatively spliced forms of human killer inhibitory receptors.

PubMed ID: 8662091

DOI: 10.1007/bf02602590

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 22020283

Title: Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B.

PubMed ID: 22020283

DOI: 10.1038/nature10517

Sequence Information:

  • Length: 444
  • Mass: 49098
  • Checksum: 47DEA12BBAFDEC53
  • Sequence:
    • MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML 
YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN 
HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF 
SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV 
TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL 
HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT 
PPTDTILYTE LPNAKPRSKV VSCP

Genular Protein ID: 3177857429

Symbol: Q8N6C9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N6C9

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 14 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 3 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19411600

Title: Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes.

PubMed ID: 19411600

DOI: 10.1101/gr.085738.108

Sequence Information:

  • Length: 444
  • Mass: 49086
  • Checksum: DD465C0E774AA6D4
  • Sequence:
    • MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML 
YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPMVIMVTGN 
HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF 
SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV 
TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL 
HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT 
PPTDTILYTE LPNAKPRSKV VSCP

Genular Protein ID: 2988955348

Symbol: Q6H2G3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6H2G3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 34 Ensembl 5 GO 1 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 4 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMART 2 SMR 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 14607943

Title: Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.

PubMed ID: 14607943

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19411600

Title: Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes.

PubMed ID: 19411600

DOI: 10.1101/gr.085738.108

Sequence Information:

  • Length: 444
  • Mass: 49112
  • Checksum: C535D7963242A5CE
  • Sequence:
    • MLLMVVSMAC VGFFLVQRAG PHVGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML 
YKEDRIHVPI FHGRLFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN 
HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF 
SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV 
TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL 
HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT 
PPTDTILYTE LPNAKPRSKV VSCP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.