Details for: CD46P1

Gene ID: 4182

Symbol: CD46P1

Ensembl ID: ENSG00000244703

Description: CD46 molecule pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1528
    Cell Significance Index: 2.5700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.1427
    Cell Significance Index: 1.8700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0331
    Cell Significance Index: 0.3500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0213
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0164
    Cell Significance Index: 2.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0161
    Cell Significance Index: -1.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0358
    Cell Significance Index: -1.8600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0386
    Cell Significance Index: -0.4600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0632
    Cell Significance Index: -0.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0657
    Cell Significance Index: -3.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0714
    Cell Significance Index: -2.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0750
    Cell Significance Index: -1.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0904
    Cell Significance Index: -1.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0925
    Cell Significance Index: -2.4800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0979
    Cell Significance Index: -1.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1025
    Cell Significance Index: -1.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1089
    Cell Significance Index: -1.5100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1125
    Cell Significance Index: -1.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1153
    Cell Significance Index: -3.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1301
    Cell Significance Index: -1.8700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1460
    Cell Significance Index: -1.6800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1562
    Cell Significance Index: -2.5300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1630
    Cell Significance Index: -1.8200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1648
    Cell Significance Index: -2.1900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1653
    Cell Significance Index: -2.2700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1673
    Cell Significance Index: -2.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1685
    Cell Significance Index: -2.0100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1693
    Cell Significance Index: -1.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1751
    Cell Significance Index: -2.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1781
    Cell Significance Index: -1.9400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1783
    Cell Significance Index: -2.1000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1800
    Cell Significance Index: -2.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1806
    Cell Significance Index: -1.8700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1826
    Cell Significance Index: -2.1600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1850
    Cell Significance Index: -2.2300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1944
    Cell Significance Index: -2.3700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1953
    Cell Significance Index: -2.4000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1962
    Cell Significance Index: -2.4800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1985
    Cell Significance Index: -2.2600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1985
    Cell Significance Index: -2.4800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1999
    Cell Significance Index: -2.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2012
    Cell Significance Index: -2.9700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.2030
    Cell Significance Index: -2.3100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.2056
    Cell Significance Index: -1.8600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2086
    Cell Significance Index: -2.1300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2086
    Cell Significance Index: -2.3200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.2125
    Cell Significance Index: -2.4600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2138
    Cell Significance Index: -3.0000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2149
    Cell Significance Index: -2.7000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2152
    Cell Significance Index: -2.5300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2194
    Cell Significance Index: -2.0600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.2198
    Cell Significance Index: -2.4400
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.2211
    Cell Significance Index: -1.7000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2236
    Cell Significance Index: -2.5300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2238
    Cell Significance Index: -2.8700
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.2248
    Cell Significance Index: -2.4400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2265
    Cell Significance Index: -2.9100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2269
    Cell Significance Index: -2.4100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2276
    Cell Significance Index: -2.4800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2316
    Cell Significance Index: -2.6900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2317
    Cell Significance Index: -2.4400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2322
    Cell Significance Index: -2.4700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2341
    Cell Significance Index: -2.5100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2355
    Cell Significance Index: -2.5800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2465
    Cell Significance Index: -3.0900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2518
    Cell Significance Index: -2.9300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2578
    Cell Significance Index: -2.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2630
    Cell Significance Index: -3.0100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2692
    Cell Significance Index: -2.7500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2711
    Cell Significance Index: -2.5700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2740
    Cell Significance Index: -3.0900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2764
    Cell Significance Index: -3.3500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2836
    Cell Significance Index: -3.5400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2868
    Cell Significance Index: -3.6000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2869
    Cell Significance Index: -2.9100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2889
    Cell Significance Index: -3.4600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2889
    Cell Significance Index: -2.7000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2904
    Cell Significance Index: -3.2500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3025
    Cell Significance Index: -3.1200
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.3231
    Cell Significance Index: -3.4800
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.3285
    Cell Significance Index: -3.0600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3441
    Cell Significance Index: -3.0300
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: -0.3678
    Cell Significance Index: -3.2500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4133
    Cell Significance Index: -3.4100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4419
    Cell Significance Index: -3.4000
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.4750
    Cell Significance Index: -2.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD46P1 is a pseudogene, meaning it does not encode a protein. However, its expression has been detected in multiple cell types, including erythroblast, retinal rod cell, hepatoblast, astrocyte, megakaryocyte, GABAergic neuron, and endothelial cells. Notably, CD46P1 is also expressed in neutrophils, a type of white blood cell involved in the innate immune response. This widespread expression suggests that CD46P1 may play a role in maintaining tissue homeostasis and regulating immune cell function. **Pathways and Functions:** While the exact mechanisms by which CD46P1 regulates cellular processes are not fully understood, several pathways have been implicated. One possible pathway involves the regulation of immune cell activation and function. CD46P1 has been shown to interact with CD46, a protein that plays a crucial role in regulating the complement system, a key component of the innate immune response. The interaction between CD46P1 and CD46 may modulate the activity of immune cells, such as neutrophils, and influence the development of autoimmune diseases. Another potential function of CD46P1 involves the regulation of cellular proliferation and differentiation. CD46P1 has been shown to interact with the Wnt/β-catenin signaling pathway, which is involved in the regulation of cell growth and differentiation. This interaction may influence the development and maintenance of tissues, including the nervous system and the vascular system. **Clinical Significance:** The discovery of CD46P1 has significant implications for our understanding of immune regulation and disease. As a pseudogene, CD46P1 may have evolved to regulate immune responses without generating a protein product. The widespread expression of CD46P1 in various cell types suggests that it may play a role in maintaining tissue homeostasis and preventing autoimmune diseases. Furthermore, CD46P1 has been implicated in several neurological disorders, including multiple sclerosis and Alzheimer's disease. The interaction between CD46P1 and CD46 has been shown to influence the activity of immune cells in the central nervous system, which may contribute to the development of these diseases. In conclusion, CD46P1 is a pseudogene that has far-reaching implications for our understanding of immune regulation and disease. Further research is needed to fully elucidate the mechanisms by which CD46P1 regulates cellular processes and to explore its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.