Details for: IFIT1B

Gene ID: 439996

Symbol: IFIT1B

Ensembl ID: ENSG00000204010

Description: interferon induced protein with tetratricopeptide repeats 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 2.6809
    Cell Significance Index: -0.6800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2485
    Cell Significance Index: 4.1800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0796
    Cell Significance Index: 0.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0751
    Cell Significance Index: 1.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0464
    Cell Significance Index: 2.8500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0372
    Cell Significance Index: 0.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0330
    Cell Significance Index: 0.8900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.0305
    Cell Significance Index: 0.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0208
    Cell Significance Index: 0.5000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0182
    Cell Significance Index: 0.2300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0175
    Cell Significance Index: 0.2200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0163
    Cell Significance Index: 0.2400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0112
    Cell Significance Index: 0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0103
    Cell Significance Index: 2.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0063
    Cell Significance Index: 4.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0027
    Cell Significance Index: 0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0016
    Cell Significance Index: 3.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0016
    Cell Significance Index: 0.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0008
    Cell Significance Index: 0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: 0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0002
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0009
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0023
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0027
    Cell Significance Index: -0.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0030
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0032
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0038
    Cell Significance Index: -0.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0041
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0041
    Cell Significance Index: -0.4700
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.0057
    Cell Significance Index: -0.0300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0058
    Cell Significance Index: -0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0059
    Cell Significance Index: -0.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0068
    Cell Significance Index: -0.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0075
    Cell Significance Index: -0.1900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0075
    Cell Significance Index: -0.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0076
    Cell Significance Index: -0.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0078
    Cell Significance Index: -0.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0086
    Cell Significance Index: -0.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0095
    Cell Significance Index: -0.1400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0099
    Cell Significance Index: -0.1200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0103
    Cell Significance Index: -0.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0103
    Cell Significance Index: -0.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0107
    Cell Significance Index: -0.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0108
    Cell Significance Index: -0.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0111
    Cell Significance Index: -0.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0113
    Cell Significance Index: -0.2200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: -0.0116
    Cell Significance Index: -0.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0121
    Cell Significance Index: -0.4600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0122
    Cell Significance Index: -0.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0123
    Cell Significance Index: -0.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0123
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0126
    Cell Significance Index: -0.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0132
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0133
    Cell Significance Index: -0.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0137
    Cell Significance Index: -0.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0152
    Cell Significance Index: -0.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0171
    Cell Significance Index: -0.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0175
    Cell Significance Index: -0.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0191
    Cell Significance Index: -0.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0196
    Cell Significance Index: -0.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0204
    Cell Significance Index: -0.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0206
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0216
    Cell Significance Index: -0.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0217
    Cell Significance Index: -0.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0217
    Cell Significance Index: -0.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0217
    Cell Significance Index: -0.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0225
    Cell Significance Index: -0.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0226
    Cell Significance Index: -0.6500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0228
    Cell Significance Index: -0.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0229
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0230
    Cell Significance Index: -0.3300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0233
    Cell Significance Index: -0.2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0246
    Cell Significance Index: -0.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0247
    Cell Significance Index: -0.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0248
    Cell Significance Index: -0.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0249
    Cell Significance Index: -0.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0257
    Cell Significance Index: -0.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0258
    Cell Significance Index: -0.3200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0258
    Cell Significance Index: -0.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0264
    Cell Significance Index: -0.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0270
    Cell Significance Index: -0.4600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0272
    Cell Significance Index: -0.2400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0274
    Cell Significance Index: -0.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0276
    Cell Significance Index: -0.6900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0280
    Cell Significance Index: -0.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0282
    Cell Significance Index: -0.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0290
    Cell Significance Index: -0.3000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0299
    Cell Significance Index: -0.3400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0300
    Cell Significance Index: -0.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Induction by interferons**: IFIT1B is induced by interferons, which are proteins that play a critical role in the innate immune response against viral infections. 2. **Tetratricopeptide repeats**: The gene contains four tetratricopeptide repeats, which are protein-protein interaction domains that facilitate the interaction with other proteins. 3. **Significant expression in various tissues**: IFIT1B is expressed in endothelial cells, immune cells, neural cells, and stem cells, indicating its involvement in multiple physiological processes. 4. **Cell type-specific expression**: The gene's expression is cell type-specific, with variations in expression levels across different cell types. **Pathways and Functions:** 1. **Defense response to virus**: IFIT1B is induced by interferons, which are key players in the innate immune response against viral infections. The gene's expression is regulated by interferon-stimulated genes (ISGs), which are involved in the production of antiviral proteins. 2. **Protein binding**: The tetratricopeptide repeats in IFIT1B facilitate the interaction with other proteins, which may be involved in protein complex formation, regulation of gene expression, or signal transduction. 3. **RNA binding**: The gene's ability to bind RNA may be involved in regulating gene expression, RNA processing, or translation. 4. **Cellular regulation**: IFIT1B may play a role in regulating cellular processes, including cell growth, differentiation, and survival. **Clinical Significance:** 1. **Viral infections**: IFIT1B may play a role in the innate immune response against viral infections, and its dysregulation may contribute to the development of viral diseases. 2. **Autoimmune diseases**: The gene's expression in immune cells may be involved in the regulation of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 3. **Cancer**: IFIT1B's expression in stem cells and cancer cells may be involved in the regulation of cancer progression and metastasis. 4. **Neurological disorders**: The gene's expression in neural cells may be involved in the regulation of neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, IFIT1B is a gene that plays a crucial role in the innate immune response and cellular regulation. Its expression patterns and functional roles suggest its involvement in multiple physiological processes, including the defense response to viral infections, protein binding, RNA binding, and cellular regulation. Further research is needed to fully understand the significance of IFIT1B in human disease and to elucidate its role in the regulation of immune homeostasis and cellular processes.

Genular Protein ID: 2032551308

Symbol: IFT1B_HUMAN

Name: Interferon-induced protein with tetratricopeptide repeats 1B

UniProtKB Accession Codes:

Q5T764 A7E245

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 474
  • Mass: 54993
  • Checksum: 163BB9DCFFCEF8DE
  • Sequence:
    • MSEESDGKLI EDSLIQLRCH FTWKLLIEAP EIPDLENRIW EEIQFLDTKY NVGIHNLLAY 
VKHLKGQNEE ALVSLKKAED LIQKEHANQA DIRSLVTWGN FAWVYYHMGR LAEAQTYLDK 
VENTCKKFAN PSRYRMECPE VDCEEGWALA KCGGKNYERA KTCFEKALEG NPENPEFNTG 
YAITVYRLDK FNTASGRNKA FSLHVLKRAV RLNPDDVYIR VLLALKLQDE GQEAEGEKYI 
EEALTSISSQ AYVFQYAAKF YRRKGSVDKA LELLKMALET TPTSAFLHHQ MGLCYRAQMI 
QIKEATNWQP RGQDRETVDR LVQLAICKFE KTIMLKRTFE MAYVDLAETY AEIGHHRKAE 
EHFQKGLRMK IFEDQLKQEI HYHYGRFQEH HGKSQDKAIT HYLKGLKIEK MSHSREKLLN 
ALEKLAKRCI HQNVRVVESV SLLGLIHKLK GEVSDALLCY ERALRLAADL NPIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.