Details for: CRNN

Gene ID: 49860

Symbol: CRNN

Ensembl ID: ENSG00000143536

Description: cornulin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 31.6261
    Cell Significance Index: 1160.9700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 6.5815
    Cell Significance Index: 82.6700
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 2.5973
    Cell Significance Index: 2.9900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.5389
    Cell Significance Index: 52.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5587
    Cell Significance Index: 43.5600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.0795
    Cell Significance Index: 16.1500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.3144
    Cell Significance Index: 5.3400
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.3036
    Cell Significance Index: 2.4800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1848
    Cell Significance Index: 3.7600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0927
    Cell Significance Index: 1.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0920
    Cell Significance Index: 1.7000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0551
    Cell Significance Index: 0.6700
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.0425
    Cell Significance Index: 0.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0083
    Cell Significance Index: 3.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0005
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0016
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0045
    Cell Significance Index: -2.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0069
    Cell Significance Index: -0.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0070
    Cell Significance Index: -2.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0114
    Cell Significance Index: -2.2800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0139
    Cell Significance Index: -0.1900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0152
    Cell Significance Index: -0.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0159
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0168
    Cell Significance Index: -1.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0194
    Cell Significance Index: -1.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0230
    Cell Significance Index: -2.8300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0269
    Cell Significance Index: -0.2700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0296
    Cell Significance Index: -0.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0342
    Cell Significance Index: -1.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0409
    Cell Significance Index: -2.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0416
    Cell Significance Index: -2.8000
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0431
    Cell Significance Index: -0.4000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0434
    Cell Significance Index: -1.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0477
    Cell Significance Index: -1.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0511
    Cell Significance Index: -2.8700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0511
    Cell Significance Index: -0.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0519
    Cell Significance Index: -2.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0522
    Cell Significance Index: -1.7100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0528
    Cell Significance Index: -0.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0582
    Cell Significance Index: -3.0300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0588
    Cell Significance Index: -0.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0628
    Cell Significance Index: -2.7800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0646
    Cell Significance Index: -0.7700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0660
    Cell Significance Index: -0.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0663
    Cell Significance Index: -1.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0664
    Cell Significance Index: -1.7800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0696
    Cell Significance Index: -1.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0739
    Cell Significance Index: -2.8000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0750
    Cell Significance Index: -1.2200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0788
    Cell Significance Index: -0.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0816
    Cell Significance Index: -2.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0817
    Cell Significance Index: -1.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0822
    Cell Significance Index: -2.4200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0856
    Cell Significance Index: -1.6900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0879
    Cell Significance Index: -0.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0903
    Cell Significance Index: -2.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0916
    Cell Significance Index: -1.9800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0937
    Cell Significance Index: -0.7200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0986
    Cell Significance Index: -1.0400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1013
    Cell Significance Index: -1.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1019
    Cell Significance Index: -1.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1023
    Cell Significance Index: -2.2400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1054
    Cell Significance Index: -1.1200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1080
    Cell Significance Index: -1.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1088
    Cell Significance Index: -2.3100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1089
    Cell Significance Index: -1.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1097
    Cell Significance Index: -2.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1148
    Cell Significance Index: -2.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1156
    Cell Significance Index: -2.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1158
    Cell Significance Index: -1.9800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1214
    Cell Significance Index: -1.7700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1253
    Cell Significance Index: -1.5900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1256
    Cell Significance Index: -1.0000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1296
    Cell Significance Index: -1.4600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1314
    Cell Significance Index: -1.3400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1316
    Cell Significance Index: -1.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1342
    Cell Significance Index: -2.3200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1450
    Cell Significance Index: -1.5400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1467
    Cell Significance Index: -2.1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1483
    Cell Significance Index: -1.9400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1501
    Cell Significance Index: -1.8000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1502
    Cell Significance Index: -1.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1551
    Cell Significance Index: -2.6000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1593
    Cell Significance Index: -2.4200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1608
    Cell Significance Index: -1.9000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1623
    Cell Significance Index: -2.6100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1649
    Cell Significance Index: -1.5600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1655
    Cell Significance Index: -1.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1707
    Cell Significance Index: -2.5200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1740
    Cell Significance Index: -2.0700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1755
    Cell Significance Index: -2.4100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1798
    Cell Significance Index: -2.3600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1806
    Cell Significance Index: -2.0000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1812
    Cell Significance Index: -2.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CRNN protein exhibits several key characteristics that contribute to its multifaceted role in cellular processes. These include: 1. **Cell-cell adhesion**: CRNN has been shown to interact with other proteins involved in cell-cell adhesion, such as cadherins and integrins, which are essential for maintaining tissue structure and function. 2. **Cell cycle regulation**: CRNN has been implicated in the regulation of the cell cycle, specifically in the G1/S phase transition, which is a critical checkpoint in cell proliferation. 3. **Immune response**: CRNN has been expressed in leukocytes, suggesting its involvement in immune function and response. 4. **Signal transduction**: CRNN has been shown to interact with various signaling molecules, including phosphatidylinositol 3-kinase/protein kinase B, which is involved in cell growth and survival. **Pathways and Functions** The CRNN protein is involved in several signaling pathways, including: 1. **Calcium-dependent protein binding**: CRNN interacts with calcium-dependent protein binding proteins, which are involved in various cellular processes, including cell-cell adhesion and cell cycle regulation. 2. **Cell-cell adhesion**: CRNN interacts with other proteins involved in cell-cell adhesion, such as cadherins and integrins, which are essential for maintaining tissue structure and function. 3. **Cellular response to cytokine stimulus**: CRNN has been shown to interact with cytokine receptors, which are involved in the regulation of immune responses. 4. **Regulation of gene expression**: CRNN has been implicated in the regulation of gene expression, specifically in the regulation of keratinocyte proliferation and NF-κB transcription factor activity. **Clinical Significance** The CRNN protein has been associated with several diseases, including: 1. **Cancer**: Alterations in CRNN expression have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: CRNN has been expressed in the cerebral cortex, suggesting its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: CRNN has been expressed in leukocytes, suggesting its involvement in immune disorders, such as autoimmune diseases and inflammatory disorders. In conclusion, the CRNN protein plays a multifaceted role in various cellular processes, including cell-cell adhesion, cell cycle regulation, and immune response. Its involvement in multiple signaling pathways and diseases highlights the importance of further research into the functions and dysregulation of this protein.

Genular Protein ID: 2685646597

Symbol: CRNN_HUMAN

Name: Cornulin

UniProtKB Accession Codes:

Q9UBG3 B2RE60 Q8N613

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11056050

Title: Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer.

PubMed ID: 11056050

DOI: 10.1006/geno.2000.6344

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11606197

Title: The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response.

PubMed ID: 11606197

DOI: 10.1046/j.0014-2956.2001.02468.x

PubMed ID: 15896671

Title: Chromosome 1 open reading frame 10 (C1orf10) gene is frequently down-regulated and inhibits cell proliferation in oral squamous cell carcinoma.

PubMed ID: 15896671

DOI: 10.1016/j.biocel.2005.02.005

PubMed ID: 15854041

Title: Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation.

PubMed ID: 15854041

DOI: 10.1111/j.0022-202x.2005.23694.x

PubMed ID: 16466100

Title: Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease.

PubMed ID: 16466100

DOI: 10.1177/000348940611500108

PubMed ID: 16640557

Title: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury.

PubMed ID: 16640557

DOI: 10.1111/j.1742-4658.2006.05206.x

PubMed ID: 17289885

Title: Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers.

PubMed ID: 17289885

DOI: 10.1158/1078-0432.ccr-06-1577

PubMed ID: 30009832

Title: Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.

PubMed ID: 30009832

DOI: 10.1016/j.jid.2018.06.184

PubMed ID: 19558548

Title: Genetic variants of C1orf10 and risk of esophageal squamous cell carcinoma in a Chinese population.

PubMed ID: 19558548

DOI: 10.1111/j.1349-7006.2009.01240.x

Sequence Information:

  • Length: 495
  • Mass: 53533
  • Checksum: C4882A11B4E64DC3
  • Sequence:
    • MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL 
LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG 
TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATG SAWVSSYDRQ AESQSQERIS 
PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ 
TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ 
TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ AGSHTETVEQ 
DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST ESGRQEWSST 
HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG 
ITARELYSYL RSTKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.