Details for: ORM1

Gene ID: 5004

Symbol: ORM1

Ensembl ID: ENSG00000229314

Description: orosomucoid 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 135.6015
    Cell Significance Index: 357.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.9040
    Cell Significance Index: -14.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 9.3282
    Cell Significance Index: 327.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.5377
    Cell Significance Index: 130.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.4037
    Cell Significance Index: 110.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.2242
    Cell Significance Index: 258.9800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 4.0097
    Cell Significance Index: 58.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.8119
    Cell Significance Index: 79.0800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 2.0459
    Cell Significance Index: 15.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8589
    Cell Significance Index: 40.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8418
    Cell Significance Index: 58.9900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.6118
    Cell Significance Index: 23.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5116
    Cell Significance Index: 68.5200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.4895
    Cell Significance Index: 5.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3847
    Cell Significance Index: 23.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0975
    Cell Significance Index: 208.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8301
    Cell Significance Index: 82.1200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7823
    Cell Significance Index: 4.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7391
    Cell Significance Index: 146.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7213
    Cell Significance Index: 10.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6852
    Cell Significance Index: 618.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5232
    Cell Significance Index: 89.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5001
    Cell Significance Index: 58.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4718
    Cell Significance Index: 349.4500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4414
    Cell Significance Index: 5.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4085
    Cell Significance Index: 66.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3652
    Cell Significance Index: 76.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2848
    Cell Significance Index: 4.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2794
    Cell Significance Index: 30.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1434
    Cell Significance Index: 9.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1160
    Cell Significance Index: 87.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0707
    Cell Significance Index: 1.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0600
    Cell Significance Index: 7.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0519
    Cell Significance Index: 32.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0472
    Cell Significance Index: 0.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0106
    Cell Significance Index: -1.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0215
    Cell Significance Index: -11.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0278
    Cell Significance Index: -1.2100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0368
    Cell Significance Index: -0.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0368
    Cell Significance Index: -2.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0520
    Cell Significance Index: -1.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0728
    Cell Significance Index: -14.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0869
    Cell Significance Index: -9.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0885
    Cell Significance Index: -12.1500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1045
    Cell Significance Index: -1.2500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1078
    Cell Significance Index: -1.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1472
    Cell Significance Index: -9.0500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1713
    Cell Significance Index: -1.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1874
    Cell Significance Index: -19.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2202
    Cell Significance Index: -4.6100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2331
    Cell Significance Index: -1.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2426
    Cell Significance Index: -11.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2531
    Cell Significance Index: -14.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2672
    Cell Significance Index: -13.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2782
    Cell Significance Index: -14.4500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2877
    Cell Significance Index: -3.5000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2885
    Cell Significance Index: -3.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2928
    Cell Significance Index: -13.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3036
    Cell Significance Index: -3.3000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3146
    Cell Significance Index: -2.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3255
    Cell Significance Index: -21.0000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3292
    Cell Significance Index: -3.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3738
    Cell Significance Index: -9.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3748
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3758
    Cell Significance Index: -4.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3799
    Cell Significance Index: -9.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3865
    Cell Significance Index: -11.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3947
    Cell Significance Index: -14.4900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4028
    Cell Significance Index: -4.7600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4147
    Cell Significance Index: -4.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4150
    Cell Significance Index: -11.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4168
    Cell Significance Index: -10.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4384
    Cell Significance Index: -10.9500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4398
    Cell Significance Index: -5.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4557
    Cell Significance Index: -12.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4620
    Cell Significance Index: -15.1300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.4858
    Cell Significance Index: -1.6900
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.4981
    Cell Significance Index: -4.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5067
    Cell Significance Index: -5.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5558
    Cell Significance Index: -14.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5679
    Cell Significance Index: -14.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5688
    Cell Significance Index: -11.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5821
    Cell Significance Index: -11.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5857
    Cell Significance Index: -14.6100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5955
    Cell Significance Index: -14.8500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.5991
    Cell Significance Index: -1.6100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6275
    Cell Significance Index: -8.1200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.6340
    Cell Significance Index: -5.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6713
    Cell Significance Index: -14.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6734
    Cell Significance Index: -14.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6809
    Cell Significance Index: -11.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6822
    Cell Significance Index: -14.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6900
    Cell Significance Index: -11.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6958
    Cell Significance Index: -13.6100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6986
    Cell Significance Index: -14.5800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.7392
    Cell Significance Index: -11.9700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7423
    Cell Significance Index: -14.6100
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.7451
    Cell Significance Index: -4.8500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.7470
    Cell Significance Index: -7.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ORM1 is a member of the orosomucoid family of glycoproteins, which are involved in various biological processes. It is highly expressed in cells of the immune system, including oligodendrocyte precursor cells, microglial cells, and inflammatory macrophages. ORM1 is also found in the liver, where it is involved in the regulation of acute-phase response and the production of cytokines. The protein has a unique structure, consisting of a large glycosylated protein core and a shorter non-glycosylated region. **Pathways and Functions:** ORM1 is involved in several signaling pathways, including: * **Acute-phase response**: ORM1 is upregulated during inflammation and is involved in the regulation of cytokine production, including interleukin-6 (IL-6) and tumor necrosis factor (TNF). * **Immune system regulation**: ORM1 modulates the activity of immune cells, including neutrophils and macrophages, and regulates the production of cytokines. * **Hemostasis**: ORM1 is involved in the regulation of platelet activation and aggregation, which is essential for blood clotting. * **Extracellular matrix regulation**: ORM1 interacts with collagen-containing extracellular matrix proteins, which is important for tissue remodeling and repair. ORM1 also regulates the activity of various enzymes and transcription factors, including: * **Interleukin-1 beta (IL-1β) production**: ORM1 promotes the production of IL-1β, a pro-inflammatory cytokine. * **Tumor necrosis factor (TNF) production**: ORM1 regulates the production of TNF, another pro-inflammatory cytokine. * **Platelet degranulation**: ORM1 inhibits platelet degranulation, which is essential for preventing excessive bleeding. **Clinical Significance:** ORM1 has been implicated in various diseases, including: * **Inflammatory disorders**: ORM1 is overexpressed in inflammatory conditions, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. * **Cancer**: ORM1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. * **Hemostatic disorders**: ORM1 is involved in the regulation of platelet activation and aggregation, which is essential for preventing bleeding disorders, such as hemophilia. * **Neurological disorders**: ORM1 is involved in the regulation of immune responses in the central nervous system, which is essential for preventing neuroinflammatory disorders, such as multiple sclerosis. In conclusion, ORM1 is a multifaceted protein that plays a crucial role in various physiological and pathological processes, including the regulation of the immune system, inflammation, and hemostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ORM1 and its potential therapeutic applications.

Genular Protein ID: 3445804824

Symbol: A1AG1_HUMAN

Name: Alpha-1-acid glycoprotein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2409529

Title: Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.

PubMed ID: 2409529

DOI: 10.1093/nar/13.11.3941

PubMed ID: 3770479

Title: Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.

PubMed ID: 3770479

DOI: 10.1016/0378-1119(86)90051-x

PubMed ID: 2822385

Title: Structure and expression of the genes coding for human alpha 1-acid glycoprotein.

PubMed ID: 2822385

DOI: 10.1002/j.1460-2075.1987.tb02503.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4711474

Title: Structure of alpha 1-acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.

PubMed ID: 4711474

DOI: 10.1021/bi00738a026

PubMed ID: 4561179

Title: Isolation and partial characterization of the cyanogen bromide fragments of alpha 1-acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.

PubMed ID: 4561179

DOI: 10.1021/bi00770a022

PubMed ID: 4603214

Title: The disulfide bonds of alpha1-acid glycoprotein.

PubMed ID: 4603214

DOI: 10.1021/bi00710a006

PubMed ID: 1567356

Title: Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.

PubMed ID: 1567356

DOI: 10.1042/bj2830105

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15253437

Title: A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.

PubMed ID: 15253437

DOI: 10.1021/pr034112b

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17008009

Title: Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein.

PubMed ID: 17008009

DOI: 10.1016/j.bbagen.2006.08.015

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 17321687

Title: The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra.

PubMed ID: 17321687

DOI: 10.1016/j.bbagen.2007.01.009

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 18823996

Title: The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin.

PubMed ID: 18823996

DOI: 10.1016/j.jmb.2008.09.020

PubMed ID: 9050929

Title: Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.

PubMed ID: 9050929

DOI: 10.1007/s004390050378

Sequence Information:

  • Length: 201
  • Mass: 23540
  • Checksum: CC2AD1FD9C8CBFA4
  • Sequence:
  • MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF RNEEYNKSVQ 
    EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ RENGTISRYV GGQEHFAHLL 
    ILRDTKTYML AFDVNDEKNW GLSVYADKPE TTKEQLGEFY EALDCLRIPK SDVVYTDWKK 
    DKCEPLEKQH EKERKQEEGE S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.