Details for: ORM1

Gene ID: 5004

Symbol: ORM1

Ensembl ID: ENSG00000229314

Description: orosomucoid 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.28
    Marker Score: 5,293
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.4
    Marker Score: 18,304
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.43
    Marker Score: 4,419
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.26
    Marker Score: 495
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.2
    Marker Score: 9,479
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 2.14
    Marker Score: 664
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1,996
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.92
    Marker Score: 12,326
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.86
    Marker Score: 1,993
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,171
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.35
    Marker Score: 921
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.2
    Marker Score: 330
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,814
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.09
    Marker Score: 822
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.07
    Marker Score: 2,031
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.03
    Marker Score: 371
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15,859
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,049
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.99
    Marker Score: 6,017
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 452
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.97
    Marker Score: 1,566
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.83
    Marker Score: 313
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 796
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5,294
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.78
    Marker Score: 477
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.78
    Marker Score: 4,662
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1,491
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 330
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.68
    Marker Score: 677
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 480
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.51
    Marker Score: 3,313
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 305
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.5
    Marker Score: 218
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 204
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.46
    Marker Score: 406
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 435
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 185
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.4
    Marker Score: 443
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.36
    Marker Score: 136
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.36
    Marker Score: 208
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.35
    Marker Score: 105
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.34
    Marker Score: 714
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 191
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.31
    Marker Score: 491
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 189
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.29
    Marker Score: 657
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.29
    Marker Score: 1,830
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 184
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.28
    Marker Score: 179
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.27
    Marker Score: 841
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.23
    Marker Score: 102
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.21
    Marker Score: 207
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.21
    Marker Score: 105
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 189
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.19
    Marker Score: 213
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.18
    Marker Score: 119
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.18
    Marker Score: 432
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.17
    Marker Score: 174
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.17
    Marker Score: 200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.17
    Marker Score: 83
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.17
    Marker Score: 870
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 60
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.14
    Marker Score: 2,304
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.14
    Marker Score: 70
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 204
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.12
    Marker Score: 212
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 30

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ORM1 is a member of the orosomucoid family of glycoproteins, which are involved in various biological processes. It is highly expressed in cells of the immune system, including oligodendrocyte precursor cells, microglial cells, and inflammatory macrophages. ORM1 is also found in the liver, where it is involved in the regulation of acute-phase response and the production of cytokines. The protein has a unique structure, consisting of a large glycosylated protein core and a shorter non-glycosylated region. **Pathways and Functions:** ORM1 is involved in several signaling pathways, including: * **Acute-phase response**: ORM1 is upregulated during inflammation and is involved in the regulation of cytokine production, including interleukin-6 (IL-6) and tumor necrosis factor (TNF). * **Immune system regulation**: ORM1 modulates the activity of immune cells, including neutrophils and macrophages, and regulates the production of cytokines. * **Hemostasis**: ORM1 is involved in the regulation of platelet activation and aggregation, which is essential for blood clotting. * **Extracellular matrix regulation**: ORM1 interacts with collagen-containing extracellular matrix proteins, which is important for tissue remodeling and repair. ORM1 also regulates the activity of various enzymes and transcription factors, including: * **Interleukin-1 beta (IL-1β) production**: ORM1 promotes the production of IL-1β, a pro-inflammatory cytokine. * **Tumor necrosis factor (TNF) production**: ORM1 regulates the production of TNF, another pro-inflammatory cytokine. * **Platelet degranulation**: ORM1 inhibits platelet degranulation, which is essential for preventing excessive bleeding. **Clinical Significance:** ORM1 has been implicated in various diseases, including: * **Inflammatory disorders**: ORM1 is overexpressed in inflammatory conditions, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. * **Cancer**: ORM1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. * **Hemostatic disorders**: ORM1 is involved in the regulation of platelet activation and aggregation, which is essential for preventing bleeding disorders, such as hemophilia. * **Neurological disorders**: ORM1 is involved in the regulation of immune responses in the central nervous system, which is essential for preventing neuroinflammatory disorders, such as multiple sclerosis. In conclusion, ORM1 is a multifaceted protein that plays a crucial role in various physiological and pathological processes, including the regulation of the immune system, inflammation, and hemostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ORM1 and its potential therapeutic applications.

Genular Protein ID: 3445804824

Symbol: A1AG1_HUMAN

Name: Alpha-1-acid glycoprotein 1

UniProtKB Accession Codes:

P02763 B7ZKQ5 Q5T539 Q5U067 Q8TC16

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 19 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SASBDB 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2409529

Title: Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.

PubMed ID: 2409529

DOI: 10.1093/nar/13.11.3941

PubMed ID: 3770479

Title: Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.

PubMed ID: 3770479

DOI: 10.1016/0378-1119(86)90051-x

PubMed ID: 2822385

Title: Structure and expression of the genes coding for human alpha 1-acid glycoprotein.

PubMed ID: 2822385

DOI: 10.1002/j.1460-2075.1987.tb02503.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4711474

Title: Structure of alpha 1-acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.

PubMed ID: 4711474

DOI: 10.1021/bi00738a026

PubMed ID: 4561179

Title: Isolation and partial characterization of the cyanogen bromide fragments of alpha 1-acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.

PubMed ID: 4561179

DOI: 10.1021/bi00770a022

PubMed ID: 4603214

Title: The disulfide bonds of alpha1-acid glycoprotein.

PubMed ID: 4603214

DOI: 10.1021/bi00710a006

PubMed ID: 1567356

Title: Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.

PubMed ID: 1567356

DOI: 10.1042/bj2830105

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15253437

Title: A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.

PubMed ID: 15253437

DOI: 10.1021/pr034112b

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17008009

Title: Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein.

PubMed ID: 17008009

DOI: 10.1016/j.bbagen.2006.08.015

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 17321687

Title: The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra.

PubMed ID: 17321687

DOI: 10.1016/j.bbagen.2007.01.009

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 18823996

Title: The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin.

PubMed ID: 18823996

DOI: 10.1016/j.jmb.2008.09.020

PubMed ID: 9050929

Title: Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.

PubMed ID: 9050929

DOI: 10.1007/s004390050378

Sequence Information:

  • Length: 201
  • Mass: 23540
  • Checksum: CC2AD1FD9C8CBFA4
  • Sequence:
    • MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF RNEEYNKSVQ 
EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ RENGTISRYV GGQEHFAHLL 
ILRDTKTYML AFDVNDEKNW GLSVYADKPE TTKEQLGEFY EALDCLRIPK SDVVYTDWKK 
DKCEPLEKQH EKERKQEEGE S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.