Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: liver dendritic cell (CL2000055)
Fold Change: 135.6015
Cell Significance Index: 357.7100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 34.9040
Cell Significance Index: -14.1800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 9.3282
Cell Significance Index: 327.7800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 4.5377
Cell Significance Index: 130.7400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 4.4037
Cell Significance Index: 110.0800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 4.2242
Cell Significance Index: 258.9800 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 4.0097
Cell Significance Index: 58.2200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 3.8119
Cell Significance Index: 79.0800 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 2.0459
Cell Significance Index: 15.7200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.8589
Cell Significance Index: 40.2700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.8418
Cell Significance Index: 58.9900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.6118
Cell Significance Index: 23.7900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.5116
Cell Significance Index: 68.5200 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 1.4895
Cell Significance Index: 5.6100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.3847
Cell Significance Index: 23.3300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0975
Cell Significance Index: 208.8700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8301
Cell Significance Index: 82.1200 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.7823
Cell Significance Index: 4.5100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7391
Cell Significance Index: 146.6700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.7213
Cell Significance Index: 10.8700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6852
Cell Significance Index: 618.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5232
Cell Significance Index: 89.3400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5001
Cell Significance Index: 58.2800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.4718
Cell Significance Index: 349.4500 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.4414
Cell Significance Index: 5.4600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4085
Cell Significance Index: 66.4500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.3652
Cell Significance Index: 76.9300 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.2848
Cell Significance Index: 4.7900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2794
Cell Significance Index: 30.3900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1434
Cell Significance Index: 9.9200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1160
Cell Significance Index: 87.8100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0707
Cell Significance Index: 1.5100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0600
Cell Significance Index: 7.6900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0519
Cell Significance Index: 32.4200 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0472
Cell Significance Index: 0.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0056
Cell Significance Index: -3.1700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0106
Cell Significance Index: -1.2100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0215
Cell Significance Index: -11.7500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0278
Cell Significance Index: -1.2100 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0368
Cell Significance Index: -0.5100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0368
Cell Significance Index: -2.2100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0520
Cell Significance Index: -1.3400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0728
Cell Significance Index: -14.6100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0869
Cell Significance Index: -9.9200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0885
Cell Significance Index: -12.1500 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.1045
Cell Significance Index: -1.2500 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.1078
Cell Significance Index: -1.0300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1472
Cell Significance Index: -9.0500 - Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.1713
Cell Significance Index: -1.6900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1874
Cell Significance Index: -19.1400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2202
Cell Significance Index: -4.6100 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2331
Cell Significance Index: -1.5200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2426
Cell Significance Index: -11.4000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2531
Cell Significance Index: -14.2000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2672
Cell Significance Index: -13.9200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2782
Cell Significance Index: -14.4500 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.2877
Cell Significance Index: -3.5000 - Cell Name: erythroblast (CL0000765)
Fold Change: -0.2885
Cell Significance Index: -3.4400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2928
Cell Significance Index: -13.6500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3036
Cell Significance Index: -3.3000 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.3146
Cell Significance Index: -2.6800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3255
Cell Significance Index: -21.0000 - Cell Name: pro-B cell (CL0000826)
Fold Change: -0.3292
Cell Significance Index: -3.5400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3738
Cell Significance Index: -9.1200 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.3748
Cell Significance Index: -4.7300 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.3758
Cell Significance Index: -4.7300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3799
Cell Significance Index: -9.1100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3865
Cell Significance Index: -11.0800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3947
Cell Significance Index: -14.4900 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.4028
Cell Significance Index: -4.7600 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.4147
Cell Significance Index: -4.3800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4150
Cell Significance Index: -11.3000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4168
Cell Significance Index: -10.9600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4384
Cell Significance Index: -10.9500 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4398
Cell Significance Index: -5.6500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4557
Cell Significance Index: -12.2100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4620
Cell Significance Index: -15.1300 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: -0.4858
Cell Significance Index: -1.6900 - Cell Name: M cell of gut (CL0000682)
Fold Change: -0.4981
Cell Significance Index: -4.1500 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.5067
Cell Significance Index: -5.5200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5558
Cell Significance Index: -14.8400 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.5679
Cell Significance Index: -14.4700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5688
Cell Significance Index: -11.4200 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5821
Cell Significance Index: -11.5100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5857
Cell Significance Index: -14.6100 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.5955
Cell Significance Index: -14.8500 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: -0.5991
Cell Significance Index: -1.6100 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.6275
Cell Significance Index: -8.1200 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.6340
Cell Significance Index: -5.0100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.6713
Cell Significance Index: -14.7000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.6734
Cell Significance Index: -14.5500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6809
Cell Significance Index: -11.4000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6822
Cell Significance Index: -14.4800 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.6900
Cell Significance Index: -11.3700 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.6958
Cell Significance Index: -13.6100 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.6986
Cell Significance Index: -14.5800 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.7392
Cell Significance Index: -11.9700 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.7423
Cell Significance Index: -14.6100 - Cell Name: mature B cell (CL0000785)
Fold Change: -0.7451
Cell Significance Index: -4.8500 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.7470
Cell Significance Index: -7.7100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3445804824
Symbol: A1AG1_HUMAN
Name: Alpha-1-acid glycoprotein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2409529
Title: Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.
PubMed ID: 2409529
PubMed ID: 3770479
Title: Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.
PubMed ID: 3770479
PubMed ID: 2822385
Title: Structure and expression of the genes coding for human alpha 1-acid glycoprotein.
PubMed ID: 2822385
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 4711474
Title: Structure of alpha 1-acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.
PubMed ID: 4711474
DOI: 10.1021/bi00738a026
PubMed ID: 4561179
Title: Isolation and partial characterization of the cyanogen bromide fragments of alpha 1-acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.
PubMed ID: 4561179
DOI: 10.1021/bi00770a022
PubMed ID: 4603214
PubMed ID: 1567356
Title: Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.
PubMed ID: 1567356
DOI: 10.1042/bj2830105
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 15253437
Title: A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.
PubMed ID: 15253437
DOI: 10.1021/pr034112b
PubMed ID: 15084671
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 17008009
Title: Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein.
PubMed ID: 17008009
PubMed ID: 16740002
Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.
PubMed ID: 16740002
DOI: 10.1021/pr050492k
PubMed ID: 17321687
Title: The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra.
PubMed ID: 17321687
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19838169
Title: Enrichment of glycopeptides for glycan structure and attachment site identification.
PubMed ID: 19838169
DOI: 10.1038/nmeth.1392
PubMed ID: 22171320
Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.
PubMed ID: 22171320
PubMed ID: 18823996
Title: The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin.
PubMed ID: 18823996
PubMed ID: 9050929
Title: Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.
PubMed ID: 9050929
Sequence Information:
- Length: 201
- Mass: 23540
- Checksum: CC2AD1FD9C8CBFA4
- Sequence:
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ RENGTISRYV GGQEHFAHLL ILRDTKTYML AFDVNDEKNW GLSVYADKPE TTKEQLGEFY EALDCLRIPK SDVVYTDWKK DKCEPLEKQH EKERKQEEGE S
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.