Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 4.28
Marker Score: 5,293 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 3.4
Marker Score: 18,304 - Cell Name: microglial cell (CL0000129)
Fold Change: 2.43
Marker Score: 4,419 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 2.26
Marker Score: 495 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2.2
Marker Score: 9,479 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 2.14
Marker Score: 664 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1,996 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.92
Marker Score: 12,326 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.86
Marker Score: 1,993 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,171 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.35
Marker Score: 921 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 857 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.2
Marker Score: 330 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 489 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,814 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.09
Marker Score: 822 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.07
Marker Score: 2,031 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 798 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.03
Marker Score: 371 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.01
Marker Score: 15,859 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,823 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,049 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.99
Marker Score: 6,017 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 511 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.98
Marker Score: 452 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: pneumocyte (CL0000322)
Fold Change: 0.97
Marker Score: 1,566 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 377 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,349 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,743 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 329 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.83
Marker Score: 313 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.81
Marker Score: 796 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.8
Marker Score: 5,294 - Cell Name: neutrophil (CL0000775)
Fold Change: 0.78
Marker Score: 477 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,267 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.78
Marker Score: 4,662 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 400 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.73
Marker Score: 1,491 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 464 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 181 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.69
Marker Score: 330 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.68
Marker Score: 677 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 480 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.56
Marker Score: 176 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.51
Marker Score: 3,313 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.51
Marker Score: 305 - Cell Name: myelocyte (CL0002193)
Fold Change: 0.5
Marker Score: 218 - Cell Name: peptic cell (CL0000155)
Fold Change: 0.49
Marker Score: 206 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 280 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.46
Marker Score: 204 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.46
Marker Score: 406 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 435 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.43
Marker Score: 185 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.4
Marker Score: 443 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.38
Marker Score: 102 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.36
Marker Score: 136 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.36
Marker Score: 208 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.35
Marker Score: 105 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.34
Marker Score: 714 - Cell Name: mast cell (CL0000097)
Fold Change: 0.33
Marker Score: 191 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.31
Marker Score: 491 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.3
Marker Score: 189 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.29
Marker Score: 657 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.29
Marker Score: 1,830 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.28
Marker Score: 184 - Cell Name: promonocyte (CL0000559)
Fold Change: 0.28
Marker Score: 179 - Cell Name: Unknown (CL0000003)
Fold Change: 0.27
Marker Score: 841 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 91 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.23
Marker Score: 102 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.21
Marker Score: 207 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.21
Marker Score: 105 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.2
Marker Score: 85 - Cell Name: B cell (CL0000236)
Fold Change: 0.2
Marker Score: 189 - Cell Name: macrophage (CL0000235)
Fold Change: 0.19
Marker Score: 213 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.18
Marker Score: 119 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.18
Marker Score: 432 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.17
Marker Score: 81 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.17
Marker Score: 174 - Cell Name: stromal cell (CL0000499)
Fold Change: 0.17
Marker Score: 200 - Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.17
Marker Score: 83 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.17
Marker Score: 870 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.15
Marker Score: 60 - Cell Name: granulocyte (CL0000094)
Fold Change: 0.15
Marker Score: 67 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.14
Marker Score: 2,304 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.14
Marker Score: 81 - Cell Name: pericyte (CL0000669)
Fold Change: 0.14
Marker Score: 81 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.14
Marker Score: 70 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.13
Marker Score: 204 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.12
Marker Score: 112 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.12
Marker Score: 43 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.12
Marker Score: 212 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.12
Marker Score: 67 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.12
Marker Score: 30
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3445804824
Symbol: A1AG1_HUMAN
Name: Alpha-1-acid glycoprotein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2409529
Title: Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.
PubMed ID: 2409529
PubMed ID: 3770479
Title: Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.
PubMed ID: 3770479
PubMed ID: 2822385
Title: Structure and expression of the genes coding for human alpha 1-acid glycoprotein.
PubMed ID: 2822385
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 4711474
Title: Structure of alpha 1-acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.
PubMed ID: 4711474
DOI: 10.1021/bi00738a026
PubMed ID: 4561179
Title: Isolation and partial characterization of the cyanogen bromide fragments of alpha 1-acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.
PubMed ID: 4561179
DOI: 10.1021/bi00770a022
PubMed ID: 4603214
PubMed ID: 1567356
Title: Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.
PubMed ID: 1567356
DOI: 10.1042/bj2830105
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 15253437
Title: A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.
PubMed ID: 15253437
DOI: 10.1021/pr034112b
PubMed ID: 15084671
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 17008009
Title: Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein.
PubMed ID: 17008009
PubMed ID: 16740002
Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.
PubMed ID: 16740002
DOI: 10.1021/pr050492k
PubMed ID: 17321687
Title: The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra.
PubMed ID: 17321687
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19838169
Title: Enrichment of glycopeptides for glycan structure and attachment site identification.
PubMed ID: 19838169
DOI: 10.1038/nmeth.1392
PubMed ID: 22171320
Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.
PubMed ID: 22171320
PubMed ID: 18823996
Title: The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin.
PubMed ID: 18823996
PubMed ID: 9050929
Title: Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.
PubMed ID: 9050929
Sequence Information:
- Length: 201
- Mass: 23540
- Checksum: CC2AD1FD9C8CBFA4
- Sequence:
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ RENGTISRYV GGQEHFAHLL ILRDTKTYML AFDVNDEKNW GLSVYADKPE TTKEQLGEFY EALDCLRIPK SDVVYTDWKK DKCEPLEKQH EKERKQEEGE S
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.