Details for: TAS2R7

Gene ID: 50837

Symbol: TAS2R7

Ensembl ID: ENSG00000121377

Description: taste 2 receptor member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0304
    Cell Significance Index: 0.3100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0153
    Cell Significance Index: 0.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0027
    Cell Significance Index: 0.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0018
    Cell Significance Index: 0.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0025
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0045
    Cell Significance Index: -0.5100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0063
    Cell Significance Index: -0.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0067
    Cell Significance Index: -0.2200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0077
    Cell Significance Index: -0.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0079
    Cell Significance Index: -0.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0079
    Cell Significance Index: -0.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0097
    Cell Significance Index: -0.1900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0105
    Cell Significance Index: -0.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0110
    Cell Significance Index: -0.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0122
    Cell Significance Index: -0.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0126
    Cell Significance Index: -0.2500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0175
    Cell Significance Index: -0.1900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0182
    Cell Significance Index: -0.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0204
    Cell Significance Index: -0.3300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0207
    Cell Significance Index: -0.2000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0213
    Cell Significance Index: -0.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0215
    Cell Significance Index: -0.4200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0222
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0228
    Cell Significance Index: -0.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0233
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0234
    Cell Significance Index: -0.4900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0234
    Cell Significance Index: -0.2600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0243
    Cell Significance Index: -0.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0255
    Cell Significance Index: -0.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0281
    Cell Significance Index: -0.3500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0282
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0293
    Cell Significance Index: -0.3600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0296
    Cell Significance Index: -0.4000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0299
    Cell Significance Index: -0.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0299
    Cell Significance Index: -0.5000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0300
    Cell Significance Index: -0.3600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0307
    Cell Significance Index: -0.4100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0314
    Cell Significance Index: -0.3700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0316
    Cell Significance Index: -0.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0321
    Cell Significance Index: -0.4200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0328
    Cell Significance Index: -0.3800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0328
    Cell Significance Index: -0.4200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0335
    Cell Significance Index: -0.4200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0337
    Cell Significance Index: -0.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0339
    Cell Significance Index: -0.4200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0349
    Cell Significance Index: -0.4500
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0350
    Cell Significance Index: -0.4400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0351
    Cell Significance Index: -0.4400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0352
    Cell Significance Index: -0.4400
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0353
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0355
    Cell Significance Index: -0.3600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0357
    Cell Significance Index: -0.4700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0357
    Cell Significance Index: -0.4500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0358
    Cell Significance Index: -0.3800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0359
    Cell Significance Index: -0.4300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0360
    Cell Significance Index: -0.4300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0363
    Cell Significance Index: -0.3300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0363
    Cell Significance Index: -0.4400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0363
    Cell Significance Index: -0.4700
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: -0.0365
    Cell Significance Index: -0.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0369
    Cell Significance Index: -0.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0370
    Cell Significance Index: -0.4100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0370
    Cell Significance Index: -0.4500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0381
    Cell Significance Index: -0.4200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0384
    Cell Significance Index: -0.4400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0389
    Cell Significance Index: -0.4400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0389
    Cell Significance Index: -0.5400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0391
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0394
    Cell Significance Index: -0.3700
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0407
    Cell Significance Index: -0.4500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0408
    Cell Significance Index: -0.4400
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0409
    Cell Significance Index: -0.4400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0415
    Cell Significance Index: -0.4500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0415
    Cell Significance Index: -0.4900
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0416
    Cell Significance Index: -0.4200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0417
    Cell Significance Index: -0.4200
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0419
    Cell Significance Index: -0.4900
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0419
    Cell Significance Index: -0.4400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0421
    Cell Significance Index: -0.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Bitter taste receptor**: TAS2R7 is a member of the TAS2R family, which consists of bitter taste receptors. These receptors are responsible for detecting bitter compounds, such as those found in certain foods, chemicals, and toxins. 2. **Metabotropic glutamate/pheromone receptors**: TAS2R7 also belongs to the Class C/3 receptor family, which is involved in signaling pathways related to metabotropic glutamate receptors and pheromone receptors. 3. **Wide tissue expression**: TAS2R7 is expressed in various cell types, including progenitor cells, microglial cells, endothelial cells, and immune cells, suggesting its involvement in multiple physiological processes beyond taste perception. 4. **G protein-coupled receptor activity**: TAS2R7 is a G protein-coupled receptor (GPCR), which enables it to respond to ligands and trigger downstream signaling pathways. **Pathways and Functions** 1. **G protein signaling**: TAS2R7 activates G proteins, which initiate downstream signaling cascades that regulate various cellular processes. 2. **Detection of chemical stimuli**: TAS2R7 detects bitter compounds, such as those found in certain foods, chemicals, and toxins, and triggers a response to protect the body. 3. **Sensory perception**: TAS2R7 is involved in the sensory perception of bitter taste, which is essential for maintaining the body's homeostasis. 4. **Immune function**: The expression of TAS2R7 in immune cells, such as microglial cells and naive T cells, suggests its involvement in immune responses and the detection of pathogens. **Clinical Significance** 1. **Bitter taste disorders**: Mutations in the TAS2R7 gene have been associated with bitter taste disorders, such as supertasters, who have a heightened sensitivity to bitter compounds. 2. **Toxicity and carcinogenesis**: The ability of TAS2R7 to detect toxic substances, such as certain chemicals and heavy metals, highlights its importance in protecting against carcinogenesis and other toxic effects. 3. **Neurological disorders**: The expression of TAS2R7 in the nervous system and its involvement in G protein signaling suggest its potential role in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Cancer research**: The TAS2R7 gene has been identified as a potential biomarker for cancer diagnosis and prognosis, as it is differentially expressed in various types of cancer. In conclusion, TAS2R7 plays a crucial role in the perception of bitter taste, as well as in immune responses and other physiological processes. Further research on this gene and its downstream signaling pathways will provide valuable insights into the molecular mechanisms underlying taste perception and immune function, and may lead to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3325994582

Symbol: TA2R7_HUMAN

Name: Taste receptor type 2 member 7

UniProtKB Accession Codes:

Q9NYW3 Q645Y1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 3 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10761934

Title: A novel family of mammalian taste receptors.

PubMed ID: 10761934

DOI: 10.1016/s0092-8674(00)80705-9

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10761935

Title: T2Rs function as bitter taste receptors.

PubMed ID: 10761935

DOI: 10.1016/s0092-8674(00)80706-0

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

Sequence Information:

  • Length: 318
  • Mass: 36550
  • Checksum: F187ADB2D8274B8A
  • Sequence:
    • MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS LAISRICLLC 
VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA TCLSIYYFFK IGNFFHPLFL 
WMKWRIDRVI SWILLGCVVL SVFISLPATE NLNADFRFCV KAKRKTNLTW SCRVNKTQHA 
STKLFLNLAT LLPFCVCLMS FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF 
LLLFIAYYLS FLIATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI 
WKVMSILKGR KFQQHKQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.