Details for: PCK1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 30.8672
Cell Significance Index: -12.5400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 12.0282
Cell Significance Index: 202.6200 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 9.9490
Cell Significance Index: 26.2500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 4.8742
Cell Significance Index: 140.4400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.6064
Cell Significance Index: -12.3400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 3.5574
Cell Significance Index: 77.0700 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.5231
Cell Significance Index: 13.4900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.5696
Cell Significance Index: 116.4700 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 2.3907
Cell Significance Index: 25.9100 - Cell Name: proerythroblast (CL0000547)
Fold Change: 2.2467
Cell Significance Index: 32.2000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.1189
Cell Significance Index: 31.7500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.0190
Cell Significance Index: 29.8000 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.7998
Cell Significance Index: 14.3700 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1.7219
Cell Significance Index: 17.3700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.5467
Cell Significance Index: 122.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3270
Cell Significance Index: 1198.1700 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.1767
Cell Significance Index: 9.9200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.9922
Cell Significance Index: 31.7800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9760
Cell Significance Index: 158.7300 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.9230
Cell Significance Index: 15.5300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9127
Cell Significance Index: 181.1300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.8142
Cell Significance Index: 17.3400 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.8014
Cell Significance Index: 4.6200 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.6432
Cell Significance Index: 2.8000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6163
Cell Significance Index: 37.0000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5769
Cell Significance Index: 14.4200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5747
Cell Significance Index: 56.8500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.4114
Cell Significance Index: 14.4600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.4055
Cell Significance Index: 297.2800 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.3660
Cell Significance Index: 3.2000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3487
Cell Significance Index: 66.3600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2946
Cell Significance Index: 4.0200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2427
Cell Significance Index: 16.7900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.1905
Cell Significance Index: 4.6200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1650
Cell Significance Index: 19.2300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0959
Cell Significance Index: 2.5700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.0773
Cell Significance Index: 1.1000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0164
Cell Significance Index: 0.1700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0140
Cell Significance Index: 1.7900 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.0026
Cell Significance Index: 0.0200 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.0016
Cell Significance Index: 0.0100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0006
Cell Significance Index: -0.4400 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0009
Cell Significance Index: -0.0100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0011
Cell Significance Index: -0.6400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0016
Cell Significance Index: -1.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0030
Cell Significance Index: -5.6700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0034
Cell Significance Index: -5.1600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0035
Cell Significance Index: -6.4600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0051
Cell Significance Index: -6.9600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0063
Cell Significance Index: -3.4300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0078
Cell Significance Index: -5.9300 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.0080
Cell Significance Index: -0.0300 - Cell Name: colonocyte (CL1000347)
Fold Change: -0.0081
Cell Significance Index: -0.0500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0084
Cell Significance Index: -3.8300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0106
Cell Significance Index: -2.2300 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.0142
Cell Significance Index: -0.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0163
Cell Significance Index: -10.3800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0169
Cell Significance Index: -2.8900 - Cell Name: urothelial cell (CL0000731)
Fold Change: -0.0186
Cell Significance Index: -0.1300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0214
Cell Significance Index: -2.4400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0229
Cell Significance Index: -2.3400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0268
Cell Significance Index: -1.1600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0321
Cell Significance Index: -6.4400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0342
Cell Significance Index: -9.8300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0349
Cell Significance Index: -4.7900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0381
Cell Significance Index: -0.3200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0392
Cell Significance Index: -1.1000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0423
Cell Significance Index: -4.8500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0471
Cell Significance Index: -0.7100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0554
Cell Significance Index: -6.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0559
Cell Significance Index: -8.1300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0559
Cell Significance Index: -6.5900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0570
Cell Significance Index: -5.9300 - Cell Name: stem cell (CL0000034)
Fold Change: -0.0619
Cell Significance Index: -0.4500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0626
Cell Significance Index: -3.1600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0646
Cell Significance Index: -1.0000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0660
Cell Significance Index: -11.9000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0718
Cell Significance Index: -1.8500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0744
Cell Significance Index: -2.1900 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: -0.0852
Cell Significance Index: -0.5000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0855
Cell Significance Index: -5.2400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0889
Cell Significance Index: -10.9300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0915
Cell Significance Index: -6.1500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0929
Cell Significance Index: -5.7100 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.1001
Cell Significance Index: -0.7900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1005
Cell Significance Index: -7.7100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1007
Cell Significance Index: -13.0100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1088
Cell Significance Index: -5.7100 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.1141
Cell Significance Index: -1.4900 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.1306
Cell Significance Index: -1.4300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1333
Cell Significance Index: -2.7900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1374
Cell Significance Index: -7.7100 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1380
Cell Significance Index: -1.3300 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1464
Cell Significance Index: -3.6500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1471
Cell Significance Index: -6.8600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1579
Cell Significance Index: -8.2000 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1630
Cell Significance Index: -2.8100 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.1764
Cell Significance Index: -1.5900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1782
Cell Significance Index: -13.2800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1802
Cell Significance Index: -2.5800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1461498223
Symbol: PCKGC_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8490617
Title: cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young.
PubMed ID: 8490617
DOI: 10.1093/hmg/2.1.1
PubMed ID: 8325643
Title: Phosphoenolpyruvate carboxykinase (GTP): characterization of the human PCK1 gene and localization distal to MODY on chromosome 20.
PubMed ID: 8325643
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8547315
Title: Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter.
PubMed ID: 8547315
PubMed ID: 1656199
Title: Regulation of phosphoenolpyruvate carboxykinase (GTP) gene transcription.
PubMed ID: 1656199
PubMed ID: 20167786
Title: Regulation of cellular metabolism by protein lysine acetylation.
PubMed ID: 20167786
PubMed ID: 21726808
Title: Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.
PubMed ID: 21726808
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 30193097
Title: Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions.
PubMed ID: 30193097
PubMed ID: 32322062
Title: The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
PubMed ID: 32322062
PubMed ID: 11851336
Title: Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
PubMed ID: 11851336
PubMed ID: 14552798
Title: X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines.
PubMed ID: 14552798
PubMed ID: 17532214
Title: C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase.
PubMed ID: 17532214
PubMed ID: 24863970
Title: Three rare diseases in one sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
PubMed ID: 24863970
PubMed ID: 26971250
Title: Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.
PubMed ID: 26971250
PubMed ID: 28216384
Title: Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction.
PubMed ID: 28216384
Sequence Information:
- Length: 622
- Mass: 69195
- Checksum: 78D309E0845CC181
- Sequence:
MPPQLQNGLN LSAKVVQGSL DSLPQAVREF LENNAELCQP DHIHICDGSE EENGRLLGQM EEEGILRRLK KYDNCWLALT DPRDVARIES KTVIVTQEQR DTVPIPKTGL SQLGRWMSEE DFEKAFNARF PGCMKGRTMY VIPFSMGPLG SPLSKIGIEL TDSPYVVASM RIMTRMGTPV LEAVGDGEFV KCLHSVGCPL PLQKPLVNNW PCNPELTLIA HLPDRREIIS FGSGYGGNSL LGKKCFALRM ASRLAKEEGW LAEHMLILGI TNPEGEKKYL AAAFPSACGK TNLAMMNPSL PGWKVECVGD DIAWMKFDAQ GHLRAINPEN GFFGVAPGTS VKTNPNAIKT IQKNTIFTNV AETSDGGVYW EGIDEPLASG VTITSWKNKE WSSEDGEPCA HPNSRFCTPA SQCPIIDAAW ESPEGVPIEG IIFGGRRPAG VPLVYEALSW QHGVFVGAAM RSEATAAAEH KGKIIMHDPF AMRPFFGYNF GKYLAHWLSM AQHPAAKLPK IFHVNWFRKD KEGKFLWPGF GENSRVLEWM FNRIDGKAST KLTPIGYIPK EDALNLKGLG HINMMELFSI SKEFWEKEVE DIEKYLEDQV NADLPCEIER EILALKQRIS QM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.