Details for: NUTM2F

Gene ID: 54754

Symbol: NUTM2F

Ensembl ID: ENSG00000130950

Description: NUT family member 2F

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1887
    Cell Significance Index: 2.7500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1229
    Cell Significance Index: 1.9900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0832
    Cell Significance Index: 1.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0208
    Cell Significance Index: 0.4600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.0136
    Cell Significance Index: 0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0054
    Cell Significance Index: 1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0036
    Cell Significance Index: 0.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0009
    Cell Significance Index: 0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0006
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0032
    Cell Significance Index: -0.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0050
    Cell Significance Index: -0.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0055
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0057
    Cell Significance Index: -0.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0066
    Cell Significance Index: -1.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0073
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0096
    Cell Significance Index: -1.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0111
    Cell Significance Index: -1.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0113
    Cell Significance Index: -0.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0118
    Cell Significance Index: -0.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0133
    Cell Significance Index: -1.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0158
    Cell Significance Index: -1.0600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0180
    Cell Significance Index: -0.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0203
    Cell Significance Index: -0.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0207
    Cell Significance Index: -0.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0226
    Cell Significance Index: -1.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0227
    Cell Significance Index: -0.4900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0239
    Cell Significance Index: -0.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0242
    Cell Significance Index: -1.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0257
    Cell Significance Index: -1.4400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0261
    Cell Significance Index: -0.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0275
    Cell Significance Index: -1.3900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0279
    Cell Significance Index: -0.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0291
    Cell Significance Index: -2.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0309
    Cell Significance Index: -0.6500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0317
    Cell Significance Index: -0.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0363
    Cell Significance Index: -1.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0404
    Cell Significance Index: -0.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0411
    Cell Significance Index: -0.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0413
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0417
    Cell Significance Index: -1.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0434
    Cell Significance Index: -1.1600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0458
    Cell Significance Index: -0.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0494
    Cell Significance Index: -1.3000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0526
    Cell Significance Index: -0.5000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0531
    Cell Significance Index: -1.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0581
    Cell Significance Index: -1.4800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0588
    Cell Significance Index: -0.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0611
    Cell Significance Index: -1.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0630
    Cell Significance Index: -1.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0631
    Cell Significance Index: -2.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0639
    Cell Significance Index: -1.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0718
    Cell Significance Index: -2.7200
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0732
    Cell Significance Index: -0.7400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0761
    Cell Significance Index: -0.9100
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0779
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0819
    Cell Significance Index: -1.3500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0820
    Cell Significance Index: -1.0700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0859
    Cell Significance Index: -0.9700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0894
    Cell Significance Index: -1.2400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0901
    Cell Significance Index: -1.2600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0905
    Cell Significance Index: -1.0500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0908
    Cell Significance Index: -0.6300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0909
    Cell Significance Index: -1.3200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0920
    Cell Significance Index: -1.2900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0926
    Cell Significance Index: -0.8800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0933
    Cell Significance Index: -1.2800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0948
    Cell Significance Index: -1.2300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0953
    Cell Significance Index: -0.9600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0955
    Cell Significance Index: -1.2100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0962
    Cell Significance Index: -1.1000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0990
    Cell Significance Index: -1.1800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1027
    Cell Significance Index: -1.3000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1034
    Cell Significance Index: -1.1500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1034
    Cell Significance Index: -1.3100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1044
    Cell Significance Index: -1.3700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1071
    Cell Significance Index: -1.4100
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1071
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1072
    Cell Significance Index: -1.3500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1075
    Cell Significance Index: -1.3400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1086
    Cell Significance Index: -1.2800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1095
    Cell Significance Index: -1.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1104
    Cell Significance Index: -1.8600
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1114
    Cell Significance Index: -1.4000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1116
    Cell Significance Index: -1.1400
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.1130
    Cell Significance Index: -1.4200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1132
    Cell Significance Index: -1.3600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1135
    Cell Significance Index: -1.2600
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.1140
    Cell Significance Index: -1.4200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1145
    Cell Significance Index: -1.3000
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.1145
    Cell Significance Index: -1.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** NUTM2F is widely expressed in various cell types, including progenitor cells, endothelial cells, plasma cells, goblet cells, and stem cells from different tissues. Its expression is also notable in abnormal cells, which suggests a potential role in cancer development and progression. 2. **Protein Structure:** The NUTM2F protein is a member of the NUT family of proteins, which contain a characteristic N-terminal domain and a C-terminal domain. These domains are essential for protein-protein interactions and regulation of cellular processes. 3. **Function:** NUTM2F is involved in regulating cell growth, apoptosis, and immune responses. It interacts with other proteins to modulate these processes, which are critical for maintaining tissue homeostasis and preventing disease. **Pathways and Functions:** The NUTM2F gene is involved in several signaling pathways, including: 1. **PI3K/AKT pathway:** NUTM2F interacts with PI3K to regulate cell growth and survival. This pathway is critical for maintaining tissue homeostasis and preventing disease. 2. **MAPK/ERK pathway:** NUTM2F is involved in regulating cell proliferation and differentiation through the MAPK/ERK pathway. This pathway is essential for development and tissue repair. 3. **NF-κB pathway:** NUTM2F interacts with NF-κB to regulate immune responses and inflammation. This pathway is critical for maintaining tissue homeostasis and preventing disease. 4. **Apoptosis pathway:** NUTM2F is involved in regulating apoptosis, a critical process for maintaining tissue homeostasis and preventing disease. **Clinical Significance:** The NUTM2F gene has been implicated in various diseases, including: 1. **Cancer:** NUTM2F is overexpressed in several types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with poor prognosis and increased tumor aggressiveness. 2. **Autoimmune disorders:** NUTM2F is involved in regulating immune responses and inflammation. Its dysregulation is associated with autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders:** NUTM2F is expressed in the brain and is involved in regulating neural development and function. Its dysregulation is associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the NUTM2F gene is a complex gene that plays a critical role in regulating cell growth, apoptosis, and immune responses. Its dysregulation is associated with various diseases, including cancer, autoimmune disorders, and neurological disorders. Further research is needed to fully understand the mechanisms by which NUTM2F regulates cellular processes and to develop therapeutic strategies for targeting this gene in disease prevention and treatment.

Genular Protein ID: 1135521662

Symbol: NTM2F_HUMAN

Name: NUT family member 2F

UniProtKB Accession Codes:

A1L443 B6ZDF0 Q5SR58 Q5SR59 Q9UFB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

Sequence Information:

  • Length: 756
  • Mass: 80770
  • Checksum: 51642CA607C736E0
  • Sequence:
    • MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPAPGPAHR PPLVTAVVPP AGPLVLSAFP 
STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL ILTQAPLVWQ APGTLCGGVM 
CPPPLLLAAA PGVPVTSAQV VGGTQACEGG WSHGLPLPPP PPAAQVAPIV SPGNARPWPQ 
GAHGEGSLAP SQAKARPDDS CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV 
LRSLARRKPT MTLEEGLWQA MREWQHTSNF DRMIFYEMAE KFLEFEAEEE MQIQKSQWMK 
GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR PAETKAHLPP 
PRPQRPAETN AHLPPPRPQR PAETKVPEEI PPEVVQEYVD IMEELLGSHP GDTGEPEGQR 
EKGKVEQPQE EDGITSDPGL LSYIDKLCSQ EDFVTKVEAV IHPRFLEELL SPDPQMDFLA 
LSQELEQEEG LTLAQLVEKR LLSLKEKGCG RAAPRHGTAR LDSSPSEFAA GQEAAREVPD 
PQQRVSVETS PPQTAAQDPQ GQGRVRTGMA RSEDPAVLLG CQDSPRLKAV RPTSPPQDHR 
PTCPGLGTKD ALGLPGESPV KESHGLAKGS SEETELPGMV YVVGSHHRLR PWRLSQSPVP 
SSGLLSPGGR GPQGALQSPS AQKRGLSPSP SPASKSKKRP LFGSPSPAEK TPHPGPGLRV 
SGEQSLAWGL GGPSQSQKRK GDPLASRRKK KRHCSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.