Details for: PPP1R3A

Gene ID: 5506

Symbol: PPP1R3A

Ensembl ID: ENSG00000154415

Description: protein phosphatase 1 regulatory subunit 3A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.4995
    Cell Significance Index: 40.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.0751
    Cell Significance Index: 50.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8377
    Cell Significance Index: 141.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1873
    Cell Significance Index: 30.5200
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 0.5354
    Cell Significance Index: 3.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4562
    Cell Significance Index: 11.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3743
    Cell Significance Index: 5.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2626
    Cell Significance Index: 4.5000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2004
    Cell Significance Index: 2.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1917
    Cell Significance Index: 2.8300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1391
    Cell Significance Index: 1.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1388
    Cell Significance Index: 3.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1284
    Cell Significance Index: 3.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1275
    Cell Significance Index: 2.6500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1053
    Cell Significance Index: 1.3600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0840
    Cell Significance Index: 1.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0489
    Cell Significance Index: 1.7200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0368
    Cell Significance Index: 0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0213
    Cell Significance Index: 3.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0188
    Cell Significance Index: 0.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0180
    Cell Significance Index: 0.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0169
    Cell Significance Index: 4.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0142
    Cell Significance Index: 0.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0059
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 3.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0012
    Cell Significance Index: 0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0012
    Cell Significance Index: 0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0004
    Cell Significance Index: -0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0017
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0053
    Cell Significance Index: -1.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0076
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0086
    Cell Significance Index: -1.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0124
    Cell Significance Index: -1.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0136
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0153
    Cell Significance Index: -1.7500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0186
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0191
    Cell Significance Index: -0.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0193
    Cell Significance Index: -2.0100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0199
    Cell Significance Index: -0.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0222
    Cell Significance Index: -0.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0231
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0232
    Cell Significance Index: -1.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0238
    Cell Significance Index: -0.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0244
    Cell Significance Index: -1.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0260
    Cell Significance Index: -1.6000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0273
    Cell Significance Index: -0.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0318
    Cell Significance Index: -0.6200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0320
    Cell Significance Index: -0.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0343
    Cell Significance Index: -0.3600
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0344
    Cell Significance Index: -0.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0347
    Cell Significance Index: -1.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0348
    Cell Significance Index: -0.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0361
    Cell Significance Index: -1.8800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0366
    Cell Significance Index: -0.6300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0372
    Cell Significance Index: -0.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0419
    Cell Significance Index: -0.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0495
    Cell Significance Index: -1.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0532
    Cell Significance Index: -1.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0553
    Cell Significance Index: -1.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0554
    Cell Significance Index: -1.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0584
    Cell Significance Index: -1.5600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0587
    Cell Significance Index: -0.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0593
    Cell Significance Index: -2.9900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0596
    Cell Significance Index: -0.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0597
    Cell Significance Index: -0.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0603
    Cell Significance Index: -1.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0619
    Cell Significance Index: -1.3400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0623
    Cell Significance Index: -0.6500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0629
    Cell Significance Index: -0.7000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0671
    Cell Significance Index: -0.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0680
    Cell Significance Index: -1.7000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0691
    Cell Significance Index: -0.9700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0717
    Cell Significance Index: -0.6800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0720
    Cell Significance Index: -0.6300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0746
    Cell Significance Index: -0.9000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0764
    Cell Significance Index: -1.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0771
    Cell Significance Index: -1.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0771
    Cell Significance Index: -3.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0783
    Cell Significance Index: -2.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0801
    Cell Significance Index: -1.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0836
    Cell Significance Index: -1.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0843
    Cell Significance Index: -1.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0869
    Cell Significance Index: -2.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0870
    Cell Significance Index: -1.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0884
    Cell Significance Index: -1.4800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0889
    Cell Significance Index: -0.9200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0917
    Cell Significance Index: -1.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0927
    Cell Significance Index: -1.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0928
    Cell Significance Index: -1.8400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0945
    Cell Significance Index: -1.8600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0966
    Cell Significance Index: -1.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** PPP1R3A shares a high degree of structural similarity with other PP1 regulatory subunits, suggesting conserved functional mechanisms across species. 2. **Glycogen Binding:** PPP1R3A binds to glycogen, a key energy storage molecule, influencing its metabolism and storage. 3. **Cell Type-Specific Expression:** PPP1R3A is significantly expressed in various cell types, including progenitor cells, amacrine cells, blood vessel endothelial cells, and cardiac myocytes, indicating its diverse roles in different tissues. 4. **PP1 Complex Formation:** PPP1R3A forms a complex with PP1, a serine/threonine phosphatase, to regulate its activity and substrate specificity. **Pathways and Functions:** 1. **Glycogen Metabolic Process:** PPP1R3A regulates glycogen synthesis, breakdown, and storage by modulating the activity of key enzymes involved in these processes. 2. **Glycogen Binding:** The interaction between PPP1R3A and glycogen influences its binding to enzymes, such as glycogen synthase and glycogen phosphorylase, thereby controlling glycogen metabolism. 3. **Membrane Dynamics:** PPP1R3A regulates membrane trafficking and morphology by modulating the activity of proteins involved in these processes. 4. **Protein Phosphatase 1 Binding:** PPP1R3A interacts with PP1, influencing its activity and substrate specificity, thereby regulating various cellular processes. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** Alterations in PPP1R3A expression and function may contribute to the development of diabetes and metabolic disorders, such as insulin resistance and glycogen storage diseases. 2. **Cardiac Function:** PPP1R3A plays a critical role in regulating cardiac function, particularly in the heart's energy metabolism and contractility. 3. **Neurological Disorders:** PPP1R3A may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where glycogen metabolism and protein function are disrupted. 4. **Cancer:** PPP1R3A has been implicated in cancer progression, where its dysregulation can influence cell growth, proliferation, and survival. In conclusion, PPP1R3A is a multifunctional protein that plays a critical role in regulating glycogen metabolism, membrane dynamics, and protein function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying its functions and its potential as a therapeutic target.

Genular Protein ID: 1335706204

Symbol: PPR3A_HUMAN

Name: Protein phosphatase 1 regulatory subunit 3A

UniProtKB Accession Codes:

Q16821 A0AVQ2 A4D0T6 O43476 Q75LN8 Q7KYM8 Q86UI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9726244

Title: A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.

PubMed ID: 9726244

DOI: 10.2337/diabetes.47.9.1519

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7926294

Title: Sequence of the human glycogen-associated regulatory subunit of type I protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with non-insulin-dependent diabetes.

PubMed ID: 7926294

DOI: 10.2337/diabetes.43.10.1234

PubMed ID: 7581368

Title: A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.

PubMed ID: 7581368

DOI: 10.1093/hmg/4.8.1313

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1122
  • Mass: 125767
  • Checksum: FACB2CEA7C00E75B
  • Sequence:
    • MEPSEVPSQI SKDNFLEVPN LSDSLCEDEE VTFQPGFSPQ PSRRGSDSSE DIYLDTPSSG 
TRRVSFADSF GFNLVSVKEF DCWELPSAST TFDLGTDIFH TEEYVLAPLF DLPSSKEDLM 
QQLQIQKAIL ESTESLLGST SIKGIIRVLN VSFEKLVYVR MSLDDWQTHY DILAEYVPNS 
CDGETDQFSF KIVLVPPYQK DGSKVEFCIR YETSVGTFWS NNNGTNYTFI CQKKEQEPEP 
VKPWKEVPNR QIKGCLKVKS SKEESSVTSE ENNFENPKNT DTYIPTIICS HEDKEDLEAS 
NRNVKDVNRE HDEHNEKELE LMINQHLIRT RSTASRDERN TFSTDPVNFP NKAEGLEKKQ 
IHGEICTDLF QRSLSPSSSA ESSVKGDFYC NEKYSSGDDC THQPSEETTS NMGEIKPSLG 
DTSSDELVQL HTGSKEVLDD NANPAHGNGT VQIPCPSSDQ LMAGNLNKKH EGGAKNIEVK 
DLGCLRRDFH SDTSACLKES TEEGSSKEDY YGNGKDDEEQ RIYLGVNEKQ RKNFQTILHD 
QERKMGNPKI SVAGIGASNR DLATLLSEHT AIPTRAITAD VSHSPRTNLS WEEAVLTPEH 
HHLTSEGSAL GGITGQVCSS RTGNVLRNDY LFQVEEKSGG INSEDQDNSP QHKQSWNVLE 
SQGKSRENKT NITEHIKGQT DCEDVWGKRD NTRSLKATTE ELFTCQETVC CELSSLADHG 
ITEKAEAGTA YIIKTTSEST PESMSAREKA IIAKLPQETA RSDRPIEVKE TAFDPHEGRN 
DDSHYTLCQR DTVGVIYDND FEKESRLGIC NVRVDEMEKE ETMSMYNPRK THDREKCGTG 
NITSVEESSW VITEYQKATS KLDLQLGMLP TDKTVFSENR DLRQVQELSK KTDSDAIVHS 
AFNSDTNRAP QNSSPFSKHH TEISVSTNEQ AIAVENAVTT MASQPISTKS ENICNSTREI 
QGIEKHPYPE SKPEEVSRSS GIVTSGSRKE RCIGQIFQTE EYSVEKSLGP MILINKPLEN 
MEEARHENEG LVSSGQSLYT SGEKESDSSA STSLPVEESQ AQGNESLFSK YTNSKIPYFL 
LFLIFLITVY HYDLMIGLTF YVLSLSWLSW EEGRQKESVK KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.