Details for: PRB1

Gene ID: 5542

Symbol: PRB1

Ensembl ID: ENSG00000251655

Description: proline rich protein BstNI subfamily 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 2.4323
    Cell Significance Index: 76.9300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 2.0253
    Cell Significance Index: 42.2400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.9367
    Cell Significance Index: 10.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.8747
    Cell Significance Index: 12.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8273
    Cell Significance Index: 20.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5926
    Cell Significance Index: 26.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5416
    Cell Significance Index: 20.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4648
    Cell Significance Index: 12.4600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3788
    Cell Significance Index: 4.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2921
    Cell Significance Index: 4.9200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2418
    Cell Significance Index: 2.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2360
    Cell Significance Index: 46.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.1302
    Cell Significance Index: 4.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0455
    Cell Significance Index: 2.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0413
    Cell Significance Index: 14.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0405
    Cell Significance Index: 1.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0394
    Cell Significance Index: 53.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0292
    Cell Significance Index: 8.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0289
    Cell Significance Index: 4.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0150
    Cell Significance Index: 23.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0135
    Cell Significance Index: 0.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0119
    Cell Significance Index: 21.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0064
    Cell Significance Index: 12.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0045
    Cell Significance Index: 0.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0040
    Cell Significance Index: -0.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0062
    Cell Significance Index: -1.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0064
    Cell Significance Index: -0.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0082
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0107
    Cell Significance Index: -1.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0176
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0181
    Cell Significance Index: -3.8200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0189
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0218
    Cell Significance Index: -2.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0229
    Cell Significance Index: -2.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0257
    Cell Significance Index: -2.6800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0267
    Cell Significance Index: -0.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0310
    Cell Significance Index: -0.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0368
    Cell Significance Index: -0.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0385
    Cell Significance Index: -1.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0386
    Cell Significance Index: -0.5500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0406
    Cell Significance Index: -0.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0445
    Cell Significance Index: -1.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0449
    Cell Significance Index: -0.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0471
    Cell Significance Index: -1.5000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0493
    Cell Significance Index: -0.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0501
    Cell Significance Index: -1.6400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0527
    Cell Significance Index: -1.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0573
    Cell Significance Index: -1.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0588
    Cell Significance Index: -1.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0597
    Cell Significance Index: -0.6500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0601
    Cell Significance Index: -0.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0614
    Cell Significance Index: -1.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0614
    Cell Significance Index: -0.8800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0660
    Cell Significance Index: -0.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0664
    Cell Significance Index: -4.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0677
    Cell Significance Index: -2.3800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0694
    Cell Significance Index: -1.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0699
    Cell Significance Index: -1.5300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0701
    Cell Significance Index: -1.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0820
    Cell Significance Index: -1.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0847
    Cell Significance Index: -1.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0880
    Cell Significance Index: -1.7400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0897
    Cell Significance Index: -1.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0909
    Cell Significance Index: -2.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0917
    Cell Significance Index: -1.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0931
    Cell Significance Index: -1.6100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0933
    Cell Significance Index: -1.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0948
    Cell Significance Index: -1.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0948
    Cell Significance Index: -2.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0963
    Cell Significance Index: -1.8800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0978
    Cell Significance Index: -1.3200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0981
    Cell Significance Index: -1.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0996
    Cell Significance Index: -1.2400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0998
    Cell Significance Index: -2.0300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1026
    Cell Significance Index: -2.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1056
    Cell Significance Index: -1.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1057
    Cell Significance Index: -2.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1078
    Cell Significance Index: -2.6300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1098
    Cell Significance Index: -1.6000
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.1125
    Cell Significance Index: -0.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1136
    Cell Significance Index: -1.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1175
    Cell Significance Index: -2.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1206
    Cell Significance Index: -4.9400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1275
    Cell Significance Index: -0.8600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1287
    Cell Significance Index: -1.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1292
    Cell Significance Index: -2.8000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1379
    Cell Significance Index: -1.9800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1395
    Cell Significance Index: -1.2600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1396
    Cell Significance Index: -1.6700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1398
    Cell Significance Index: -1.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1417
    Cell Significance Index: -3.6100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1432
    Cell Significance Index: -1.8100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1442
    Cell Significance Index: -1.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Proline-rich protein domain**: PRB1 contains a proline-rich protein domain, which is characterized by a high content of proline and hydroxyproline residues. This domain is essential for forming complex networks with other extracellular matrix proteins. 2. **BstNI subfamily**: PRB1 belongs to the BstNI subfamily of proline-rich proteins, which are known for their ability to interact with other extracellular matrix proteins and influence cellular behavior. 3. **High expression in retinal cells**: PRB1 is highly expressed in retinal ganglion cells, amacrine cells, and other retinal neurons, suggesting a critical role in retinal development and function. 4. **Widespread expression**: PRB1 is expressed in various tissues, including the salivary gland, cerebral cortex, and lens fiber cells, highlighting its importance in multiple cellular contexts. **Pathways and Functions** 1. **Cell adhesion and migration**: PRB1 interacts with other extracellular matrix proteins to regulate cell adhesion and migration, which are essential for tissue development and repair. 2. **Signaling pathways**: PRB1 modulates signaling pathways involved in cellular behavior, including the regulation of cell growth, differentiation, and survival. 3. **Extracellular matrix organization**: PRB1 contributes to the organization and structure of the extracellular matrix, which is critical for maintaining tissue homeostasis. 4. **Neurotransmission and synaptic plasticity**: PRB1 is expressed in neurons and plays a role in neurotransmission and synaptic plasticity, which are essential for learning and memory. **Clinical Significance** 1. **Retinal diseases**: Alterations in PRB1 expression have been linked to various retinal diseases, including retinitis pigmentosa and age-related macular degeneration. 2. **Salivary gland disorders**: PRB1 expression is altered in salivary gland disorders, such as Sjögren's syndrome and salivary gland cancer. 3. **Neurological disorders**: PRB1 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 4. **Cancer**: PRB1 expression is altered in certain types of cancer, including breast and colon cancer, suggesting a potential role in tumorigenesis and metastasis. In conclusion, the PRB1 gene plays a vital role in maintaining tissue homeostasis and modulating cellular behavior. Its diverse expression pattern and functional significance underscore its importance in various diseases and disorders. Further research is necessary to fully elucidate the mechanisms by which PRB1 influences cellular behavior and to explore its potential as a therapeutic target for diseases affecting the retina, salivary gland, and nervous system.

Genular Protein ID: 1374487037

Symbol: PRP1_HUMAN

Name: Basic salivary proline-rich protein 1

UniProtKB Accession Codes:

P04280 G5E9X6 Q08805 Q15186 Q15187 Q15214 Q15215 Q16038

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 15 GO 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PIR 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMART 1 STRING 1 TopDownProteomics 1 UCSC 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2993301

Title: Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.

PubMed ID: 2993301

DOI: 10.1016/s0021-9258(17)39156-1

PubMed ID: 8422499

Title: The structure and evolution of the human salivary proline-rich protein gene family.

PubMed ID: 8422499

DOI: 10.1007/bf00364656

PubMed ID: 1849422

Title: Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual.

PubMed ID: 1849422

DOI: 10.1021/bi00228a001

PubMed ID: 6089212

Title: Clones from the human gene complex coding for salivary proline-rich proteins.

PubMed ID: 6089212

DOI: 10.1073/pnas.81.17.5561

PubMed ID: 2851479

Title: Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.

PubMed ID: 2851479

DOI: 10.1093/genetics/120.1.267

PubMed ID: 8317492

Title: PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs).

PubMed ID: 8317492

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 3521730

Title: Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6.

PubMed ID: 3521730

DOI: 10.1021/bi00357a013

PubMed ID: 6671974

Title: Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H.

PubMed ID: 6671974

DOI: 10.1093/oxfordjournals.jbchem.a134553

PubMed ID: 18463091

Title: Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.

PubMed ID: 18463091

DOI: 10.1074/jbc.m708282200

PubMed ID: 20879038

Title: Finding new posttranslational modifications in salivary proline-rich proteins.

PubMed ID: 20879038

DOI: 10.1002/pmic.201000261

Sequence Information:

  • Length: 392
  • Mass: 38562
  • Checksum: 31F4D7B21F335CAF
  • Sequence:
    • MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGPS PQGGNKPQGP PPPPGKPQGP 
PPQGGNKPQG PPPPGKPQGP PPQGDKSRSP RSPPGKPQGP PPQGGNQPQG PPPPPGKPQG 
PPPQGGNKPQ GPPPPGKPQG PPPQGDKSQS PRSPPGKPQG PPPQGGNQPQ GPPPPPGKPQ 
GPPPQGGNKP QGPPPPGKPQ GPPPQGDKSQ SPRSPPGKPQ GPPPQGGNQP QGPPPPPGKP 
QGPPQQGGNR PQGPPPPGKP QGPPPQGDKS RSPQSPPGKP QGPPPQGGNQ PQGPPPPPGK 
PQGPPPQGGN KPQGPPPPGK PQGPPAQGGS KSQSARSPPG KPQGPPQQEG NNPQGPPPPA 
GGNPQQPQAP PAGQPQGPPR PPQGGRPSRP PQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.