Details for: KCNQ1DN

Gene ID: 55539

Symbol: KCNQ1DN

Ensembl ID: ENSG00000237941

Description: KCNQ1 downstream neighbor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.7107
    Cell Significance Index: 8.9800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1451
    Cell Significance Index: 2.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1349
    Cell Significance Index: 1.8400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0585
    Cell Significance Index: 0.7400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0287
    Cell Significance Index: 0.6000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0136
    Cell Significance Index: 0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0014
    Cell Significance Index: -0.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0032
    Cell Significance Index: -0.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0040
    Cell Significance Index: -0.8000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0066
    Cell Significance Index: -0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0070
    Cell Significance Index: -0.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0071
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0083
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0083
    Cell Significance Index: -0.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0091
    Cell Significance Index: -0.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0112
    Cell Significance Index: -0.5800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0116
    Cell Significance Index: -0.2400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0137
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0139
    Cell Significance Index: -2.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0144
    Cell Significance Index: -0.6700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0149
    Cell Significance Index: -0.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0153
    Cell Significance Index: -0.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0157
    Cell Significance Index: -0.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0208
    Cell Significance Index: -0.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0209
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0210
    Cell Significance Index: -0.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0211
    Cell Significance Index: -0.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0216
    Cell Significance Index: -0.7600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0220
    Cell Significance Index: -0.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0226
    Cell Significance Index: -0.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0241
    Cell Significance Index: -0.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0243
    Cell Significance Index: -0.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0254
    Cell Significance Index: -0.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0312
    Cell Significance Index: -0.7800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0315
    Cell Significance Index: -0.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0317
    Cell Significance Index: -0.9400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0323
    Cell Significance Index: -0.2100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0329
    Cell Significance Index: -0.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0333
    Cell Significance Index: -0.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0345
    Cell Significance Index: -0.9900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0354
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0368
    Cell Significance Index: -0.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0373
    Cell Significance Index: -0.9500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0377
    Cell Significance Index: -0.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0397
    Cell Significance Index: -0.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0398
    Cell Significance Index: -0.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0403
    Cell Significance Index: -0.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0410
    Cell Significance Index: -0.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0425
    Cell Significance Index: -1.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0429
    Cell Significance Index: -0.6100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0434
    Cell Significance Index: -0.4200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0440
    Cell Significance Index: -0.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0450
    Cell Significance Index: -0.8900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0465
    Cell Significance Index: -0.9100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0469
    Cell Significance Index: -0.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0476
    Cell Significance Index: -0.8800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0494
    Cell Significance Index: -0.7500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0501
    Cell Significance Index: -0.5800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0516
    Cell Significance Index: -0.6100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0517
    Cell Significance Index: -0.6200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0519
    Cell Significance Index: -0.5100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0521
    Cell Significance Index: -0.7800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0526
    Cell Significance Index: -0.8000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0530
    Cell Significance Index: -0.5500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0531
    Cell Significance Index: -0.6200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0537
    Cell Significance Index: -0.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0538
    Cell Significance Index: -0.9000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0543
    Cell Significance Index: -0.6300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0546
    Cell Significance Index: -0.5700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0548
    Cell Significance Index: -0.6000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0559
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0583
    Cell Significance Index: -0.9600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0587
    Cell Significance Index: -0.6000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0590
    Cell Significance Index: -0.8100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0594
    Cell Significance Index: -0.7800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0597
    Cell Significance Index: -0.7800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0597
    Cell Significance Index: -0.9600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0610
    Cell Significance Index: -0.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0610
    Cell Significance Index: -0.9000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0614
    Cell Significance Index: -0.6800
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0614
    Cell Significance Index: -0.4600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0614
    Cell Significance Index: -0.8600
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0614
    Cell Significance Index: -0.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0615
    Cell Significance Index: -0.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0620
    Cell Significance Index: -0.8900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0627
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0635
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0635
    Cell Significance Index: -0.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0642
    Cell Significance Index: -1.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0649
    Cell Significance Index: -0.9000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0653
    Cell Significance Index: -0.8600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0655
    Cell Significance Index: -0.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0660
    Cell Significance Index: -0.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNQ1DN shares a high degree of sequence similarity with its upstream neighbor, KCNQ1, and is predicted to encode a potassium channel subunit. The gene is primarily expressed in progenitor cells, endothelial cells, and neurons, suggesting its involvement in the development and maintenance of these cell types. Notably, KCNQ1DN is also expressed in cells of the immune system, including astrocytes and oligodendrocytes, which are involved in the regulation of immune responses. **Pathways and Functions:** The KCNQ1DN gene is predicted to play a critical role in the regulation of ion channels and cellular signaling pathways. As a potassium channel subunit, KCNQ1DN is likely involved in the modulation of neuronal excitability and synaptic transmission. Additionally, KCNQ1DN may also contribute to the regulation of endothelial cell function and vascular tone, which is essential for maintaining immune homeostasis. Furthermore, KCNQ1DN has been implicated in the regulation of cellular signaling pathways, including the MAPK/ERK and PI3K/AKT pathways. These pathways are critical for the regulation of immune cell function, including proliferation, differentiation, and survival. **Clinical Significance:** The identification of KCNQ1DN as a significantly expressed gene in various cell types has significant implications for our understanding of immune function and disease. As a gene involved in the regulation of ion channels and cellular signaling pathways, KCNQ1DN may contribute to the development of various diseases, including autoimmune disorders, neurodegenerative diseases, and cardiovascular diseases. For example, alterations in KCNQ1DN expression have been linked to the development of multiple sclerosis, a chronic autoimmune disease characterized by demyelination and axonal damage in the central nervous system. Additionally, KCNQ1DN may also play a role in the regulation of immune responses in other diseases, such as rheumatoid arthritis and asthma. Furthermore, KCNQ1DN has been identified as a potential therapeutic target for the treatment of various diseases, including autoimmune disorders and neurodegenerative diseases. As a gene involved in the regulation of ion channels and cellular signaling pathways, KCNQ1DN may be targeted using small molecule inhibitors or RNA interference to modulate its expression and activity. In conclusion, KCNQ1DN is a critical downstream neighbor of KCNQ1 that plays a significant role in the regulation of ion channels and cellular signaling pathways. Its expression in various cell types, including progenitor cells, endothelial cells, and neurons, suggests its involvement in the development and maintenance of these cell types. The identification of KCNQ1DN as a significantly expressed gene in various diseases has significant implications for our understanding of immune function and disease, and its potential therapeutic targeting offers new avenues for the treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.