RPS5 | ENSG00000083845 | NCBI 6193

Details for: RPS5

Gene ID: 6193

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPS5

Ensembl ID: ENSG00000083845

Description: ribosomal protein S5

Cell Significance Landscape

Display Count:

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Mrna binding
(GO:0003729)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Regulation of translational fidelity
(GO:0006450)
Ribonucleoprotein complex
(GO:1990904)
Ribosomal small subunit assembly
(GO:0000028)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Small-subunit processome
(GO:0032040)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)
Translational initiation
(GO:0006413)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 154.77

rCSI 91.4%

PRS 2.85
hematopoietic stem cell CL0000037

CSI 142.84

rCSI 94.94%

PRS 2.42
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 131.28

rCSI 88.45%

PRS 2.46
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 129.81

rCSI 91.17%

PRS 6.22
plasmacytoid dendritic cell, human CL0001058

CSI 129.38

rCSI 90.33%

PRS 2.14
naive T cell CL0000898

CSI 127.77

rCSI 88.92%

PRS 2.97
class switched memory B cell CL0000972

CSI 124.71

rCSI 93.1%

PRS 3.45
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 123.79

rCSI 92.83%

PRS 6.15
CD4-positive, alpha-beta memory T cell CL0000897

CSI 123.52

rCSI 88.67%

PRS 2.78
double negative thymocyte CL0002489

CSI 120.35

rCSI 83.67%

PRS 2.38
epithelial cell of lower respiratory tract CL0002632

CSI 119.89

rCSI 92.94%

PRS 1.95
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 116.9

rCSI 77.91%

PRS 5.78
group 3 innate lymphoid cell CL0001071

CSI 116.49

rCSI 87.52%

PRS 2.09
T follicular helper cell CL0002038

CSI 116.24

rCSI 86.99%

PRS 3.34
common myeloid progenitor CL0000049

CSI 115.82

rCSI 93.65%

PRS 2
epithelial cell of lung CL0000082

CSI 114.65

rCSI 95.04%

PRS 1.91
keratinocyte CL0000312

CSI 113.58

rCSI 95.21%

PRS 2.45
immature B cell CL0000816

CSI 113.48

rCSI 84.31%

PRS 3.04
CD4-positive, alpha-beta thymocyte CL0000810

CSI 112.81

rCSI 90.36%

PRS 3.82
CD4-positive helper T cell CL0000492

CSI 111.51

rCSI 84.35%

PRS 2.86
granulocyte monocyte progenitor cell CL0000557

CSI 111.05

rCSI 96.16%

PRS 2.28
mature B cell CL0000785

CSI 110.07

rCSI 95.68%

PRS 2.5
early lymphoid progenitor CL0000936

CSI 108.8

rCSI 95.55%

PRS 2.27
neural crest cell CL0011012

CSI 107.96

rCSI 85.34%

PRS 1.41
plasmablast CL0000980

CSI 107.95

rCSI 84.92%

PRS 2.42
bronchus fibroblast of lung CL2000093

CSI 107.31

rCSI 87.19%

PRS 2.14
pro-B cell CL0000826

CSI 107.24

rCSI 88.81%

PRS 2.04
unswitched memory B cell CL0000970

CSI 106.42

rCSI 89.53%

PRS 3.43
naive B cell CL0000788

CSI 104.31

rCSI 89.47%

PRS 6.63
megakaryocyte-erythroid progenitor cell CL0000050

CSI 104.12

rCSI 94.03%

PRS 1.79
mucosal invariant T cell CL0000940

CSI 103.83

rCSI 83.89%

PRS 5.35
T-helper 17 cell CL0000899

CSI 103.36

rCSI 82.07%

PRS 3.63
precursor B cell CL0000817

CSI 101.5

rCSI 88.91%

PRS 2.75
skin fibroblast CL0002620

CSI 101.46

rCSI 87.46%

PRS 3.41
memory B cell CL0000787

CSI 95.72

rCSI 94.52%

PRS 9.04
CD14-low, CD16-positive monocyte CL0002396

CSI 94.55

rCSI 72.84%

PRS 1.83
fibroblast of lung CL0002553

CSI 93.59

rCSI 87.1%

PRS 2.03
activated CD4-positive, alpha-beta T cell CL0000896

CSI 93.33

rCSI 86.28%

PRS 3.74
intestine goblet cell CL0019031

CSI 93.07

rCSI 82.61%

PRS 2.04
intestinal epithelial cell CL0002563

CSI 92.12

rCSI 96.28%

PRS 2.19
effector CD8-positive, alpha-beta T cell CL0001050

CSI 92.09

rCSI 70.05%

PRS 2.7
respiratory basal cell CL0002633

CSI 91.5

rCSI 94.78%

PRS 2.38
goblet cell CL0000160

CSI 90.52

rCSI 85.54%

PRS 2.13
double-positive, alpha-beta thymocyte CL0000809

CSI 90.38

rCSI 92.11%

PRS 2.96
fallopian tube secretory epithelial cell CL4030006

CSI 90.27

rCSI 86.9%

PRS 2.12
mature T cell CL0002419

CSI 87.94

rCSI 68.4%

PRS 2.93
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 84.68

rCSI 77.13%

PRS 3.19
IgA plasma cell CL0000987

CSI 83.6

rCSI 85.58%

PRS 3.86
fraction A pre-pro B cell CL0002045

CSI 80.66

rCSI 92.34%

PRS 4.25
CD8-positive, alpha-beta memory T cell CL0000909

CSI 79.67

rCSI 83.21%

PRS 6.58
hematopoietic precursor cell CL0008001

CSI 79.42

rCSI 81.71%

PRS 3.32
transit amplifying cell of colon CL0009011

CSI 78.16

rCSI 91.79%

PRS 2.49
pancreatic A cell CL0000171

CSI 77.95

rCSI 81.66%

PRS 2.2
secretory cell CL0000151

CSI 77.4

rCSI 80.76%

PRS 2.08
elicited macrophage CL0000861

CSI 77.26

rCSI 70.94%

PRS 2.33
small pre-B-II cell CL0000954

CSI 76.95

rCSI 74%

PRS 4.46
common dendritic progenitor CL0001029

CSI 76.74

rCSI 96.31%

PRS 2.58
ciliated epithelial cell CL0000067

CSI 76.69

rCSI 67.44%

PRS 1.48
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 75.04

rCSI 73.69%

PRS 3.26
pancreatic acinar cell CL0002064

CSI 75.03

rCSI 99.73%

PRS 2.24
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 74.33

rCSI 93.41%

PRS 11.24
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 72.98

rCSI 84.28%

PRS 1.91
gamma-delta T cell CL0000798

CSI 72.97

rCSI 85.71%

PRS 20.74
respiratory suprabasal cell CL4033048

CSI 72.94

rCSI 93.55%

PRS 2.35
alveolar type 1 fibroblast cell CL4028004

CSI 72.78

rCSI 79.71%

PRS 2.4
pulmonary ionocyte CL0017000

CSI 70.55

rCSI 85.88%

PRS 2.58
extravillous trophoblast CL0008036

CSI 70.29

rCSI 86.95%

PRS 1.8
CD1c-positive myeloid dendritic cell CL0002399

CSI 69.79

rCSI 84.29%

PRS 2.36
B cell CL0000236

CSI 69.14

rCSI 92.5%

PRS 12.64
multi-ciliated epithelial cell CL0005012

CSI 68.87

rCSI 68.73%

PRS 1.72
pancreatic D cell CL0000173

CSI 68.66

rCSI 67.53%

PRS 2.25
mesodermal cell CL0000222

CSI 67.35

rCSI 80.84%

PRS 2.04
conventional dendritic cell CL0000990

CSI 67.22

rCSI 56.12%

PRS 6.81
peripheral nervous system neuron CL2000032

CSI 67.02

rCSI 91.32%

PRS 1.87
common lymphoid progenitor CL0000051

CSI 66.71

rCSI 89.14%

PRS 3.9
renal alpha-intercalated cell CL0005011

CSI 66.58

rCSI 89.02%

PRS 2.78
activated CD8-positive, alpha-beta T cell CL0000906

CSI 66.32

rCSI 65.19%

PRS 6.1
nasal mucosa goblet cell CL0002480

CSI 66.02

rCSI 76.57%

PRS 3.05
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 65.99

rCSI 89.9%

PRS 5.12
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 64.38

rCSI 88.45%

PRS 4.38
CD4-positive, alpha-beta T cell CL0000624

CSI 64.19

rCSI 82.14%

PRS 45.02
promyelocyte CL0000836

CSI 64.08

rCSI 92.42%

PRS 2.83
enteroendocrine cell CL0000164

CSI 63.32

rCSI 86.51%

PRS 2.25
mucous neck cell CL0000651

CSI 63.31

rCSI 91.25%

PRS 3.32
enteric smooth muscle cell CL0002504

CSI 63.12

rCSI 90.07%

PRS 2.33
mature NK T cell CL0000814

CSI 62.9

rCSI 80.46%

PRS 9.49
plasma cell CL0000786

CSI 62.46

rCSI 81.86%

PRS 11.15
club cell CL0000158

CSI 61.98

rCSI 90.79%

PRS 2.41
acinar cell CL0000622

CSI 61.62

rCSI 90.36%

PRS 2.7
activated type II NK T cell CL0000931

CSI 61.45

rCSI 69.16%

PRS 3.43
colon epithelial cell CL0011108

CSI 61.43

rCSI 64.35%

PRS 1.9
lung ciliated cell CL1000271

CSI 61.35

rCSI 70.94%

PRS 1.48
neuroblast (sensu Vertebrata) CL0000031

CSI 60.44

rCSI 77.56%

PRS 2.05
perivascular cell CL4033054

CSI 60.43

rCSI 82.62%

PRS 2.34
transit amplifying cell CL0009010

CSI 60.03

rCSI 91.82%

PRS 3.34
M cell of gut CL0000682

CSI 59.15

rCSI 62.85%

PRS 3.69
melanocyte CL0000148

CSI 58.65

rCSI 43.44%

PRS 1.94
interstitial cell of Cajal CL0002088

CSI 58.4

rCSI 74.33%

PRS 2.39
myofibroblast cell CL0000186

CSI 58.32

rCSI 80.77%

PRS 2.94
dendritic cell CL0000451

CSI 58.22

rCSI 71.73%

PRS 6.82

kidney interstitial alternatively activated macrophage CL1000695

CSI -31.2

rCSI -81.4%

PRS 2.6%
inhibitory interneuron CL0000498

CSI -29.1

rCSI -67.1%

PRS 2.1%
VIP GABAergic cortical interneuron CL4023016

CSI -27.8

rCSI -33.2%

PRS 1.4%
vascular leptomeningeal cell CL4023051

CSI -25.7

rCSI -45.0%

PRS 1.6%
professional antigen presenting cell CL0000145

CSI -24.3

rCSI -83.6%

PRS 9.5%
endocrine cell CL0000163

CSI -19.6

rCSI -100.0%

PRS 9.9%
GABAergic neuron CL0000617

CSI -19.6

rCSI -65.7%

PRS 2.2%
kidney interstitial fibroblast CL1000692

CSI -19.5

rCSI -100.0%

PRS 14.9%
astrocyte of the cerebral cortex CL0002605

CSI -19.1

rCSI -42.7%

PRS 1.4%
sncg GABAergic cortical interneuron CL4023015

CSI -17.1

rCSI -27.5%

PRS 1.6%
pvalb GABAergic cortical interneuron CL4023018

CSI -15.4

rCSI -19.2%

PRS 1.2%
pulmonary capillary endothelial cell CL4028001

CSI -14.4

rCSI -27.5%

PRS 3.3%
lamp5 GABAergic cortical interneuron CL4023011

CSI -13.3

rCSI -22.4%

PRS 1.3%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -12.7

rCSI -23.1%

PRS 2.3%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -12.4

rCSI -30.2%

PRS 1.3%
cerebral cortex neuron CL0010012

CSI -12.2

rCSI -49.8%

PRS 2.9%
adipocyte CL0000136

CSI -12.0

rCSI -15.4%

PRS 2.7%
kidney collecting duct principal cell CL1001431

CSI -10.8

rCSI -54.4%

PRS 14.4%
OFFx cell CL4033036

CSI -9.9

rCSI -46.4%

PRS 5.8%
renal interstitial pericyte CL1001318

CSI -9.6

rCSI -26.3%

PRS 2.3%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -8.5

rCSI -49.9%

PRS 1.6%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -8.2

rCSI -25.7%

PRS 1.6%
diffuse bipolar 3b cell CL4033030

CSI -8.0

rCSI -53.4%

PRS 5.4%
diffuse bipolar 6 cell CL4033032

CSI -8.0

rCSI -41.8%

PRS 6.2%
neural cell CL0002319

CSI -7.9

rCSI -29.7%

PRS 4.8%
retinal bipolar neuron CL0000748

CSI -7.8

rCSI -14.6%

PRS 1.7%
near-projecting glutamatergic cortical neuron CL4023012

CSI -7.7

rCSI -29.0%

PRS 1.4%
glutamatergic neuron CL0000679

CSI -7.4

rCSI -15.3%

PRS 2.5%
exhausted T cell CL0011025

CSI -7.3

rCSI -100.0%

PRS 11.6%
cardiac endothelial cell CL0010008

CSI -7.3

rCSI -29.4%

PRS 2.4%
glycinergic amacrine cell CL4030028

CSI -6.4

rCSI -16.7%

PRS 3.3%
diffuse bipolar 2 cell CL4033028

CSI -6.1

rCSI -47.4%

PRS 5.7%
rod bipolar cell CL0000751

CSI -5.4

rCSI -9.8%

PRS 1.8%
kidney collecting duct intercalated cell CL1001432

CSI -5.0

rCSI -35.6%

PRS 9.5%
erythroid lineage cell CL0000764

CSI -4.9

rCSI -31.5%

PRS 5.9%
diffuse bipolar 3a cell CL4033029

CSI -4.6

rCSI -31.4%

PRS 5.0%
cell of skeletal muscle CL0000188

CSI -4.6

rCSI -49.5%

PRS 15.0%
cord blood hematopoietic stem cell CL2000095

CSI -4.6

rCSI -87.3%

PRS 18.1%
primordial germ cell CL0000670

CSI -4.1

rCSI -20.6%

PRS 16.7%
periportal region hepatocyte CL0019026

CSI -3.4

rCSI -13.3%

PRS 3.6%
cerebral cortex endothelial cell CL1001602

CSI -2.8

rCSI -4.9%

PRS 1.6%
ON midget ganglion cell CL4033046

CSI -2.4

rCSI -48.7%

PRS 2.6%
renal intercalated cell CL0005010

CSI -2.2

rCSI -19.3%

PRS 20.3%
OFF midget ganglion cell CL4033047

CSI -1.9

rCSI -38.0%

PRS 2.8%
kidney resident macrophage CL1000698

CSI -1.5

rCSI -29.5%

PRS 51.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI -1.2

rCSI -2.2%

PRS 1.3%
sst GABAergic cortical interneuron CL4023017

CSI -1.2

rCSI -1.5%

PRS 1.4%
epicardial adipocyte CL1000309

CSI -1.2

rCSI -3.8%

PRS 3.6%
H2 horizontal cell CL0004218

CSI -1.2

rCSI -5.7%

PRS 4.1%
H1 horizontal cell CL0004217

CSI -0.8

rCSI -3.0%

PRS 5.8%
endocardial cell CL0002350

CSI -0.4

rCSI -1.7%

PRS 3.7%
squamous epithelial cell CL0000076

CSI -0.3

rCSI -0.7%

PRS 2.8%
platelet CL0000233

CSI -0.3

rCSI -1.3%

PRS 6.4%
GABAergic amacrine cell CL4030027

CSI -0.2

rCSI -0.6%

PRS 3.0%
L6b glutamatergic cortical neuron CL4023038

CSI -0.1

rCSI -0.3%

PRS 1.4%
amacrine cell CL0000561

CSI 1.5

rCSI 4.3%

PRS 1.9%
group 3 innate lymphoid cell, human CL0001078

CSI 1.6

rCSI 34.1%

PRS 41.3%
cerebellar granule cell CL0001031

CSI 1.8

rCSI 2.6%

PRS 2.3%
endothelial cell of arteriole CL1000412

CSI 2.0

rCSI 11.1%

PRS 11.0%
kidney loop of Henle epithelial cell CL1000909

CSI 2.2

rCSI 46.0%

PRS 19.0%
Purkinje cell CL0000121

CSI 2.4

rCSI 31.2%

PRS 21.4%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 2.5

rCSI 78.2%

PRS 28.7%
forebrain neuroblast CL1000042

CSI 2.7

rCSI 28.7%

PRS 31.5%
cone retinal bipolar cell CL0000752

CSI 2.8

rCSI 36.7%

PRS 14.5%
lung microvascular endothelial cell CL2000016

CSI 2.8

rCSI 54.9%

PRS 7.6%
slow muscle cell CL0000189

CSI 3.1

rCSI 40.7%

PRS 28.5%
odontoblast CL0000060

CSI 3.1

rCSI 70.1%

PRS 12.4%
uterine smooth muscle cell CL0002601

CSI 3.2

rCSI 21.0%

PRS 16.1%
pluripotent stem cell CL0002248

CSI 3.2

rCSI 95.8%

PRS 5.3%
airway submucosal gland duct basal cell CL4033024

CSI 3.3

rCSI 21.1%

PRS 10.5%
eye photoreceptor cell CL0000287

CSI 3.5

rCSI 39.7%

PRS 8.6%
retinal ganglion cell CL0000740

CSI 3.6

rCSI 7.8%

PRS 1.6%
osteoblast CL0000062

CSI 3.6

rCSI 88.4%

PRS 20.4%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 3.6

rCSI 38.0%

PRS 3.6%
mesenchymal lymphangioblast CL0005021

CSI 3.6

rCSI 94.5%

PRS 12.0%
Merkel cell CL0000242

CSI 3.7

rCSI 85.6%

PRS 15.4%
B-1 B cell CL0000819

CSI 3.7

rCSI 96.5%

PRS 12.7%
epithelial cell of urethra CL1000296

CSI 3.7

rCSI 94.3%

PRS 7.2%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 3.8

rCSI 32.8%

PRS 5.8%
cardiac muscle cell CL0000746

CSI 3.8

rCSI 5.5%

PRS 1.8%
kidney interstitial cell CL1000500

CSI 3.8

rCSI 62.4%

PRS 23.6%
prostate gland microvascular endothelial cell CL2000059

CSI 4.0

rCSI 94.5%

PRS 7.8%
microglial cell CL0000129

CSI 4.0

rCSI 16.2%

PRS 10.3%
follicular dendritic cell CL0000442

CSI 4.3

rCSI 68.3%

PRS 13.8%
Bergmann glial cell CL0000644

CSI 4.4

rCSI 6.1%

PRS 2.3%
B-2 B cell CL0000822

CSI 4.6

rCSI 96.7%

PRS 13.6%
epithelial cell of proximal tubule segment 3 CL4030011

CSI 4.7

rCSI 37.3%

PRS 29.4%
pre-conventional dendritic cell CL0002010

CSI 4.8

rCSI 63.4%

PRS 7.1%
enterocyte of epithelium of small intestine CL1000334

CSI 4.8

rCSI 74.9%

PRS 5.6%
endothelial cell of uterus CL0009095

CSI 4.9

rCSI 35.5%

PRS 5.9%
enterocyte of epithelium of large intestine CL0002071

CSI 5.1

rCSI 26.7%

PRS 4.3%
enteric neuron CL0007011

CSI 5.1

rCSI 75.5%

PRS 6.5%
immature alpha-beta T cell CL0000790

CSI 5.4

rCSI 76.7%

PRS 34.0%
collagen secreting cell CL0000667

CSI 5.5

rCSI 31.4%

PRS 12.2%
hair follicular keratinocyte CL2000092

CSI 5.5

rCSI 96.3%

PRS 8.5%
bronchiolar smooth muscle cell CL4033017

CSI 5.7

rCSI 84.9%

PRS 7.0%
neutrophil CL0000775

CSI 6.0

rCSI 33.5%

PRS 8.3%
parietal epithelial cell CL1000452

CSI 6.1

rCSI 16.4%

PRS 2.1%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 6.2

rCSI 8.7%

PRS 2.0%
Schwann cell CL0002573

CSI 6.5

rCSI 18.4%

PRS 2.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPS5](/details-gene/6193) is a protein-coding gene located on chromosome 19q13.43 that encodes ribosomal protein S5. As an integral component of the 40S small ribosomal subunit, [RPS5](/details-gene/6193) plays a fundamental role in the structural integrity and function of the ribosome. Its primary functions, as defined by Gene Ontology, include being a '[structural constituent of ribosome](/details-ontology/GO:0003735)' and participating in essential processes such as '[cytoplasmic translation](/details-ontology/GO:0002181)', '[ribosomal small subunit biogenesis](/details-ontology/GO:0042274)', and the '[regulation of translational fidelity](/details-ontology/GO:0006450)'. Expression data indicates that [RPS5](/details-gene/6193) is a highly significant gene in metabolically active and proliferative cells, particularly within the hematopoietic system, showing high significance in cell types like the [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904) and [hematopoietic stem cell](/details-cell/CL0000037). This expression pattern underscores its housekeeping yet vital role in supporting the high protein synthesis demands of these cell populations. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [RPS5](/details-gene/6193) highlights its critical importance in cells characterized by high rates of proliferation, differentiation, and protein turnover. The gene shows its highest significance across a broad spectrum of immune cells, including both the adaptive and innate lineages. Key cell types include [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), [naive T cell](/details-cell/CL0000898), [class switched memory B cell](/details-cell/CL0000972), and [plasmacytoid dendritic cell, human](/details-cell/CL0001058). Furthermore, its high significance in progenitor populations such as [hematopoietic stem cell](/details-cell/CL0000037) and [common myeloid progenitor](/details-cell/CL0000049) is consistent with the extensive protein synthesis required to build new cells and differentiate into various lineages. The presence of [epithelial cell of lower respiratory tract](/details-cell/CL0002632) among the top expressed cells may reflect the high protein synthesis demands associated with cellular turnover and mucosal defense. In contrast, [RPS5](/details-gene/6193) shows markedly lower significance in terminally differentiated and post-mitotic cell types. The list of bottom-expressed cells is dominated by various neuronal subtypes, including [inhibitory interneuron](/details-cell/CL0000498) and [GABAergic neuron](/details-cell/CL0000617), as well as stromal cells like [kidney interstitial fibroblast](/details-cell/CL1000692) and [vascular leptomeningeal cell](/details-cell/CL4023051). This pattern strongly suggests that while [RPS5](/details-gene/6193) is a ubiquitous housekeeping gene, its expression level and significance are tightly correlated with the metabolic state and proliferative capacity of a cell, rather than specialized functions in quiescent tissues like the nervous system. ## Pathways and Molecular Function The molecular functions of [RPS5](/details-gene/6193) are intrinsically linked to its role as a core component of the translational machinery. It is a key player in the Reactome pathway for '[Translation](/details-pathway/R-HSA-72766)', participating in all major phases including '[Eukaryotic translation initiation](/details-pathway/R-HSA-72613)', '[Eukaryotic translation elongation](/details-pathway/R-HSA-156842)', and '[Eukaryotic translation termination](/details-pathway/R-HSA-72764)'. Its involvement in '[Metabolism of proteins](/details-pathway/R-HSA-392499)' and '[Rrna processing](/details-pathway/R-HSA-72312)' further solidifies its central role in proteostasis. This is consistent with its high expression in immune and stem cells, which require robust protein synthesis to execute their functions. Beyond its basal functions, pathway analysis implicates [RPS5](/details-gene/6193) in cellular responses to environmental cues. Its participation in pathways such as '[Cellular responses to stress](/details-pathway/R-HSA-2262752)' and '[Response of eif2ak4 (gcn2) to amino acid deficiency](/details-pathway/R-HSA-9633012)' suggests the ribosome acts as a sensor for cellular health and nutrient availability. Notably, [RPS5](/details-gene/6193) is annotated in numerous pathways related to viral pathogenesis, including '[Influenza infection](/details-pathway/R-HSA-168255)' and '[Sars-cov-2 infection](/details-pathway/R-HSA-9694516)'. This reflects the common strategy of viruses to hijack the host's ribosomal machinery, including components like [RPS5](/details-gene/6193), to prioritize the translation of viral proteins and facilitate replication. ## Research Directions The ubiquitous and essential nature of [RPS5](/details-gene/6193) makes it a central node in cellular physiology and pathophysiology. Based on its functional annotations and expression patterns, several testable hypotheses can be proposed: 1. **Role in Viral Tropism and Replication:** Given its annotation in multiple viral infection pathways, it is hypothesized that post-translational modifications of [RPS5](/details-gene/6193) induced by viral proteins serve as a regulatory switch to favor the translation of viral mRNA over host mRNA. The efficiency of this hijacking mechanism may contribute to viral tropism and replication rates in different cell types. 2. **Implication in Ribosomopathies and Cancer:** Dysregulation of ribosomal protein expression can lead to diseases known as ribosomopathies and is frequently observed in cancer. It is hypothesized that haploinsufficiency of [RPS5](/details-gene/6193) could selectively impair the development of [hematopoietic stem cell](/details-cell/CL0000037), leading to bone marrow failure phenotypes, while its overexpression in malignant cells may enhance the translation of specific oncoproteins, thereby promoting tumor growth. To test the first hypothesis regarding the role of [RPS5](/details-gene/6193) in viral infection, a key experiment would be to investigate its molecular state during infection. One could infect a permissive cell line, such as human lung epithelial cells, with SARS-CoV-2 and use advanced proteomic techniques like mass spectrometry to map post-translational modifications (PTMs) on [RPS5](/details-gene/6193) in infected versus mock-infected cells. Subsequently, CRISPR-Cas9 could be used to generate cell lines with mutations at the identified PTM sites. A comparison of viral replication kinetics and an analysis of translated mRNAs via polysome profiling or Ribo-seq in these mutant cell lines would reveal whether specific modifications to [RPS5](/details-gene/6193) are critical for the virus to co-opt the host's translational machinery. From a therapeutic standpoint, [RPS5](/details-gene/6193) itself is a poor direct drug target. As an essential internal component of the ribosome, its inhibition would likely cause unacceptable, widespread toxicity. However, its specific interactions, particularly in a disease context, may offer therapeutic avenues. For instance, if a specific viral protein is found to bind [RPS5](/details-gene/6193) to facilitate viral translation, small molecules designed to disrupt this specific protein-protein interaction could serve as potent and highly specific antiviral agents without affecting the ribosome's general function. Similarly, in cancers where [RPS5](/details-gene/6193) is overexpressed, therapeutic strategies may focus on indirectly modulating its expression or targeting downstream pathways that are selectively enhanced by its abundance.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S5

Genular Protein ID: 4291020941

Symbol: RS5_HUMAN

Name: 40S ribosomal protein S5

UniProtKB Accession Codes:

P46782 B2R4T2 Q96BN0

Database IDs:

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 204
Mass: 22876
Checksum: DFE2FD5AAFCFD894
Sequence:

MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP HSAGRYAAKR 
FRKAQCPIVE RLTNSMMMHG RNNGKKLMTV RIVKHAFEII HLLTGENPLQ VLVNAIINSG 
PREDSTRIGR AGTVRRQAVD VSPLRRVNQA IWLLCTGARE AAFRNIKTIA ECLADELINA 
AKGSSNSYAI KKKDELERVA KSNR

Details for: RPS5

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. PubMed ID: 7772601

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797