Gene RPS5 - ENSG00000083845 | NCBI Gene ID: 6193

Details for: RPS5

Gene ID: 6193

Symbol: RPS5

Ensembl ID: ENSG00000083845

Description: ribosomal protein S5

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Mrna binding
(GO:0003729)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Regulation of translational fidelity
(GO:0006450)
Ribonucleoprotein complex
(GO:1990904)
Ribosomal small subunit assembly
(GO:0000028)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Small-subunit processome
(GO:0032040)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)
Translational initiation
(GO:0006413)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 7.95
Marker Score: 6003
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.02
Marker Score: 29578
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.73
Marker Score: 12006
Cell Name: malignant cell (CL0001064)
Fold Change: 5.61
Marker Score: 75352
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 5.49
Marker Score: 3094
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.24
Marker Score: 8075
Cell Name: mature T cell (CL0002419)
Fold Change: 5.18
Marker Score: 51332
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.15
Marker Score: 1898
Cell Name: acinar cell (CL0000622)
Fold Change: 5.09
Marker Score: 3589.5
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.07
Marker Score: 8690
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.01
Marker Score: 3638
Cell Name: naive T cell (CL0000898)
Fold Change: 4.96
Marker Score: 3198
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.94
Marker Score: 2540
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.93
Marker Score: 14400
Cell Name: theca cell (CL0000503)
Fold Change: 4.88
Marker Score: 3496
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.87
Marker Score: 165859
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.86
Marker Score: 6333
Cell Name: naive B cell (CL0000788)
Fold Change: 4.84
Marker Score: 4318
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.77
Marker Score: 15050.5
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.68
Marker Score: 247654
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.66
Marker Score: 3967
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.44
Marker Score: 58576
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.33
Marker Score: 2635
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.32
Marker Score: 22691
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.32
Marker Score: 1031
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.25
Marker Score: 4725
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.22
Marker Score: 25651
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.22
Marker Score: 1372
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.2
Marker Score: 10249.5
Cell Name: blood cell (CL0000081)
Fold Change: 4.17
Marker Score: 48434
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.16
Marker Score: 11502
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.16
Marker Score: 11658
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.13
Marker Score: 9401
Cell Name: memory T cell (CL0000813)
Fold Change: 4.1
Marker Score: 1764
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.07
Marker Score: 3474
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.06
Marker Score: 3928
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.06
Marker Score: 17399
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.05
Marker Score: 9888
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.05
Marker Score: 2375
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 4.05
Marker Score: 3080
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.04
Marker Score: 3164
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.02
Marker Score: 3152.5
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.01
Marker Score: 5909
Cell Name: granulocyte (CL0000094)
Fold Change: 4.01
Marker Score: 1796
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4
Marker Score: 29752
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4
Marker Score: 3937
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.98
Marker Score: 1791
Cell Name: supporting cell (CL0000630)
Fold Change: 3.97
Marker Score: 7453
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.96
Marker Score: 4234
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.96
Marker Score: 221391
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.91
Marker Score: 25515.5
Cell Name: club cell (CL0000158)
Fold Change: 3.85
Marker Score: 4491
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.84
Marker Score: 3609
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.81
Marker Score: 2563
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.8
Marker Score: 870
Cell Name: reticular cell (CL0000432)
Fold Change: 3.78
Marker Score: 1379
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.77
Marker Score: 3088
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.76
Marker Score: 3305.5
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.76
Marker Score: 1718.5
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 3.75
Marker Score: 1936.5
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.75
Marker Score: 987
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.72
Marker Score: 4114
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.71
Marker Score: 3301
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.71
Marker Score: 32563
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.7
Marker Score: 3304
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.7
Marker Score: 24093
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.7
Marker Score: 1219
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.7
Marker Score: 9917
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.69
Marker Score: 4556
Cell Name: memory B cell (CL0000787)
Fold Change: 3.68
Marker Score: 2786
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.68
Marker Score: 3837
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.65
Marker Score: 1029
Cell Name: immature B cell (CL0000816)
Fold Change: 3.65
Marker Score: 2418
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.65
Marker Score: 2594
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.65
Marker Score: 23259
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.64
Marker Score: 9065
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.64
Marker Score: 1884
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.64
Marker Score: 12908
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.63
Marker Score: 1032
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.63
Marker Score: 3011
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.62
Marker Score: 3189
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.61
Marker Score: 2076
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.6
Marker Score: 2109
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.6
Marker Score: 3392
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.59
Marker Score: 5709
Cell Name: paneth cell (CL0000510)
Fold Change: 3.59
Marker Score: 2496
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.59
Marker Score: 5879.5
Cell Name: stromal cell (CL0000499)
Fold Change: 3.58
Marker Score: 4192
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.57
Marker Score: 3008
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.57
Marker Score: 1968
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.56
Marker Score: 8074
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.55
Marker Score: 1529
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.55
Marker Score: 1138
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.54
Marker Score: 4278
Cell Name: basophil (CL0000767)
Fold Change: 3.53
Marker Score: 1679
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.53
Marker Score: 3167
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.53
Marker Score: 4035
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 3.51
Marker Score: 1039
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.51
Marker Score: 4143
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.51
Marker Score: 1001

Hover over a box to see details here...

**Key characteristics:** - Gene name: RPS5 - Ensembl ID: ENSG00000083845 - Protein: 40S ribosomal protein S5 - Pathway: Axon guidance, Cellular responses to stimuli, Cellular responses to stress, Developmental biology, Disease, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Metabolism of rna, Nervous system development **Pathways and functions:** - The RPS5 gene is significantly expressed in cells of the immune system, including cord blood hematopoietic stem cells, myoepithelial cells of the mammary gland, CD38-negative naive B cells, malignant cells, epithelial cells of the exocrine pancreas, mesenchymal stem cells, mature T cells, radial glial cells, and acinar cells. - The protein is involved in the initiation, elongation, and termination of protein translation. - Mutations in the RPS5 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. **Clinical significance:** - Mutations in the RPS5 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. - The protein is a key target for cancer immunotherapy, as it is frequently overexpressed in cancer cells. - Targeting the RPS5 gene has been shown to be effective in inhibiting cancer growth and metastasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S5

Genular Protein ID: 4291020941

Symbol: RS5_HUMAN

Name: 40S ribosomal protein S5

UniProtKB Accession Codes:

P46782 B2R4T2 Q96BN0

Database IDs:

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 204
Mass: 22876
Checksum: DFE2FD5AAFCFD894
Sequence:

MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP HSAGRYAAKR 
FRKAQCPIVE RLTNSMMMHG RNNGKKLMTV RIVKHAFEII HLLTGENPLQ VLVNAIINSG 
PREDSTRIGR AGTVRRQAVD VSPLRRVNQA IWLLCTGARE AAFRNIKTIA ECLADELINA 
AKGSSNSYAI KKKDELERVA KSNR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPS5

Associated with

Cells (max top 100)

Other Information

Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. PubMed ID: 7772601

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797