Details for: CCL1

Gene ID: 6346

Symbol: CCL1

Ensembl ID: ENSG00000108702

Description: C-C motif chemokine ligand 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.51
    Marker Score: 882
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 878
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.29
    Marker Score: 2628
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 804
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.04
    Marker Score: 1976
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2584
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12520
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 479
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.72
    Marker Score: 942
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 524
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 224
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 455
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.47
    Marker Score: 2809
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 261
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 237.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.38
    Marker Score: 787.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 172
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.35
    Marker Score: 376
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.29
    Marker Score: 180
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.21
    Marker Score: 247
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.19
    Marker Score: 266.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 173
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 56
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.17
    Marker Score: 91
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.11
    Marker Score: 297
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 209
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.08
    Marker Score: 146
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.07
    Marker Score: 237
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 40.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.05
    Marker Score: 79
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 15.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.03
    Marker Score: 1028
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 66
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 47
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.02
    Marker Score: 77
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.02
    Marker Score: 142
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 51
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.01
    Marker Score: 10.5

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Other Information

**Key characteristics:** - It is a protein of the chemokine family, which are a group of proteins that are responsible for the attraction of immune cells. - It is a cell surface protein that is expressed on various immune cells, including monocytes, macrophages, and dendritic cells. - It is a chemoattractant for a variety of immune cells, including monocytes, macrophages, and dendritic cells. - It is a key regulator of inflammation and immune responses. **Pathways and functions:** - CCL1 binds to the CCR2 receptor, which is expressed on various immune cells. - Upon binding to CCR2, CCL1 triggers a signaling cascade that involves the activation of G alpha (i) proteins. - G alpha (i) proteins activate downstream signaling pathways that lead to the activation of p38 MAPK and STAT3 signaling pathways. - These pathways regulate the expression of various immune-related genes, including those involved in inflammation and cell migration. - CCL1 also plays a role in regulating blood-brain barrier function. **Clinical significance:** - Mutations in the CCL1 gene have been linked to several autoimmune diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - CCL1 is a potential therapeutic target for autoimmune diseases that are characterized by chronic inflammation. - By blocking the activity of CCL1, it is possible to dampen inflammation and reduce the symptoms of autoimmune diseases. **Conclusion:** The CCL1 gene plays a critical role in regulating immune responses by binding to the CCR2 receptor and triggering a signaling cascade that leads to the activation of various downstream signaling pathways. This cascade ultimately regulates the expression of immune-related genes and promotes inflammation.

Genular Protein ID: 599098615

Symbol: CCL1_HUMAN

Name: C-C motif chemokine 1

UniProtKB Accession Codes:

P22362 B2R5G9 Q2M309

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2809212

Title: A novel polypeptide secreted by activated human T lymphocytes.

PubMed ID: 2809212

PubMed ID: 2212659

Title: Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines.

PubMed ID: 2212659

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1557400

Title: The human cytokine I-309 is a monocyte chemoattractant.

PubMed ID: 1557400

DOI: 10.1073/pnas.89.7.2950

PubMed ID: 10821677

Title: Human CC chemokine I-309, structural consequences of the additional disulfide bond.

PubMed ID: 10821677

DOI: 10.1021/bi000089l

Sequence Information:

  • Length: 96
  • Mass: 10992
  • Checksum: 7E67F1F82892F3C7
  • Sequence:
    • MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY RNTSSICSNE 
GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.