Details for: CCL1

Gene ID: 6346

Symbol: CCL1

Ensembl ID: ENSG00000108702

Description: C-C motif chemokine ligand 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.3994
    Cell Significance Index: 58.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1849
    Cell Significance Index: 2.8600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0737
    Cell Significance Index: 0.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0025
    Cell Significance Index: -0.0200
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0160
    Cell Significance Index: -4.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0167
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0167
    Cell Significance Index: -0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0239
    Cell Significance Index: -4.7900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0276
    Cell Significance Index: -0.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0358
    Cell Significance Index: -3.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0392
    Cell Significance Index: -4.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0467
    Cell Significance Index: -2.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0643
    Cell Significance Index: -4.1500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0656
    Cell Significance Index: -0.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0708
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0829
    Cell Significance Index: -0.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1286
    Cell Significance Index: -3.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1314
    Cell Significance Index: -3.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1460
    Cell Significance Index: -3.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1504
    Cell Significance Index: -4.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1568
    Cell Significance Index: -7.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1579
    Cell Significance Index: -5.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1617
    Cell Significance Index: -2.7200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1758
    Cell Significance Index: -4.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1789
    Cell Significance Index: -4.2900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1795
    Cell Significance Index: -2.1100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1907
    Cell Significance Index: -2.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2057
    Cell Significance Index: -4.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2130
    Cell Significance Index: -4.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2180
    Cell Significance Index: -4.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2210
    Cell Significance Index: -3.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2215
    Cell Significance Index: -4.7900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2227
    Cell Significance Index: -3.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2245
    Cell Significance Index: -3.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2307
    Cell Significance Index: -4.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2311
    Cell Significance Index: -4.5700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2330
    Cell Significance Index: -4.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2462
    Cell Significance Index: -4.9100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2463
    Cell Significance Index: -5.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2486
    Cell Significance Index: -3.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2550
    Cell Significance Index: -4.1300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2588
    Cell Significance Index: -3.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2597
    Cell Significance Index: -3.7700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2636
    Cell Significance Index: -3.2600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2638
    Cell Significance Index: -4.5100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2643
    Cell Significance Index: -3.3400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2697
    Cell Significance Index: -3.2600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2735
    Cell Significance Index: -3.7500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2757
    Cell Significance Index: -3.8700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2794
    Cell Significance Index: -3.3500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2803
    Cell Significance Index: -7.0000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2867
    Cell Significance Index: -3.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2931
    Cell Significance Index: -4.9100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2979
    Cell Significance Index: -3.4100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2980
    Cell Significance Index: -3.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2997
    Cell Significance Index: -5.0900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3007
    Cell Significance Index: -3.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3030
    Cell Significance Index: -7.0000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3074
    Cell Significance Index: -5.3200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3169
    Cell Significance Index: -4.1000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3185
    Cell Significance Index: -3.7600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3185
    Cell Significance Index: -3.4700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3212
    Cell Significance Index: -3.8300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3215
    Cell Significance Index: -3.7000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3289
    Cell Significance Index: -3.6100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3289
    Cell Significance Index: -3.9100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3343
    Cell Significance Index: -3.5700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3414
    Cell Significance Index: -3.9600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3424
    Cell Significance Index: -4.4400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3426
    Cell Significance Index: -4.2800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3443
    Cell Significance Index: -4.5900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3528
    Cell Significance Index: -4.4700
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.3551
    Cell Significance Index: -3.7900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3557
    Cell Significance Index: -5.7200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3579
    Cell Significance Index: -4.8300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3587
    Cell Significance Index: -3.7800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3594
    Cell Significance Index: -4.0500
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.3638
    Cell Significance Index: -3.8500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3664
    Cell Significance Index: -5.3400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3673
    Cell Significance Index: -3.8500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3710
    Cell Significance Index: -4.9300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3753
    Cell Significance Index: -4.5300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3783
    Cell Significance Index: -4.4700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.3823
    Cell Significance Index: -3.7400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3828
    Cell Significance Index: -4.2400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3851
    Cell Significance Index: -3.6200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3867
    Cell Significance Index: -4.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3883
    Cell Significance Index: -3.9400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3905
    Cell Significance Index: -4.8000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3917
    Cell Significance Index: -4.0300
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.3938
    Cell Significance Index: -4.6000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3940
    Cell Significance Index: -4.4600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3950
    Cell Significance Index: -4.0100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.3958
    Cell Significance Index: -4.1000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3968
    Cell Significance Index: -4.3400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3973
    Cell Significance Index: -4.7900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3973
    Cell Significance Index: -4.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chemokine Structure:** CCL1 is a small, 8-kDa protein consisting of 8 amino acids, with a characteristic C-C motif. 2. **Cellular Expression:** CCL1 is expressed in various cell types, including pericytes, granulocyte-monocyte progenitor cells, goblet cells, and immune cells. 3. **Signaling Pathways:** CCL1 is involved in multiple signaling pathways, including chemokine-mediated signaling, G protein-coupled receptor signaling, and inflammatory response pathways. 4. **Chemotaxis:** CCL1 is a potent chemoattractant for various immune cells, including monocytes, neutrophils, and eosinophils. **Pathways and Functions:** 1. **Chemokine-Mediated Signaling:** CCL1 binds to its receptor, CCR1, triggering a signaling cascade that leads to the activation of various transcription factors, including NF-κB and AP-1. 2. **G Protein-Coupled Receptor Signaling:** CCL1 binds to its receptor, CCR1, activating G proteins that trigger the activation of various downstream signaling pathways. 3. **Inflammatory Response:** CCL1 is involved in the regulation of inflammatory responses, including the recruitment of immune cells to sites of inflammation and the production of pro-inflammatory cytokines. 4. **Immune Cell Recruitment:** CCL1 is a potent chemoattractant for various immune cells, including monocytes, neutrophils, and eosinophils. **Clinical Significance:** 1. **Inflammatory Diseases:** CCL1 has been implicated in various inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and asthma. 2. **Cancer:** CCL1 has been shown to promote tumor growth and metastasis in various types of cancer, including breast and lung cancer. 3. **Immunodeficiency:** CCL1 has been implicated in immunodeficiency disorders, including chronic granulomatous disease and Whipple's disease. 4. **Therapeutic Target:** CCL1 has been identified as a potential therapeutic target for the treatment of inflammatory diseases and cancer. In conclusion, CCL1 is a key player in chemokine signaling and immune response, and its dysregulation has been implicated in various inflammatory diseases and cancer. Further research is needed to fully understand the mechanisms of CCL1 and its role in human disease.

Genular Protein ID: 599098615

Symbol: CCL1_HUMAN

Name: C-C motif chemokine 1

UniProtKB Accession Codes:

P22362 B2R5G9 Q2M309

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2809212

Title: A novel polypeptide secreted by activated human T lymphocytes.

PubMed ID: 2809212

PubMed ID: 2212659

Title: Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines.

PubMed ID: 2212659

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1557400

Title: The human cytokine I-309 is a monocyte chemoattractant.

PubMed ID: 1557400

DOI: 10.1073/pnas.89.7.2950

PubMed ID: 10821677

Title: Human CC chemokine I-309, structural consequences of the additional disulfide bond.

PubMed ID: 10821677

DOI: 10.1021/bi000089l

Sequence Information:

  • Length: 96
  • Mass: 10992
  • Checksum: 7E67F1F82892F3C7
  • Sequence:
    • MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY RNTSSICSNE 
GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.