Details for: SNCB

Gene ID: 6620

Symbol: SNCB

Ensembl ID: ENSG00000074317

Description: synuclein beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30407
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.64
    Marker Score: 4394.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.4
    Marker Score: 3212
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.34
    Marker Score: 6792.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1515
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2218
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8
    Marker Score: 537
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.7
    Marker Score: 4836
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92234
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.41
    Marker Score: 14521
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.39
    Marker Score: 51373
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2040
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.31
    Marker Score: 5436
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.28
    Marker Score: 10979
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.26
    Marker Score: 1253
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.25
    Marker Score: 5104
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.24
    Marker Score: 18594
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.23
    Marker Score: 24396
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.21
    Marker Score: 11530
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.21
    Marker Score: 11398
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2
    Marker Score: 4637
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.17
    Marker Score: 44265
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.09
    Marker Score: 719.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.01
    Marker Score: 4671
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.01
    Marker Score: 7714
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2437
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.86
    Marker Score: 4529
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.79
    Marker Score: 3280
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.74
    Marker Score: 366
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1148
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.68
    Marker Score: 311
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.68
    Marker Score: 264
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 519
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.64
    Marker Score: 231
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.62
    Marker Score: 3332
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.61
    Marker Score: 371
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.6
    Marker Score: 1754
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.59
    Marker Score: 186
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.53
    Marker Score: 218
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.53
    Marker Score: 507
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.52
    Marker Score: 216
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.5
    Marker Score: 3802
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 327.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.48
    Marker Score: 1112
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 455.5
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.46
    Marker Score: 1354
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.46
    Marker Score: 501
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.45
    Marker Score: 553
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.44
    Marker Score: 1258
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.4
    Marker Score: 348.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.39
    Marker Score: 107
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.39
    Marker Score: 6036
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.38
    Marker Score: 201
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.37
    Marker Score: 702
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.35
    Marker Score: 3576
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.34
    Marker Score: 624.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.34
    Marker Score: 202
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.33
    Marker Score: 1719
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.32
    Marker Score: 188
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.32
    Marker Score: 911.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.32
    Marker Score: 10713
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.32
    Marker Score: 502
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.3
    Marker Score: 322
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 593
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.29
    Marker Score: 956
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 573
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.27
    Marker Score: 472
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.26
    Marker Score: 77
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.26
    Marker Score: 361
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.26
    Marker Score: 254
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 135.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.24
    Marker Score: 278
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 82
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 141
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 120
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.22
    Marker Score: 4714
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.22
    Marker Score: 517
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.21
    Marker Score: 206
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.21
    Marker Score: 92
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 378.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.21
    Marker Score: 346
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2
    Marker Score: 131

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Other Information

**Key Characteristics:** 1. **Expression Patterns:** SNCB is significantly expressed in various cell types, including progenitor cells, glycinergic neurons, and photoreceptor cells in the eye. This widespread expression suggests a potential role in maintaining tissue homeostasis and neuronal function. 2. **Protein Structure:** The SNCB protein is a member of the synuclein family, characterized by its ability to bind to calcium ions, lipids, and other molecules. This binding capacity is crucial for its function in neuronal signaling and synaptic plasticity. 3. **Function:** SNCB has been implicated in several cellular processes, including dopamine metabolism, synaptic vesicle endocytosis, and the regulation of neuronal apoptosis. Its involvement in these processes highlights its importance in maintaining neuronal health and function. **Pathways and Functions:** 1. **Calcium Ion Binding:** SNCB's ability to bind to calcium ions plays a critical role in neuronal signaling and synaptic plasticity. This binding capacity allows SNCB to modulate the activity of calcium channels and pumps, influencing the excitability of neurons. 2. **Synaptic Vesicle Endocytosis:** SNCB has been shown to regulate the endocytosis of synaptic vesicles, a process essential for neurotransmitter release and synaptic plasticity. This function highlights SNCB's role in maintaining the integrity of the synaptic terminal. 3. **Dopamine Metabolic Process:** SNCB has been implicated in the regulation of dopamine metabolism, a process crucial for motor control, reward processing, and motivation. Abnormalities in SNCB expression or function have been linked to various neurological disorders, including Parkinson's disease and schizophrenia. 4. **Neuronal Apoptosis:** SNCB has been shown to regulate the apoptotic process in neurons, influencing the survival and death of neuronal cells. This function highlights SNCB's role in maintaining neuronal homeostasis and preventing neurodegeneration. **Clinical Significance:** 1. **Neurological Disorders:** Abnormalities in SNCB expression or function have been linked to various neurological disorders, including Parkinson's disease, schizophrenia, and Alzheimer's disease. Understanding the role of SNCB in these disorders may provide insights into the development of novel therapeutic strategies. 2. **Cancer:** SNCB has been implicated in the regulation of immune responses, including the activation of plasma cells and the production of cytokines. Abnormalities in SNCB expression or function may contribute to the development of cancer. 3. **Neurodevelopmental Disorders:** SNCB has been shown to play a critical role in the development and maturation of neurons. Abnormalities in SNCB expression or function may contribute to neurodevelopmental disorders, such as autism spectrum disorder and attention deficit hyperactivity disorder. In conclusion, synuclein beta (SNCB) is a gene of enduring interest in immunology and neuroscience, with a complex role in maintaining neuronal function and survival. Its involvement in various cellular processes, including calcium ion binding, synaptic vesicle endocytosis, and dopamine metabolism, highlights its importance in maintaining tissue homeostasis and preventing neurodegeneration. Further research into the clinical significance of SNCB may provide insights into the development of novel therapeutic strategies for various neurological and immunological disorders.

Genular Protein ID: 3452543091

Symbol: SYUB_HUMAN

Name: Beta-synuclein

UniProtKB Accession Codes:

Q16143 Q6IAX7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8194594

Title: Identification of two distinct synucleins from human brain.

PubMed ID: 8194594

DOI: 10.1016/0014-5793(94)00395-5

PubMed ID: 9806846

Title: Genomic organization and expression of the human beta-synuclein gene (SNCB).

PubMed ID: 9806846

DOI: 10.1006/geno.1998.5556

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10852916

Title: Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

PubMed ID: 10852916

DOI: 10.1074/jbc.m003542200

Sequence Information:

  • Length: 134
  • Mass: 14288
  • Checksum: 5BCA9FCA615AC4EF
  • Sequence:
    • MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK 
EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE 
DPPQEEYQEY EPEA

Genular Protein ID: 44521175

Symbol: G4Y815_HUMAN

Name: N/A

UniProtKB Accession Codes:

G4Y815

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 104
  • Mass: 10952
  • Checksum: AF07685F7A8A2B15
  • Sequence:
    • MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK 
EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKEEYQEY EPEA

Genular Protein ID: 1183887027

Symbol: G4Y816_HUMAN

Name: N/A

UniProtKB Accession Codes:

G4Y816

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 Pfam 1 Proteomes 2 RefSeq 2 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 120
  • Mass: 12931
  • Checksum: B4F318D2A3CEA74D
  • Sequence:
    • MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV VAEKTKEQAS HLGGAVFSGA 
GNIAAATGLV KREEFPTDLK PEEVAQEAAE EPLIEPLMEP EGESYEDPPQ EEYQEYEPEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.