Details for: SNCB

Gene ID: 6620

Symbol: SNCB

Ensembl ID: ENSG00000074317

Description: synuclein beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 9.3424
    Cell Significance Index: 72.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.1536
    Cell Significance Index: 375.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 6.5313
    Cell Significance Index: 411.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4433
    Cell Significance Index: 289.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.4158
    Cell Significance Index: 17.5600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.4065
    Cell Significance Index: 12.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9706
    Cell Significance Index: 11.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6213
    Cell Significance Index: 222.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3659
    Cell Significance Index: 24.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1541
    Cell Significance Index: 106.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1389
    Cell Significance Index: 2.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1216
    Cell Significance Index: 3.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1000
    Cell Significance Index: 2.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0266
    Cell Significance Index: 14.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0144
    Cell Significance Index: -27.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0146
    Cell Significance Index: -0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0169
    Cell Significance Index: -31.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0203
    Cell Significance Index: -31.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0228
    Cell Significance Index: -31.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0401
    Cell Significance Index: -29.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0426
    Cell Significance Index: -27.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0431
    Cell Significance Index: -24.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0496
    Cell Significance Index: -31.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0572
    Cell Significance Index: -25.9700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0587
    Cell Significance Index: -0.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0787
    Cell Significance Index: -22.6400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0800
    Cell Significance Index: -0.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1079
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1463
    Cell Significance Index: -30.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1511
    Cell Significance Index: -29.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1779
    Cell Significance Index: -30.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1847
    Cell Significance Index: -26.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1888
    Cell Significance Index: -1.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2000
    Cell Significance Index: -4.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2014
    Cell Significance Index: -12.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2207
    Cell Significance Index: -30.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2316
    Cell Significance Index: -4.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2532
    Cell Significance Index: -29.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2591
    Cell Significance Index: -30.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2610
    Cell Significance Index: -26.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2722
    Cell Significance Index: -31.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2736
    Cell Significance Index: -28.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2756
    Cell Significance Index: -6.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3457
    Cell Significance Index: -9.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3789
    Cell Significance Index: -9.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3950
    Cell Significance Index: -7.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4160
    Cell Significance Index: -13.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4218
    Cell Significance Index: -27.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4305
    Cell Significance Index: -4.6900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4621
    Cell Significance Index: -5.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4808
    Cell Significance Index: -15.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5210
    Cell Significance Index: -18.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5275
    Cell Significance Index: -29.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5324
    Cell Significance Index: -27.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5695
    Cell Significance Index: -25.1900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5840
    Cell Significance Index: -7.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5957
    Cell Significance Index: -14.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6516
    Cell Significance Index: -13.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6639
    Cell Significance Index: -25.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6681
    Cell Significance Index: -31.4000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.7508
    Cell Significance Index: -9.8300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.7567
    Cell Significance Index: -7.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7628
    Cell Significance Index: -19.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7966
    Cell Significance Index: -27.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8058
    Cell Significance Index: -11.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8147
    Cell Significance Index: -17.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8219
    Cell Significance Index: -28.8800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.8250
    Cell Significance Index: -6.8100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8278
    Cell Significance Index: -9.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8524
    Cell Significance Index: -31.2900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.8927
    Cell Significance Index: -11.9000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9125
    Cell Significance Index: -17.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9394
    Cell Significance Index: -27.6700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.9646
    Cell Significance Index: -12.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9830
    Cell Significance Index: -12.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9893
    Cell Significance Index: -31.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0048
    Cell Significance Index: -28.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0101
    Cell Significance Index: -27.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0184
    Cell Significance Index: -26.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0229
    Cell Significance Index: -30.0400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0417
    Cell Significance Index: -12.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0466
    Cell Significance Index: -20.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.0766
    Cell Significance Index: -26.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0922
    Cell Significance Index: -29.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0936
    Cell Significance Index: -31.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.1059
    Cell Significance Index: -29.5300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.1126
    Cell Significance Index: -22.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.1638
    Cell Significance Index: -29.6500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.1784
    Cell Significance Index: -20.3800
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -1.2091
    Cell Significance Index: -9.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.2160
    Cell Significance Index: -29.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2390
    Cell Significance Index: -30.2300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.2431
    Cell Significance Index: -15.6900
  • Cell Name: interneuron (CL0000099)
    Fold Change: -1.2516
    Cell Significance Index: -14.6200
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -1.3090
    Cell Significance Index: -14.0700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -1.3129
    Cell Significance Index: -16.3900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -1.3246
    Cell Significance Index: -12.4600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -1.3588
    Cell Significance Index: -15.4700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -1.3818
    Cell Significance Index: -15.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.3946
    Cell Significance Index: -28.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Patterns:** SNCB is significantly expressed in various cell types, including progenitor cells, glycinergic neurons, and photoreceptor cells in the eye. This widespread expression suggests a potential role in maintaining tissue homeostasis and neuronal function. 2. **Protein Structure:** The SNCB protein is a member of the synuclein family, characterized by its ability to bind to calcium ions, lipids, and other molecules. This binding capacity is crucial for its function in neuronal signaling and synaptic plasticity. 3. **Function:** SNCB has been implicated in several cellular processes, including dopamine metabolism, synaptic vesicle endocytosis, and the regulation of neuronal apoptosis. Its involvement in these processes highlights its importance in maintaining neuronal health and function. **Pathways and Functions:** 1. **Calcium Ion Binding:** SNCB's ability to bind to calcium ions plays a critical role in neuronal signaling and synaptic plasticity. This binding capacity allows SNCB to modulate the activity of calcium channels and pumps, influencing the excitability of neurons. 2. **Synaptic Vesicle Endocytosis:** SNCB has been shown to regulate the endocytosis of synaptic vesicles, a process essential for neurotransmitter release and synaptic plasticity. This function highlights SNCB's role in maintaining the integrity of the synaptic terminal. 3. **Dopamine Metabolic Process:** SNCB has been implicated in the regulation of dopamine metabolism, a process crucial for motor control, reward processing, and motivation. Abnormalities in SNCB expression or function have been linked to various neurological disorders, including Parkinson's disease and schizophrenia. 4. **Neuronal Apoptosis:** SNCB has been shown to regulate the apoptotic process in neurons, influencing the survival and death of neuronal cells. This function highlights SNCB's role in maintaining neuronal homeostasis and preventing neurodegeneration. **Clinical Significance:** 1. **Neurological Disorders:** Abnormalities in SNCB expression or function have been linked to various neurological disorders, including Parkinson's disease, schizophrenia, and Alzheimer's disease. Understanding the role of SNCB in these disorders may provide insights into the development of novel therapeutic strategies. 2. **Cancer:** SNCB has been implicated in the regulation of immune responses, including the activation of plasma cells and the production of cytokines. Abnormalities in SNCB expression or function may contribute to the development of cancer. 3. **Neurodevelopmental Disorders:** SNCB has been shown to play a critical role in the development and maturation of neurons. Abnormalities in SNCB expression or function may contribute to neurodevelopmental disorders, such as autism spectrum disorder and attention deficit hyperactivity disorder. In conclusion, synuclein beta (SNCB) is a gene of enduring interest in immunology and neuroscience, with a complex role in maintaining neuronal function and survival. Its involvement in various cellular processes, including calcium ion binding, synaptic vesicle endocytosis, and dopamine metabolism, highlights its importance in maintaining tissue homeostasis and preventing neurodegeneration. Further research into the clinical significance of SNCB may provide insights into the development of novel therapeutic strategies for various neurological and immunological disorders.

Genular Protein ID: 3452543091

Symbol: SYUB_HUMAN

Name: Beta-synuclein

UniProtKB Accession Codes:

Q16143 Q6IAX7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8194594

Title: Identification of two distinct synucleins from human brain.

PubMed ID: 8194594

DOI: 10.1016/0014-5793(94)00395-5

PubMed ID: 9806846

Title: Genomic organization and expression of the human beta-synuclein gene (SNCB).

PubMed ID: 9806846

DOI: 10.1006/geno.1998.5556

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10852916

Title: Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

PubMed ID: 10852916

DOI: 10.1074/jbc.m003542200

Sequence Information:

  • Length: 134
  • Mass: 14288
  • Checksum: 5BCA9FCA615AC4EF
  • Sequence:
    • MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK 
EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE 
DPPQEEYQEY EPEA

Genular Protein ID: 1183887027

Symbol: G4Y816_HUMAN

Name: N/A

UniProtKB Accession Codes:

G4Y816

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 120
  • Mass: 12931
  • Checksum: B4F318D2A3CEA74D
  • Sequence:
    • MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV VAEKTKEQAS HLGGAVFSGA 
GNIAAATGLV KREEFPTDLK PEEVAQEAAE EPLIEPLMEP EGESYEDPPQ EEYQEYEPEA

Genular Protein ID: 44521175

Symbol: G4Y815_HUMAN

Name: N/A

UniProtKB Accession Codes:

G4Y815

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 GO 7 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 104
  • Mass: 10952
  • Checksum: AF07685F7A8A2B15
  • Sequence:
    • MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK 
EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKEEYQEY EPEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.