Details for: STATH

Gene ID: 6779

Symbol: STATH

Ensembl ID: ENSG00000126549

Description: statherin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 104.2370
    Cell Significance Index: 580.1900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 76.5393
    Cell Significance Index: 1596.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 9.2344
    Cell Significance Index: 430.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.3911
    Cell Significance Index: 32.7900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.5178
    Cell Significance Index: 19.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.3870
    Cell Significance Index: -4.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4459
    Cell Significance Index: 10.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0705
    Cell Significance Index: 1.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0019
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0069
    Cell Significance Index: -13.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0070
    Cell Significance Index: -0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0222
    Cell Significance Index: -12.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0345
    Cell Significance Index: -15.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0461
    Cell Significance Index: -1.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0483
    Cell Significance Index: -13.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0503
    Cell Significance Index: -1.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0613
    Cell Significance Index: -12.1600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0614
    Cell Significance Index: -1.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0640
    Cell Significance Index: -1.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0659
    Cell Significance Index: -13.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0814
    Cell Significance Index: -11.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1018
    Cell Significance Index: -13.9800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1148
    Cell Significance Index: -1.4500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1157
    Cell Significance Index: -1.1800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1261
    Cell Significance Index: -1.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1547
    Cell Significance Index: -1.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1553
    Cell Significance Index: -3.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1593
    Cell Significance Index: -7.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1929
    Cell Significance Index: -7.0800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.2009
    Cell Significance Index: -1.0600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2150
    Cell Significance Index: -2.7200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2238
    Cell Significance Index: -3.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2245
    Cell Significance Index: -14.1500
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.2330
    Cell Significance Index: -2.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2343
    Cell Significance Index: -2.6600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2405
    Cell Significance Index: -3.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2435
    Cell Significance Index: -3.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2856
    Cell Significance Index: -7.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2943
    Cell Significance Index: -15.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3068
    Cell Significance Index: -13.5700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3084
    Cell Significance Index: -3.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3221
    Cell Significance Index: -8.2800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3558
    Cell Significance Index: -3.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3581
    Cell Significance Index: -13.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3642
    Cell Significance Index: -12.7600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3732
    Cell Significance Index: -5.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3969
    Cell Significance Index: -9.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4020
    Cell Significance Index: -11.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4041
    Cell Significance Index: -13.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4179
    Cell Significance Index: -13.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4347
    Cell Significance Index: -13.7500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4571
    Cell Significance Index: -5.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4658
    Cell Significance Index: -12.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4755
    Cell Significance Index: -13.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5019
    Cell Significance Index: -10.9900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5030
    Cell Significance Index: -9.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5102
    Cell Significance Index: -14.7000
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.5180
    Cell Significance Index: -3.9800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.5338
    Cell Significance Index: -3.2700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.5406
    Cell Significance Index: -6.7900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.5495
    Cell Significance Index: -4.4500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.5500
    Cell Significance Index: -6.8300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.5571
    Cell Significance Index: -3.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5613
    Cell Significance Index: -14.0200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.5696
    Cell Significance Index: -5.7000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5765
    Cell Significance Index: -8.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5892
    Cell Significance Index: -12.7300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5912
    Cell Significance Index: -11.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5920
    Cell Significance Index: -14.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6179
    Cell Significance Index: -16.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6238
    Cell Significance Index: -13.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6253
    Cell Significance Index: -17.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6417
    Cell Significance Index: -10.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6533
    Cell Significance Index: -13.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6686
    Cell Significance Index: -13.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6721
    Cell Significance Index: -13.1400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.6744
    Cell Significance Index: -7.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6785
    Cell Significance Index: -14.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7047
    Cell Significance Index: -13.0300
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.7096
    Cell Significance Index: -6.5900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7156
    Cell Significance Index: -9.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.7259
    Cell Significance Index: -8.5700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.7346
    Cell Significance Index: -7.7000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7450
    Cell Significance Index: -12.5300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.7616
    Cell Significance Index: -12.5500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.7811
    Cell Significance Index: -8.2400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.7856
    Cell Significance Index: -9.0400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.7959
    Cell Significance Index: -8.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8107
    Cell Significance Index: -11.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8158
    Cell Significance Index: -8.4500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.8267
    Cell Significance Index: -14.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.8355
    Cell Significance Index: -12.6900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.8452
    Cell Significance Index: -13.5900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.8473
    Cell Significance Index: -12.3500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8705
    Cell Significance Index: -13.8100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.9079
    Cell Significance Index: -10.0600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.9089
    Cell Significance Index: -14.6700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.9261
    Cell Significance Index: -10.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STATH is a small, acidic protein that belongs to the statherin family. Its primary function is to regulate the mineralization of tissues, particularly in the context of tooth enamel and bone development. Statherin's unique structure, comprising a short N-terminal domain and a longer C-terminal domain, enables it to interact with hydroxyapatite, a key component of bone and tooth mineralization. This interaction is crucial for maintaining the mineralization process and preventing excessive mineralization, which can lead to dental caries and bone disorders. **Pathways and Functions:** STATH is involved in several key biological pathways, including: 1. **Biomineral tissue development:** Statherin plays a critical role in the regulation of mineralization in tooth enamel and bone development. It interacts with hydroxyapatite, promoting the deposition of minerals and maintaining the structural integrity of these tissues. 2. **Defense response to bacterium:** Statherin has been shown to exhibit antimicrobial properties, inhibiting the growth of certain bacteria that contribute to oral infections and diseases. 3. **Extracellular matrix constituent:** Statherin is a key component of the extracellular matrix, providing structural support and facilitating cell-cell interactions. 4. **Lubricant activity:** Statherin's hydrophobic properties enable it to act as a lubricant, reducing friction and facilitating smooth movement between cells and tissues. **Significantly Expressed Cells:** STATH is expressed in various cell types, including: 1. **Megakaryocytes:** These blood cells are responsible for producing platelets and are known to express STATH. 2. **Acinar cells of salivary gland:** These cells produce saliva, which contains STATH, playing a crucial role in oral health. 3. **Tracheal goblet cells:** These cells produce mucin, a glycoprotein that interacts with STATH, contributing to the maintenance of airway function. 4. **Hematopoietic stem cells:** These cells give rise to blood cells, including megakaryocytes, which express STATH. **Clinical Significance:** Dysregulation of STATH has been implicated in various diseases, including: 1. **Dental caries:** Excessive mineralization of tooth enamel, often associated with STATH overexpression, can lead to dental caries. 2. **Bone disorders:** Altered STATH expression has been linked to bone disorders, such as osteoporosis and osteopenia. 3. **Oral infections:** STATH's antimicrobial properties make it an attractive target for the development of novel antimicrobial therapies. 4. **Airway diseases:** Abnormal STATH expression has been implicated in airway diseases, such as chronic obstructive pulmonary disease (COPD). In conclusion, STATH is a multifunctional protein that plays a critical role in various biological processes, including biomineral tissue development, defense response to bacteria, and extracellular matrix constituent. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of STATH's action and its potential therapeutic applications.

Genular Protein ID: 1076479495

Symbol: STAT_HUMAN

Name: Statherin

UniProtKB Accession Codes:

P02808 A6NKE9 B2R4F8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 4 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3502720

Title: cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva.

PubMed ID: 3502720

PubMed ID: 3426601

Title: Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence.

PubMed ID: 3426601

DOI: 10.1016/0006-291x(87)90436-0

PubMed ID: 2373369

Title: Structure and sequence determination of the gene encoding human salivary statherin.

PubMed ID: 2373369

DOI: 10.1016/0378-1119(90)90012-g

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 838735

Title: Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva.

PubMed ID: 838735

DOI: 10.1016/s0021-9258(17)40603-x

PubMed ID: 1663737

Title: Multiple forms of statherin in human salivary secretions.

PubMed ID: 1663737

DOI: 10.1016/0003-9969(91)90147-m

PubMed ID: 3476566

Title: Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides.

PubMed ID: 3476566

DOI: 10.1177/00220345870660021301

PubMed ID: 17389930

Title: Tyrosine sulfation of statherin.

PubMed ID: 17389930

DOI: 10.7150/ijbs.3.237

PubMed ID: 17313100

Title: HPLC-MS characterization of cyclo-statherin Q-37, a specific cyclization product of human salivary statherin generated by transglutaminase 2.

PubMed ID: 17313100

DOI: 10.1002/jssc.200600244

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 62
  • Mass: 7304
  • Checksum: CFE32EC235CA3A22
  • Sequence:
    • MKFLVFAFIL ALMVSMIGAD SSEEKFLRRI GRFGYGYGPY QPVPEQPLYP QPYQPQYQQY 
TF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.