Details for: UGT2B4

Gene ID: 7363

Symbol: UGT2B4

Ensembl ID: ENSG00000156096

Description: UDP glucuronosyltransferase family 2 member B4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 10.8120
    Cell Significance Index: 181.8500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.5408
    Cell Significance Index: 25.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8541
    Cell Significance Index: 169.5100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.7806
    Cell Significance Index: 2.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7306
    Cell Significance Index: 56.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5784
    Cell Significance Index: 8.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4173
    Cell Significance Index: 6.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4168
    Cell Significance Index: 10.1000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4011
    Cell Significance Index: 2.3100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1365
    Cell Significance Index: 0.3600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1350
    Cell Significance Index: 1.1500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1247
    Cell Significance Index: 1.2300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1027
    Cell Significance Index: 0.2800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.1018
    Cell Significance Index: 0.7800
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.0969
    Cell Significance Index: 0.7700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0963
    Cell Significance Index: 0.7600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0807
    Cell Significance Index: 1.0200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0673
    Cell Significance Index: 0.6400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.0561
    Cell Significance Index: 0.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0493
    Cell Significance Index: 1.3200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0194
    Cell Significance Index: 0.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0129
    Cell Significance Index: 0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0011
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0011
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -0.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0020
    Cell Significance Index: -1.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0023
    Cell Significance Index: -1.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0023
    Cell Significance Index: -0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0033
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0036
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0044
    Cell Significance Index: -0.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0063
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0063
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0068
    Cell Significance Index: -0.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0116
    Cell Significance Index: -0.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0123
    Cell Significance Index: -0.4300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0131
    Cell Significance Index: -0.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0134
    Cell Significance Index: -0.6800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0144
    Cell Significance Index: -0.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0156
    Cell Significance Index: -0.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0174
    Cell Significance Index: -0.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0178
    Cell Significance Index: -0.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0185
    Cell Significance Index: -0.8200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0193
    Cell Significance Index: -0.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0195
    Cell Significance Index: -0.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0208
    Cell Significance Index: -0.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0214
    Cell Significance Index: -0.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0216
    Cell Significance Index: -0.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0229
    Cell Significance Index: -0.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0234
    Cell Significance Index: -0.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0235
    Cell Significance Index: -0.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0247
    Cell Significance Index: -1.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0251
    Cell Significance Index: -0.6300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0252
    Cell Significance Index: -0.3300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0260
    Cell Significance Index: -0.2600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0268
    Cell Significance Index: -0.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0294
    Cell Significance Index: -0.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0303
    Cell Significance Index: -1.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0307
    Cell Significance Index: -0.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0307
    Cell Significance Index: -0.7500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0309
    Cell Significance Index: -0.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0312
    Cell Significance Index: -0.7800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0320
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0322
    Cell Significance Index: -0.9200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0341
    Cell Significance Index: -0.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0342
    Cell Significance Index: -0.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0342
    Cell Significance Index: -0.9300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0347
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0347
    Cell Significance Index: -0.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0349
    Cell Significance Index: -0.7400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0356
    Cell Significance Index: -0.3300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0365
    Cell Significance Index: -0.4000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0375
    Cell Significance Index: -0.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0376
    Cell Significance Index: -0.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0381
    Cell Significance Index: -0.9700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0388
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0390
    Cell Significance Index: -0.5600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0399
    Cell Significance Index: -0.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0400
    Cell Significance Index: -0.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0400
    Cell Significance Index: -0.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0401
    Cell Significance Index: -0.8000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0403
    Cell Significance Index: -0.4900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0412
    Cell Significance Index: -0.4500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0418
    Cell Significance Index: -0.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0420
    Cell Significance Index: -0.8300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0423
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0424
    Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UGT2B4 is a member of the UGT family, which consists of enzymes responsible for conjugating glucuronic acid to various substrates, including drugs, hormones, and endogenous compounds. UGT2B4 is a specific isoform of the UGT2 enzyme, characterized by its high glucuronidation activity and tissue distribution. The gene is highly expressed in cells involved in metabolism, such as hepatocytes, endothelial cells, and renal proximal tubule epithelial cells. **Pathways and Functions:** UGT2B4 is involved in several key pathways, including: 1. **Glucuronidation:** UGT2B4 catalyzes the conjugation of glucuronic acid to various substrates, including aspirin, retinoic acid, and estrogen, facilitating their excretion and detoxification. 2. **Cellular Oxidations:** UGT2B4 is also involved in the oxidation of certain substrates, contributing to the regulation of cellular redox balance. 3. **Drug Metabolism:** UGT2B4 plays a crucial role in the metabolism of various drugs, including aspirin, which is conjugated by this enzyme to facilitate its excretion. **Functions:** UGT2B4 has several functions, including: 1. **Detoxification:** UGT2B4 helps eliminate xenobiotics and endogenous substances from the body, protecting against toxicity and promoting metabolic homeostasis. 2. **Regulation of Hormone Metabolism:** UGT2B4 is involved in the conjugation and metabolism of hormones, such as estrogen, which regulates reproductive and developmental processes. 3. **Maintenance of Cellular Homeostasis:** UGT2B4 contributes to the regulation of cellular redox balance and the maintenance of cellular homeostasis. **Clinical Significance:** UGT2B4 has significant clinical implications, including: 1. **Aspirin Tolerance:** Variations in UGT2B4 expression and function can influence aspirin tolerance, with reduced activity leading to increased risk of cardiovascular events. 2. **Hormone Metabolism Disorders:** UGT2B4 is involved in the metabolism of hormones, such as estrogen, which is essential for reproductive health. Abnormalities in UGT2B4 function can lead to hormone-related disorders, including infertility and cancer. 3. **Cancer Prevention:** UGT2B4's role in detoxifying carcinogens and metabolizing hormone-related compounds makes it a potential target for cancer prevention strategies. In conclusion, UGT2B4 is a vital enzyme involved in the phase II conjugation of compounds, playing a crucial role in detoxification, hormone metabolism, and cellular homeostasis. Its clinical significance is evident in its impact on aspirin tolerance, hormone-related disorders, and cancer prevention. Further research is necessary to fully elucidate the functions and clinical implications of UGT2B4, highlighting its potential as a therapeutic target for various diseases.

Genular Protein ID: 1654798283

Symbol: UD2B4_HUMAN

Name: HLUG25

UniProtKB Accession Codes:

P06133 A6NCP7 B4DT75 G5E9X8 O60731 O60867 O75614 P36538 Q1HBF9 Q6QQX7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 30 EC 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 3 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3109396

Title: Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA.

PubMed ID: 3109396

DOI: 10.1042/bj2420581

PubMed ID: 8333863

Title: cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.

PubMed ID: 8333863

DOI: 10.1006/bbrc.1993.1847

PubMed ID: 10376768

Title: Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene.

PubMed ID: 10376768

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18177842

Title: Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation.

PubMed ID: 18177842

DOI: 10.1016/j.bcp.2007.11.008

PubMed ID: 18719240

Title: The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

PubMed ID: 18719240

DOI: 10.1124/dmd.108.022731

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23288867

Title: Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.

PubMed ID: 23288867

DOI: 10.1124/dmd.112.049072

Sequence Information:

  • Length: 528
  • Mass: 60513
  • Checksum: 6B45E6769971A078
  • Sequence:
    • MSMKWTSALL LIQLSCYFSS GSCGKVLVWP TEFSHWMNIK TILDELVQRG HEVTVLASSA 
SISFDPNSPS TLKFEVYPVS LTKTEFEDII KQLVKRWAEL PKDTFWSYFS QVQEIMWTFN 
DILRKFCKDI VSNKKLMKKL QESRFDVVLA DAVFPFGELL AELLKIPFVY SLRFSPGYAI 
EKHSGGLLFP PSYVPVVMSE LSDQMTFIER VKNMIYVLYF EFWFQIFDMK KWDQFYSEVL 
GRPTTLSETM AKADIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG 
ENGVVVFSLG SMVSNTSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN TRLYKWIPQN 
DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP DNIAHMKAKG AAVSLDFHTM 
SSTDLLNALK TVINDPLYKE NAMKLSRIHH DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA 
HDLTWFQYHS LDVTGFLLAC VATVIFIITK CLFCVWKFVR TGKKGKRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.