Details for: WNT8A

Gene ID: 7478

Symbol: WNT8A

Ensembl ID: ENSG00000061492

Description: Wnt family member 8A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0036
    Cell Significance Index: 24.3100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4366
    Cell Significance Index: 5.7300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2525
    Cell Significance Index: 3.6800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2077
    Cell Significance Index: 2.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1874
    Cell Significance Index: 1.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1143
    Cell Significance Index: 4.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1039
    Cell Significance Index: 20.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0868
    Cell Significance Index: 3.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0659
    Cell Significance Index: 1.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0385
    Cell Significance Index: 0.6600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0379
    Cell Significance Index: 0.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0330
    Cell Significance Index: 11.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0265
    Cell Significance Index: 1.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0203
    Cell Significance Index: 4.0300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0190
    Cell Significance Index: 0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0032
    Cell Significance Index: 4.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0020
    Cell Significance Index: 3.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0041
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.1100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0069
    Cell Significance Index: -0.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0122
    Cell Significance Index: -0.1800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0144
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0150
    Cell Significance Index: -3.1700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0152
    Cell Significance Index: -0.1500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0154
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0156
    Cell Significance Index: -2.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0162
    Cell Significance Index: -0.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0172
    Cell Significance Index: -3.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0182
    Cell Significance Index: -2.6400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0195
    Cell Significance Index: -0.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0205
    Cell Significance Index: -0.4400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0209
    Cell Significance Index: -0.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0215
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0230
    Cell Significance Index: -2.4000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0238
    Cell Significance Index: -0.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0243
    Cell Significance Index: -0.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0245
    Cell Significance Index: -0.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0249
    Cell Significance Index: -0.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0250
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0262
    Cell Significance Index: -3.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0267
    Cell Significance Index: -0.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0268
    Cell Significance Index: -1.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0270
    Cell Significance Index: -3.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0270
    Cell Significance Index: -2.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0270
    Cell Significance Index: -0.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0315
    Cell Significance Index: -0.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0323
    Cell Significance Index: -1.8100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0324
    Cell Significance Index: -0.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0336
    Cell Significance Index: -0.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0364
    Cell Significance Index: -0.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0386
    Cell Significance Index: -0.4200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0405
    Cell Significance Index: -0.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0414
    Cell Significance Index: -0.9000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0420
    Cell Significance Index: -0.5600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0474
    Cell Significance Index: -0.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0496
    Cell Significance Index: -1.3300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0502
    Cell Significance Index: -0.5500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0515
    Cell Significance Index: -0.4500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0559
    Cell Significance Index: -0.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0570
    Cell Significance Index: -1.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0580
    Cell Significance Index: -1.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0581
    Cell Significance Index: -2.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0592
    Cell Significance Index: -1.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0594
    Cell Significance Index: -0.8100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0637
    Cell Significance Index: -0.6500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0667
    Cell Significance Index: -0.8100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0682
    Cell Significance Index: -0.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0684
    Cell Significance Index: -1.0100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0700
    Cell Significance Index: -1.4600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0754
    Cell Significance Index: -1.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0812
    Cell Significance Index: -1.6200
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0837
    Cell Significance Index: -0.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0858
    Cell Significance Index: -1.1200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0873
    Cell Significance Index: -0.7900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0898
    Cell Significance Index: -0.4700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0907
    Cell Significance Index: -1.3800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0911
    Cell Significance Index: -1.1500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0917
    Cell Significance Index: -1.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0918
    Cell Significance Index: -2.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0920
    Cell Significance Index: -1.3100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0945
    Cell Significance Index: -1.1300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0958
    Cell Significance Index: -1.9500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0958
    Cell Significance Index: -1.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0969
    Cell Significance Index: -1.4300
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0971
    Cell Significance Index: -1.2200
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0973
    Cell Significance Index: -1.0500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0973
    Cell Significance Index: -0.9800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0983
    Cell Significance Index: -1.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0996
    Cell Significance Index: -2.6200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1030
    Cell Significance Index: -1.3900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1038
    Cell Significance Index: -1.3900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1055
    Cell Significance Index: -1.3500
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1104
    Cell Significance Index: -1.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** WNT8A is a secreted glycoprotein belonging to the Wnt family, which consists of a group of signaling molecules that regulate various cellular processes. The WNT8A gene is located on chromosome 11q24.3 and is highly conserved across species. It encodes a protein that binds to the Frizzled receptor and triggers a canonical Wnt signaling pathway, which is essential for cell fate commitment, differentiation, and survival. WNT8A is also involved in regulating the activity of other signaling pathways, including the canonical Wnt pathway, the TCF/β-catenin pathway, and the MAPK/ERK pathway. **Pathways and Functions** WNT8A is involved in various signaling pathways, including: 1. **Canonical Wnt signaling pathway**: WNT8A binds to the Frizzled receptor, triggering a cascade of downstream events that regulate cell fate commitment, differentiation, and survival. 2. **TCF/β-catenin pathway**: WNT8A regulates the activity of TCF/β-catenin transcription factors, which are essential for cell differentiation and proliferation. 3. **MAPK/ERK pathway**: WNT8A regulates the activity of the MAPK/ERK pathway, which is involved in cell differentiation, survival, and proliferation. 4. **Neural crest cell fate commitment**: WNT8A regulates the fate of neural crest cells, which are essential for the development of the nervous system and other organs. 5. **Retinal development**: WNT8A is involved in regulating retinal development, including the differentiation of retinal cells and the formation of the retina. **Clinical Significance** Dysregulation of WNT8A has been implicated in several diseases, including: 1. **Cancer**: WNT8A overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Developmental disorders**: WNT8A dysregulation has been implicated in developmental disorders, including neural tube defects and congenital heart defects. 3. **Neurological disorders**: WNT8A dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Retinal diseases**: WNT8A dysregulation has been implicated in retinal diseases, including retinitis pigmentosa and age-related macular degeneration. In conclusion, WNT8A is a critical signaling molecule that regulates various cellular processes, including cell fate commitment, differentiation, and survival. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand the role of WNT8A in human health and disease.

Genular Protein ID: 4144817027

Symbol: WNT8A_HUMAN

Name: Protein Wnt-8a

UniProtKB Accession Codes:

Q9H1J5 Q96S51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11408932

Title: Molecular cloning and characterization of human WNT8A.

PubMed ID: 11408932

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

Sequence Information:

  • Length: 351
  • Mass: 38849
  • Checksum: B3432171301C17E5
  • Sequence:
    • MGNLFMLWAA LGICCAAFSA SAWSVNNFLI TGPKAYLTYT TSVALGAQSG IEECKFQFAW 
ERWNCPENAL QLSTHNRLRS ATRETSFIHA ISSAGVMYII TKNCSMGDFE NCGCDGSNNG 
KTGGHGWIWG GCSDNVEFGE RISKLFVDSL EKGKDARALM NLHNNRAGRL AVRATMKRTC 
KCHGISGSCS IQTCWLQLAE FREMGDYLKA KYDQALKIEM DKRQLRAGNS AEGHWVPAEA 
FLPSAEAELI FLEESPDYCT CNSSLGIYGT EGRECLQNSH NTSRWERRSC GRLCTECGLQ 
VEERKTEVIS SCNCKFQWCC TVKCDQCRHV VSKYYCARSP GSAQSLGKGS A

Genular Protein ID: 2887772032

Symbol: D6RF47_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RF47

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 369
  • Mass: 40892
  • Checksum: AF8F9A9B71878843
  • Sequence:
    • MLCCIQCLCL VSPFPTLTPC QGGPHCLIPI HLCLTFSLFG RSVNNFLITG PKAYLTYTTS 
VALGAQSGIE ECKFQFAWER WNCPENALQL STHNRLRSAT RETSFIHAIS SAGVMYIITK 
NCSMGDFENC GCDGSNNGKT GGHGWIWGGC SDNVEFGERI SKLFVDSLEK GKDARALMNL 
HNNRAGRLAV RATMKRTCKC HGISGSCSIQ TCWLQLAEFR EMGDYLKAKY DQALKIEMDK 
RQLRAGNSAE GHWVPAEAFL PSAEAELIFL EESPDYCTCN SSLGIYGTEG RECLQNSHNT 
SRWERRSCGR LCTECGLQVE ERKTEVISSC NCKFQWCCTV KCDQCRHVVS KYYCARSPGS 
AQSLGKGSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.