Details for: WNT8A

Gene ID: 7478

Symbol: WNT8A

Ensembl ID: ENSG00000061492

Description: Wnt family member 8A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.49
    Marker Score: 30402
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.92
    Marker Score: 6140
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.62
    Marker Score: 29783
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.47
    Marker Score: 4288
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 4.12
    Marker Score: 5717
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.59
    Marker Score: 13896
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3174
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2220
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.4
    Marker Score: 1543
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7254
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.08
    Marker Score: 3164
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.06
    Marker Score: 3035
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.89
    Marker Score: 2540
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.75
    Marker Score: 439
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11609
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1169
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.66
    Marker Score: 1254
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 520
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.58
    Marker Score: 992
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.54
    Marker Score: 510
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1040
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.45
    Marker Score: 3802
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.41
    Marker Score: 637
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.41
    Marker Score: 242
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 230
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.31
    Marker Score: 295
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 122.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.27
    Marker Score: 1108
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.27
    Marker Score: 120
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.25
    Marker Score: 217
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 113
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 235
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.2
    Marker Score: 1750
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.17
    Marker Score: 1628.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 347
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.15
    Marker Score: 1391
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.14
    Marker Score: 8461
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 99
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1
    Marker Score: 1013
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1
    Marker Score: 372
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 109
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.09
    Marker Score: 3405
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.08
    Marker Score: 3137
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.08
    Marker Score: 340
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 486
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.07
    Marker Score: 25.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.07
    Marker Score: 118
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.06
    Marker Score: 135
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.06
    Marker Score: 23.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.06
    Marker Score: 837
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.05
    Marker Score: 1044
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.05
    Marker Score: 149
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.05
    Marker Score: 208
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.05
    Marker Score: 356
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.05
    Marker Score: 61

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Other Information

**Key Characteristics** WNT8A is a secreted glycoprotein belonging to the Wnt family, which consists of a group of signaling molecules that regulate various cellular processes. The WNT8A gene is located on chromosome 11q24.3 and is highly conserved across species. It encodes a protein that binds to the Frizzled receptor and triggers a canonical Wnt signaling pathway, which is essential for cell fate commitment, differentiation, and survival. WNT8A is also involved in regulating the activity of other signaling pathways, including the canonical Wnt pathway, the TCF/β-catenin pathway, and the MAPK/ERK pathway. **Pathways and Functions** WNT8A is involved in various signaling pathways, including: 1. **Canonical Wnt signaling pathway**: WNT8A binds to the Frizzled receptor, triggering a cascade of downstream events that regulate cell fate commitment, differentiation, and survival. 2. **TCF/β-catenin pathway**: WNT8A regulates the activity of TCF/β-catenin transcription factors, which are essential for cell differentiation and proliferation. 3. **MAPK/ERK pathway**: WNT8A regulates the activity of the MAPK/ERK pathway, which is involved in cell differentiation, survival, and proliferation. 4. **Neural crest cell fate commitment**: WNT8A regulates the fate of neural crest cells, which are essential for the development of the nervous system and other organs. 5. **Retinal development**: WNT8A is involved in regulating retinal development, including the differentiation of retinal cells and the formation of the retina. **Clinical Significance** Dysregulation of WNT8A has been implicated in several diseases, including: 1. **Cancer**: WNT8A overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Developmental disorders**: WNT8A dysregulation has been implicated in developmental disorders, including neural tube defects and congenital heart defects. 3. **Neurological disorders**: WNT8A dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Retinal diseases**: WNT8A dysregulation has been implicated in retinal diseases, including retinitis pigmentosa and age-related macular degeneration. In conclusion, WNT8A is a critical signaling molecule that regulates various cellular processes, including cell fate commitment, differentiation, and survival. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand the role of WNT8A in human health and disease.

Genular Protein ID: 4144817027

Symbol: WNT8A_HUMAN

Name: Protein Wnt-8a

UniProtKB Accession Codes:

Q9H1J5 Q96S51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11408932

Title: Molecular cloning and characterization of human WNT8A.

PubMed ID: 11408932

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

Sequence Information:

  • Length: 351
  • Mass: 38849
  • Checksum: B3432171301C17E5
  • Sequence:
    • MGNLFMLWAA LGICCAAFSA SAWSVNNFLI TGPKAYLTYT TSVALGAQSG IEECKFQFAW 
ERWNCPENAL QLSTHNRLRS ATRETSFIHA ISSAGVMYII TKNCSMGDFE NCGCDGSNNG 
KTGGHGWIWG GCSDNVEFGE RISKLFVDSL EKGKDARALM NLHNNRAGRL AVRATMKRTC 
KCHGISGSCS IQTCWLQLAE FREMGDYLKA KYDQALKIEM DKRQLRAGNS AEGHWVPAEA 
FLPSAEAELI FLEESPDYCT CNSSLGIYGT EGRECLQNSH NTSRWERRSC GRLCTECGLQ 
VEERKTEVIS SCNCKFQWCC TVKCDQCRHV VSKYYCARSP GSAQSLGKGS A

Genular Protein ID: 2887772032

Symbol: D6RF47_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RF47

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 369
  • Mass: 40892
  • Checksum: AF8F9A9B71878843
  • Sequence:
    • MLCCIQCLCL VSPFPTLTPC QGGPHCLIPI HLCLTFSLFG RSVNNFLITG PKAYLTYTTS 
VALGAQSGIE ECKFQFAWER WNCPENALQL STHNRLRSAT RETSFIHAIS SAGVMYIITK 
NCSMGDFENC GCDGSNNGKT GGHGWIWGGC SDNVEFGERI SKLFVDSLEK GKDARALMNL 
HNNRAGRLAV RATMKRTCKC HGISGSCSIQ TCWLQLAEFR EMGDYLKAKY DQALKIEMDK 
RQLRAGNSAE GHWVPAEAFL PSAEAELIFL EESPDYCTCN SSLGIYGTEG RECLQNSHNT 
SRWERRSCGR LCTECGLQVE ERKTEVISSC NCKFQWCCTV KCDQCRHVVS KYYCARSPGS 
AQSLGKGSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.