Details for: WNT9B

Gene ID: 7484

Symbol: WNT9B

Ensembl ID: ENSG00000158955

Description: Wnt family member 9B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.6889
    Cell Significance Index: 63.0600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.5037
    Cell Significance Index: 17.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.9207
    Cell Significance Index: 13.1900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3150
    Cell Significance Index: 4.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2596
    Cell Significance Index: 37.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1237
    Cell Significance Index: 2.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1027
    Cell Significance Index: 2.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0772
    Cell Significance Index: 1.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0763
    Cell Significance Index: 1.6700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0737
    Cell Significance Index: 1.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0646
    Cell Significance Index: 12.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0382
    Cell Significance Index: 0.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0239
    Cell Significance Index: 1.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0199
    Cell Significance Index: 0.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0171
    Cell Significance Index: 3.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0097
    Cell Significance Index: 3.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0074
    Cell Significance Index: 1.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0028
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0040
    Cell Significance Index: -2.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0087
    Cell Significance Index: -1.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0097
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0116
    Cell Significance Index: -2.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0149
    Cell Significance Index: -1.1500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0158
    Cell Significance Index: -0.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0158
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0167
    Cell Significance Index: -1.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0175
    Cell Significance Index: -2.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0197
    Cell Significance Index: -0.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0203
    Cell Significance Index: -2.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0213
    Cell Significance Index: -0.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0232
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0251
    Cell Significance Index: -0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0251
    Cell Significance Index: -0.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0253
    Cell Significance Index: -0.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0254
    Cell Significance Index: -0.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0269
    Cell Significance Index: -0.8800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0283
    Cell Significance Index: -0.4300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0294
    Cell Significance Index: -0.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0300
    Cell Significance Index: -1.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0309
    Cell Significance Index: -1.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0326
    Cell Significance Index: -2.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0347
    Cell Significance Index: -1.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0374
    Cell Significance Index: -2.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0376
    Cell Significance Index: -0.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0393
    Cell Significance Index: -0.7900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0440
    Cell Significance Index: -0.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0451
    Cell Significance Index: -1.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0461
    Cell Significance Index: -1.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0462
    Cell Significance Index: -2.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0468
    Cell Significance Index: -2.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0478
    Cell Significance Index: -2.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0499
    Cell Significance Index: -0.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0501
    Cell Significance Index: -1.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0502
    Cell Significance Index: -1.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0504
    Cell Significance Index: -1.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0525
    Cell Significance Index: -1.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0529
    Cell Significance Index: -1.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0569
    Cell Significance Index: -1.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0580
    Cell Significance Index: -1.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0587
    Cell Significance Index: -1.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0591
    Cell Significance Index: -0.5600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0624
    Cell Significance Index: -1.2700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0630
    Cell Significance Index: -0.8400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0642
    Cell Significance Index: -1.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0667
    Cell Significance Index: -2.4500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0678
    Cell Significance Index: -0.9400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0680
    Cell Significance Index: -2.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0680
    Cell Significance Index: -1.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0687
    Cell Significance Index: -1.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0703
    Cell Significance Index: -1.7200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0727
    Cell Significance Index: -1.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0775
    Cell Significance Index: -1.3400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0781
    Cell Significance Index: -1.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0786
    Cell Significance Index: -2.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0788
    Cell Significance Index: -1.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0810
    Cell Significance Index: -2.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0820
    Cell Significance Index: -1.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0822
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0841
    Cell Significance Index: -2.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0853
    Cell Significance Index: -2.1300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0862
    Cell Significance Index: -1.2900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0871
    Cell Significance Index: -1.1000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0920
    Cell Significance Index: -1.8400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0928
    Cell Significance Index: -1.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0959
    Cell Significance Index: -2.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0964
    Cell Significance Index: -1.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1002
    Cell Significance Index: -1.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1004
    Cell Significance Index: -1.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WNT9B is a secreted Wnt ligand that belongs to the Wnt family, which consists of approximately 20 proteins that play critical roles in various biological processes. WNT9B is characterized by its ability to bind to Frizzled receptors and co-receptors, triggering the activation of downstream signaling pathways. Notably, WNT9B is highly expressed in various cell types, including hematopoietic stem cells, colon goblet cells, and renal beta-intercalated cells. **Pathways and Functions:** WNT9B is involved in several key signaling pathways, including: 1. **Canonical Wnt Signaling Pathway:** WNT9B activates the canonical Wnt signaling pathway, which regulates cell proliferation, differentiation, and survival. This pathway is critical for the development and maintenance of various tissues, including the kidney and intestine. 2. **Non-canonical Wnt Signaling Pathway:** WNT9B also activates the non-canonical Wnt signaling pathway, which regulates cell migration, polarity, and asymmetric cell division. This pathway is essential for the development of the embryo and the formation of tissues such as the kidney and brain. 3. **Regulation of Stem Cell Maintenance:** WNT9B has been shown to regulate the maintenance of stem cells in various tissues, including the hematopoietic system and the kidney. 4. **Regulation of Cell Fate Commitment:** WNT9B can influence cell fate commitment by regulating the expression of genes involved in differentiation and proliferation. **Clinical Significance:** WNT9B has been implicated in various human diseases, including: 1. **Kidney Disease:** Abnormal WNT9B expression has been linked to kidney disease, including polycystic kidney disease (PKD) and kidney failure. 2. **Cancer:** WNT9B has been shown to be overexpressed in various types of cancer, including colorectal, breast, and prostate cancer. 3. **Neurological Disorders:** WNT9B has been implicated in the development of neurological disorders, including autism and schizophrenia. 4. **Immunological Disorders:** WNT9B has been shown to play a role in the regulation of the immune system, and abnormalities in WNT9B expression have been linked to immunological disorders such as rheumatoid arthritis. In conclusion, WNT9B is a critical regulator of Wnt signaling pathways involved in development, tissue homeostasis, and disease progression. Further research is needed to fully elucidate the mechanisms by which WNT9B regulates these pathways and to explore its potential as a therapeutic target for various human diseases.

Genular Protein ID: 2602242990

Symbol: WNT9B_HUMAN

Name: Protein Wnt-9b

UniProtKB Accession Codes:

O14905 Q6UXT4 Q96Q09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11604992

Title: Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family.

PubMed ID: 11604992

DOI: 10.3892/ijo.19.5.947

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 9441749

Title: Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.

PubMed ID: 9441749

DOI: 10.1006/geno.1997.5041

PubMed ID: 20093360

Title: Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

PubMed ID: 20093360

DOI: 10.1074/jbc.m109.092130

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

Sequence Information:

  • Length: 357
  • Mass: 39001
  • Checksum: CC22162F9D294CB8
  • Sequence:
    • MRPPPALALA GLCLLALPAA AASYFGLTGR EVLTPFPGLG TAAAPAQGGA HLKQCDLLKL 
SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC SLEGRMGLLK RGFKETAFLY 
AVSSAALTHT LARACSAGRM ERCTCDDSPG LESRQAWQWG VCGDNLKYST KFLSNFLGSK 
RGNKDLRARA DAHNTHVGIK AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL 
RYDSAVKVSS ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT 
AGRVCSREAS CSSLCCGRGY DTQSRLVAFS CHCQVQWCCY VECQQCVQEE LVYTCKH

Genular Protein ID: 3421683996

Symbol: E7EPC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EPC3

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 3 GeneTree 1 HGNC 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 329
  • Mass: 35637
  • Checksum: 3280D468FD626662
  • Sequence:
    • MRPPPALALA GLCLLALPAA AASYFGLTGR EVLTPFPGLG TAAAPAQGGA HLKQCDLLKL 
SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC SLEGRMGLLK RGFKETAFLY 
AVSSAALTHT LARACSAGRM ERCTCDDSPG LESRQAWQWG VCGDNLKYST KFLSNFLGSK 
RGNKDLRARA DAHNTHVGIK AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL 
RYDSAVKVSS ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT 
AGWSAVARSQ LITTSTSRIQ AILPSQLPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.