Details for: XPNPEP2

Gene ID: 7512

Symbol: XPNPEP2

Ensembl ID: ENSG00000122121

Description: X-prolyl aminopeptidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.6054
    Cell Significance Index: -2.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 3.8804
    Cell Significance Index: 40.1700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 3.2931
    Cell Significance Index: 27.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.5080
    Cell Significance Index: 37.5800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.2392
    Cell Significance Index: 16.9800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.0197
    Cell Significance Index: 33.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3442
    Cell Significance Index: 38.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1752
    Cell Significance Index: 70.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9282
    Cell Significance Index: -2.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7123
    Cell Significance Index: 11.3000
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.6200
    Cell Significance Index: 3.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4967
    Cell Significance Index: 54.0300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.3482
    Cell Significance Index: 2.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3380
    Cell Significance Index: 23.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2951
    Cell Significance Index: 6.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2843
    Cell Significance Index: 6.1600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2222
    Cell Significance Index: 1.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2113
    Cell Significance Index: 190.8300
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1731
    Cell Significance Index: 1.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1564
    Cell Significance Index: 3.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1206
    Cell Significance Index: 3.2300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.1064
    Cell Significance Index: 0.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0991
    Cell Significance Index: 19.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0842
    Cell Significance Index: 2.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0788
    Cell Significance Index: 15.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0750
    Cell Significance Index: 3.7900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0742
    Cell Significance Index: 1.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0574
    Cell Significance Index: 1.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0538
    Cell Significance Index: 8.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0484
    Cell Significance Index: 0.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0456
    Cell Significance Index: 0.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0333
    Cell Significance Index: 0.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0270
    Cell Significance Index: 2.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0114
    Cell Significance Index: 0.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0050
    Cell Significance Index: 3.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0043
    Cell Significance Index: 0.0900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0041
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0031
    Cell Significance Index: 0.6300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0026
    Cell Significance Index: 0.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0023
    Cell Significance Index: -0.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0047
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0053
    Cell Significance Index: -2.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0058
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0062
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0072
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0086
    Cell Significance Index: -1.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0105
    Cell Significance Index: -1.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0131
    Cell Significance Index: -1.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0143
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0150
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0211
    Cell Significance Index: -2.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0215
    Cell Significance Index: -2.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0219
    Cell Significance Index: -0.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0228
    Cell Significance Index: -2.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0255
    Cell Significance Index: -2.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0256
    Cell Significance Index: -0.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0273
    Cell Significance Index: -3.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0296
    Cell Significance Index: -3.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0305
    Cell Significance Index: -1.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0314
    Cell Significance Index: -0.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0335
    Cell Significance Index: -0.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0348
    Cell Significance Index: -2.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0365
    Cell Significance Index: -1.7000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0396
    Cell Significance Index: -0.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0399
    Cell Significance Index: -2.6800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0446
    Cell Significance Index: -0.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0448
    Cell Significance Index: -0.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0474
    Cell Significance Index: -3.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0488
    Cell Significance Index: -3.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0495
    Cell Significance Index: -2.5700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0506
    Cell Significance Index: -0.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0522
    Cell Significance Index: -2.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0527
    Cell Significance Index: -2.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0538
    Cell Significance Index: -3.0200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0548
    Cell Significance Index: -0.3400
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0564
    Cell Significance Index: -0.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0614
    Cell Significance Index: -0.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0618
    Cell Significance Index: -2.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0619
    Cell Significance Index: -2.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0621
    Cell Significance Index: -1.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0634
    Cell Significance Index: -2.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0652
    Cell Significance Index: -2.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0661
    Cell Significance Index: -1.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0665
    Cell Significance Index: -1.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0710
    Cell Significance Index: -2.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0721
    Cell Significance Index: -2.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0767
    Cell Significance Index: -2.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0790
    Cell Significance Index: -2.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Aminopeptidase activity:** XPNPEP2 exhibits aminopeptidase activity, which involves the hydrolysis of amino acids from the N-terminus of proteins. 2. **Metal ion-dependent:** The enzyme requires metal ions, such as zinc, for its catalytic activity. 3. **Protein processing:** XPNPEP2 is involved in the processing of various proteins, including those involved in immune regulation and cellular signaling. 4. **Cellular localization:** The enzyme is localized to the plasma membrane and extracellular region, suggesting its involvement in cell-cell interactions and protein secretion. **Pathways and Functions:** 1. **Protein synthesis and modification:** XPNPEP2 is involved in the synthesis of GPI-anchored proteins, which are crucial for cell-cell interactions and immune regulation. 2. **Protein degradation:** The enzyme is also involved in the degradation of proteins, which is essential for maintaining protein homeostasis and regulating cellular signaling. 3. **Immune regulation:** XPNPEP2 is expressed in immune cells, suggesting its involvement in immune regulation and the processing of immune-related proteins. 4. **Cellular signaling:** The enzyme is involved in cellular signaling pathways, including those involved in cell growth, differentiation, and survival. **Clinical Significance:** 1. **Immune disorders:** Alterations in XPNPEP2 expression or function may contribute to immune disorders, such as autoimmune diseases and immunodeficiency disorders. 2. **Cancer:** XPNPEP2 may play a role in cancer progression, as it is involved in the processing of proteins involved in cell growth and survival. 3. **Neurological disorders:** The enzyme's involvement in protein processing and degradation may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Gastrointestinal disorders:** XPNPEP2's expression in enterocytes and tuft cells suggests its involvement in gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome. In conclusion, X-Prolyl Aminopeptidase 2 is a critical enzyme involved in protein processing, regulation, and immune function. Further research is necessary to fully elucidate the molecular mechanisms underlying XPNPEP2's functions and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 1507116992

Symbol: XPP2_HUMAN

Name: Xaa-Pro aminopeptidase 2

UniProtKB Accession Codes:

O43895 A0AV16 O75994

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9375790

Title: Cloning and tissue distribution of human membrane-bound aminopeptidase P.

PubMed ID: 9375790

DOI: 10.1016/s0167-4781(97)00126-7

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16175507

Title: A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors.

PubMed ID: 16175507

DOI: 10.1086/496899

PubMed ID: 15361070

Title: Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates.

PubMed ID: 15361070

DOI: 10.1042/bj20040849

PubMed ID: 20625347

Title: Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema.

PubMed ID: 20625347

DOI: 10.1097/fpc.0b013e32833d3acb

PubMed ID: 21898657

Title: A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.

PubMed ID: 21898657

DOI: 10.1002/humu.21579

Sequence Information:

  • Length: 674
  • Mass: 75625
  • Checksum: 75949336EDD0F3B4
  • Sequence:
    • MARAHWGCCP WLVLLCACAW GHTKPVDLGG QDVRNCSTNP PYLPVTVVNT TMSLTALRQQ 
MQTQNLSAYI IPGTDAHMNE YIGQHDERRA WITGFTGSAG TAVVTMKKAA VWTDSRYWTQ 
AERQMDCNWE LHKEVGTTPI VTWLLTEIPA GGRVGFDPFL LSIDTWESYD LALQGSNRQL 
VSITTNLVDL VWGSERPPVP NQPIYALQEA FTGSTWQEKV SGVRSQMQKH QKVPTAVLLS 
ALEETAWLFN LRASDIPYNP FFYSYTLLTD SSIRLFANKS RFSSETLSYL NSSCTGPMCV 
QIEDYSQVRD SIQAYSLGDV RIWIGTSYTM YGIYEMIPKE KLVTDTYSPV MMTKAVKNSK 
EQALLKASHV RDAVAVIRYL VWLEKNVPKG TVDEFSGAEI VDKFRGEEQF SSGPSFETIS 
ASGLNAALAH YSPTKELNRK LSSDEMYLLD SGGQYWDGTT DITRTVHWGT PSAFQKEAYT 
RVLIGNIDLS RLIFPAATSG RMVEAFARRA LWDAGLNYGH GTGHGIGNFL CVHEWPVGFQ 
SNNIAMAKGM FTSIEPGYYK DGEFGIRLED VALVVEAKTK YPGSYLTFEV VSFVPYDRNL 
IDVSLLSPEH LQYLNRYYQT IREKVGPELQ RRQLLEEFEW LQQHTEPLAA RAPDTASWAS 
VLVVSTLAIL GWSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.