Details for: GATD3

Gene ID: 8209

Symbol: GATD3

Ensembl ID: ENSG00000160221

Description: glutamine amidotransferase class 1 domain containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 25.2923
    Cell Significance Index: -13.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.1207
    Cell Significance Index: -8.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3897
    Cell Significance Index: -7.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4251
    Cell Significance Index: 41.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3238
    Cell Significance Index: 22.3000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.1573
    Cell Significance Index: 7.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0304
    Cell Significance Index: 296.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0006
    Cell Significance Index: -2.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4074
    Cell Significance Index: 222.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3731
    Cell Significance Index: 22.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3716
    Cell Significance Index: 9.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3155
    Cell Significance Index: 40.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3016
    Cell Significance Index: 8.6900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2284
    Cell Significance Index: 1.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2262
    Cell Significance Index: 4.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1939
    Cell Significance Index: 8.7900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.1911
    Cell Significance Index: 1.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1842
    Cell Significance Index: 9.5700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1552
    Cell Significance Index: 0.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1394
    Cell Significance Index: 15.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1371
    Cell Significance Index: 2.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0983
    Cell Significance Index: 3.1500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0886
    Cell Significance Index: 0.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0838
    Cell Significance Index: 15.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0710
    Cell Significance Index: 3.3100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0467
    Cell Significance Index: 0.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0364
    Cell Significance Index: 7.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0363
    Cell Significance Index: 5.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0354
    Cell Significance Index: 2.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0284
    Cell Significance Index: 1.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0260
    Cell Significance Index: 0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0208
    Cell Significance Index: 0.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0176
    Cell Significance Index: 2.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0157
    Cell Significance Index: 29.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0145
    Cell Significance Index: 0.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0131
    Cell Significance Index: 0.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0093
    Cell Significance Index: 8.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0066
    Cell Significance Index: 2.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0035
    Cell Significance Index: 4.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0024
    Cell Significance Index: 3.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0035
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0057
    Cell Significance Index: -0.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0083
    Cell Significance Index: -6.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0136
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0143
    Cell Significance Index: -10.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0167
    Cell Significance Index: -1.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0174
    Cell Significance Index: -7.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0174
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0191
    Cell Significance Index: -11.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0193
    Cell Significance Index: -0.4100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0196
    Cell Significance Index: -0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0206
    Cell Significance Index: -3.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0216
    Cell Significance Index: -4.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0276
    Cell Significance Index: -2.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0309
    Cell Significance Index: -3.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0491
    Cell Significance Index: -7.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0563
    Cell Significance Index: -7.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0568
    Cell Significance Index: -11.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0577
    Cell Significance Index: -2.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0637
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0663
    Cell Significance Index: -8.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0714
    Cell Significance Index: -1.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0716
    Cell Significance Index: -2.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0724
    Cell Significance Index: -1.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0732
    Cell Significance Index: -3.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0836
    Cell Significance Index: -2.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0869
    Cell Significance Index: -4.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0916
    Cell Significance Index: -9.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0940
    Cell Significance Index: -7.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1020
    Cell Significance Index: -6.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1060
    Cell Significance Index: -7.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1080
    Cell Significance Index: -4.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1106
    Cell Significance Index: -7.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1172
    Cell Significance Index: -2.0200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1209
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1211
    Cell Significance Index: -5.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1336
    Cell Significance Index: -10.5800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1462
    Cell Significance Index: -1.9500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.1546
    Cell Significance Index: -0.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1623
    Cell Significance Index: -9.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1648
    Cell Significance Index: -4.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1774
    Cell Significance Index: -4.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2044
    Cell Significance Index: -11.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2196
    Cell Significance Index: -8.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2284
    Cell Significance Index: -7.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2339
    Cell Significance Index: -3.0000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2372
    Cell Significance Index: -4.9500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2410
    Cell Significance Index: -2.2300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2435
    Cell Significance Index: -4.2100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2452
    Cell Significance Index: -1.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2521
    Cell Significance Index: -8.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2596
    Cell Significance Index: -8.5000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.2614
    Cell Significance Index: -3.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2652
    Cell Significance Index: -9.2900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2690
    Cell Significance Index: -5.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2697
    Cell Significance Index: -8.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GATD3 is a member of the glutamine amidotransferase class 1 domain containing family, which suggests its involvement in amino acid metabolism and transfer reactions. The gene is significantly expressed in various cell types, including CD4-positive T cells, thymocytes, smooth muscle cells, skeletal muscle satellite cells, and neurons. This widespread expression indicates a potential role in maintaining cellular homeostasis and function. **Pathways and Functions:** GATD3 is primarily associated with the mitochondrion, a crucial organelle involved in energy production and metabolism. The gene's involvement in mitochondrial function suggests that GATD3 may play a role in regulating amino acid metabolism, which is essential for energy production and cellular growth. Furthermore, the protein's association with various cell types and its expression in the central nervous system (CNS) and peripheral nervous system (PNS) imply that GATD3 may be involved in neurotransmitter synthesis and regulation. **Clinical Significance:** The expression of GATD3 in immune cells, such as CD4-positive T cells and memory T cells, suggests that the gene may be involved in immune regulation and response. Alterations in GATD3 expression or function could potentially impact immune function and contribute to the development of autoimmune diseases or immunodeficiencies. Additionally, the gene's association with CNS and PNS neurons implies that GATD3 may be involved in neurological disorders, such as neurodegenerative diseases or neuropathies. In conclusion, the study of GATD3 provides valuable insights into the role of glutamine amidotransferase class 1 domain containing genes in cellular metabolism, immune regulation, and neurological function. Further research is necessary to fully elucidate the functions and clinical significance of GATD3. **Potential Research Directions:** 1. Investigating the role of GATD3 in immune regulation and autoimmune diseases. 2. Exploring the gene's involvement in neurological disorders, such as neurodegenerative diseases or neuropathies. 3. Examining the protein's function in mitochondrial metabolism and energy production. 4. Investigating the gene's expression and regulation in various cell types and tissues. By addressing these research directions, we can gain a deeper understanding of GATD3's role in human health and disease, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 2461384315

Symbol: GAL3A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9205129

Title: Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21.

PubMed ID: 9205129

DOI: 10.1006/geno.1997.4761

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 268
  • Mass: 28170
  • Checksum: FCDE084D43173330
  • Sequence:
  • MAAVRVLVAS RLAAASAFTS LSPGGRTPSQ RAALHLSVPR PAARVALVLS GCGVYDGTEI 
    HEASAILVHL SRGGAEVQIF APDVPQMHVI DHTKGQPSEG ESRNVLTESA RIARGKITDL 
    ANLSAANHDA AIFPGGFGAA KNLSTFAVDG KDCKVNKEVE RVLKEFHQAG KPIGLCCIAP 
    VLAAKVLRGV EVTVGHEQEE GGKWPYAGTA EAIKALGAKH CVKEVVEAHV DQKNKVVTTP 
    AFMCETALHY IHDGIGAMVR KVLELTGK

Genular Protein ID: 3090205502

Symbol: GAL3B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8753807

Title: Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3.

PubMed ID: 8753807

DOI: 10.1006/bbrc.1996.1218

PubMed ID: 8975701

Title: Isolation and characterization of GT335, a novel human gene conserved in Escherichia coli and mapping to 21q22.3.

PubMed ID: 8975701

DOI: 10.1006/geno.1996.0627

PubMed ID: 9150728

Title: Isolation of a human gene (HES1) with homology to an Escherichia coli and a zebrafish protein that maps to chromosome 21q22.3.

PubMed ID: 9150728

DOI: 10.1007/s004390050416

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 268
  • Mass: 28142
  • Checksum: 8BDE027113173497
  • Sequence:
  • MAAVRALVAS RLAAASAFTS LSPGGRTPSQ RAALHLSVPR PAARVALVLS GCGVYDGTEI 
    HEASAILVHL SRGGAEVQIF APDVPQMHVI DHTKGQPSEG ESRNVLTESA RIARGKITDL 
    ANLSAANHDA AIFPGGFGAA KNLSTFAVDG KDCKVNKEVE RVLKEFHQAG KPIGLCCIAP 
    VLAAKVLRGV EVTVGHEQEE GGKWPYAGTA EAIKALGAKH CVKEVVEAHV DQKNKVVTTP 
    AFMCETALHY IHDGIGAMVR KVLELTGK

Genular Protein ID: 590690483

Symbol: F2Z2Q0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 217
  • Mass: 22801
  • Checksum: 65AF60DED1B1A245
  • Sequence:
  • MAAVRVLVAS RLAAASAFTS LSPGGRTPSQ RAALHLSVPR PAARVALVLS GCGVYDGTEI 
    HEASAILVHL SRGGAEVQIF APDVPQMHVI DHTKGQPSEG ESRNVLTESA RIARGKITDL 
    ANLSAANHDA AIFPGGFGAA KNLSTFAVDG KDCKVNKEVE RVLKEFHQAG KPIGCDASTS 
    LPAPAPWWSW NAALCCPGLS CVWCWQGESR TCVGEHQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.