Details for: F8A1

Gene ID: 8263

Symbol: F8A1

Ensembl ID: ENSG00000288722

Description: coagulation factor VIII associated 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6022
    Cell Significance Index: 59.3600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.5456
    Cell Significance Index: 15.9900
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.3075
    Cell Significance Index: 12.3500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7520
    Cell Significance Index: 10.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3209
    Cell Significance Index: 37.4000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.2317
    Cell Significance Index: 2.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2254
    Cell Significance Index: 30.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1922
    Cell Significance Index: 6.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1105
    Cell Significance Index: 14.1700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.1051
    Cell Significance Index: 0.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.1008
    Cell Significance Index: -0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0991
    Cell Significance Index: 17.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0838
    Cell Significance Index: 2.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0549
    Cell Significance Index: 6.7500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.0396
    Cell Significance Index: 0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0348
    Cell Significance Index: 6.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0035
    Cell Significance Index: 1.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0052
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -5.9900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0086
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0133
    Cell Significance Index: -7.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0379
    Cell Significance Index: -6.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0380
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0387
    Cell Significance Index: -8.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0643
    Cell Significance Index: -3.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1032
    Cell Significance Index: -8.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1191
    Cell Significance Index: -7.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1252
    Cell Significance Index: -8.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1468
    Cell Significance Index: -9.0000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1668
    Cell Significance Index: -3.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1713
    Cell Significance Index: -3.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1770
    Cell Significance Index: -6.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1936
    Cell Significance Index: -6.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2039
    Cell Significance Index: -6.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2476
    Cell Significance Index: -4.0100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2568
    Cell Significance Index: -2.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2663
    Cell Significance Index: -7.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2790
    Cell Significance Index: -6.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2918
    Cell Significance Index: -6.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3028
    Cell Significance Index: -5.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3159
    Cell Significance Index: -6.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3211
    Cell Significance Index: -8.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3439
    Cell Significance Index: -7.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3511
    Cell Significance Index: -6.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3519
    Cell Significance Index: -12.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3590
    Cell Significance Index: -18.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3659
    Cell Significance Index: -7.2400
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.3708
    Cell Significance Index: -3.9200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3728
    Cell Significance Index: -6.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3773
    Cell Significance Index: -7.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3811
    Cell Significance Index: -9.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3829
    Cell Significance Index: -6.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4082
    Cell Significance Index: -8.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4284
    Cell Significance Index: -11.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4355
    Cell Significance Index: -17.8500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.4423
    Cell Significance Index: -9.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4722
    Cell Significance Index: -8.0200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.4779
    Cell Significance Index: -7.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4964
    Cell Significance Index: -6.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4984
    Cell Significance Index: -14.6800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.5093
    Cell Significance Index: -5.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5145
    Cell Significance Index: -12.8300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5166
    Cell Significance Index: -6.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5370
    Cell Significance Index: -6.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5392
    Cell Significance Index: -9.2200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.5585
    Cell Significance Index: -4.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5801
    Cell Significance Index: -6.3200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.5823
    Cell Significance Index: -6.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5845
    Cell Significance Index: -8.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5877
    Cell Significance Index: -8.4400
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.5895
    Cell Significance Index: -5.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5964
    Cell Significance Index: -7.1100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.6092
    Cell Significance Index: -7.0100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.6092
    Cell Significance Index: -6.0100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.6118
    Cell Significance Index: -8.2500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.6164
    Cell Significance Index: -9.2200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6179
    Cell Significance Index: -9.1200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6195
    Cell Significance Index: -8.9100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.6209
    Cell Significance Index: -6.7400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6262
    Cell Significance Index: -8.0300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.6339
    Cell Significance Index: -8.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.6378
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.6432
    Cell Significance Index: -8.1000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6437
    Cell Significance Index: -6.7900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.6484
    Cell Significance Index: -8.3300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.6528
    Cell Significance Index: -5.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6597
    Cell Significance Index: -11.0400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.6621
    Cell Significance Index: -7.8600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.6637
    Cell Significance Index: -8.2500
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.6644
    Cell Significance Index: -8.2000
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.6668
    Cell Significance Index: -8.3800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.6797
    Cell Significance Index: -7.4500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.6809
    Cell Significance Index: -8.5000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.6813
    Cell Significance Index: -5.3000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.6865
    Cell Significance Index: -7.9000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.6879
    Cell Significance Index: -9.0100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.6965
    Cell Significance Index: -7.4100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.6995
    Cell Significance Index: -8.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** F8A1 is a gene that shares structural and functional similarities with coagulation factor VIII (F8), a crucial component of the blood coagulation cascade. Notably, F8A1 is specifically associated with the regulation of proteasomal protein catabolic processes, which are essential for maintaining immune cell homeostasis. This gene is significantly expressed in various immune cells, including central memory CD4-positive T cells, alpha-beta T cells, macrophages, B cells, natural killer cells, and transitional stage B cells. **Pathways and Functions:** F8A1 is involved in several key pathways, including: 1. **Negative regulation of proteasomal protein catabolic process:** F8A1 plays a crucial role in regulating the degradation of proteins within the proteasome, a complex responsible for protein breakdown. This process is essential for maintaining immune cell homeostasis and preventing excessive protein degradation. 2. **Early endosome and vesicle cytoskeletal trafficking:** F8A1 is also involved in the regulation of early endosome and vesicle trafficking, which is essential for the proper functioning of immune cells. 3. **Nuclear body and nucleus:** F8A1 is localized to the nucleus and nuclear bodies, where it regulates gene expression and transcription. **Functions:** The functions of F8A1 are multifaceted, including: 1. **Immune cell homeostasis:** F8A1 plays a critical role in maintaining immune cell homeostasis by regulating proteasomal protein catabolic processes. 2. **Antigen presentation:** F8A1 is involved in the regulation of antigen presentation, which is essential for the activation of immune cells. 3. **Inflammation regulation:** F8A1 may also play a role in regulating inflammation, which is a complex process involving the coordinated action of multiple immune cells. **Clinical Significance:** The clinical significance of F8A1 is multifaceted, with potential implications in various immune-related disorders, including: 1. **Autoimmune diseases:** Dysregulation of F8A1 may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** F8A1 may play a role in cancer progression, particularly in the regulation of proteasomal protein catabolic processes. 3. **Immunodeficiency disorders:** F8A1 may also be involved in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, F8A1 is a complex gene that plays a critical role in the regulation of proteasomal protein catabolic processes within immune cells. Further research is necessary to fully elucidate the functions and clinical significance of F8A1, with potential implications in various immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.