Details for: OR1E1

Gene ID: 8387

Symbol: OR1E1

Ensembl ID: ENSG00000180016

Description: olfactory receptor family 1 subfamily E member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 11.5326
    Cell Significance Index: 186.7900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 7.2172
    Cell Significance Index: 123.3700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 5.1975
    Cell Significance Index: 71.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 4.9255
    Cell Significance Index: 63.7400
  • Cell Name: mast cell (CL0000097)
    Fold Change: 4.1884
    Cell Significance Index: 55.1200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4635
    Cell Significance Index: 6.7300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2562
    Cell Significance Index: 3.3600
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1084
    Cell Significance Index: 1.2900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0757
    Cell Significance Index: 0.9200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0734
    Cell Significance Index: 0.9400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0532
    Cell Significance Index: 0.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0464
    Cell Significance Index: 0.7800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0434
    Cell Significance Index: 0.4200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0413
    Cell Significance Index: 0.2600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0404
    Cell Significance Index: 0.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0273
    Cell Significance Index: 0.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0261
    Cell Significance Index: 0.2700
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0183
    Cell Significance Index: 0.2000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0126
    Cell Significance Index: 0.1400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0118
    Cell Significance Index: 0.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0098
    Cell Significance Index: 0.1400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0066
    Cell Significance Index: 0.0700
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.0061
    Cell Significance Index: 0.0700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0054
    Cell Significance Index: 0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0006
    Cell Significance Index: -0.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0009
    Cell Significance Index: -0.0500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0023
    Cell Significance Index: -0.1800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0025
    Cell Significance Index: -0.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0031
    Cell Significance Index: -0.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0032
    Cell Significance Index: -0.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0033
    Cell Significance Index: -0.1200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0037
    Cell Significance Index: -0.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0038
    Cell Significance Index: -0.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0039
    Cell Significance Index: -0.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0043
    Cell Significance Index: -0.1400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0050
    Cell Significance Index: -0.1900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0070
    Cell Significance Index: -0.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0073
    Cell Significance Index: -0.1500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0074
    Cell Significance Index: -0.1100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0074
    Cell Significance Index: -0.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0078
    Cell Significance Index: -0.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0082
    Cell Significance Index: -0.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0088
    Cell Significance Index: -0.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0090
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0094
    Cell Significance Index: -0.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0097
    Cell Significance Index: -0.2100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0104
    Cell Significance Index: -0.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0104
    Cell Significance Index: -0.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0105
    Cell Significance Index: -0.2100
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0105
    Cell Significance Index: -0.0900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0106
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0107
    Cell Significance Index: -0.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0107
    Cell Significance Index: -0.2100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0111
    Cell Significance Index: -0.1200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0118
    Cell Significance Index: -0.1700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0122
    Cell Significance Index: -0.2400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0125
    Cell Significance Index: -0.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0127
    Cell Significance Index: -0.1600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0128
    Cell Significance Index: -0.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0130
    Cell Significance Index: -0.1600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0135
    Cell Significance Index: -0.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0137
    Cell Significance Index: -0.1600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0140
    Cell Significance Index: -0.1800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0143
    Cell Significance Index: -0.2300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0145
    Cell Significance Index: -0.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0146
    Cell Significance Index: -0.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0147
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0151
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0161
    Cell Significance Index: -0.2300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0161
    Cell Significance Index: -0.1700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0162
    Cell Significance Index: -0.1700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0166
    Cell Significance Index: -0.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0169
    Cell Significance Index: -0.2200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0171
    Cell Significance Index: -0.2100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0172
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0173
    Cell Significance Index: -0.2300
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.0174
    Cell Significance Index: -0.2100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0175
    Cell Significance Index: -0.2000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0176
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0177
    Cell Significance Index: -0.1700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0178
    Cell Significance Index: -0.1700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR1E1 is a G protein-coupled receptor (GPCR) that plays a pivotal role in the detection of chemical stimuli, enabling humans to perceive odors. 2. **Cellular Expression:** OR1E1 is widely expressed in hematopoietic stem cells, erythrocytes, and other cell types involved in blood vessel formation and immune response, underscoring its importance in maintaining the integrity of the olfactory system. 3. **Signaling Pathways:** OR1E1 is involved in G protein-coupled receptor signaling pathways, which regulate various cellular processes, including cell proliferation, differentiation, and survival. 4. **Pathway Involvement:** OR1E1 is also implicated in the expression and translocation of olfactory receptors, suggesting a critical role in the development and maintenance of the olfactory system. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR1E1 is responsible for detecting chemical stimuli involved in the perception of smell, enabling humans to distinguish between various odors. 2. **Expression and Translocation of Olfactory Receptors:** OR1E1 plays a crucial role in the expression and translocation of olfactory receptors, ensuring the proper functioning of the olfactory system. 3. **G Protein-Coupled Receptor Signaling Pathways:** OR1E1 is involved in G protein-coupled receptor signaling pathways, regulating various cellular processes, including cell proliferation, differentiation, and survival. 4. **Sensory Perception:** OR1E1 is critical for the sensory perception of smell, enabling humans to detect and differentiate between various chemical stimuli. **Clinical Significance:** 1. **Olfactory Disorders:** OR1E1 dysfunction has been implicated in various olfactory disorders, including anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological Diseases:** OR1E1 has been linked to various neurological diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, highlighting its potential role in neurodegenerative processes. 3. **Cancer:** OR1E1 has been found to be overexpressed in certain types of cancer, suggesting its potential as a biomarker for cancer diagnosis and treatment. 4. **Immune Response:** OR1E1 plays a critical role in the immune response, particularly in the detection of chemical stimuli involved in the perception of smell, highlighting its potential implications in immunological disorders. In conclusion, OR1E1 is a critical gene involved in the detection of chemical stimuli and the expression and translocation of olfactory receptors. Its significant expression in hematopoietic stem cells, erythrocytes, and other cell types highlights its importance in maintaining the integrity of the olfactory system. Further research is necessary to fully elucidate the functions and clinical significance of OR1E1, with potential implications in the diagnosis and treatment of various diseases.

Genular Protein ID: 687814268

Symbol: OR1E1_HUMAN

Name: Olfactory receptor 1E1

UniProtKB Accession Codes:

P30953 O43884 P47882 P47885 Q6IFA9 Q6IFM5 Q9UBJ1 Q9UM60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1370859

Title: Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

PubMed ID: 1370859

DOI: 10.1038/355453a0

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 9500546

Title: Distribution of olfactory receptor genes in the human genome.

PubMed ID: 9500546

DOI: 10.1038/ng0398-243

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 314
  • Mass: 35264
  • Checksum: BA24A1E6F60A208E
  • Sequence:
    • MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPMY 
LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ MYFFLLFGDL ESFLLVAMAY 
DRYVAICFPL HYTAIMSPML CLALVALSWV LTTFHAMLHT LLMARLCFCA DNVIPHFFCD 
MSALLKLAFS DTRVNEWVIF IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST 
CGSHLSVVSL FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA 
LSRVIHQKKT FFSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.